Benjamin D Medoff

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 168:5278-86. 2002
  2. ncbi request reprint Invasive and noninvasive ventilation in patients with asthma
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Pulmonary and Critical Care Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Respir Care 53:740-48; discussion 749-50. 2008
  3. doi request reprint Fat, fire and muscle--the role of adiponectin in pulmonary vascular inflammation and remodeling
    Benjamin D Medoff
    Pulmonary and Critical Care Unit and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Pulm Pharmacol Ther 26:420-6. 2013
  4. pmc Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension
    M Weng
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, 02114, USA
    Am J Physiol Lung Cell Mol Physiol 301:L927-36. 2011
  5. pmc CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells
    Benjamin D Medoff
    Center for Computational and Integrative Biology, Massachusetts General Hospital, Simches Research Building, Room 7222, 185 Cambridge Street, Boston, MA 02114, USA
    Am J Respir Cell Mol Biol 40:286-94. 2009
  6. pmc Differential requirement for CARMA1 in agonist-selected T-cell development
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02114, USA
    Eur J Immunol 39:78-84. 2009
  7. pmc Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, CNY 8301, 149 13th Street, Charlestown, MA 02129, USA
    Am J Respir Cell Mol Biol 41:397-406. 2009
  8. ncbi request reprint CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 176:7087-95. 2006
  9. ncbi request reprint CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
    J Immunol 176:7272-7. 2006
  10. ncbi request reprint Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Am J Physiol Lung Cell Mol Physiol 290:L170-8. 2006

Research Grants

  1. Role of the Leukotriene B4 Receptors in Asthma
    BENJAMIN MEDOFF; Fiscal Year: 2003
  2. Chemokines in lung transplantation
    BENJAMIN MEDOFF; Fiscal Year: 2007

Collaborators

Detail Information

Publications37

  1. ncbi request reprint IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 168:5278-86. 2002
    ..Our results demonstrate that IP-10, a Th1-type chemokine, is up-regulated in allergic pulmonary inflammation and that this contributes to the airway hyperreactivity and Th2-type inflammation seen in this model of asthma...
  2. ncbi request reprint Invasive and noninvasive ventilation in patients with asthma
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Pulmonary and Critical Care Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Respir Care 53:740-48; discussion 749-50. 2008
    ..Although there is controversy on exactly what is the optimal method for mechanical ventilation in asthma, most experts agree that a general approach based on controlled hypoventilation is ideal...
  3. doi request reprint Fat, fire and muscle--the role of adiponectin in pulmonary vascular inflammation and remodeling
    Benjamin D Medoff
    Pulmonary and Critical Care Unit and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Pulm Pharmacol Ther 26:420-6. 2013
    ..This review aims to synthesize the existing data related to adiponectin's effects on the pulmonary vasculature and to discuss how changes in adiponectin levels might contribute to the development of pulmonary hypertension...
  4. pmc Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension
    M Weng
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, 02114, USA
    Am J Physiol Lung Cell Mol Physiol 301:L927-36. 2011
    ..These results may have implications for the pathogenesis and treatment of PH caused by vascular inflammation...
  5. pmc CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells
    Benjamin D Medoff
    Center for Computational and Integrative Biology, Massachusetts General Hospital, Simches Research Building, Room 7222, 185 Cambridge Street, Boston, MA 02114, USA
    Am J Respir Cell Mol Biol 40:286-94. 2009
    ..In conclusion, these data demonstrate that LPA stimulates TSLP and CCL20 expression in bronchial epithelial cells via CARMA3-mediated NF-kappaB activation...
  6. pmc Differential requirement for CARMA1 in agonist-selected T-cell development
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02114, USA
    Eur J Immunol 39:78-84. 2009
    ..Overall, these data reveal an important but differential role for CARMA1-mediated TCR signaling in T-cell development...
  7. pmc Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, CNY 8301, 149 13th Street, Charlestown, MA 02129, USA
    Am J Respir Cell Mol Biol 41:397-406. 2009
    ..These data provide a possible mechanism for the association between obesity and asthma, and suggest a potential novel link between obesity, inflammatory lung disease, and pulmonary hypertension...
  8. ncbi request reprint CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 176:7087-95. 2006
    ....
  9. ncbi request reprint CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
    J Immunol 176:7272-7. 2006
    ..Furthermore, the data clearly show that CARMA1 is essential for the development of allergic airway inflammation through its role in T lymphocytes, and may provide a novel means to inhibit NF-kappaB for therapy in asthma...
  10. ncbi request reprint Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Am J Physiol Lung Cell Mol Physiol 290:L170-8. 2006
    ..We conclude that BLT1 mediates early recruitment of granulocytes into the airway in response to antigen-antibody interactions in a murine model of acute asthma...
  11. ncbi request reprint Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway
    Seddon Y Thomas
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 179:1901-12. 2007
    ..Our data therefore suggests a role for CCR6 and CXCR3, in conjunction with other chemoattractant receptors, in the recruitment of inflammatory T cells into the BAL during the allergic asthmatic response...
  12. pmc CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 182:623-35. 2009
    ..These data reveal that CD11b(+) myeloid cells in the lung help orchestrate the adaptive immune response in asthma, in part, through the production of STAT6-inducible chemokines and the recruitment of Th2 lymphocytes into the airway...
  13. ncbi request reprint STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells
    Zamaneh Mikhak
    Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 176:4959-67. 2006
    ....
  14. pmc The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans
    Sabina A Islam
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Blood 107:444-53. 2006
    ..Our studies provide novel insights into the LTB(4)-BLT1 lipid chemoattractant pathway in human T-cell responses, and how it may link innate and adaptive immunity...
  15. pmc Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation
    Roshi Afshar
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Allergy Clin Immunol 131:1644-52. 2013
    ..Understanding these aspects of Treg cell biology will be important for harnessing their power in the clinic...
  16. pmc Development of a novel chemokine-mediated in vivo T cell recruitment assay
    Gabriele S V Campanella
    Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Immunol Methods 331:127-39. 2008
    ..This assay will therefore help elucidate a deeper understanding of the chemokine system in vivo...
  17. pmc Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation
    Zamaneh Mikhak
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Allergy Clin Immunol 123:67-73.e3. 2009
    ....
  18. ncbi request reprint Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment
    Andrew M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Immunol 4:982-90. 2003
    ..Our findings show that the LTB4-BLT1 pathway is involved in linking early immune system activation and early effector T cell recruitment...
  19. pmc BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 202:97-110. 2005
    ..This is the first report that describes a pathologic role for BLT1-mediated T lymphocyte recruitment in disease and identifies BLT1 as a potential therapeutic target after lung transplantation...
  20. ncbi request reprint Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activity
    Gabriele S V Campanella
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 177:6991-8. 2006
    ..We therefore propose that oligomerization of IP-10 is required for presentation on endothelial cells and subsequent transendothelial migration, an essential step for lymphocyte recruitment in vivo...
  21. pmc Adiponectin decreases pulmonary arterial remodeling in murine models of pulmonary hypertension
    Meiqian Weng
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Respir Cell Mol Biol 45:340-7. 2011
    ..Hence, the activation of APN-like activity in the pulmonary vasculature may be beneficial in pulmonary hypertension...
  22. pmc CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthma
    Ravisankar A Ramadas
    Pulmonary and Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 187:6197-207. 2011
    ..These data demonstrate a novel role for CARMA1 in effector and memory T cell responses and suggest that therapeutic strategies targeting CARMA1 could help treat chronic inflammatory disorders such as asthma...
  23. ncbi request reprint Cutting edge: Th2 cell trafficking into the allergic lung is dependent on chemoattractant receptor signaling
    Anuja Mathew
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 169:651-5. 2002
    ..These studies conclusively demonstrate that trafficking of Th2 cells into the lung is an active process dependent on chemoattractant receptors...
  24. pmc CXCR3-deficiency protects influenza-infected CCR5-deficient mice from mortality
    Shaza A Fadel
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Eur J Immunol 38:3376-87. 2008
    ..In conclusion, CXCR3-deficiency attenuated the lethal cellular immune response in CCR5(-/-) influenza-infected mice without hindering viral clearance or long-term immunity...
  25. doi request reprint T cell trafficking in allergic asthma: the ins and outs
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Annu Rev Immunol 26:205-32. 2008
    ....
  26. ncbi request reprint Pathogenic T-cell recruitment into the airway in human disease
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Bldg 149 8301, 13th St, Charlestown, MA 02129, USA
    Ann N Y Acad Sci 1062:220-41. 2005
    ..We then speculate on the potential role of these chemokine receptors in the pathogenesis of these disorders and potential novel therapeutic approaches suggested by these data...
  27. pmc Enhanced Tim3 activity improves survival after influenza infection
    JOSALYN L CHO
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Immunol 189:2879-89. 2012
    ..These data suggest that Tim3 could be targeted to prevent immunopathology during influenza infection and demonstrate a potentially novel signaling mechanism used by Tim3 to downregulate the Tc1 response...
  28. pmc Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection
    Edward Seung
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 186:6830-8. 2011
    ..These data suggest that transplantation tolerance can be achieved by reducing the recruitment of some, but not necessarily all, CD8(+) Teff into the target organ and suggest a novel approach to achieve transplant tolerance...
  29. pmc IL-36α exerts pro-inflammatory effects in the lungs of mice
    Ravisankar A Ramadas
    Center for Immunology and Inflammatory Diseases, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    PLoS ONE 7:e45784. 2012
    ....
  30. pmc The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells
    Dawang Zhou
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:20321-6. 2008
    ..The Nore1B/RAPL-Mst1 complex is a negative regulator of naïve T cell proliferation...
  31. pmc Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology
    Lida P Hariri
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Chest 143:64-74. 2013
    ..Bronchoscopic OFDI has been evaluated in vivo, but a lack of correlated histopathology has limited the ability to develop accurate image interpretation criteria...
  32. doi request reprint Variant alveolar lipoproteinosis: a syndrome with distinct clinical and pathological features
    Michiya Nishino
    Pathology Service Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Pathol Int 61:509-17. 2011
    ....
  33. pmc 18F-FDG uptake rate is a biomarker of eosinophilic inflammation and airway response in asthma
    R Scott Harris
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Nucl Med 52:1713-20. 2011
    ..Methods to noninvasively assess these relationships in human subjects are needed. We sought to determine whether (18)F-FDG uptake rate (K(i), min(-1)) could serve as a biomarker of eosinophilic inflammation and local lung function...
  34. doi request reprint Dedifferentiation of committed epithelial cells into stem cells in vivo
    Purushothama Rao Tata
    1 Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA 2 Departments of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts 02114, USA 3 Department of Internal Medicine, Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA 4 Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA
    Nature 503:218-23. 2013
    ..This capacity of committed cells to dedifferentiate into stem cells may have a more general role in the regeneration of many tissues and in multiple disease states, notably cancer. ..
  35. pmc The role of CARMA1 in T cells
    Marly I Roche
    Pulmonary and Critical Care Unit and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Crit Rev Immunol 33:219-43. 2013
    ..Thus, comprehensively defining its mechanisms of action and regulation could reveal novel therapeutic targets for T-cell-mediated diseases and lymphoproliferative disorders...
  36. ncbi request reprint Case records of the Massachusetts General Hospital. Case 17-2005. A 22-year-old woman with back and leg pain and respiratory failure
    Benjamin D Medoff
    Pulmonary and Critical Care Unit, Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, USA
    N Engl J Med 352:2425-34. 2005
  37. pmc Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography
    Claudio Vinegoni
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Opt Lett 35:1088-90. 2010
    ....

Research Grants2

  1. Role of the Leukotriene B4 Receptors in Asthma
    BENJAMIN MEDOFF; Fiscal Year: 2003
    ..Repeat experiments in the presence of a BLTR2 antagonist will also allow characterization of the role of this receptor in asthma. ..
  2. Chemokines in lung transplantation
    BENJAMIN MEDOFF; Fiscal Year: 2007
    ..abstract_text> ..