Research Topics
Genomes and Genes
| Benjamin D MedoffSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthmaBenjamin D Medoff
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Immunol 168:5278-86. 2002..Our results demonstrate that IP-10, a Th1-type chemokine, is up-regulated in allergic pulmonary inflammation and that this contributes to the airway hyperreactivity and Th2-type inflammation seen in this model of asthma...- Invasive and noninvasive ventilation in patients with asthmaBenjamin D Medoff
Center for Immunology and Inflammatory Diseases, Pulmonary and Critical Care Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
Respir Care 53:740-48; discussion 749-50. 2008..Although there is controversy on exactly what is the optimal method for mechanical ventilation in asthma, most experts agree that a general approach based on controlled hypoventilation is ideal... 
CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cellsBenjamin D Medoff
Center for Computational and Integrative Biology, Massachusetts General Hospital, Simches Research Building, Room 7222, 185 Cambridge Street, Boston, MA 02114, USA
Am J Respir Cell Mol Biol 40:286-94. 2009..In conclusion, these data demonstrate that LPA stimulates TSLP and CCL20 expression in bronchial epithelial cells via CARMA3-mediated NF-kappaB activation...- Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodelingBenjamin D Medoff
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, CNY 8301, 149 13th Street, Charlestown, MA 02129, USA
Am J Respir Cell Mol Biol 41:397-406. 2009..These data provide a possible mechanism for the association between obesity and asthma, and suggest a potential novel link between obesity, inflammatory lung disease, and pulmonary hypertension... - Differential requirement for CARMA1 in agonist-selected T-cell developmentBenjamin D Medoff
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02114, USA
Eur J Immunol 39:78-84. 2009..Overall, these data reveal an important but differential role for CARMA1-mediated TCR signaling in T-cell development... - Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertensionM Weng
Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, 02114, USA
Am J Physiol Lung Cell Mol Physiol 301:L927-36. 2011..These results may have implications for the pathogenesis and treatment of PH caused by vascular inflammation... - CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and functionBenjamin D Medoff
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
J Immunol 176:7087-95. 2006.... - CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthmaBenjamin D Medoff
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
J Immunol 176:7272-7. 2006..Furthermore, the data clearly show that CARMA1 is essential for the development of allergic airway inflammation through its role in T lymphocytes, and may provide a novel means to inhibit NF-kappaB for therapy in asthma... - Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1Benjamin D Medoff
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Am J Physiol Lung Cell Mol Physiol 290:L170-8. 2006..We conclude that BLT1 mediates early recruitment of granulocytes into the airway in response to antigen-antibody interactions in a murine model of acute asthma... - Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airwaySeddon Y Thomas
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
J Immunol 179:1901-12. 2007..Our data therefore suggests a role for CCR6 and CXCR3, in conjunction with other chemoattractant receptors, in the recruitment of inflammatory T cells into the BAL during the allergic asthmatic response... - CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammationBenjamin D Medoff
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
J Immunol 182:623-35. 2009..These data reveal that CD11b(+) myeloid cells in the lung help orchestrate the adaptive immune response in asthma, in part, through the production of STAT6-inducible chemokines and the recruitment of Th2 lymphocytes into the airway... - STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cellsZamaneh Mikhak
Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Immunol 176:4959-67. 2006.... - The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humansSabina A Islam
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Blood 107:444-53. 2006..Our studies provide novel insights into the LTB(4)-BLT1 lipid chemoattractant pathway in human T-cell responses, and how it may link innate and adaptive immunity... - Development of a novel chemokine-mediated in vivo T cell recruitment assayGabriele S V Campanella
Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Immunol Methods 331:127-39. 2008..This assay will therefore help elucidate a deeper understanding of the chemokine system in vivo... - Leukotriene B4 receptor BLT1 mediates early effector T cell recruitmentAndrew M Tager
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Nat Immunol 4:982-90. 2003..Our findings show that the LTB4-BLT1 pathway is involved in linking early immune system activation and early effector T cell recruitment... - Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammationZamaneh Mikhak
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
J Allergy Clin Immunol 123:67-73.e3. 2009.... - Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activityGabriele S V Campanella
Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
J Immunol 177:6991-8. 2006..We therefore propose that oligomerization of IP-10 is required for presentation on endothelial cells and subsequent transendothelial migration, an essential step for lymphocyte recruitment in vivo... - BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantationBenjamin D Medoff
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
J Exp Med 202:97-110. 2005..This is the first report that describes a pathologic role for BLT1-mediated T lymphocyte recruitment in disease and identifies BLT1 as a potential therapeutic target after lung transplantation... - Adiponectin decreases pulmonary arterial remodeling in murine models of pulmonary hypertensionMeiqian Weng
Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Respir Cell Mol Biol 45:340-7. 2011..Hence, the activation of APN-like activity in the pulmonary vasculature may be beneficial in pulmonary hypertension... - CARMA1 is necessary for optimal T cell responses in a murine model of allergic asthmaRavisankar A Ramadas
Pulmonary and Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Immunol 187:6197-207. 2011..These data demonstrate a novel role for CARMA1 in effector and memory T cell responses and suggest that therapeutic strategies targeting CARMA1 could help treat chronic inflammatory disorders such as asthma... - Cutting edge: Th2 cell trafficking into the allergic lung is dependent on chemoattractant receptor signalingAnuja Mathew
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Immunol 169:651-5. 2002..These studies conclusively demonstrate that trafficking of Th2 cells into the lung is an active process dependent on chemoattractant receptors... - CXCR3-deficiency protects influenza-infected CCR5-deficient mice from mortalityShaza A Fadel
Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Eur J Immunol 38:3376-87. 2008..In conclusion, CXCR3-deficiency attenuated the lethal cellular immune response in CCR5(-/-) influenza-infected mice without hindering viral clearance or long-term immunity... 
T cell trafficking in allergic asthma: the ins and outsBenjamin D Medoff
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Annu Rev Immunol 26:205-32. 2008....- Pathogenic T-cell recruitment into the airway in human diseaseBenjamin D Medoff
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Bldg. 149-8301, 13th St, Charlestown, MA 02129, USA
Ann N Y Acad Sci 1062:220-41. 2005..We then speculate on the potential role of these chemokine receptors in the pathogenesis of these disorders and potential novel therapeutic approaches suggested by these data... - Enhanced Tim3 activity improves survival after influenza infectionJOSALYN L CHO
Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, MA 02114, USA
J Immunol 189:2879-89. 2012..These data suggest that Tim3 could be targeted to prevent immunopathology during influenza infection and demonstrate a potentially novel signaling mechanism used by Tim3 to downregulate the Tc1 response... - Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejectionEdward Seung
Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
J Immunol 186:6830-8. 2011..These data suggest that transplantation tolerance can be achieved by reducing the recruitment of some, but not necessarily all, CD8(+) Teff into the target organ and suggest a novel approach to achieve transplant tolerance... - IL-36α exerts pro-inflammatory effects in the lungs of miceRavisankar A Ramadas
Center for Immunology and Inflammatory Diseases, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
PLoS ONE 7:e45784. 2012.... - The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cellsDawang Zhou
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 105:20321-6. 2008..The Nore1B/RAPL-Mst1 complex is a negative regulator of naïve T cell proliferation... - Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathologyLida P Hariri
Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
Chest 143:64-74. 2013..Bronchoscopic OFDI has been evaluated in vivo, but a lack of correlated histopathology has limited the ability to develop accurate image interpretation criteria... - 18F-FDG uptake rate is a biomarker of eosinophilic inflammation and airway response in asthmaR Scott Harris
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Nucl Med 52:1713-20. 2011..Methods to noninvasively assess these relationships in human subjects are needed. We sought to determine whether (18)F-FDG uptake rate (K(i), min(-1)) could serve as a biomarker of eosinophilic inflammation and local lung function... - Case records of the Massachusetts General Hospital. Case 17-2005. A 22-year-old woman with back and leg pain and respiratory failureBenjamin D Medoff
Pulmonary and Critical Care Unit, Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, USA
N Engl J Med 352:2425-34. 2005 - Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomographyClaudio Vinegoni
Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Opt Lett 35:1088-90. 2010....
Research Grants
- Role of the Leukotriene B4 Receptors in AsthmaBENJAMIN MEDOFF; Fiscal Year: 2003..Repeat experiments in the presence of a BLTR2 antagonist will also allow characterization of the role of this receptor in asthma. ..
- Chemokines in lung transplantationBENJAMIN MEDOFF; Fiscal Year: 2007..abstract_text> ..