Madhu S Malo

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Positive selection vectors for high-fidelity PCR cloning
    Madhu S Malo
    SyntheGen Systems, Medford, MA, USA
    Biotechniques 34:1250-8. 2003
  2. doi Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota
    M S Malo
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Gut 59:1476-84. 2010
  3. ncbi Thyroid hormone positively regulates the enterocyte differentiation marker intestinal alkaline phosphatase gene via an atypical response element
    Madhu S Malo
    Department of Surgery, Massachusetts General Hospital, Gray Bigelow 504, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Mol Endocrinol 18:1941-62. 2004
  4. ncbi Convergence of the thyroid hormone and gut-enriched Krüppel-like factor pathways in the context of enterocyte differentiation
    Aleem Siddique
    Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    J Gastrointest Surg 7:1053-61; discussion 1061. 2003
  5. pmc Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates
    Madhu S Malo
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
    Am J Physiol Gastrointest Liver Physiol 306:G826-38. 2014
  6. ncbi Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2
    Fuad Alkhoury
    Dept of Surgery, Massachusetts General Hospital, Gray 504, 55 Fruit Street, Boston, MA 02114, USA
    Am J Physiol Gastrointest Liver Physiol 289:G285-90. 2005
  7. pmc Intestinal alkaline phosphatase prevents antibiotic-induced susceptibility to enteric pathogens
    Sayeda Nasrin Alam
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Ann Surg 259:715-22. 2014
  8. ncbi The pro-inflammatory cytokines, IL-1beta and TNF-alpha, inhibit intestinal alkaline phosphatase gene expression
    Madhu S Malo
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    DNA Cell Biol 25:684-95. 2006
  9. pmc Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate
    Angela K Moss
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Gastrointest Liver Physiol 304:G597-604. 2013
  10. pmc A role for intestinal alkaline phosphatase in the maintenance of local gut immunity
    Kathryn T Chen
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Dig Dis Sci 56:1020-7. 2011

Collaborators

  • Jose Luis Millan
  • Kathryn T Chen
  • Deanna D Nguyen
  • H S Warren
  • S Ramasamy
  • Emiko Mizoguchi
  • C L Kitts
  • E L Hohmann
  • Richard A Hodin
  • Angela K Moss
  • Kanakaraju Kaliannan
  • Sayeda Nasrin Alam
  • Nur Muhammad
  • Omeed Moaven
  • Sulaiman R Hamarneh
  • Nondita S Malo
  • Halim Yammine
  • Brian F Hinnebusch
  • Aleem Siddique
  • Madhury Ray
  • Atul K Bhan
  • Rizwan Ahmed
  • Atri Raychowdhury
  • Sonoko Narisawa
  • Palak Patel
  • Mussa M Rafat Mohamed
  • Abeba Teshager
  • Brishti Biswas
  • Farzad Ebrahimi
  • Wenying Zhang
  • Mario A Abedrapo
  • J Welles Henderson
  • Golam Mostafa
  • Fuad Alkhoury
  • Moushumi Mozumder
  • Vincent W Yang
  • Sathi Ghosh
  • Rakesh Biswas
  • Soumik Barua
  • Seyed M Abtahi
  • Shahrad Hakimian
  • Sayeda N Alam
  • Konstantinos P Economopoulos
  • Xinming Chen
  • Christopher P Athaide
  • Lee M Ocuin

Detail Information

Publications20

  1. ncbi Positive selection vectors for high-fidelity PCR cloning
    Madhu S Malo
    SyntheGen Systems, Medford, MA, USA
    Biotechniques 34:1250-8. 2003
    ....
  2. doi Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota
    M S Malo
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Gut 59:1476-84. 2010
    ..In this study the role of IAP in the preservation of the normal homeostasis of the gut microbiota was investigated...
  3. ncbi Thyroid hormone positively regulates the enterocyte differentiation marker intestinal alkaline phosphatase gene via an atypical response element
    Madhu S Malo
    Department of Surgery, Massachusetts General Hospital, Gray Bigelow 504, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Mol Endocrinol 18:1941-62. 2004
    ..We have thus identified a novel response element that appears to mediate the T3-induced activation of the enterocyte differentiation marker, intestinal alkaline phosphatase...
  4. ncbi Convergence of the thyroid hormone and gut-enriched Krüppel-like factor pathways in the context of enterocyte differentiation
    Aleem Siddique
    Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    J Gastrointest Surg 7:1053-61; discussion 1061. 2003
    ..The thyroid hormone receptor complex and KLF4 synergistically activate the enterocyte differentiation marker gene IAP, suggesting a previously unrecognized interrelationship between these two transcription factor pathways...
  5. pmc Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates
    Madhu S Malo
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
    Am J Physiol Gastrointest Liver Physiol 306:G826-38. 2014
    ..In conclusion, IAP appears to promote the growth of intestinal commensal bacteria by inhibiting the concentration of luminal nucleotide triphosphates...
  6. ncbi Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2
    Fuad Alkhoury
    Dept of Surgery, Massachusetts General Hospital, Gray 504, 55 Fruit Street, Boston, MA 02114, USA
    Am J Physiol Gastrointest Liver Physiol 289:G285-90. 2005
    ..Cdx1 activates the IAP gene via a novel cis element, whereas Cdx2 inhibits the Cdx1 effects...
  7. pmc Intestinal alkaline phosphatase prevents antibiotic-induced susceptibility to enteric pathogens
    Sayeda Nasrin Alam
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Ann Surg 259:715-22. 2014
    ..Typhimurium) and Clostridium difficile...
  8. ncbi The pro-inflammatory cytokines, IL-1beta and TNF-alpha, inhibit intestinal alkaline phosphatase gene expression
    Madhu S Malo
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    DNA Cell Biol 25:684-95. 2006
    ..Cytokine-mediated IAP gene silencing may have important implications for gut epithelial function in the setting of intestinal inflammatory conditions...
  9. pmc Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate
    Angela K Moss
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Gastrointest Liver Physiol 304:G597-604. 2013
    ..The benefits of IAP in intestinal disease may be partly due to inhibition of the proinflammatory activity of UDP...
  10. pmc A role for intestinal alkaline phosphatase in the maintenance of local gut immunity
    Kathryn T Chen
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Dig Dis Sci 56:1020-7. 2011
    ..We investigated immune responses of wild-type (WT) and IAP-knockout (IAP-KO) mice to LPS and Salmonella typhimurium challenges...
  11. ncbi Intestinal alkaline phosphatase gene expression is activated by ZBP-89
    Madhu S Malo
    Gastrointestinal Unit and Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Am J Physiol Gastrointest Liver Physiol 290:G737-46. 2006
    ..These findings are consistent with the role that this transcription factor is thought to play as a tumor suppressor and suggests its possible function in the physiology of fat absorption...
  12. ncbi pFRL7: an ideal vector for eukaryotic promoter analysis
    Madhu S Malo
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Anal Biochem 350:307-9. 2006
  13. pmc Intestinal alkaline phosphatase prevents metabolic syndrome in mice
    Kanakaraju Kaliannan
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 110:7003-8. 2013
    ..Furthermore, IAP supplementation improves the lipid profile in mice fed a standard, low-fat chow diet. These results point to a potentially unique therapy against metabolic syndrome in at-risk humans...
  14. ncbi Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor
    Brian F Hinnebusch
    Deptartment of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Gastrointest Liver Physiol 286:G23-30. 2004
    ..We have identified the enterocyte differentiation marker IAP as a KLF4 target gene. IAP transactivation by KLF4 is likely mediated through a critical region located within the proximal IAP promoter region...
  15. pmc Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase
    Kathryn T Chen
    Dept of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Physiol Gastrointest Liver Physiol 299:G467-75. 2010
    ..IAP likely targets these bacterially derived molecules in its role as a gut mucosal defense factor...
  16. doi Local peritoneal irrigation with intestinal alkaline phosphatase is protective against peritonitis in mice
    Farzad Ebrahimi
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Jackson 812, 55 Fruit Street, Boston, MA 02114, USA
    J Gastrointest Surg 15:860-9. 2011
    ..This study aimed to determine the therapeutic effects of locally administered calf IAP (cIAP) in a cecal ligation and puncture (CLP) model of polymicrobial sepsis...
  17. ncbi Improved eukaryotic promoter-detection vector carrying two luciferase reporter genes
    Madhu S Malo
    Harvard Medical School, Boston, MA, USA
    Biotechniques 35:1150-2, 1154. 2003
  18. pmc Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis
    Sundaram Ramasamy
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Inflamm Bowel Dis 17:532-42. 2011
    ....
  19. ncbi A 'Swinging Cradle' model for in vitro classification of different types of response elements of a nuclear receptor
    Madhu S Malo
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    Biochem Biophys Res Commun 337:490-7. 2005
    ..We also show that among these TREs, the everted repeat mediates the highest biological activity...
  20. ncbi Transcriptional activation of the enterocyte differentiation marker intestinal alkaline phosphatase is associated with changes in the acetylation state of histone H3 at a specific site within its promoter region in vitro
    Brian F Hinnebusch
    Department of Surgery, Massachusetts General Hospital Harvard Medical School, Grey Bigelow 504, 55 Fruit Street, Boston, MA 02114, USA
    J Gastrointest Surg 7:237-44; discussion 244-5. 2003
    ..These changes within the endogenous IAP gene may underlie its transcriptional activation in the context of the enterocyte differentiation program...