Gad A Marshall

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Functional Activities Questionnaire Items that Best Discriminate and Predict Progression from Clinically Normal to Mild Cognitive Impairment
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, BL 104H, Boston, MA 02115, USA
    Curr Alzheimer Res 12:493-502. 2015
  2. pmc Everyday cognition scale items that best discriminate between and predict progression from clinically normal to mild cognitive impairment
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, BL 104H, Boston, MA 02115, USA
    Curr Alzheimer Res 11:853-61. 2014
  3. pmc SIST-M-IR activities of daily living items that best discriminate clinically normal elderly from those with mild cognitive impairment
    Amy S Zoller
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, BL 104H, Boston, MA 02115, USA
    Curr Alzheimer Res 11:785-91. 2014
  4. pmc Instrumental activities of daily living impairment is associated with increased amyloid burden
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Dement Geriatr Cogn Disord 31:443-50. 2011
  5. pmc Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer's disease
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    Alzheimers Dement 7:300-8. 2011
  6. ncbi request reprint Early-onset Alzheimer's disease is associated with greater pathologic burden
    Gad A Marshall
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA
    J Geriatr Psychiatry Neurol 20:29-33. 2007
  7. pmc Amyloid-β associated cortical thinning in clinically normal elderly
    J Alex Becker
    Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 69:1032-42. 2011
  8. ncbi request reprint Neuropathologic correlates of activities of daily living in Alzheimer disease
    Gad A Marshall
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1769, USA
    Alzheimer Dis Assoc Disord 20:56-9. 2006
  9. doi request reprint The Apathy Evaluation Scale: A Comparison of Subject, Informant, and Clinician Report in Cognitively Normal Elderly and Mild Cognitive Impairment
    Brendan J Guercio
    Harvard Medical School, Boston, MA, USA
    J Alzheimers Dis 47:421-32. 2015
  10. doi request reprint Neuropsychiatric Symptoms and Functional Connectivity in Mild Cognitive Impairment
    Catherine E Munro
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Alzheimers Dis 46:727-35. 2015

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Functional Activities Questionnaire Items that Best Discriminate and Predict Progression from Clinically Normal to Mild Cognitive Impairment
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, BL 104H, Boston, MA 02115, USA
    Curr Alzheimer Res 12:493-502. 2015
    ..Some IADL scales are sensitive to early deficits in MCI, but none have been validated for detecting subtle functional changes in clinically normal (CN) elderly at risk for AD...
  2. pmc Everyday cognition scale items that best discriminate between and predict progression from clinically normal to mild cognitive impairment
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, BL 104H, Boston, MA 02115, USA
    Curr Alzheimer Res 11:853-61. 2014
    ..The objective of this study was to determine which of the IADL-related Everyday Cognition (ECog) scale items are most sensitive for detection of early functional changes...
  3. pmc SIST-M-IR activities of daily living items that best discriminate clinically normal elderly from those with mild cognitive impairment
    Amy S Zoller
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, 221 Longwood Avenue, BL 104H, Boston, MA 02115, USA
    Curr Alzheimer Res 11:785-91. 2014
    ..Of the 60 SIST-M-IR items, 41 address IADL; we aimed to determine which of these best discriminate individuals with MCI from clinically normal (CN) elderly...
  4. pmc Instrumental activities of daily living impairment is associated with increased amyloid burden
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Dement Geriatr Cogn Disord 31:443-50. 2011
    ..We sought to determine whether IADL impairment is associated with increased cortical Pittsburgh Compound B (PiB) retention...
  5. pmc Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer's disease
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital Harvard Medical School, Boston, MA, USA
    Alzheimers Dement 7:300-8. 2011
    ....
  6. ncbi request reprint Early-onset Alzheimer's disease is associated with greater pathologic burden
    Gad A Marshall
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA
    J Geriatr Psychiatry Neurol 20:29-33. 2007
    ..This suggests that late-onset AD patients have less cognitive reserve than early-onset patients and require fewer pathologic changes to exhibit cognitive deterioration...
  7. pmc Amyloid-β associated cortical thinning in clinically normal elderly
    J Alex Becker
    Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 69:1032-42. 2011
    ....
  8. ncbi request reprint Neuropathologic correlates of activities of daily living in Alzheimer disease
    Gad A Marshall
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1769, USA
    Alzheimer Dis Assoc Disord 20:56-9. 2006
    ..Deteriorating activities of daily living in Alzheimer Disease subjects correlate with greater overall pathologic burden and possibly selectively with involvement of the medial temporal, occipital, and orbital frontal regions...
  9. doi request reprint The Apathy Evaluation Scale: A Comparison of Subject, Informant, and Clinician Report in Cognitively Normal Elderly and Mild Cognitive Impairment
    Brendan J Guercio
    Harvard Medical School, Boston, MA, USA
    J Alzheimers Dis 47:421-32. 2015
    ..Detecting apathy accurately may facilitate earlier diagnosis of AD. The Apathy Evaluation Scale (AES) is a promising tool for measurement of apathy in prodromal and possibly preclinical AD...
  10. doi request reprint Neuropsychiatric Symptoms and Functional Connectivity in Mild Cognitive Impairment
    Catherine E Munro
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Alzheimers Dis 46:727-35. 2015
    ..Prior studies have shown associations between affective NPS and neurodegeneration of medial frontal and inferior temporal regions in mild cognitive impairment (MCI) and AD dementia...
  11. doi request reprint Depressive Symptoms and Biomarkers of Alzheimer's Disease in Cognitively Normal Older Adults
    Nancy J Donovan
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Alzheimers Dis 46:63-73. 2015
    ..Amyloid was not a significant predictor in any model. In conclusion, very low-level dysphoria, apathy and anhedonia may point to neurodegeneration in AD-related regions but this association appears to be independent of amyloid burden...
  12. pmc Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease
    Nancy J Donovan
    Center for Alzheimer Research and Treatment and Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Electronic address
    Am J Geriatr Psychiatry 22:1642-51. 2014
    ..To examine neuropsychiatric and neuropsychological predictors of progression from normal to early clinical stages of Alzheimer disease (AD)...
  13. pmc Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum
    Nancy J Donovan
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Electronic address
    Am J Geriatr Psychiatry 22:1168-79. 2014
    ....
  14. pmc Neuropsychiatric symptoms and global functional impairment along the Alzheimer's continuum
    Lauren P Wadsworth
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dement Geriatr Cogn Disord 34:96-111. 2012
    ..We sought to determine whether neuropsychiatric symptoms were related to global functional impairment at baseline and over a 3-year period in older normal control (NC), mild cognitive impairment (MCI) and mild AD dementia subjects...
  15. pmc Apathy is associated with lower inferior temporal cortical thickness in mild cognitive impairment and normal elderly individuals
    Brendan J Guercio
    From the Harvard Medical School BG, NJD, Rea, DMR, KAJ, RAS, GAM Center for Alzheimer Research and Treatment BG, NJD, NL, Rea, DMR, KAJ, RAS, GAM Dept of Neurology NJD, AW, NL, REA DMR, KAJ, RAS, GAM and Dept of Psychiatry NJD, Rea, DMR Brigham and Women s Hospital, Boston, MA Dept of Neurology AW, As, NL, Rea, DMR, KAJ, RAS, GAM and Dept of Radiology KAJ, Massachusetts General Hospital, Boston, MA
    J Neuropsychiatry Clin Neurosci 27:e22-7. 2015
    ..Lower inferior temporal cortical thickness was predictive of greater apathy. Greater anterior cingulate cortical thickness was also predictive of greater apathy, suggesting an underlying reactive process...
  16. pmc Regional fluorodeoxyglucose metabolism and instrumental activities of daily living across the Alzheimer's disease spectrum
    Kamolika Roy
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Alzheimers Dis 42:291-300. 2014
    ..IADL impairment in AD dementia has been associated with inferior parietal, inferior temporal, and superior occipital hypometabolism using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)...
  17. pmc Subjective cognitive concerns, amyloid-β, and neurodegeneration in clinically normal elderly
    Rebecca E Amariglio
    From the Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital R E A, A C P, G A M, P V, K A J, R A S, D M R, and the Departments of Neurology R E A, E C M, G A M, P V, K A J, R A S, D M R and Radiology K A J, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Neurology 85:56-62. 2015
    ..To determine whether neuroimaging biomarkers of amyloid-β (Aβ) and neurodegeneration (ND) are associated with greater self-reported subjective cognitive concerns (SCC) in clinically normal older individuals...
  18. pmc Cognitive activity relates to cognitive performance but not to Alzheimer disease biomarkers
    Christopher M Gidicsin
    From the Division of Nuclear Medicine and Molecular Imaging C M G, J E M, L C P, M P, J A B, K A J and Departments of Neurology J J L, A P S, R E A, G A M, D M R, R A S, K A J, Psychiatry A P Y, A P S, and Radiology T H, K A J, Massachusetts General Hospital, Harvard Medical School, Boston Athinoula A Martinos Center for Biomedical Imaging A P Y, A P S, T H, R A S, Department of Radiology, Massachusetts General Hospital, Charlestown and Center for Alzheimer Research and Treatment M D, R E A, G A M, D M R, R A S, K A J, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    Neurology 85:48-55. 2015
    ..We aimed to determine whether there was a relationship between lifestyle factors and Alzheimer disease biomarkers...
  19. pmc Vascular disease and risk factors are associated with cognitive decline in the alzheimer disease spectrum
    Natacha Lorius
    Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women s Hospital Departments of Neurology Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Alzheimer Dis Assoc Disord 29:18-25. 2015
    ..These results suggest a significant association of increased vascular disease and risk factors with cognitive impairment at baseline and over time in the AD spectrum in a sample that was selected to have low vascular burden at baseline. ..
  20. pmc Regional cortical thinning and cerebrospinal biomarkers predict worsening daily functioning across the Alzheimer's disease spectrum
    Gad A Marshall
    Center for Alzheimer Research and Treatment, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Massachusetts Alzheimer s Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Alzheimers Dis 41:719-28. 2014
    ..Impairment in instrumental activities of daily living (IADL) heralds the transition from mild cognitive impairment (MCI) to dementia and is a major source of burden for both the patient and caregiver...
  21. ncbi request reprint Positron emission tomography metabolic correlates of apathy in Alzheimer disease
    Gad A Marshall
    Department of Neurology, University of California, Los Angeles, CA, USA
    Arch Neurol 64:1015-20. 2007
    ....
  22. pmc Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument
    Rebecca E Amariglio
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts2Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts3Harvar
    JAMA Neurol 72:446-54. 2015
    ..The success of these trials depends on validated outcome measures that are sensitive to early clinical progression in individuals who are initially asymptomatic...
  23. pmc Amyloid-β deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression
    Willem Huijbers
    1 Centre for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA 2 Athinoula A Martinos Centre for Biomedical Imaging, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Brain 138:1023-35. 2015
    ..Increased hippocampal activity is discussed in relation to neuronal compensation and/or amyloid-β induced excitoxicity...
  24. ncbi request reprint Neuropathologic correlates of apathy in Alzheimer's disease
    Gad A Marshall
    Department of Neurology, University of California at Los Angeles, Reed Neurological Research Center, 2 238, 710 Westwood Plaza, CA 90095 1769, USA
    Dement Geriatr Cogn Disord 21:144-7. 2006
    ..01, and r = 0.438, p = 0.032). This analysis suggests that chronic apathy in AD correlates with a greater anterior cingulate NFT burden and that chronic behavioral changes are more reflective than acute changes of disease pathology...
  25. ncbi request reprint Long-term treatment of Hashimoto's encephalopathy
    Gad A Marshall
    University of California at Los Angeles, Department of Neurology, Los Angeles, CA 90095 1769, USA
    J Neuropsychiatry Clin Neurosci 18:14-20. 2006
    ..The authors present two cases of HE, demonstrating an excellent response to high dose steroids acutely followed by long-term treatment with steroids and other immunomodulatory agents. A review of the literature is also provided...