Research Topics
| Francisco M MartySummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Treatment of human disseminated strongyloidiasis with a parenteral veterinary formulation of ivermectinFrancisco M Marty
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
Clin Infect Dis 41:e5-8. 2005..To our knowledge, ivermectin levels are reported for the first time in this situation...- Infliximab use in patients with severe graft-versus-host disease and other emerging risk factors of non-Candida invasive fungal infections in allogeneic hematopoietic stem cell transplant recipients: a cohort studyFrancisco M Marty
Division of Infectious Diseases and Hematopoietic Stem Cell Transpalntation Service, Brigham and Women s Hospital and Dana Farber Cancer Instiute, Harvard Medical School, Boston, MA 02115, USA
Blood 102:2768-76. 2003..Pre-emptive systemic antifungal therapy against molds should be considered in patients who develop severe GVHD after HSCT if infliximab is used... 
Role of (1-->3)-beta-D-glucan in the diagnosis of invasive aspergillosisFrancisco M Marty
Division of Infectious Diseases, Brigham and Women s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Med Mycol 47:S233-40. 2009..Factors affecting the production and clearance of BG during IA and other IFD need additional study to further refine its diagnostic utility...- Voriconazole and sirolimus coadministration after allogeneic hematopoietic stem cell transplantationFrancisco M Marty
Division of Infectious Diseases, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
Biol Blood Marrow Transplant 12:552-9. 2006..Sirolimus and voriconazole may be safely coadministered if there is an empiric initial 90% sirolimus dose reduction combined with systematic monitoring of trough levels... 
Emergence of a clinical daptomycin-resistant Staphylococcus aureus isolate during treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitisFrancisco M Marty
Division of Infectious Diseases, Brigham and Women s Hospital, 75 Francis Street, PBB A4, Boston, MA 02115, USA
J Clin Microbiol 44:595-7. 2006..The breakthrough isolate was indistinguishable from pretreatment daptomycin-susceptible isolates by pulsed-field gel electrophoresis. Daptomycin nonsusceptibility was confirmed by MIC and time-kill curve analyses...- Reactivity of (1-->3)-beta-d-glucan assay with commonly used intravenous antimicrobialsFrancisco M Marty
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
Antimicrob Agents Chemother 50:3450-3. 2006..False-positive BG assays may occur when some antimicrobials are administered; however, this needs to be confirmed... - Invasive fungal disease after remote inoculation in transplant recipientsFrancisco M Marty
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Clin Infect Dis 52:e7-10. 2011..Invasive fungal disease resulting from remote inoculation is a distinct syndrome in immunocompromised patients presenting with soft-tissue abnormalities in areas of prior trauma... - Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double-blind, placebo-controlled, randomised trialFrancisco M Marty
Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA
Lancet Infect Dis 11:284-92. 2011..We assessed the safety, tolerability, and antiviral activity of oral maribavir in such patients... - Disseminated trichosporonosis caused by Trichosporon loubieriFrancisco M Marty
Division of Infectious Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Microbiol 41:5317-20. 2003..Trichosporonosis is an emerging invasive fungal infection in immunosuppressed patients; a case of disseminated infection caused by Trichosporon loubieri presented confirms its role as a human pathogen... - Sirolimus-based graft-versus-host disease prophylaxis protects against cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation: a cohort analysisFrancisco M Marty
Division of Infectious Diseases, Boston, MA 02115, USA
Blood 110:490-500. 2007..66; P = .14 and P = .35, respectively). The protective effect of sirolimus-containing GVHD prophylaxis regimens on CMV reactivation should be confirmed in randomized trials... - A targeted peritransplant antifungal strategy for the prevention of invasive fungal disease after lung transplantation: a sequential cohort analysisSophia Koo
Division of Infectious Diseases, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Transplantation 94:281-6. 2012.... - Serum galactomannan and (1->3)-β-D-glucan assays for patients with multiple myeloma and Waldenstrom's macroglobulinemiaNicolas C Issa
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts, USA
J Clin Microbiol 50:1054-6. 2012..1→3)-β-d-glucan assay results were uninterpretable in 24% of patients. Patients with IgG levels of >2,000 mg/dl had higher odds of uninterpretable (1→3)-β-d-glucan results... - How do we manage oral infections in allogeneic stem cell transplantation and other severely immunocompromised patients?Stefan Palmason
Division of Oral Medicine and Dentistry, Brigham and Women s Hospital, 1620 Tremont Street, Boston, MA 02120, USA
Oral Maxillofac Surg Clin North Am 23:579-99, vii. 2011..This article discusses the current knowledge of the most frequent presentations of infections in this patient population and reviews contemporary approaches to prevention, diagnosis, and management... - Seroprotective titers against 2009 H1N1 influenza A virus after vaccination in allogeneic hematopoietic stem cell transplantation recipientsNicolas C Issa
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Biol Blood Marrow Transplant 17:434-8. 2011..11; 95% confidence interval, 0.01-0.97). The vaccine was safe and well tolerated. Strategies are needed to improve the influenza vaccine response in this population, especially those receiving immunotherapy... - Respiratory virus detection in immunocompromised patients with FilmArray respiratory panel compared to conventional methodsSarah P Hammond
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA, USA
J Clin Microbiol 50:3216-21. 2012..The FilmArray respiratory panel assay allowed for increased identification of respiratory viral pathogens in this cohort of immunocompromised patients... - Mortality in hematologic malignancy and hematopoietic stem cell transplant patients with mucormycosis, 2001 to 2009Sarah P Hammond
Division of Infectious Diseases, Brigham and Women s Hospital, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
Antimicrob Agents Chemother 55:5018-21. 2011..04]), as did 12-week mortality (78% in 2001 to 2003 versus 55% in 2004 to 2006 versus 20% in 2007 to 2009 [P = 0.01])... - Evaluation of caspofungin or micafungin as empiric antifungal therapy in adult patients with persistent febrile neutropenia: a retrospective, observational, sequential cohort analysisDavid W Kubiak
Division of Infectious Diseases and Department of Pharmacy, Brigham and Women s Hospital, Boston, Massachusetts 02115 6110, USA
Clin Ther 32:637-48. 2010..Caspofungin is approved in the United States for empiric antifungal therapy for persistent febrile neutropenia (FN). There are limited data about the use of other echinocandins in this setting... - Molecular methods to improve diagnosis and identification of mucormycosisSarah P Hammond
Division of Infectious Diseases, Brigham and Women s Hospital, Dana Farber Cancer Institute, and Harvard Medical School, 4 Boston, Massachusetts 02115, USA
J Clin Microbiol 49:2151-3. 2011..Mucorales PCR is useful for confirmation of the diagnosis of mucormycosis and for further characterization of the infection in cases where cultures are negative... - Hepatitis B virus reactivation following allogeneic hematopoietic stem cell transplantationSarah P Hammond
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts, USA
Biol Blood Marrow Transplant 15:1049-59. 2009..In this cohort, HBV reactivation often developed in patients with cGVHD. Liver biopsy was useful in those patients with both to delineate the contribution of each to liver dysfunction... - Fonsecaea monophora cerebral phaeohyphomycosis: case report of successful surgical excision and voriconazole treatment and reviewSophia Koo
Division of Infectious Diseases, Brigham and Women s Hospital, 75 Francis Street, PBB A4, Boston, MA 02115, USA
Med Mycol 48:769-74. 2010..She discontinued antifungal therapy after an 18-month treatment course, and has remained free of any clinical or radiographic evidence of recurrent abscess formation three years later... - Invasive Mycoleptodiscus fungal cellulitis and myositisSophia Koo
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
Med Mycol 50:740-5. 2012..This is the first case of Mycoleptodiscus invasive fungal disease in which the causative agent could not be resolved at the species level because of inconsistencies between morphological and molecular data... - Cord-blood hematopoietic stem cell transplant confers an increased risk for human herpesvirus-6-associated acute limbic encephalitis: a cohort analysisJoshua A Hill
Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Biol Blood Marrow Transplant 18:1638-48. 2012..1-17.3; P = .04). Death from HHV-6-PALE occurred in 50% of affected patients undergoing UCBT and no recipients of adult-donor cells. Patients receiving UCBT have increased risk for HHV-6-PALE and greater morbidity from this disease... - Safety of posaconazole and sirolimus coadministration in allogeneic hematopoietic stem cell transplantsDavid W Kubiak
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Biol Blood Marrow Transplant 18:1462-5. 2012..Concurrent sirolimus and posaconazole use seems to be well tolerated with a 33% to 50% empiric sirolimus dose reduction and close monitoring of serum sirolimus trough levels at the time of posaconazole initiation... - Cord colitis syndrome in cord-blood stem-cell transplantationAlex F Herrera
Department of Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
N Engl J Med 365:815-24. 2011..After the transplantation and engraftment of hematopoietic stem cells from umbilical-cord blood, we observed a new syndrome of culture-negative, antibiotic-responsive diarrhea not attributable to any known cause... - Invasive fungal disease in patients treated for newly diagnosed acute leukemiaSarah P Hammond
Division of Infectious Diseases, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Hematol 85:695-9. 2010..52, 15.4). Those patients with more days of neutropenia in the first 100 days after AL diagnosis, such as those who did not achieve remission after a first course of induction chemotherapy, were more likely to develop IFD... - Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditionsTimothy J Henrich
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts, USA
J Infect Dis 202:1478-81. 2010..XMRV DNA was not detected in any participant samples. We found no association between XMRV and patients with chronic fatigue syndrome or chronic immunomodulatory conditions... - Maribavir and human cytomegalovirus-what happened in the clinical trials and why might the drug have failed?Francisco M Marty
Brigham and Women s Hospital, Harvard Medical School, United States
Curr Opin Virol 1:555-62. 2011..We discuss key aspects of study design that should be considered in the study of new interventions needed to advance the prevention and treatment of CMV in transplant recipients... - Prognostic features of galactomannan antigenemia in galactomannan-positive invasive aspergillosisSophia Koo
Division of Infectious Diseases, Brigham and Women s Hospital, 75 Francis Street, PBB A4, Boston, MA 02115, USA
J Clin Microbiol 48:1255-60. 2010.... - Diagnostic performance of the (1-->3)-beta-D-glucan assay for invasive fungal diseaseSophia Koo
Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, and 4Harvard School of Public Health, Boston, Massachusetts 02115, USA
Clin Infect Dis 49:1650-9. 2009..The (1-->3)-beta-D-glucan (BG) assay may be a useful adjunct, but its diagnostic performance is not well characterized... - Management of oral infections in cancer patientsMark A Lerman
Division of Oral Medicine and Dentistry, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Dent Clin North Am 52:129-53, ix. 2008..With the majority of cancer patients treated as outpatients in the community setting, oral health care professionals play an important role in managing such infectious complications of cancer therapy... - Treatment of cavitary pulmonary zygomycosis with surgical resection and posaconazoleSubroto Paul
Division of Thoracic Surgery, and Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Ann Thorac Surg 82:338-40. 2006..The current report demonstrates successful treatment, even in the setting of subsequent bone marrow transplantation and immunosuppression, using a combination of surgical resection and posaconazole therapy... - Infectious complications associated with alemtuzumab use for lymphoproliferative disordersStanley I Martin
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts, USA
Clin Infect Dis 43:16-24. 2006..Alemtuzumab is an emerging therapy for refractory lymphoproliferative disorders. The associated long-term risks of infection remain poorly defined... - Treatment of parainfluenza 3 infection with DAS181 in a patient after allogeneic stem cell transplantationYi Bin Chen
Bone Marrow Transplant Unit, Massachusetts General Hospital, Boston, MA, USA
Clin Infect Dis 53:e77-80. 2011..Symptoms, oxygenation, and pulmonary function tests improved. Nasopharyngeal samples showed a reduction in viral load. DAS181 should be systematically evaluated for severe PIV infection... - Infectious complications associated with immunomodulating biologic agentsSophia Koo
Division of Infectious Diseases, Brigham and Women s Hospital, 75 Francis Street, PBB A4, Boston, MA 02115, USA
Infect Dis Clin North Am 24:285-306. 2010..This review describes the spectrum of infectious complications associated to date with each of the immunomodulating biologic therapies approved by the US Food and Drug Administration... - Gordonia bronchialis bacteremia and pleural infection: case report and review of the literatureJennifer A Johnson
Division of Infectious Diseases, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Clin Microbiol 49:1662-6. 2011..We describe a case of Gordonia bronchialis bacteremia and pleural space infection in the absence of an indwelling intravascular catheter and review the breadth of reported infections with this emerging pathogen... - Infectious granulomatous dermatitis associated with Rothia mucilaginosa bacteremia: A case reportElizabeth A Morgan
Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Am J Dermatopathol 32:175-9. 2010..mucilaginosa bacteremia and raises awareness of this unusual histopathological presentation in the setting of a bacterial infection affecting the skin... - The prevention of infection post-transplant: the role of prophylaxis, preemptive and empiric therapyFrancisco M Marty
Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA
Transpl Int 19:2-11. 2006..This review provides a conceptual framework to approach the risk and risk periods for infection in solid organ and hematopoietic stem cell transplant recipients as well as an approach to antimicrobial use in this population... - Recovery of Herbaspirillum species from persons with cystic fibrosisTheodore Spilker
Division of Infectious Diseases, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan 48109 0646, USA
J Clin Microbiol 46:2774-7. 2008..Although the role that these species play in lung disease in persons with CF is not known, their differentiation from other species is important and has serious implications for clinical care and patient well-being... - Persistent and relapsing babesiosis in immunocompromised patientsPeter J Krause
Division of Infectious Diseases, Connecticut Children s Medical Center, and Department of Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut 06106, USA
Clin Infect Dis 46:370-6. 2008..Although patients experiencing babesiosis that is unresponsive to standard antimicrobial therapy have been described, the pathogenesis, clinical course, and optimal treatment regimen of such cases remain uncertain... - Diagnostic efficacy and safety of computed tomography-guided transthoracic needle biopsy in patients with hematologic malignanciesMarije H Kallenberg
Division of Infectious Diseases, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Acad Radiol 16:1408-15. 2009..Hence, the diagnostic efficacy and safety of computed tomography-guided TTNB were retrospectively evaluated in this population... - Candidaemia associated with decreased in vitro fluconazole susceptibility: is Candida speciation predictive of the susceptibility pattern?David A Oxman
Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
J Antimicrob Chemother 65:1460-5. 2010..Candidaemia is often treated with fluconazole in the absence of susceptibility testing. We examined factors associated with candidaemia caused by Candida isolates with reduced susceptibility to fluconazole... - Infectious complications associated with immunomodulating biologic agentsSophia Koo
Division of Infectious Diseases, Brigham and Women s Hospital, 75 Francis Street, PBB A4, Boston, MA 02115, USA Division of Infectious Diseases, Dana Farber Cancer Institute, Boston, MA, USA Harvard Medical School, Boston, MA, USA
Hematol Oncol Clin North Am 25:117-38. 2011..This review describes the spectrum of infectious complications associated to date with each of the immunomodulating biologic therapies approved by the US Food and Drug Administration... - Lyme meningoradiculitis and myositis after allogeneic hematopoietic stem cell transplantationMartin Rodriguez
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Clin Infect Dis 41:e112-4. 2005..To our knowledge, this is the first report of such an infection occurring after allogeneic hematopoietic stem cell transplantation in the United States... - Breakthrough zygomycosis after voriconazole treatment in recipients of hematopoietic stem-cell transplantsFrancisco M Marty
N Engl J Med 350:950-2. 2004 - Caspofungin versus liposomal amphotericin B for empirical therapyFrancisco M Marty
N Engl J Med 352:410-4; author reply 410-4. 2005 - Transmission of lymphocytic choriomeningitis virus by organ transplantationStaci A Fischer
Rhode Island Hospital and Brown Medical School, Providence, USA
N Engl J Med 354:2235-49. 2006..One recipient, who received ribavirin and reduced levels of immunosuppressive therapy, survived. CONCLUSIONS: We document two clusters of LCMV infection transmitted through organ transplantation... - Posaconazole for invasive aspergillosis?Lindsey R Baden
Clin Infect Dis 45:664; author reply 665-6. 2007 - (1->3)beta-D-glucan assay positivity in patients with Pneumocystis (carinii) jiroveci pneumoniaFrancisco M Marty
Ann Intern Med 147:70-2. 2007