Amity L Manning

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc pRB, a tumor suppressor with a stabilizing presence
    Amity L Manning
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, USA
    Trends Cell Biol 21:433-41. 2011
  2. pmc RB: mitotic implications of a tumour suppressor
    Amity L Manning
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Rev Cancer 12:220-6. 2012
  3. pmc Loss of pRB causes centromere dysfunction and chromosomal instability
    Amity L Manning
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 24:1364-76. 2010
  4. pmc CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase
    Richard C Centore
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell 40:22-33. 2010

Collaborators

  • Lee Zou
  • Richard C Centore
  • Rachel Litman Flynn
  • Courtney G Havens
  • Johannes C Walter
  • Ju mei Li
  • Nicholas J Dyson
  • Alice Tse
  • Jianping Jin

Detail Information

Publications4

  1. pmc pRB, a tumor suppressor with a stabilizing presence
    Amity L Manning
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, USA
    Trends Cell Biol 21:433-41. 2011
    ..We review the evidence that pRB promotes genome stability and discuss the mechanisms that probably contribute to this effect...
  2. pmc RB: mitotic implications of a tumour suppressor
    Amity L Manning
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Rev Cancer 12:220-6. 2012
    ..Several studies have provided potential explanations for these phenomena that occur following RB loss, and they suggest that this new function of RB may contribute to its role in tumour suppression...
  3. pmc Loss of pRB causes centromere dysfunction and chromosomal instability
    Amity L Manning
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 24:1364-76. 2010
    ..These observations explain an important consequence of RB1 inactivation, and suggest that subtle defects in centromere function are a frequent source of merotely and CIN in cancer...
  4. pmc CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase
    Richard C Centore
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell 40:22-33. 2010
    ..Thus, CRL4(Cdt2)-dependent destruction of Set8 in S phase preserves genome stability by preventing aberrant chromatin compaction during DNA synthesis...