Eric Mick

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Comparative acute efficacy and tolerability of OROS and immediate release formulations of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD at the Massachusetts General Hospital, Boston, MA 02114, USA
    BMC Psychiatry 7:49. 2007
  2. pmc Absence of association with DAT1 polymorphism and response to methylphenidate in a sample of adults with ADHD
    Eric Mick
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 141:890-4. 2006
  3. ncbi Assessing the validity of the Quality of Life Enjoyment and Satisfaction Questionnaire Short Form in adults with ADHD
    Eric Mick
    Massachusetts General Hospital, Pediatric Psychopharmacology Research Unit, Boston MA 02114, USA
    J Atten Disord 11:504-9. 2008
  4. pmc Predictors of ADHD persistence in girls at 5-year follow-up
    Eric Mick
    Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Atten Disord 15:183-92. 2011
  5. pmc Family-based genome-wide association scan of attention-deficit/hyperactivity disorder
    Eric Mick
    Massachusetts General Hospital, 55 Fruit Street Warren 705, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 49:898-905.e3. 2010
  6. pmc Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Department, Massachusetts General Hospital, Boston, MA, USA
    Psychiatry Res 170:199-203. 2009
  7. pmc Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study
    Joseph Biederman
    Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1511-8. 2008
  8. ncbi Is oppositional defiant disorder a meaningful diagnosis in adults? Results from a large sample of adults with ADHD
    Theresa Harpold
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:601-5. 2007
  9. pmc Parsing the familiality of oppositional defiant disorder from that of conduct disorder: a familial risk analysis
    Carter R Petty
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Psychiatr Res 43:345-52. 2009
  10. ncbi How cardinal are cardinal symptoms in pediatric bipolar disorder? An examination of clinical correlates
    Janet Wozniak
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 58:583-8. 2005

Detail Information

Publications95

  1. pmc Comparative acute efficacy and tolerability of OROS and immediate release formulations of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD at the Massachusetts General Hospital, Boston, MA 02114, USA
    BMC Psychiatry 7:49. 2007
    ..The main aim of this study was to compare the safety and efficacy of IR MPH administered three times daily to those of once daily OROS-MPH...
  2. pmc Absence of association with DAT1 polymorphism and response to methylphenidate in a sample of adults with ADHD
    Eric Mick
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 141:890-4. 2006
    ..We failed to identify an association with DAT1 and the response or tolerability of methylphenidate in adults with ADHD...
  3. ncbi Assessing the validity of the Quality of Life Enjoyment and Satisfaction Questionnaire Short Form in adults with ADHD
    Eric Mick
    Massachusetts General Hospital, Pediatric Psychopharmacology Research Unit, Boston MA 02114, USA
    J Atten Disord 11:504-9. 2008
    ..The authors assessed the psychometric properties of the Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-QSF) in adults with ADHD...
  4. pmc Predictors of ADHD persistence in girls at 5-year follow-up
    Eric Mick
    Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Atten Disord 15:183-92. 2011
    ..The main aim of this study was to examine the age-dependent remission from ADHD in girls transitioning through childhood into adolescence and early adulthood...
  5. pmc Family-based genome-wide association scan of attention-deficit/hyperactivity disorder
    Eric Mick
    Massachusetts General Hospital, 55 Fruit Street Warren 705, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 49:898-905.e3. 2010
    ..We have conducted a third, independent, multisite GWAS of DSM-IV-TR ADHD...
  6. pmc Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Department, Massachusetts General Hospital, Boston, MA, USA
    Psychiatry Res 170:199-203. 2009
    ..94) and 5HTTLPR long allele. Our findings suggest that the DRD4 7-repeat allele is associated with a more persistent course of ADHD...
  7. pmc Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study
    Joseph Biederman
    Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1511-8. 2008
    ..Although our results are not fully validated yet, they should motivate further investigation of gender effects in ADHD genetic association studies...
  8. ncbi Is oppositional defiant disorder a meaningful diagnosis in adults? Results from a large sample of adults with ADHD
    Theresa Harpold
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:601-5. 2007
    ..A better understanding of the course, phenomenology, and clinical significance of ODD in adults is needed to better understand therapeutic approaches for this disorder...
  9. pmc Parsing the familiality of oppositional defiant disorder from that of conduct disorder: a familial risk analysis
    Carter R Petty
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Psychiatr Res 43:345-52. 2009
    ..Family risk analysis can provide an improved understanding of the association between attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD), attending to the comorbidity with conduct disorder (CD)...
  10. ncbi How cardinal are cardinal symptoms in pediatric bipolar disorder? An examination of clinical correlates
    Janet Wozniak
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 58:583-8. 2005
    ..The main goal of this study was to test whether the hypothesized cardinal symptom of euphoria results in differences in clinical correlates in bipolar youth ascertained with no a priori assumptions about cardinal symptoms...
  11. pmc The influence of sex on the course and psychiatric correlates of ADHD from childhood to adolescence: a longitudinal study
    Michael C Monuteaux
    Clinical and Research Programs in Pediatric Psychiatry and Adult ADHD, Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Child Psychol Psychiatry 51:233-41. 2010
    ..The purpose of this study was to examine the effect of sex on the course and psychiatric correlates of ADHD from childhood into adolescence...
  12. ncbi A randomized, placebo-controlled trial of OROS methylphenidate in adults with attention-deficit/hyperactivity disorder
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology at the Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 59:829-35. 2006
    ..The objective of this study was to evaluate the safety and efficacy of once-daily OROS methylphenidate (MPH) in the treatment of adults with DSM-IV attention-deficit/hyperactivity disorder (ADHD)...
  13. doi Examination of concordance between maternal and youth reports in the diagnosis of pediatric bipolar disorder
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit Street, Warren 705, Boston, MA 02114, USA
    Bipolar Disord 11:298-306. 2009
    ..To this end we compared discordant (mother positive and youth negative) and concordant (mother and youth positive) cases...
  14. doi New insights into the comorbidity between ADHD and major depression in adolescent and young adult females
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 47:426-34. 2008
    ..The main aim of this study was to evaluate the association between attention-deficit/hyperactivity disorder (ADHD) and major depression (MD) in adolescent and young adult females...
  15. doi A prospective open-label trial of extended-release carbamazepine monotherapy in children with bipolar disorder
    Gagan Joshi
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 20:7-14. 2010
    ..The aim of this study was to evaluate the safety and efficacy of extended release carbamazepine (CBZ-ER) monotherapy in the treatment of pediatric bipolar disorder (BD)...
  16. ncbi Familial risk analyses of attention deficit hyperactivity disorder and substance use disorders
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit St, Warren 705, Boston, MA 02114, USA
    Am J Psychiatry 165:107-15. 2008
    ..A robust and bidirectional comorbidity between attention deficit hyperactivity disorder (ADHD) and psychoactive substance use disorder (alcohol or drug abuse or dependence) has been consistently reported in the extant literature...
  17. pmc Evidence for genetic association of RORB with bipolar disorder
    Casey L McGrath
    Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Psychiatry 9:70. 2009
    ..Here we report association studies between bipolar disorder and single-nucleotide polymorphisms (SNPs) in RORA and RORB...
  18. ncbi Absence of gender differences in pediatric bipolar disorder: findings from a large sample of referred youth
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology of the Child Psychiatry Service, Massachusetts General Hospital, Pediatric Psychopharmacology Unit WACC 725, 15 Parkman Street, Boston, MA 02114, USA
    J Affect Disord 83:207-14. 2004
    ..Because little is known about gender differences in pediatric bipolar disorder, we evaluated whether gender moderates the expression of pediatric bipolar disorder in a large clinical sample...
  19. pmc Relationship of DAT1 and adult ADHD to task-positive and task-negative working memory networks
    Ariel Beth Brown
    Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States
    Psychiatry Res 193:7-16. 2011
    ..Further, we show that DMN suppression is likely linked to DAT1 and to severity of inattention in ADHD. DMN may therefore be a target of DAT1 effects, and lie on the path between the gene and inattention in ADHD...
  20. doi A prospective open-label trial of lamotrigine monotherapy in children and adolescents with bipolar disorder
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA, USA
    CNS Neurosci Ther 16:91-102. 2010
    ..To evaluate the safety and efficacy of lamotrigine monotherapy as an acute treatment of bipolar mood elevation in children with bipolar spectrum disorders...
  21. pmc The longitudinal course of comorbid oppositional defiant disorder in girls with attention-deficit/hyperactivity disorder: findings from a controlled 5-year prospective longitudinal follow-up study
    Joseph Biederman
    Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Dev Behav Pediatr 29:501-7. 2008
    ..However, most of the available information on the subject derives from predominantly male samples. This study evaluated the longitudinal course and impact of comorbid ODD in a large sample of girls with ADHD...
  22. ncbi A double-blind comparison of galantamine hydrogen bromide and placebo in adults with attention-deficit/hyperactivity disorder: a pilot study
    Joseph Biederman
    Clinical and Research Program, Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychopharmacol 26:163-6. 2006
    ..Because of its cholinergic nicotinic mechanism of action, galantamine HBr was hypothesized to have therapeutic activity in the treatment of attention-deficit/hyperactivity disorder (ADHD)...
  23. doi Genetic risk for conduct disorder symptom subtypes in an ADHD sample: specificity to aggressive symptoms
    Michael C Monuteaux
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 48:757-64. 2009
    ..The aim of this study was to examine the role of the COMT and SLC6A4 genes in the risk for CD and its symptomatic subtypes in the context of ADHD...
  24. doi A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHD
    Michael C Monuteaux
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1436-41. 2008
    ..These result support the heterogeneity of ADHD and provides insights as to its underlying pathophysiology...
  25. ncbi Absence of gender effects on attention deficit hyperactivity disorder: findings in nonreferred subjects
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Psychiatry 162:1083-9. 2005
    ..However, because referral bias can affect outcome, these findings require replication in nonreferred groups of ADHD subjects...
  26. ncbi Can bipolar disorder-specific neuropsychological impairments in children be identified?
    Aude Henin
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Cambridge, MA 02138, USA
    J Consult Clin Psychol 75:210-20. 2007
    ..Thus, comorbidity with ADHD may account for many of the neuropsychological deficits observed in children with bipolar disorder...
  27. pmc Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in attention-deficit/hyperactivity disorder
    Ariel B Brown
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Am J Med Genet B Neuropsychiatr Genet 153:365-75. 2010
    ..Alterations in activation of attention and EF networks found previously to be involved in ADHD are likely influenced by SLC6A3 genotype. This genotype may contribute to heterogeneity of brain alterations found within ADHD samples...
  28. pmc Case-control genome-wide association study of attention-deficit/hyperactivity disorder
    Benjamin M Neale
    Center for Human Genetic Research, Massachusettes General Hospital, Boston, MA, USA
    J Am Acad Child Adolesc Psychiatry 49:906-20. 2010
    ..Thus additional genomewide association studies (GWAS) are needed...
  29. ncbi An open-label trial of OROS methylphenidate in adults with late-onset ADHD
    Joseph Biederman
    Joint Program, Pediatric Psychopharmacology Research Office, Massachusetts General Hospital, Boston, MA 02114, USA
    CNS Spectr 11:390-6. 2006
    ..We hypothesized that treatment with oral release osmotic system (OROS) methylphenidate (MPH) will be safe and efficacious for the treatment of adults with late-onset ADHD...
  30. ncbi Is cigarette smoking a gateway to alcohol and illicit drug use disorders? A study of youths with and without attention deficit hyperactivity disorder
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, USA
    Biol Psychiatry 59:258-64. 2006
    ....
  31. doi Is psychopharmacologic treatment associated with neuropsychological deficits in bipolar youth?
    Aude Henin
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, 185 Alewife Brook Pkwy, Suite 2000, Cambridge, MA 02138, USA
    J Clin Psychiatry 70:1178-85. 2009
    ..To evaluate the impact of psychopharmacologic treatments on neuropsychological functioning in bipolar youth...
  32. pmc Atomoxetine increases fronto-parietal functional MRI activation in attention-deficit/hyperactivity disorder: a pilot study
    George Bush
    Harvard Medical School, Department of Psychiatry, Boston, MA 02114, USA
    Psychiatry Res 211:88-91. 2013
    ..These results suggest that ATMX and MPH have similar but not identical brain effects...
  33. ncbi Risperidone for the treatment of affective symptoms in children with disruptive behavior disorder: a post hoc analysis of data from a 6-week, multicenter, randomized, double-blind, parallel-arm study
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
    Clin Ther 28:794-800. 2006
    ..Preliminary data from open-label trials in children suggest that these agents might be effective in treating pediatric bipolar disorder, however...
  34. ncbi Informativeness of maternal reports on the diagnosis of ADHD: an analysis of mother and youth reports
    Joseph Biederman
    Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Atten Disord 10:410-7. 2007
    ..We evaluated correlates of the diagnosis of ADHD in youth by informant source...
  35. doi Comparison of open-label, 8-week trials of olanzapine monotherapy and topiramate augmentation of olanzapine for the treatment of pediatric bipolar disorder
    Janet Wozniak
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Department of Psychiatry at Harvard Medical School, Boston, Massachusetts, USA
    J Child Adolesc Psychopharmacol 19:539-45. 2009
    ..The aim of this study was to test the efficacy and safety of olanzapine + topiramate versus olanzapine monotherapy in the treatment of bipolar disorder (BPD) and treatment-attendant weight gain in children and adolescents...
  36. pmc Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Psychiatry 9:2. 2009
    ..In this report we test for association with genes coding brain-derived neurotrophic factor (BDNF), the serotonin transporter (SLC6A4), and catechol-O-methyltransferase (COMT)...
  37. doi A randomized, single-blind, substitution study of OROS methylphenidate (Concerta) in ADHD adults receiving immediate release methylphenidate
    Thomas J Spencer
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Atten Disord 15:286-94. 2011
    ..The main aim of this study was to examine the efficacy, tolerability, and compliance of an extended-release formulation of methylphenidate (OROS-MPH) in adults with ADHD receiving immediate-release methylphenidate (IR-MPH)...
  38. doi Impact of obsessive-compulsive disorder on the antimanic response to olanzapine therapy in youth with bipolar disorder
    Gagan Joshi
    Pediatric Psychopharmacology Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Bipolar Disord 12:196-204. 2010
    ..To compare antimanic response to olanzapine therapy in youth with bipolar disorder (BPD) based on the status of comorbidity with obsessive-compulsive disorder (OCD)...
  39. ncbi Influence of gender on attention deficit hyperactivity disorder in children referred to a psychiatric clinic
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 159:36-42. 2002
    ..In this study the authors systematically examined the impact of gender on the clinical features of ADHD in a group of children referred to a clinic...
  40. doi Is response to OROS-methylphenidate treatment moderated by treatment with antidepressants or psychiatric comorbidity? A secondary analysis from a large randomized double blind study of adults with ADHD
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Warren, Boston, MA 02114, USA
    CNS Neurosci Ther 18:126-32. 2012
    ....
  41. pmc Parsing the associations between prenatal exposure to nicotine and offspring psychopathology in a nonreferred sample
    Joseph Biederman
    Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Adolesc Health 45:142-8. 2009
    ..The main aim of this study was to disentangle the association between maternal smoking during pregnancy with psychopathological outcomes, adjusting for possible confounders...
  42. ncbi An open-label trial of aripiprazole monotherapy in children and adolescents with bipolar disorder
    Joseph Biederman
    Joint Program in Pediatric Psychopharmacology Research Office, Massachusetts General Hospital, Boston, MA 02114, USA
    CNS Spectr 12:683-9. 2007
    ..Aripiprazole is a novel second-generation antipsychotic approved for the treatment of bipolar disorder in adults but there is no systematic data available in pediatric bipolar disorder...
  43. doi Family based association study of pediatric bipolar disorder and the dopamine transporter gene (SLC6A3)
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1182-5. 2008
    ..These data provide suggestive evidence supporting a role for SLC6A3 in the etiology of pediatric bipolar disorder...
  44. doi Association between attention-deficit/hyperactivity disorder and sleep impairment in adulthood: evidence from a large controlled study
    Craig B H Surman
    Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Cambridge, MA 02138, USA
    J Clin Psychiatry 70:1523-9. 2009
    ..To examine whether sleep impairment is associated with attention-deficit/hyperactivity disorder (ADHD) in adults...
  45. ncbi A prospective open-label treatment trial of ziprasidone monotherapy in children and adolescents with bipolar disorder
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Research Department, 32 Fruit Street, Yawkey Center for Outpatient Care Yaw 6A, Boston, MA 02114, USA
    Bipolar Disord 9:888-94. 2007
    ..To assess the effectiveness and tolerability of ziprasidone for treating pediatric mania...
  46. pmc Familial risk analysis of the association between attention-deficit/hyperactivity disorder and psychoactive substance use disorder in female adolescents: a controlled study
    Joseph Biederman
    Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    J Child Psychol Psychiatry 50:352-8. 2009
    ..However, this literature has been based almost exclusively on male only samples and, therefore, the findings may not generalize to females...
  47. ncbi Functional impairments in adults with self-reports of diagnosed ADHD: A controlled study of 1001 adults in the community
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Yawkey Center for Outpatient Care, Boston, MA 02114, USA
    J Clin Psychiatry 67:524-40. 2006
    ..The objective of this study was to evaluate functional impairments in a nonreferred sample of adults identifying themselves as having been diagnosed with attention-deficit/hyperactivity disorder (ADHD) by a clinician in their community...
  48. ncbi Convergence between the Achenbach youth self-report and structured diagnostic interview diagnoses in ADHD and non-ADHD youth
    Robert Doyle
    Department of Psychiatry, Harvard Medical School, Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:350-2. 2007
    ..These findings indicate that the YSR could serve as a rapid and cost-effective diagnostic tool to identify major psychopathology in high-risk adolescents...
  49. ncbi Heterogeneity of irritability in attention-deficit/hyperactivity disorder subjects with and without mood disorders
    Eric Mick
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Biol Psychiatry 58:576-82. 2005
    ..We hypothesized that irritability is a heterogeneous symptom distinguished by severity and that attending to this heterogeneity would impact the relationship between irritability and bipolar disorder...
  50. ncbi Further evidence of unique developmental phenotypic correlates of pediatric bipolar disorder: findings from a large sample of clinically referred preadolescent children assessed over the last 7 years
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    J Affect Disord 82:S45-58. 2004
    ..A comparison of the prevalence, clinical correlates, and patterns of comorbidity among children with bipolar disorder (BPD) assessed in the early 1990s (1st cohort) with those evaluated over the last 7 years (2nd cohort)...
  51. ncbi Clinical correlates of bipolar disorder in a large, referred sample of children and adolescents
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    J Psychiatr Res 39:611-22. 2005
    ..To compare the prevalence, clinical correlates, and comorbidity among children and adolescents with bipolar disorder (BPD) assessed in the early 1990s (first cohort) with those evaluated over the last 7 years (second cohort)...
  52. ncbi A preliminary meta-analysis of the child behavior checklist in pediatric bipolar disorder
    Eric Mick
    Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:1021-7. 2003
    ..To this end, we conducted a meta-analysis of several studies that have employed the Child Behavior Checklist in the assessment of children with a diagnosis of bipolar disorder...
  53. ncbi A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder
    Thomas Spencer
    Pediatric Psychopharmacology Unit, Psychiatry Service Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Biol Psychiatry 57:456-63. 2005
    ..A previous, pilot study by our group suggested that these results were due to inadequate dosing...
  54. ncbi Open-label, 8-week trial of olanzapine and risperidone for the treatment of bipolar disorder in preschool-age children
    Joseph Biederman
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 58:589-94. 2005
    ..To evaluate short-term safety and efficacy of atypical antipsychotics in a single-site, prospective, open-label, 8-week study of risperidone and olanzapine monotherapy in preschoolers with bipolar disorder (BPD)...
  55. pmc Utility of an abbreviated questionnaire to identify individuals with ADHD at risk for functional impairments
    Joseph Biederman
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Psychiatr Res 42:304-10. 2008
    ....
  56. doi Cardiovascular effects of longer-term, high-dose OROS methylphenidate in adolescents with attention deficit hyperactivity disorder
    Paul Hammerness
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02138, USA
    J Pediatr 155:84-9, 89.e1. 2009
    ..To examine the effects of high doses of extended-release methylphenidate (OROS MPH) on cardiovascular variables in adolescents with attention deficit hyperactivity disorder (ADHD)...
  57. ncbi Young adult outcome of attention deficit hyperactivity disorder: a controlled 10-year follow-up study
    Joseph Biederman
    Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychol Med 36:167-79. 2006
    ..Our objective was to estimate the lifetime prevalence of psychopathology in a sample of youth with and without attention deficit hyperactivity disorder (ADHD) through young adulthood using contemporaneous diagnostic and analytic techniques...
  58. ncbi Current concepts in the validity, diagnosis and treatment of paediatric bipolar disorder
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114 3139, USA
    Int J Neuropsychopharmacol 6:293-300. 2003
    ..The goal of this article is to review our work and the extant literature within this framework to describe the evidence supporting bipolar disorder in children as a valid clinical diagnosis...
  59. doi Functional magnetic resonance imaging of methylphenidate and placebo in attention-deficit/hyperactivity disorder during the multi-source interference task
    George Bush
    Departments of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 65:102-14. 2008
    ..Stimulant medications are effective treatments for ADHD, but their neural effects have not been fully characterized...
  60. doi Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States
    Prog Neuropsychopharmacol Biol Psychiatry 35:466-72. 2011
    ..We conducted a genome-wide association study of blood pressure in an open-label study of the methylphenidate transdermal system (MTS) for the treatment of attention-deficit/hyperactivity disorder (ADHD)...
  61. doi A randomized, 3-phase, 34-week, double-blind, long-term efficacy study of osmotic-release oral system-methylphenidate in adults with attention-deficit/hyperactivity disorder
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychopharmacol 30:549-53. 2010
    ..More work is needed to be conducted with larger samples being followed to study completion to better understand the long-lasting impact of pharmacotherapy for adult attention-deficit/hyperactivity disorder...
  62. doi Response to second generation antipsychotics in youth with comorbid bipolar disorder and autism spectrum disorder
    Gagan Joshi
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, USA
    CNS Neurosci Ther 18:28-33. 2012
    ..To assess the impact of comorbid autism spectrum disorders (ASD) on the response to second-generation antipsychotics (SGA) in pediatric bipolar disorder (BPD)...
  63. ncbi Defining a developmental subtype of bipolar disorder in a sample of nonreferred adults by age at onset
    Eric Mick
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Child Adolesc Psychopharmacol 13:453-62. 2003
    ....
  64. doi Revisiting the association between maternal smoking during pregnancy and ADHD
    Sarah W Ball
    Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA, USA
    J Psychiatr Res 44:1058-62. 2010
    ..The purpose of this study was to evaluate the association between maternal smoking during pregnancy and offspring ADHD, using detailed prospective smoking data and subsequent follow-up data from the Collaborative Perinatal Project (CPP)...
  65. doi Are stimulants effective in the treatment of executive function deficits? Results from a randomized double blind study of OROS-methylphenidate in adults with ADHD
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD at Massachusetts General Hospital, Boston, MA 02114, USA
    Eur Neuropsychopharmacol 21:508-15. 2011
    ..This randomized clinical trial showed that executive function deficits do not moderate the response to methylphenidate and measures of executive function deficits are not associated with response to OROS-MPH...
  66. ncbi Psychopathology in the offspring of parents with bipolar disorder: a controlled study
    Aude Henin
    Pediatric Psychopharmacology Unit and Harvard Bipolar Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02138, USA
    Biol Psychiatry 58:554-61. 2005
    ..To examine the risk for psychopathology in offspring at risk for bipolar disorder and the course of psychiatric disorders in these youth...
  67. doi Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1412-8. 2008
    ..These results should be considered preliminary until replicated in larger adequately powered, controlled samples but do suggest that noradrenergic and possibly glutaminergic genes may be involved with response to methylphenidate...
  68. ncbi Psychopathology in females with attention-deficit/hyperactivity disorder: a controlled, five-year prospective study
    Joseph Biederman
    Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital, 32 Fruit Street, Boston, MA 02114, USA
    Biol Psychiatry 60:1098-105. 2006
    ..This study estimated the lifetime burden of comorbid psychopathology in a large sample of girls with and without ADHD followed up over five years...
  69. ncbi Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology
    Thomas J Spencer
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Ambul Pediatr 7:73-81. 2007
    ....
  70. ncbi Can a subtype of conduct disorder linked to bipolar disorder be identified? Integration of findings from the Massachusetts General Hospital Pediatric Psychopharmacology Research Program
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 53:952-60. 2003
    ..Our data suggest that when BPD and CD co-occur in children, both are correctly diagnosed. In these comorbid cases, CD symptoms should not be viewed as secondary to BPD, and manic symptoms should not be viewed as secondary to CD...
  71. ncbi An open-label trial of risperidone in children and adolescents with bipolar disorder
    Joseph Biederman
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 15:311-7. 2005
    ..The aim of this study was to evaluate the potential of risperidone as a treatment of pediatric bipolar disorder...
  72. ncbi Childhood antecedent disorders to bipolar disorder in adults: a controlled study
    Aude Henin
    Pediatric Psychopharmacology Unit and Bipolar Clinic and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02138, United States
    J Affect Disord 99:51-7. 2007
    ..The aim of the study was to examine antecedent childhood psychiatric disorders in adult patients with bipolar disorder...
  73. ncbi Omega-3 fatty acid monotherapy for pediatric bipolar disorder: a prospective open-label trial
    Janet Wozniak
    Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, Boston, MA 02138, USA
    Eur Neuropsychopharmacol 17:440-7. 2007
    ..To test the effectiveness and safety of omega-3 fatty acids (Omegabrite(R) brand) in the treatment of pediatric bipolar disorder (BPD)...
  74. ncbi The influence of gender in the familial association between ADHD and major depression
    Eric Mick
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    J Nerv Ment Dis 191:699-705. 2003
    ....
  75. ncbi Olanzapine augmentation of fluoxetine for refractory generalized anxiety disorder: a placebo controlled study
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Biol Psychiatry 59:211-5. 2006
    ..We present one of the first randomized controlled trials for refractory GAD, comprising double blind augmentation with olanzapine or placebo for patients remaining symptomatic on fluoxetine...
  76. doi Anxiety and depressive disorders in offspring at high risk for anxiety: a meta-analysis
    Jamie A Micco
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital Harvard Medical School, Suite 2000, Cambridge, MA 02138, USA
    J Anxiety Disord 23:1158-64. 2009
    ..Results suggest that parental anxiety disorders confer significant risk for anxiety and depression in offspring. Additional studies are needed to examine whether there are differences among specific parental anxiety disorders...
  77. ncbi A prospective follow-up study of pediatric bipolar disorder in boys with attention-deficit/hyperactivity disorder
    Joseph Biederman
    WACC 725, Massachusetts General Hospital, Pediatric Psychopharmacology Unit, MGH, 55 Fruit Street, Boston, MA 02114, USA
    J Affect Disord 82:S17-23. 2004
    ....
  78. ncbi Aripiprazole in the treatment of pediatric bipolar disorder: a systematic chart review
    Joseph Biederman
    Pediatric Psychopharmacology Research Office, Massachusetts General Hospital, Boston, MA 02114, USA
    CNS Spectr 10:141-8. 2005
    ..Pediatric bipolar disorder is a serious neuropsychiatric disorder associated with high levels of morbidity and disability...
  79. ncbi Impact of low birth weight on attention-deficit hyperactivity disorder
    Eric Mick
    Department of Psychiatry, Harvard Medical School and Pediatric Psycopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Dev Behav Pediatr 23:16-22. 2002
    ..These results converge with prior studies documenting similar associations and indicate that LBW is an independent risk factor for ADHD. Children with LBW, however, make up a relatively small proportion of children with ADHD...
  80. ncbi Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology
    Thomas J Spencer
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    J Pediatr Psychol 32:631-42. 2007
    ....
  81. ncbi Comparing ADHD in velocardiofacial syndrome to idiopathic ADHD: a preliminary study
    Kevin M Antshel
    SUNY Upstate Medical University, NY, USA
    J Atten Disord 11:64-73. 2007
    ..Children with velocardiofacial syndrome (VCFS), a contiguous deletion syndrome, have an increased prevalence of attention deficit/hyperactivity disorder (ADHD)...
  82. ncbi Case-control study of attention-deficit hyperactivity disorder and maternal smoking, alcohol use, and drug use during pregnancy
    Eric Mick
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, USA
    J Am Acad Child Adolesc Psychiatry 41:378-85. 2002
    ....
  83. ncbi Correlates of ADHD among children in pediatric and psychiatric clinics
    Betsy Busch
    Department of Pediatrics, Tufts University School of Medicine in Boston, USA
    Psychiatr Serv 53:1103-11. 2002
    ..The authors sought to determine whether comorbidity and clinical correlates of ADHD differ among children in these two settings...
  84. ncbi Revisiting the association between attention-deficit/hyperactivity disorder and anxiety disorders: a familial risk analysis
    Ellen B Braaten
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 3139, USA
    Biol Psychiatry 53:93-9. 2003
    ..This study tested competing hypotheses about patterns of familial association between attention-deficit/hyperactivity disorder (ADHD) and anxiety disorders using familial risk analysis methodology...
  85. ncbi Does parental ADHD bias maternal reports of ADHD symptoms in children?
    Stephen V Faraone
    Department of Psychiatry, Harvard Medical School at Massachusetts General Hospital, Boston 02114, USA
    J Consult Clin Psychol 71:168-75. 2003
    ..Results were similar across child gender or referral status. These results do not support the notion that parental ADHD affects maternal reports of offspring ADHD...
  86. ncbi Diagnosing adult attention deficit hyperactivity disorder: are late onset and subthreshold diagnoses valid?
    Stephen V Faraone
    Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    Am J Psychiatry 163:1720-9; quiz 1859. 2006
    ....
  87. ncbi The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies
    Stephen V Faraone
    Medical Genetics Research Program and Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Psychol Med 36:159-65. 2006
    ..This study examined the persistence of attention deficit hyperactivity disorder (ADHD) into adulthood...
  88. ncbi Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: a proton magnetic resonance spectroscopy study
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 163:316-8. 2006
    ....
  89. ncbi A simulated workplace experience for nonmedicated adults with and without ADHD
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, ACC 7, Boston, Massachusetts 02114, USA
    Psychiatr Serv 56:1617-20. 2005
    ..The results of this study suggest that ADHD among adults is associated with significant deficits in performance of workplace tasks, internal experiences, and external observations of core symptoms of ADHD...
  90. pmc Mania, glutamate/glutamine and risperidone in pediatric bipolar disorder: a proton magnetic resonance spectroscopy study of the anterior cingulate cortex
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    J Affect Disord 99:19-25. 2007
    ..In this study, we hypothesized that the children with BPD in need of treatment would have lower Glx/Cr compared with the children with BPD being stably treated with risperidone...
  91. ncbi A systematic chart review of the nature of psychiatric adverse events in children and adolescents treated with selective serotonin reuptake inhibitors
    Timothy E Wilens
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 13:143-52. 2003
    ..To this end we completed a retrospective analysis of medical charts to determine the incidence, nature, and clinical correlates of treatment emergent adverse effects in the behavioral, cognitive, and emotional domains...
  92. ncbi Drug-induced disinhibition in psychiatrically hospitalized children
    Gabrielle A Carlson
    State University of New York at Stony Brook, Stony Brook, New York 11794 8790, USA
    J Child Adolesc Psychopharmacol 13:153-63. 2003
    ..To examine rates and predictors of drug-induced behavioral disinhibition (DIBD) in psychiatrically hospitalized children...
  93. doi Genetics of attention deficit hyperactivity disorder
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Warren 705, 55 Fruit Street, Boston, MA 02114 2622, USA
    Child Adolesc Psychiatr Clin N Am 17:261-84, vii-viii. 2008
    ..These small effects emphasize the need for future candidate gene studies to implement strategies that will provide enough statistical power to detect such small effects...
  94. ncbi Attention-deficit/hyperactivity disorder and sleep
    Eric Mick
    Pediatrics 110:850-2; author reply 850-2. 2002
  95. ncbi Age-dependent expression of attention-deficit/hyperactivity disorder symptoms
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Psychiatr Clin North Am 27:215-24. 2004
    ..or hyperactive/'impulsive) should be considered separately...