James Meigs

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint A controlled trial of web-based diabetes disease management: the MGH diabetes primary care improvement project
    James B Meigs
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 26:750-7. 2003
  2. pmc Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Genet 42:142-8. 2010
  3. ncbi request reprint Association of African genetic ancestry with fasting glucose and HbA1c levels in non-diabetic individuals: the Boston Area Community Health (BACH) Prediabetes Study
    James B Meigs
    Division of General Internal Medicine, Department of Medicine, Massachusetts General Hospital, 50 Staniford St, 9th Floor, Boston, MA, 02114, USA
    Diabetologia 57:1850-8. 2014
  4. pmc Diabetes Risk Perception and Intention to Adopt Healthy Lifest yles Among Primary Care Patients
    Marie France Hivert
    General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:1820-2. 2009
  5. pmc Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms
    Jose M de Miguel-Yanes
    General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes Care 34:121-5. 2011
  6. pmc Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study
    Dhayana Dallmeier
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Heart Study, Framingham, USA
    Diabetol Metab Syndr 4:28. 2012
  7. pmc Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III)
    Jonna L Grimsby
    General Medicine Division, Massachusetts General Hospital, Boston, MA, USA
    BMC Med Genet 13:30. 2012
  8. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
  9. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
  10. pmc Identifying primary care patients at risk for future diabetes and cardiovascular disease using electronic health records
    Marie France Hivert
    General Medicine Division, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    BMC Health Serv Res 9:170. 2009

Collaborators

Detail Information

Publications99

  1. ncbi request reprint A controlled trial of web-based diabetes disease management: the MGH diabetes primary care improvement project
    James B Meigs
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 26:750-7. 2003
    ..To test effects of a web-based decision support tool, the diabetes Disease Management Application (DMA), developed to improve evidence-based management of type 2 diabetes...
  2. pmc Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Genet 42:142-8. 2010
    ..Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09-1.15, P = 4.8 x 10(-18))...
  3. ncbi request reprint Association of African genetic ancestry with fasting glucose and HbA1c levels in non-diabetic individuals: the Boston Area Community Health (BACH) Prediabetes Study
    James B Meigs
    Division of General Internal Medicine, Department of Medicine, Massachusetts General Hospital, 50 Staniford St, 9th Floor, Boston, MA, 02114, USA
    Diabetologia 57:1850-8. 2014
    ....
  4. pmc Diabetes Risk Perception and Intention to Adopt Healthy Lifest yles Among Primary Care Patients
    Marie France Hivert
    General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:1820-2. 2009
    ..To examine perceived risk of developing diabetes in primary care patients...
  5. pmc Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms
    Jose M de Miguel-Yanes
    General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes Care 34:121-5. 2011
    ..To test if knowledge of type 2 diabetes genetic variants improves disease prediction...
  6. pmc Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study
    Dhayana Dallmeier
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Heart Study, Framingham, USA
    Diabetol Metab Syndr 4:28. 2012
    ..abstract:..
  7. pmc Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III)
    Jonna L Grimsby
    General Medicine Division, Massachusetts General Hospital, Boston, MA, USA
    BMC Med Genet 13:30. 2012
    ....
  8. pmc The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports
    L Adrienne Cupples
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S1. 2007
    ....
  9. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
    ..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations...
  10. pmc Identifying primary care patients at risk for future diabetes and cardiovascular disease using electronic health records
    Marie France Hivert
    General Medicine Division, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    BMC Health Serv Res 9:170. 2009
    ..Prevention of diabetes and coronary heart disease (CHD) is possible but identification of at-risk patients for targeting interventions is a challenge in primary care...
  11. pmc Racial differences in long-term adherence to oral antidiabetic drug therapy: a longitudinal cohort study
    Connie M Trinacty
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    BMC Health Serv Res 9:24. 2009
    ..Adherence differences may contribute to health disparities for black diabetes patients, including higher microvascular event rates, greater complication-related disability, and earlier mortality...
  12. pmc Documentation of body mass index and control of associated risk factors in a large primary care network
    Stephanie A Rose
    Division of General Internal Medicine, University of Kentucky, 740 South Limestone Street, Kentucky Clinic K507, Lexington, KY 40536, USA
    BMC Health Serv Res 9:236. 2009
    ..We evaluated current documentation of BMI, and documentation and control of associated risk factors by BMI category, based on electronic health records from a 12-clinic primary care network...
  13. ncbi request reprint PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Obesity (Silver Spring) 14:753-8. 2006
    ..Elevated PAI-1 levels may be associated with an increased risk for diabetes as a marker for underlying endothelial dysfunction rather than by a direct effect of genetically mediated elevated levels...
  14. ncbi request reprint Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease
    James B Meigs
    General Medicine Division, Massachusetts General Hospital, 50 Staniford Street, 9th Floor, Boston, MA 02114, USA
    J Clin Endocrinol Metab 91:2906-12. 2006
    ..Metabolic risk conferred by adiposity may be due to associated risk factor clustering...
  15. ncbi request reprint Hemostatic markers of endothelial dysfunction and risk of incident type 2 diabetes: the Framingham Offspring Study
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Diabetes 55:530-7. 2006
    ..09-1.77). We conclude that in this community-based sample, plasma markers of endothelial dysfunction increased risk of incident diabetes independent of other diabetes risk factors including obesity, insulin resistance, and inflammation...
  16. ncbi request reprint E-selectin genotypes and risk of type 2 diabetes in women
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Obes Res 13:513-8. 2005
    ..04 to 2.81) relative to those with the SS genotype. Apart from an association in this subgroup, we conclude that the E-selectin variants we examined are not important genetic risk factors for type 2 diabetes in women...
  17. ncbi request reprint Fasting and postchallenge glycemia and cardiovascular disease risk: the Framingham Offspring Study
    James B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 25:1845-50. 2002
    ..To test the hypothesis that fasting hyperglycemia (FHG) and 2-h postchallenge glycemia (2hPG) independently increase the risk for cardiovascular disease (CVD)...
  18. ncbi request reprint Impact of insulin resistance on risk of type 2 diabetes and cardiovascular disease in people with metabolic syndrome
    James B Meigs
    Harvard Medical School and the General Medicine Division, Massachusetts General Hospital, 50 Staniford St, 9th Floor, Boston, MA 02114, USA
    Diabetes Care 30:1219-25. 2007
    ..Metabolic syndrome increases the risk for type 2 diabetes and cardiovascular disease (CVD) and may be associated with insulin resistance...
  19. ncbi request reprint Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study
    James B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 30:2529-35. 2007
    ..Systemic oxidative stress causes insulin resistance in rodents. We tested the hypothesis that oxidative stress and insulin resistance are associated in humans...
  20. pmc Genome-wide association with diabetes-related traits in the Framingham Heart Study
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 8:S16. 2007
    ..Susceptibility to type 2 diabetes may be conferred by genetic variants having modest effects on risk. Genome-wide fixed marker arrays offer a novel approach to detect these variants...
  21. pmc Ordered stratification to reduce heterogeneity in linkage to diabetes-related quantitative traits
    James B Meigs
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:2314-22. 2008
    ..Such interactions might also influence trait-locus associations and may be useful to consider in diabetes genome-wide association studies...
  22. pmc Genotype score in addition to common risk factors for prediction of type 2 diabetes
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 359:2208-19. 2008
    ..We tested the hypothesis that knowledge of these loci allows better prediction of risk than knowledge of common phenotypic risk factors alone...
  23. pmc Epidemiology of type 2 diabetes and cardiovascular disease: translation from population to prevention: the Kelly West award lecture 2009
    James B Meigs
    General Internal Medicine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes Care 33:1865-71. 2010
    ..The challenge now is for us to translate these insights into effective strategies for the prevention of the modern epidemic of diabetes and vascular disease...
  24. ncbi request reprint The insulin gene variable number tandem repeat and risk of type 2 diabetes in a population-based sample of families and unrelated men and women
    James B Meigs
    General Medicine Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:1137-43. 2005
    ..These data support the hypothesis that the INS VNTR is a genetic risk factor for type 2 diabetes, with the TT genotype accounting for about 6.6% of cases in the FHS population...
  25. ncbi request reprint Using metabolic syndrome traits for efficient detection of impaired glucose tolerance
    James B Meigs
    General Internal Medicine Unit, Massachusetts General Hospital, 50 Staniford St, 9th Floor, Boston, MA 02114, USA
    Diabetes Care 27:1417-26. 2004
    ..Efficient detection of impaired glucose tolerance (IGT) is needed to implement type 2 diabetes prevention interventions...
  26. ncbi request reprint A genome-wide scan for loci linked to plasma levels of glucose and HbA(1c) in a community-based sample of Caucasian pedigrees: The Framingham Offspring Study
    James B Meigs
    General Internal Medicine and Clinical Epidemiology Units, General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes 51:833-40. 2002
    ....
  27. ncbi request reprint The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging
    James B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, 50 Staniford Street, 9th Floor, Boston, MA 02114, USA
    Diabetes 52:1475-84. 2003
    ....
  28. ncbi request reprint Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study
    J B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 24:1403-10. 2001
    ..We examined relationships between homocysteine levels and features of insulin resistance syndrome (IRS)...
  29. ncbi request reprint Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham Offspring Studies
    James B Meigs
    Department of Medicine, General Medicine Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 52:2160-7. 2003
    ..S. By any criteria, subjects with the metabolic syndrome are more insulin resistant and at increased predicted risk for CHD versus those without the metabolic syndrome...
  30. ncbi request reprint Parental transmission of type 2 diabetes: the Framingham Offspring Study
    J B Meigs
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Diabetes 49:2201-7. 2000
    ..Given equivalent risk ratios for type 2 diabetes, fathers may transmit unique paternal genetic factors of similar strength to maternal environmental factors...
  31. ncbi request reprint Invited commentary: insulin resistance syndrome? Syndrome X? Multiple metabolic syndrome? A syndrome at all? Factor analysis reveals patterns in the fabric of correlated metabolic risk factors
    J B Meigs
    General Internal Medicine Unit, Massachusetts General Hospital, Boston 02114 2698, USA
    Am J Epidemiol 152:908-11; discussion 912. 2000
    ....
  32. ncbi request reprint Epidemiology of the insulin resistance syndrome
    James B Meigs
    General Medicine Division, Massachusetts General Hospital, 50 Staniford Street, 9th Floor, Boston, MA 02114, USA
    Curr Diab Rep 3:73-9. 2003
    ..Identification of the syndrome warrants aggressive interventions known to prevent type 2 diabetes and cardiovascular disease, including weight reduction, increased physical activity, and control of hypertension and dyslipidemia...
  33. ncbi request reprint Apolipoprotein E isoform polymorphisms are not associated with insulin resistance: the Framingham Offspring Study
    J B Meigs
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Diabetes Care 23:669-74. 2000
    ..We examined the relationship between insulin resistance and apo(e) polymorphisms among participants in the Framingham Offspring Study...
  34. ncbi request reprint Sample exchange to compare insulin measurements between the San Antonio Heart Study and the Framingham Offspring Study
    J B Meigs
    The General Medicine Division, Department of Medicine, Massachusetts Hospital and Harvard Medical School, Boston, MA, USA
    J Clin Epidemiol 54:1031-6. 2001
    ..Associated regression curves can be used to calibrate insulin levels to a common reference standard, allowing epidemiology studies to compare levels of insulin and associated risk factors...
  35. ncbi request reprint Hyperinsulinemia, hyperglycemia, and impaired hemostasis: the Framingham Offspring Study
    J B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Institute for Prevention of Cardiovascular Disease, Boston 02114, USA
    JAMA 283:221-8. 2000
    ..Hyperinsulinemia associated with glucose intolerance may increase risk directly, or its effect could be mediated through impaired hemostatic function...
  36. ncbi request reprint Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    JAMA 291:1978-86. 2004
    ..Endothelial dysfunction occurs in diagnosed type 2 diabetes mellitus but may also precede development of diabetes...
  37. ncbi request reprint Longitudinal association of glycemia and microalbuminuria: the Framingham Offspring Study
    James B Meigs
    General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 25:977-83. 2002
    ..To assess current and long-term associations of glycemia with microalbuminuria, a marker of generalized endothelial injury...
  38. ncbi request reprint Risk factors for clinical benign prostatic hyperplasia in a community-based population of healthy aging men
    J B Meigs
    General Medicine Unit, Medical Services, Massachusetts General Hospital and Harvard Medical School, 50 Staniford Street, Boston, MA 02114, USA
    J Clin Epidemiol 54:935-44. 2001
    ..Risk associated with heart disease does not appear to be due solely to detection bias or to effects of heart disease medications. A wide variety of other characteristics appear to have no influence on risk for clinical BPH...
  39. ncbi request reprint Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction
    Esther Lopez-Garcia
    Department of Nutrition and the Division of Preventive Medicine, Harvard Medical School, Boston, USA
    Am J Clin Nutr 80:1029-35. 2004
    ..Endothelial dysfunction is one of the mechanisms linking diet and the risk of cardiovascular disease...
  40. ncbi request reprint Phylloquinone intake, insulin sensitivity, and glycemic status in men and women
    Makiko Yoshida
    Jean Mayer USDA Human Nutrition Research Center, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 88:210-5. 2008
    ..Limited evidence suggests that vitamin K may have a beneficial role in glucose homeostasis. No observational data exist on the associations between vitamin K intake and insulin sensitivity...
  41. ncbi request reprint The 2005 Dietary Guidelines for Americans and risk of the metabolic syndrome
    Jeanene J Fogli-Cawley
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 86:1193-201. 2007
    ..The 2005 Dietary Guidelines for Americans Index (DGAI) was created to assess adherence to the dietary recommendations of the 2005 Dietary Guidelines for Americans (DGA) in relation to chronic disease risk...
  42. ncbi request reprint The 2005 Dietary Guidelines for Americans and insulin resistance in the Framingham Offspring Cohort
    Jeanene J Fogli-Cawley
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Diabetes Care 30:817-22. 2007
    ....
  43. ncbi request reprint Risk factors for coronary artery disease in patients with elevated high-density lipoprotein cholesterol
    Doreen DeFaria Yeh
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Cardiol 99:1-4. 2007
    ..25 to 0.99, p = 0.046) than patients with normal HDL levels and CAD. In conclusion, patients with high HDL and CAD had a similar or lower prevalence of traditional CAD risk factors compared with patients with normal HDL levels and CAD...
  44. ncbi request reprint Magnesium intake is related to improved insulin homeostasis in the framingham offspring cohort
    Marcella E Rumawas
    Nutritional Epidemiology Program, JM USDA HNRC at Tufts University, Boston, MA 02111 1524, USA
    J Am Coll Nutr 25:486-92. 2006
    ..Higher dietary intake of magnesium may protect against development of type 2 diabetes. The aim of this study was to examine the association between dietary magnesium intake and metabolic risk factors for diabetes...
  45. pmc Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study
    Elliot S Stolerman
    Center for Human Genetic Research and Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:1971-7. 2008
    ..We set out to confirm the association of ENPP1 K121Q with hyperglycemia, expand this association to insulin resistance traits, and determine whether the association stems from K121Q or another variant in linkage disequilibrium with it...
  46. ncbi request reprint Dietary patterns and the metabolic syndrome in obese and non-obese Framingham women
    Lillian Sonnenberg
    Ambulatory Nutrition Service, Department of Nutrition and Food Services, Massachusetts General Hospital, Boston, MA, USA
    Obes Res 13:153-62. 2005
    ..To examine the relationship between habitual dietary patterns and the metabolic syndrome (MetS) in women and to identify foci for preventive nutrition interventions...
  47. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
    ....
  48. ncbi request reprint HFE genetic variability, body iron stores, and the risk of type 2 diabetes in U.S. women
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, Massachusetts 02115, USA
    Diabetes 54:3567-72. 2005
    ..Our data indicate significant effects of H63D and C282Y on body iron stores and suggest a potential interaction between HFE genotypes and heme iron intake in relation to the risk of type 2 diabetes...
  49. ncbi request reprint Insulin, proinsulin, proinsulin:insulin ratio, and the risk of developing type 2 diabetes mellitus in women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Med 114:438-44. 2003
    ..To assess the associations among baseline levels of fasting insulin and proinsulin, proinsulin:insulin ratio, and the development of type 2 diabetes mellitus in apparently healthy middle-aged women...
  50. pmc Racial differences in long-term self-monitoring practice among newly drug-treated diabetes patients in an HMO
    Connie Mah Trinacty
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Avenue, 6th Floor, Boston, MA 02215, USA
    J Gen Intern Med 22:1506-13. 2007
    ..However, minority patients may encounter barriers to better self-care even within settings where variations in quality of care and insurance are minimized...
  51. ncbi request reprint Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study
    Nicola M McKeown
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:390-8. 2002
    ..The influence of whole grains on cardiovascular disease risk may be mediated through multiple pathways, eg, a reduction in blood lipids and blood pressure, an enhancement of insulin sensitivity, and an improvement in blood glucose control...
  52. pmc Plasma 25-hydroxyvitamin d is associated with markers of the insulin resistant phenotype in nondiabetic adults
    Enju Liu
    Jean Mayer USDA Human Nutrition Research Center on Aging, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    J Nutr 139:329-34. 2009
    ..Among adults without diabetes, vitamin D status was inversely associated with surrogate fasting measures of insulin resistance. These results suggest that vitamin D status may be an important determinant for type 2 diabetes mellitus...
  53. pmc Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study
    Marie France Hivert
    General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 58:750-6. 2009
    ..Using comprehensive linkage disequilibrium mapping, we genotyped tag single nucleotide polymorphisms (SNPs) in RETN and tested associations with plasma resistin levels, risk of diabetes, and glycemic traits...
  54. ncbi request reprint Comparison of hyperglycemia, hypertension, and hypercholesterolemia management in patients with type 2 diabetes
    Richard W Grant
    General Medicine Division, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med 112:603-9. 2002
    ..We compared hyperglycemia management with the management of the cardiovascular disease risk factors hypertension and hypercholesterolemia in a cohort of type 2 diabetes patients...
  55. ncbi request reprint A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets
    Jose C Florez
    Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetes 56:3063-74. 2007
    ..To use genome-wide fixed marker arrays and improved analytical tools to detect genetic associations with type 2 diabetes in a carefully phenotyped human sample...
  56. ncbi request reprint Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction
    Esther Lopez-Garcia
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Nutr 135:562-6. 2005
    ....
  57. ncbi request reprint BMI modifies associations of IL-6 genotypes with insulin resistance: the Framingham Study
    Alan Herbert
    Department of Genetics and Genomics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Obesity (Silver Spring) 14:1454-61. 2006
    ..Because white fat is a major source of IL-6 in resting individuals, we tested the hypothesis that BMI modifies the association among the IL-6 genotype, insulin resistance (IR) (measured using the homeostasis model), and risk of diabetes...
  58. pmc Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
    Benjamin F Voight
    Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA
    Nat Genet 42:579-89. 2010
    ..We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits...
  59. ncbi request reprint Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women
    Esther Lopez-Garcia
    Department of Nutrition, Harvard School of Public Health, Harvard Medical School, USA
    J Nutr 134:1806-11. 2004
    ....
  60. ncbi request reprint Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort
    Nicola M McKeown
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Diabetes Care 27:538-46. 2004
    ..The aim of this study was to examine the relation between carbohydrate-related dietary factors, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort...
  61. pmc Medication adherence and racial differences in A1C control
    Alyce S Adams
    Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 31:916-21. 2008
    ..The purpose of this study was to examine medication adherence and other self-management practices as potential determinants of higher glycemic risk among black relative to white patients...
  62. ncbi request reprint Race differences in long-term diabetes management in an HMO
    Alyce S Adams
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
    Diabetes Care 28:2844-9. 2005
    ..We examined race differences in diabetes outcomes over 4-8 years in a single HMO...
  63. ncbi request reprint Inflammatory markers and risk of developing type 2 diabetes in women
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 53:693-700. 2004
    ..001). These data support the role of inflammation in the pathogenesis of type 2 diabetes. Elevated CRP levels are a strong independent predictor of type 2 diabetes and may mediate associations of TNF-alphaR2 and IL-6 with type 2 diabetes...
  64. pmc Cross-sectional association of dietary patterns with insulin-resistant phenotypes among adults without diabetes in the Framingham Offspring Study
    Enju Liu
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Br J Nutr 102:576-83. 2009
    ....
  65. ncbi request reprint Nutritional risk and the metabolic syndrome in women: opportunities for preventive intervention from the Framingham Nutrition Study
    Barbara E Millen
    Department of Family Medicine and the Graduate Medical Sciences Division, Boston University School of Medicine, Boston, MA, USA
    Am J Clin Nutr 84:434-41. 2006
    ..Diet is recognized as a key factor in the cause and management of the metabolic syndrome (MetS). However, policies to guide preventive clinical nutrition interventions of the condition are limited...
  66. pmc Resistin, adiponectin, and risk of heart failure the Framingham offspring study
    David S Frankel
    Department of Medicine, Massachusetts General Hospital, Boston, 02114, USA
    J Am Coll Cardiol 53:754-62. 2009
    ..We tested the association of the adipokines resistin and adiponectin with incident heart failure...
  67. pmc Health care resource utilization associated with a diabetes center and a general medicine clinic
    Elbert S Huang
    General Medicine Division, University of Chicago, Chicago, Illinoos 60637, USA
    J Gen Intern Med 19:28-35. 2004
    ..We compared the health care utilization associated with a diabetes center (DC) and a general medicine clinic (GMC)...
  68. pmc Indexes of kidney function and coronary artery and abdominal aortic calcium (from the Framingham Offspring Study)
    Nisha I Parikh
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 102:440-3. 2008
    ..Neither cysC nor MA was significantly associated with AAC in age- and gender- or multivariable-adjusted models. In conclusion, CKD, cysC, and MA are not associated with CAC or AAC when accounting for cardiovascular disease risk factors...
  69. pmc Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study
    Enju Liu
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 91:1627-33. 2010
    ..Accumulating evidence suggests that vitamin D is involved in the development of type 2 diabetes (T2D)...
  70. pmc Cross-sectional associations between abdominal and thoracic adipose tissue compartments and adiponectin and resistin in the Framingham Heart Study
    Shilpa H Jain
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 32:903-8. 2009
    ....
  71. ncbi request reprint Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Circulation 113:2914-8. 2006
    ..Recent studies indicate that the prevalence of type 2 diabetes mellitus is increasing in the United States; less is known about trends in the incidence of type 2 diabetes mellitus...
  72. pmc Mapping quantitative traits in unselected families: algorithms and examples
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Genet Epidemiol 33:617-27. 2009
    ..We demonstrate our methods on simulated data and on fasting insulin, a quantitative trait measured in the Framingham Heart Study...
  73. pmc Confounding by dietary patterns of the inverse association between alcohol consumption and type 2 diabetes risk
    Fumiaki Imamura
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging and the Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA
    Am J Epidemiol 170:37-45. 2009
    ..The data suggest that alcohol intake, not dietary patterns associated with alcohol intake, is responsible for the observed inverse association with type 2 diabetes mellitus risk...
  74. pmc Arterial stiffness in mild-to-moderate CKD
    Ashish Upadhyay
    Renal Section, Boston Medical Center and Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:2044-53. 2009
    ..Baseline arterial measures did not associate with incident CKD or incident microalbuminuria. In summary, arterial stiffness correlates with albuminuria but not with mild-to-moderate CKD...
  75. ncbi request reprint Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men
    Cuilin Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Diabetes 55:2645-8. 2006
    ..48-fold increased risk (P < 10(-16)). Our findings confirm that the TCF7L2 gene represents an important locus for predicting inherited susceptibility to type 2 diabetes...
  76. ncbi request reprint Genome-wide linkage analysis to urinary microalbuminuria in a community-based sample: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Kidney Int 67:70-4. 2005
    ..Microalbuminuria is a powerful risk factor for cardiovascular disease. It is not known whether genetic factors play a role in the expression of microalbuminuria in population-based samples...
  77. ncbi request reprint Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women
    Christos S Mantzoros
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA and Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 84:328-35. 2006
    ....
  78. ncbi request reprint Circulating adiponectin levels are associated with better glycemic control, more favorable lipid profile, and reduced inflammation in women with type 2 diabetes
    Christos S Mantzoros
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, ST 816, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 90:4542-8. 2005
    ..Low adiponectin levels, by regulating insulin resistance and metabolic profile, may contribute to the markedly increased risk of atherosclerosis in diabetic subjects...
  79. ncbi request reprint Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetes
    Asli Memisoglu
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Diabetes Care 26:2915-7. 2003
    ..To determine whether the Pro12Ala polymorphism in the PPARgamma gene was associated with risk of type 2 diabetes in the Nurses' Health Study...
  80. ncbi request reprint Tests of glycemia for the diagnosis of type 2 diabetes mellitus
    R Graham Barr
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Intern Med 137:263-72. 2002
    ..The glycemic threshold for type 2 diabetes should be established by cost-effectiveness analysis. The clinical diagnosis of diabetes mellitus could be streamlined by incorporation of hemoglobin A1c into established criteria...
  81. ncbi request reprint Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus
    Peter W F Wilson
    The NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
    Circulation 112:3066-72. 2005
    ..The objective was to investigate risk for CVD, CHD, and T2DM according to metabolic syndrome traits...
  82. ncbi request reprint Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study
    Karla M Pou
    Division of Endocrinology, Metabolism, and Diabetes, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 116:1234-41. 2007
    ..Excess adiposity is associated with greater systemic inflammation. Whether visceral adiposity is more proinflammatory than subcutaneous abdominal adiposity is unclear...
  83. ncbi request reprint Population-based incidence rates and risk factors for type 2 diabetes in white individuals: the Bruneck study
    Enzo Bonora
    Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
    Diabetes 53:1782-9. 2004
    ....
  84. pmc Dietary pattern, inflammation, and incidence of type 2 diabetes in women
    Matthias B Schulze
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Am J Clin Nutr 82:675-84; quiz 714-5. 2005
    ..Inflammation is considered a key mechanism leading to type 2 diabetes, but dietary exposures that lead to inflammation and diabetes are largely unknown...
  85. ncbi request reprint Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: the Framingham Heart Study
    Johan Arnlov
    Framingham Heart Study, National Heart, Lung and Blood Institute, Bethesda, MD, USA
    Circulation 112:969-75. 2005
    ..Data are limited with regard to the relations of low-grade albuminuria (below the microalbuminuria threshold) and incidence of cardiovascular disease (CVD) events in nondiabetic, nonhypertensive individuals...
  86. ncbi request reprint Low-grade albuminuria and the risks of hypertension and blood pressure progression
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Circulation 111:1370-6. 2005
    ....
  87. pmc Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring
    Wolfgang Lieb
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Hypertension 52:381-6. 2008
    ..In conclusion, serum C-reactive protein concentrations are higher in nonhypertensive offspring of parents with hypertension. These data suggest that inflammation may partly mediate the familial influences on hypertension risk...
  88. ncbi request reprint Increasing cardiovascular disease burden due to diabetes mellitus: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702 5827, USA
    Circulation 115:1544-50. 2007
    ..We tested the hypothesis that the relative burden of CVD attributable to diabetes mellitus (DM) has increased over the past 5 decades...
  89. ncbi request reprint The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study
    Ana Luiza Maia
    Endocrine Division, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Thyroid 17:199-202. 2007
    ..A single nucleotide polymorphism in DIO2 gene (A/G) in humans has been associated with a approximately 20% lower glucose disposal rate and greater insulin resistance in type 2 diabetes (DM2) patients...
  90. pmc Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection
    Renate Schnabel
    National Heart Lung and Blood Institute Framingham Study, Framingham, Mass, USA
    Hypertension 51:1651-7. 2008
    ..Additional studies are needed to determine whether variation in inflammatory marker genes is associated with tonometry measures...
  91. ncbi request reprint Insulin resistance as estimated by homeostasis model assessment predicts incident symptomatic cardiovascular disease in caucasian subjects from the general population: the Bruneck study
    Enzo Bonora
    Endocrinologia e Malattie del Metabolismo, Ospedale Maggiore, Piazzale Stefani 1, 37126 Verona, Italy
    Diabetes Care 30:318-24. 2007
    ....
  92. pmc Use of alternative thresholds defining insulin resistance to predict incident type 2 diabetes mellitus and cardiovascular disease
    Martin K Rutter
    Cardiovascular Research Group, Division of Cardiovascular and Endocrine Sciences, University of Manchester, and The Manchester Diabetes Centre, Manchester Royal Infirmary, Manchester, United Kingdom
    Circulation 117:1003-9. 2008
    ....
  93. doi request reprint Impact of impaired fasting glucose on cardiovascular disease: the Framingham Heart Study
    Yamini S Levitzky
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    J Am Coll Cardiol 51:264-70. 2008
    ..We sought to determine whether impaired fasting glucose (IFG) predicts cardiovascular disease (CVD) events...
  94. pmc A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study
    Shih Jen Hwang
    National Heart Lung and Blood Institutes, Bethesda, MD, USA
    BMC Med Genet 8:S10. 2007
    ..Many endocrine conditions have strong familial components. We tested for association between the Affymetrix GeneChip Human Mapping 100K single nucleotide polymorphism (SNP) set and measures of kidney function and endocrine traits...
  95. ncbi request reprint Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study
    Erik Ingelsson
    Framingham Heart Study, Boston University School of Medicine, Framingham, MA 01702 5803, USA
    Circulation 116:984-92. 2007
    ..We evaluated the relative contributions of circulating biomarkers representing distinct biological pathways to the incidence of MetS and to longitudinal changes of its constituent risk factors...
  96. ncbi request reprint Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community
    Ravi Dhingra
    Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702 5803, USA
    Circulation 116:480-8. 2007
    ..Consumption of soft drinks has been linked to obesity in children and adolescents, but it is unclear whether it increases metabolic risk in middle-aged individuals...
  97. ncbi request reprint Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 116:39-48. 2007
    ..The incremental utility of measuring both visceral and subcutaneous abdominal adipose tissue (SAT) in association with metabolic risk factors and underlying heritability has not been well described in a population-based setting...
  98. ncbi request reprint C-reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the Framingham Offspring Study
    Martin K Rutter
    Countess of Chester Hospital, Chester, UK
    Circulation 110:380-5. 2004
    ..Inflammation (assessed by C-reactive protein [CRP]) and the metabolic syndrome (MetS) are associated with cardiovascular disease (CVD), but population-based data are limited...

Research Grants6

  1. Phenotype-Genotype Interactions and Type 2 Diabetes
    James Meigs; Fiscal Year: 2005
    ..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
  2. Epidemiology of Precursors to Type 2 Diabetes
    James Meigs; Fiscal Year: 2007
    ..Expanded knowledge of precursors of type 2 diabetes is critical to identify novel approaches for prevention and control of the widening diabetes epidemic. ..
  3. Common Genetic Variation and Diabetes Traits in Framingham
    James Meigs; Fiscal Year: 2009
    ..Expanded knowledge of genes predisposing to type 2 diabetes and their interaction with obesity is critical to identify novel strategies for prevention and control of the worldwide diabetes epidemic. ..
  4. Common Genetic Variation and Diabetes Traits in Framingham
    James B Meigs; Fiscal Year: 2010
    ..Expanded knowledge of genes predisposing to type 2 diabetes and their interaction with obesity is critical to identify novel strategies for prevention and control of the worldwide diabetes epidemic. ..