J Mao

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Disruption of persistent nociceptive behavior in rats with learning impairment
    Yuxin Ma
    MGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America Department of Anatomy, School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China Department of Anatomy, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 8:e74533. 2013
  2. pmc Current challenges in translational pain research
    Jianren Mao
    MGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Trends Pharmacol Sci 33:568-73. 2012
  3. pmc Glutamate transporter: an unexpected target for some antibiotics
    Jianren Mao
    Mol Pain 1:5. 2005
  4. ncbi request reprint Opioid-induced abnormal pain sensitivity
    Jianren Mao
    MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, 02114, USA
    Curr Pain Headache Rep 10:67-70. 2006
  5. ncbi request reprint Central glucocorticoid receptor: a new role in the cellular mechanisms of neuropathic pain
    Jianren Mao
    Pain Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Rev Neurosci 16:233-8. 2005
  6. pmc Combination drug therapy for chronic pain: a call for more clinical studies
    Jianren Mao
    MGHCenter for Translational Pain Research, Department of Anesthesia, Harvard Medical School, Boston, MA 02114, USA
    J Pain 12:157-66. 2011
  7. ncbi request reprint Systemic lidocaine for neuropathic pain relief
    J Mao
    MGH Pain Center, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Pain 87:7-17. 2000
  8. ncbi request reprint Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapy
    Jianren Mao
    MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Pain 100:213-7. 2002
  9. ncbi request reprint Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity
    Jianren Mao
    Massachusetts General Hospital Pain Center and Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 22:8312-23. 2002
  10. ncbi request reprint Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism
    Jianren Mao
    Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 22:7650-61. 2002

Collaborators

Detail Information

Publications47

  1. pmc Disruption of persistent nociceptive behavior in rats with learning impairment
    Yuxin Ma
    MGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America Department of Anatomy, School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China Department of Anatomy, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 8:e74533. 2013
    ..These results also suggest that a preclinical model of combined learning impairment and persistent nociception may be useful to explore the brain mechanisms underlying the transition from acute to chronic pain. ..
  2. pmc Current challenges in translational pain research
    Jianren Mao
    MGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Trends Pharmacol Sci 33:568-73. 2012
    ..Several key issues of translational pain research are discussed in this review...
  3. pmc Glutamate transporter: an unexpected target for some antibiotics
    Jianren Mao
    Mol Pain 1:5. 2005
    ..These findings indicate that positive promoters of GT expression may have a unique role in neuroprotection through regulating GT expression. This is also encouraging in search for new pharmacological tools for pain management...
  4. ncbi request reprint Opioid-induced abnormal pain sensitivity
    Jianren Mao
    MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, 02114, USA
    Curr Pain Headache Rep 10:67-70. 2006
    ..Their converging effects may be part of the mechanisms leading to the reduced opioid analgesic efficacy in chronic opioid therapy...
  5. ncbi request reprint Central glucocorticoid receptor: a new role in the cellular mechanisms of neuropathic pain
    Jianren Mao
    Pain Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Rev Neurosci 16:233-8. 2005
  6. pmc Combination drug therapy for chronic pain: a call for more clinical studies
    Jianren Mao
    MGHCenter for Translational Pain Research, Department of Anesthesia, Harvard Medical School, Boston, MA 02114, USA
    J Pain 12:157-66. 2011
    ..In this article, we will focus on (1) the scientific basis and rationales for CDT, (2) current clinical data on CDT, and (3) the need for more clinical studies to establish a framework for the use of CDT...
  7. ncbi request reprint Systemic lidocaine for neuropathic pain relief
    J Mao
    MGH Pain Center, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Pain 87:7-17. 2000
    ..The thoughtful use of lidocaine therapy and the potential application of subtype-specific sodium channel blockers could provide better management of distinctive neuropathic pain symptoms...
  8. ncbi request reprint Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapy
    Jianren Mao
    MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Pain 100:213-7. 2002
  9. ncbi request reprint Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity
    Jianren Mao
    Massachusetts General Hospital Pain Center and Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 22:8312-23. 2002
    ..These results indicate that spinal GTs may contribute to the neural mechanisms of morphine tolerance and associated abnormal pain sensitivity by means of regulating regional glutamate homeostasis...
  10. ncbi request reprint Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism
    Jianren Mao
    Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 22:7650-61. 2002
    ..These results indicate an opioid-induced neurotoxic consequence regulated by the NMDAR-caspase pathway, a mechanism that may have clinical implications in opioid therapy and substance abuse...
  11. ncbi request reprint Translational pain research: bridging the gap between basic and clinical research
    Jianren Mao
    Department of Anesthesia and Critical Care, MGH Pain Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Pain 97:183-7. 2002
  12. pmc Translational pain research: achievements and challenges
    Jianren Mao
    MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Pain 10:1001-11. 2009
    ..These issues are discussed in this article in light of the achievements and challenges of translational pain research...
  13. ncbi request reprint Spinal cord neuroplasticity following repeated opioid exposure and its relation to pathological pain
    J Mao
    MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Ann N Y Acad Sci 933:175-84. 2001
    ..These observations may help understand mechanisms of chemical intolerance and multiple chemical sensitivity as well as have significant clinical implications in pain management with opioid analgesics...
  14. ncbi request reprint Central glucocorticoid receptors modulate the expression of spinal cannabinoid receptors induced by chronic morphine exposure
    Grewo Lim
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    Brain Res 1059:20-7. 2005
    ..These results indicate that the expression of spinal CBRs was altered following repeated morphine exposure and regulated by the activation of central GRs...
  15. pmc Inhibition of the ubiquitin-proteasome activity prevents glutamate transporter degradation and morphine tolerance
    Liling Yang
    MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, WACC 324, 15 Parkman Street, Boston, MA 02114, USA
    Pain 140:472-8. 2008
    ..The possible relationship between MG-132-mediated regulation of glutamate transporters, ubiquitin-proteasome system, and the cellular mechanisms of morphine tolerance is discussed in light of these findings...
  16. ncbi request reprint Central glucocorticoid receptors modulate the expression and function of spinal NMDA receptors after peripheral nerve injury
    Shuxing Wang
    Pain Research Group, Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 25:488-95. 2005
    ..These data suggest that interactions between central GRs and NMDARs through genomic and nongenomic regulation may be an important mechanism critical to neuropathic pain behaviors in rats...
  17. ncbi request reprint cAMP and protein kinase A contribute to the downregulation of spinal glutamate transporters after chronic morphine
    Grewo Lim
    Pain Research Group, MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neurosci Lett 376:9-13. 2005
    ....
  18. ncbi request reprint Expression of spinal NMDA receptor and PKCgamma after chronic morphine is regulated by spinal glucocorticoid receptor
    Grewo Lim
    Pain Research Group, Division of Pain Medicine, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 25:11145-54. 2005
    ..The data suggest that genomic interaction among spinal GR, NMDAR, and PKCgamma may be an important mechanism that contributes to the development of morphine tolerance...
  19. ncbi request reprint Expression of central glucocorticoid receptors after peripheral nerve injury contributes to neuropathic pain behaviors in rats
    Shuxing Wang
    Pain Research Group, Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 24:8595-605. 2004
    ..These findings indicate a central role of neuronal GRs in the mechanisms of neuropathic pain behaviors in rats and suggest a potential role for GR antagonists in clinical management of neuropathic pain...
  20. ncbi request reprint Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats
    Backil Sung
    Massachusetts General Hospital Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 23:2899-910. 2003
    ....
  21. pmc A combined effect of dextromethorphan and melatonin on neuropathic pain behavior in rats
    Shuxing Wang
    MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, WACC 324, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Brain Res 1288:42-9. 2009
    ..These results suggest that a combination of melatonin with a clinically available NMDA receptor antagonist might be more effective than either drug alone for the treatment of neuropathic pain...
  22. doi request reprint A survey of selected physician views on acupuncture in pain management
    Lucy Chen
    MGH Center for Translational Pain Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Pain Med 11:530-4. 2010
    ..To collect information on the role of acupuncture in pain management from pain physicians and referral physicians who manage clinical pain conditions...
  23. doi request reprint Pain and opioid addiction: what is the connection?
    Adam J Carinci
    Division of Pain Medicine, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Curr Pain Headache Rep 14:17-21. 2010
    ..The connection between chronic pain and opioid addiction is a complex interplay between psychological, epidemiological, and neurobiological factors. Herein, we explore this critical relationship...
  24. ncbi request reprint A differential diagnosis of hyperalgesia, toxicity, and withdrawal from intrathecal morphine infusion
    Aneesh Singla
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Anesth Analg 105:1816-9, table of contents. 2007
    ..This report demonstrates the complexity of treating patients with long-term continuous intrathecal opioids when modest adjustment of the intrathecal cocktail results in a paradoxical clinical course...
  25. ncbi request reprint A rat model of unilateral hindpaw burn injury: slowly developing rightwards shift of the morphine dose-response curve
    Shuxing Wang
    Pain Research Group, MGH Pain Center, WACC 324, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    Pain 116:87-95. 2005
    ....
  26. ncbi request reprint Spinal glucocorticoid receptors contribute to the development of morphine tolerance in rats
    Grewo Lim
    Pain Research Group, MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    Anesthesiology 102:832-7. 2005
    ..In a rat model of morphine tolerance, the authors examined the hypothesis that spinal GRs would play a significant role in the development of tolerance to the antinociceptive effect of morphine...
  27. ncbi request reprint Activity of adenylyl cyclase and protein kinase A contributes to morphine-induced spinal apoptosis
    Grewo Lim
    Pain Research Group, Division of Pain Medicine, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Suite WACC 324, 15 Parkman Street, Boston, MA 02114, USA
    Neurosci Lett 389:104-8. 2005
    ..The results indicate that the spinal AC and PKA pathway through intracellular MAPK may be contributory to the cellular mechanisms of morphine-induced apoptosis...
  28. ncbi request reprint Opioid tolerance and neuroplasticity
    Jianren Mao
    Pain Research Group, MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Novartis Found Symp 261:181-6; discussion 187-93. 2004
    ..The converging effects of these cellular mechanisms would significantly reduce the opioid analgesic efficacy. The current evidence also suggests new approaches for improving the clinical use of opioid analgesics...
  29. ncbi request reprint Opioid therapy for chronic pain
    Jane C Ballantyne
    Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 349:1943-53. 2003
  30. ncbi request reprint Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats
    Grewo Lim
    Department of Anesthesia and Critical Care, MGH Pain Center, WACC 324, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    Pain 105:275-83. 2003
    ..These results indicate that upregulation of spinal CB1Rs following peripheral nerve injury may contribute to the therapeutic effects of exogenous cannabinoids on neuropathic pain...
  31. ncbi request reprint Opioid tolerance and hyperalgesia
    Grace Chang
    Massachusetts General Hospital Pain Center, Division of Pain Medicine, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Med Clin North Am 91:199-211. 2007
    ..This article will review updated information from both clinical and preclinical studies regarding opioid-induced hyperalgesia, tolerance, and dependence. The implications of these issues in clinical opioid therapy also will be discussed...
  32. ncbi request reprint Evidence for a long-term influence on morphine tolerance after previous morphine exposure: role of neuronal glucocorticoid receptors
    Grewo Lim
    Pain Research Group, MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02116, USA
    Pain 114:81-92. 2005
    ..These findings may have significant implications in clinical opioid therapy and substance abuse...
  33. pmc Exacerbated mechanical allodynia in rats with depression-like behavior
    Qing Zeng
    MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Brain Res 1200:27-38. 2008
    ....
  34. pmc Altered quantitative sensory testing outcome in subjects with opioid therapy
    Lucy Chen
    MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, WACC 324, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Pain 143:65-70. 2009
    ..The data suggest that QST may be a useful tool in the clinical assessment of OIH...
  35. pmc Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents
    Grewo Lim
    MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 119:295-304. 2009
    ..Our findings reveal a critical role for spinal leptin in the pathogenesis of neuropathic pain and suggest what we believe to be a novel form of nonneuronal and neuronal interactions in the mechanisms of pathological pain...
  36. pmc Regulation of the trigeminal NR1 subunit expression induced by inflammation of the temporomandibular joint region in rats
    Shuxing Wang
    MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, WACC 324, Boston, MA 02114, USA
    Pain 141:97-103. 2009
    ....
  37. doi request reprint Animal models of acute surgical pain
    Hyangin Kim
    Department of Anesthesia and Critical Care, Massachusetts General Hospital Center for Translational Pain Research, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 617:31-9. 2010
    ..Preclinical studies using these models have provided insights into the mechanisms and causes of acute surgical pain as well as the treatment options to control postsurgical pain...
  38. ncbi request reprint Downregulation of spinal glutamate transporter EAAC1 following nerve injury is regulated by central glucocorticoid receptors in rats
    Shuxing Wang
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, WACC 324, Boston, 02114, USA
    Pain 120:78-85. 2006
    ....
  39. pmc Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation
    Liling Yang
    MGH Center for Translational Pain Research, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 75 Parkman Street, Boston, MA 02114, USA
    J Biol Chem 283:21703-13. 2008
    ....
  40. ncbi request reprint Central glucocorticoid receptors regulate the upregulation of spinal cannabinoid-1 receptors after peripheral nerve injury in rats
    Shuxing Wang
    MGH Center for Translational Pain Research, Division of Pain Medicine, WACC 324, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    Pain 131:96-105. 2007
    ....
  41. pmc Altered spinal arachidonic acid turnover after peripheral nerve injury regulates regional glutamate concentration and neuropathic pain behaviors in rats
    Backil Sung
    Pain Research Group, Division of Pain Medicine, WACC 324, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    Pain 131:121-31. 2007
    ..These data suggest that regulating spinal AA turnover may be a useful approach to improving the clinical management of neuropathic pain...
  42. pmc Intrathecal midazolam regulates spinal AMPA receptor expression and function after nerve injury in rats
    Jeongae Lim
    Department of Anesthesia and Pain Medicine, Konkuk University, Seoul, Korea
    Brain Res 1123:80-8. 2006
    ..These results indicate that modulation of spinal AMPA receptor expression and function by the GABAergic activity may serve as a mechanism contributory to the spinal nociceptive processing...
  43. pmc Time-dependent effect of epidural steroid on pain behavior induced by chronic compression of dorsal root ganglion in rats
    Xiaoping Gu
    Department of Anesthesiology, Drum Tower Hospital, Medical Department of Nanjing University, Nanjing 210008, People s Republic of China
    Brain Res 1174:39-46. 2007
    ..These results indicate that the effect of epidural steroid on radicular pain may be time-dependent. Clinical implications for epidural steroid treatment are discussed in light of these preclinical findings...
  44. ncbi request reprint The intravenous ketamine test: a predictive response tool for oral dextromethorphan treatment in neuropathic pain
    Steven P Cohen
    Pain Management Center, 550 North Broadway, Suite 301, Baltimore, MD 21205, USA
    Anesth Analg 99:1753-9, table of contents. 2004
    ..More research is needed to determine the ideal candidates for such a test, and the optimal dose and cutoff value for the response to ketamine...
  45. doi request reprint The effect of opioid dose and treatment duration on the perception of a painful standardized clinical stimulus
    Steven P Cohen
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21029, USA
    Reg Anesth Pain Med 33:199-206. 2008
    ..g., surgery. The primary objective of this study is to delineate the effect of opioid dose and treatment duration on pain intensity and unpleasantness ratings following a standardized clinical pain stimulus...
  46. ncbi request reprint The intravenous ketamine test predicts subsequent response to an oral dextromethorphan treatment regimen in fibromyalgia patients
    Steven P Cohen
    Pain Management Division, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Pain 7:391-8. 2006
    ..An association was also found between the development of side effects to the two treatments...
  47. ncbi request reprint A rat model of radicular pain induced by chronic compression of lumbar dorsal root ganglion with SURGIFLO
    Xiaoping Gu
    Department of Anesthesiology, Drum Tower Hospital, Nanjing, People s Republic of China
    Anesthesiology 108:113-21. 2008
    ..The authors report a modified rat model of radicular pain that could mimic a subset of clinical radicular pain conditions induced by the soft tissue compression on dorsal root ganglion...

Research Grants26

  1. Cellular Mechanisms of Hyperalgesia and Opioid Tolerance
    Jianren Mao; Fiscal Year: 2001
    ....
  2. Glutamate Uptake & the Pathogenesis of Neuropathic Pain
    Jianren Mao; Fiscal Year: 2007
    ..abstract_text> ..
  3. OPIOID-INDUCED PAIN SENSITIVITY: CLINICAL DIAGNOSIS AND MANAGEMENT
    Jianren Mao; Fiscal Year: 2006
    ....
  4. OPIOID-INDUCED PAIN SENSITIVITY: CLINICAL DIAGNOSIS AND MANAGEMENT
    Jianren Mao; Fiscal Year: 2007
    ....
  5. COMORBIDITY BETWEEN DEPRESSION AND OROFACIAL PAIN
    Jianren Mao; Fiscal Year: 2009
    ....
  6. OPIOID-INDUCED PAIN SENSITIVITY: CLINICAL DIAGNOSIS AND MANAGEMENT
    Jianren Mao; Fiscal Year: 2010
    ....
  7. COMORBIDITY BETWEEN DEPRESSION AND OROFACIAL PAIN
    Jianren Mao; Fiscal Year: 2010
    ....
  8. Neuropathic Pain Modulation by Cannabinoids
    Jianren Mao; Fiscal Year: 2006
    ..A better understanding of cannabinoid actions in neuropathic pain states could open a new avenue to developing novel pharmacological tools for the improved management of often intractable and debilitating neuropathic pain syndromes. ..
  9. Glutamate Uptake & the Pathogenesis of Neuropathic Pain
    Jianren Mao; Fiscal Year: 2006
    ..abstract_text> ..
  10. Neuropathic Pain Modulation by Cannabinoids
    Jianren Mao; Fiscal Year: 2005
    ..A better understanding of cannabinoid actions in neuropathic pain states could open a new avenue to developing novel pharmacological tools for the improved management of often intractable and debilitating neuropathic pain syndromes. ..
  11. Cellular Mechanisms of Hyperalgesia and Opioid Tolerance
    Jianren Mao; Fiscal Year: 2002
    ....
  12. Cellular Mechanisms of Hyperalgesia and Opioid Tolerance
    Jianren Mao; Fiscal Year: 2003
    ....
  13. Neuropathic Pain Modulation by Cannabinoids
    Jianren Mao; Fiscal Year: 2003
    ..A better understanding of cannabinoid actions in neuropathic pain states could open a new avenue to developing novel pharmacological tools for the improved management of often intractable and debilitating neuropathic pain syndromes. ..
  14. Glutamate Uptake & the Pathogenesis of Neuropathic Pain
    Jianren Mao; Fiscal Year: 2004
    ..abstract_text> ..
  15. Neuropathic Pain Modulation by Cannabinoids
    Jianren Mao; Fiscal Year: 2004
    ..A better understanding of cannabinoid actions in neuropathic pain states could open a new avenue to developing novel pharmacological tools for the improved management of often intractable and debilitating neuropathic pain syndromes. ..
  16. Cellular Mechanisms of Hyperalgesia and Opioid Tolerance
    Jianren Mao; Fiscal Year: 2004
    ....
  17. Glutamate Uptake & the Pathogenesis of Neuropathic Pain
    Jianren Mao; Fiscal Year: 2005
    ..abstract_text> ..
  18. Central Mechanisms of Orofacial Pain
    Jianren Mao; Fiscal Year: 2010
    ..The outcome of this study could lead to the development of new therapeutic tools to treat often intractable and debilitating clinical orofacial pain. ..
  19. COMORBIDITY BETWEEN DEPRESSION AND OROFACIAL PAIN
    Jianren Mao; Fiscal Year: 2007
    ....
  20. OPIOID-INDUCED PAIN SENSITIVITY: CLINICAL DIAGNOSIS AND MANAGEMENT
    Jianren Mao; Fiscal Year: 2009
    ....
  21. Central Mechanisms of Orofacial Pain
    Jianren Mao; Fiscal Year: 2009
    ..The outcome of this study could lead to the development of new therapeutic tools to treat often intractable and debilitating clinical orofacial pain. ..
  22. Cellular Mechanisms of Hyperalgesia and Opioid Tolerance
    Jianren Mao; Fiscal Year: 2005
    ....