A Malhotra

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Performance of an automated polysomnography scoring system versus computer-assisted manual scoring
    Atul Malhotra
    Department of Medicine, Harvard University, Boston, MA, USA
    Sleep 36:573-82. 2013
  2. pmc Transfer entropy estimation and directional coupling change detection in biomedical time series
    Joon Lee
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    Biomed Eng Online 11:19. 2012
  3. pmc Is the way to man's heart (and lung) through the abdomen?
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Crit Care 13:199. 2009
  4. ncbi request reprint The male predisposition to pharyngeal collapse: importance of airway length
    Atul Malhotra
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 166:1388-95. 2002
  5. pmc Obesity and the lung: 3. Obesity, respiration and intensive care
    A Malhotra
    Pulmonary and Critical Care and Sleep Medicine Divisions, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Thorax 63:925-31. 2008
  6. pmc Postural effects on pharyngeal protective reflex mechanisms
    Atul Malhotra
    Sleep Medicine and Pulmonary Critical Care Divisions, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Sleep 27:1105-12. 2004
  7. pmc What is central sleep apnea?
    Atul Malhotra
    Division of Sleep, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Respir Care 55:1168-78. 2010
  8. pmc Lung biopsy in ARDS: is it worth the risk?
    Atul Malhotra
    Pulmonary and Critical Care and Sleep Medicine Divisions, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Crit Care 10:160. 2006
  9. pmc Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse
    Atul Malhotra
    Sleep Medicine and Pulmonary Critical Care Divisions, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 119:72.e9-14. 2006
  10. pmc Low-tidal-volume ventilation in the acute respiratory distress syndrome
    Atul Malhotra
    Pulmonary and Critical Care Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 357:1113-20. 2007

Detail Information

Publications101 found, 100 shown here

  1. pmc Performance of an automated polysomnography scoring system versus computer-assisted manual scoring
    Atul Malhotra
    Department of Medicine, Harvard University, Boston, MA, USA
    Sleep 36:573-82. 2013
    ..Automation of scoring could reduce cost and improve reproducibility. The purpose of this study was to compare a new automated scoring system (YST-Limited, Winnipeg, Canada) with computer-assisted manual scoring...
  2. pmc Transfer entropy estimation and directional coupling change detection in biomedical time series
    Joon Lee
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    Biomed Eng Online 11:19. 2012
    ....
  3. pmc Is the way to man's heart (and lung) through the abdomen?
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Crit Care 13:199. 2009
    ..However, their work raises several questions for clinicians and researchers regarding the pathophysiology and management of IAP...
  4. ncbi request reprint The male predisposition to pharyngeal collapse: importance of airway length
    Atul Malhotra
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 166:1388-95. 2002
    ..This study suggests that the male predisposition to pharyngeal collapse is anatomically based, primarily as the result of an increased length of vulnerable airway as well as increased soft palate size...
  5. pmc Obesity and the lung: 3. Obesity, respiration and intensive care
    A Malhotra
    Pulmonary and Critical Care and Sleep Medicine Divisions, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Thorax 63:925-31. 2008
    ....
  6. pmc Postural effects on pharyngeal protective reflex mechanisms
    Atul Malhotra
    Sleep Medicine and Pulmonary Critical Care Divisions, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Sleep 27:1105-12. 2004
    ..We hypothesized that tongue protruder muscles are maximally responsive to negative pressure pulses during supine sleep, when posterior tongue displacement yields pharyngeal occlusion...
  7. pmc What is central sleep apnea?
    Atul Malhotra
    Division of Sleep, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Respir Care 55:1168-78. 2010
    ..A paucity of research exists in this area, emphasizing the opportunities for young investigators who are interested in this field...
  8. pmc Lung biopsy in ARDS: is it worth the risk?
    Atul Malhotra
    Pulmonary and Critical Care and Sleep Medicine Divisions, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Crit Care 10:160. 2006
    ..In the future, various biomarkers may be available to non-invasively classify ARDS patients from the standpoint of responsiveness to various therapies, such as glucocorticoids...
  9. pmc Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse
    Atul Malhotra
    Sleep Medicine and Pulmonary Critical Care Divisions, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 119:72.e9-14. 2006
  10. pmc Low-tidal-volume ventilation in the acute respiratory distress syndrome
    Atul Malhotra
    Pulmonary and Critical Care Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 357:1113-20. 2007
  11. ncbi request reprint Obstructive sleep apnoea
    Atul Malhotra
    Brigham and Women s Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
    Lancet 360:237-45. 2002
    ..Continuous positive airway pressure, the treatment of choice for obstructive sleep apnoea, reduces sleepiness and improves hypertension...
  12. ncbi request reprint Pharyngeal pressure and flow effects on genioglossus activation in normal subjects
    Atul Malhotra
    Sleep Medicine Division and Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 165:71-7. 2002
    ..These data suggest that independent of central pattern generator activity, intrapharyngeal negative pressure itself modulates genioglossus activity both within breaths and between breaths...
  13. ncbi request reprint Genioglossal activation in patients with obstructive sleep apnea versus control subjects. Mechanisms of muscle control
    R B Fogel
    Divisions of Sleep Medicine and Pulmonary and Critical Care, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 164:2025-30. 2001
    ..Thus, the increased GGEMG seen in the patient with apnea during wakefulness appears to be a product of an increased tonic activation of the muscle, combined with increased negative-pressure generation during inspiration...
  14. pmc The effect of lung stretch during sleep on airway mechanics in overweight and obese asthma
    L M Campana
    Department of Biomedical Engineering, Boston University, Boston, MA, United States
    Respir Physiol Neurobiol 185:304-12. 2013
    ..01), but R(low) was unchanged. High R(up) was observed in asthma, which reduced with BPAP. We conclude that the upper airway is a major component of R(rs) and larger lung volume changes may be required to alter R(low)...
  15. pmc Variability of respiratory mechanics during sleep in overweight and obese subjects with and without asthma
    L M Campana
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Respir Physiol Neurobiol 186:290-5. 2013
    ..We conclude that the BPAP-induced decrease in variability may indicate that those with asthma are more likely to remain in a low resistance state, and that low resistance variability may reduce arousals from sleep...
  16. ncbi request reprint Upper-airway collapsibility: measurements and sleep effects
    A Malhotra
    Sleep Disorders Section, Divisions of Endocrinology and Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Chest 120:156-61. 2001
    ....
  17. doi request reprint Effect of oxygen in obstructive sleep apnea: role of loop gain
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Respir Physiol Neurobiol 162:144-51. 2008
    ..These data suggest that ventilatory instability is an important mechanism causing obstructive sleep apnea in some patients (those with a relatively high LG), since lowering LG with oxygen in these patients significantly reduces AHI...
  18. pmc Trazodone increases arousal threshold in obstructive sleep apnoea
    R C Heinzer
    Sleep Medicine Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Eur Respir J 31:1308-12. 2008
    ..Trazodone at 100 mg increased the effort-related arousal threshold in response to hypercapnia in obstructive sleep apnoea patients and allowed them to tolerate higher CO(2) levels...
  19. ncbi request reprint Genioglossal inspiratory activation: central respiratory vs mechanoreceptive influences
    G Pillar
    Department of Medicine, Sleep Medicine Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    Respir Physiol 127:23-38. 2001
    ..We conclude that both central output to the GG and local reflex mediated activation are important in maintaining upper airway patency...
  20. pmc Effects of pentobarbital on upper airway patency during sleep
    M Eikermann
    Dept of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114 2696, USA
    Eur Respir J 36:569-76. 2010
    ..Pentobarbital did not affect the genioglossus negative-pressure reflex. Pentobarbital increases the time to arousal and stimulates genioglossus muscle activity, but it also increases upper airway resistance during sleep...
  21. pmc The influence of aging on pharyngeal collapsibility during sleep
    Matthias Eikermann
    Department of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Chest 131:1702-9. 2007
    ..We tested the hypotheses that upper airway closing pressure (PCLOSE) and the increase in pharyngeal resistance during sleep (primary outcomes) as well as measures of arousal threshold (secondary outcomes) increase with age...
  22. ncbi request reprint Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome
    R B Fogel
    Sleep Disorders Section, Divisions of Endocrinology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 86:1175-80. 2001
    ..05) in women with PCOS. We conclude that obese women with PCOS are at increased risk of OSA when compared with matched reproductively normal women. Women with PCOS should be carefully questioned regarding symptoms of sleep apnea...
  23. pmc The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep
    Danny J Eckert
    Brigham and Women s Hospital, Division of Sleep Medicine, Sleep Disorders Program, 221 Longwood Avenue, Boston, MA 02115, USA
    Chest 135:957-64. 2009
    ....
  24. pmc Chemical control stability in the elderly
    Andrew Wellman
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 581:291-8. 2007
    ..26). We conclude that the chemical control of breathing does not become unstable with ageing and is thus an unlikely cause of central (and possibly obstructive) apnoeas in this population...
  25. pmc Computational simulation of human upper airway collapse using a pressure-/state-dependent model of genioglossal muscle contraction under laminar flow conditions
    Yaqi Huang
    Department of Medicine, Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Appl Physiol (1985) 99:1138-48. 2005
    ..The model-predicted muscle deformations are consistent with previous observations regarding upper airway behavior in normal subjects...
  26. pmc The effect of sleep onset on upper airway muscle activity in patients with sleep apnoea versus controls
    Robert B Fogel
    Harvard Medical School and Division of Sleep Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Physiol 564:549-62. 2005
    ....
  27. pmc Effect of expiratory positive airway pressure on sleep disordered breathing
    Raphael Heinzer
    Sleep Medicine Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Sleep 31:429-32. 2008
    ..We sought to determine the effect of expiratory positive airway pressure on end expiratory lung volume (EELV) and sleep disordered breathing in obstructive sleep apnea patients...
  28. ncbi request reprint Genioglossus muscle responsiveness to chemical and mechanical stimuli during non-rapid eye movement sleep
    Michael L Stanchina
    Sleep Medicine and Pulmonary Critical Care Divisions, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 165:945-9. 2002
    ..When hypercapnia is combined with resistive loading, the muscle does respond. However, the possibility that higher levels of PCO2 or greater resistive loading alone could activate the muscle cannot be excluded...
  29. pmc Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea
    Amy S Jordan
    Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
    Sleep 32:361-8. 2009
    ....
  30. ncbi request reprint The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep
    Michael L Stanchina
    Pulmonary Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Sleep 26:851-6. 2003
    ..We hypothesized that lower lung volumes would lead to increased pharyngeal collapsibility, airflow resistance, and, in compensation, augmented genioglossus muscle activation...
  31. pmc Esophageal pressures in acute lung injury: do they represent artifact or useful information about transpulmonary pressure, chest wall mechanics, and lung stress?
    Stephen H Loring
    Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol (1985) 108:515-22. 2010
    ..We suggest that Pes can be used to estimate transpulmonary pressures that are consistent with known physiology and can provide meaningful information, otherwise unavailable, in critically ill patients...
  32. pmc Measuring upper and lower airway resistance during sleep with the forced oscillation technique
    Lisa M Campana
    Boston University, Boston, MA, USA
    Ann Biomed Eng 40:925-33. 2012
    ..The FOT was well tolerated and resistance was separated into upper and lower airway components. This setup is suitable for monitoring both upper and lower airway obstruction during sleep in those with and without asthma...
  33. pmc Upper airway myopathy is not important in the pathophysiology of obstructive sleep apnea
    Danny J Eckert
    Brigham and Women s Hospital, Division of Sleep Medicine, Sleep Disorders Program, Harvard Medical School, Boston, MA 02115, USA
    J Clin Sleep Med 3:570-3. 2007
    ..Thus, future studies should carefully explore the functional consequences of UAM abnormalities and define which patients, if any, are susceptible to these potentially detrimental effects...
  34. ncbi request reprint Respiratory system loop gain in normal men and women measured with proportional-assist ventilation
    Andrew Wellman
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 94:205-12. 2003
    ..We conclude that LG is low in the majority of normal men and women and that higher volume amplification factors are needed to determine whether gender differences exist in this low range...
  35. pmc Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humans
    Amy S Jordan
    Sleep Disorders Program BIDMC, 75 Francis St, Boston, Massachusetts 02115, USA
    Thorax 62:861-7. 2007
    ..The aims of this study were to compare the ability to recover ventilation and the mechanisms of compensation following a sudden reduction of continuous positive airway pressure (CPAP) in subjects with and without OSA...
  36. pmc The current prevalence of sleep disordered breathing in congestive heart failure patients treated with beta-blockers
    Mary MacDonald
    Division of Cardiovascular Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Clin Sleep Med 4:38-42. 2008
    ..Our objective was to determine the current prevalence of sleep disordered breathing in a state-of-the-art congestive heart failure clinic...
  37. pmc Pilot study of the effects of bariatric surgery and continuous positive airway pressure treatment on vascular function in obese subjects with obstructive sleep apnoea
    J P Bakker
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Intern Med J 43:993-8. 2013
    ..The mechanisms by which obesity and obstructive sleep apnoea (OSA) may contribute to endothelial dysfunction are unclear...
  38. pmc Sleep. 2: pathophysiology of obstructive sleep apnoea/hypopnoea syndrome
    R B Fogel
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Thorax 59:159-63. 2004
    ..The primary defect is probably an anatomically small or collapsible pharyngeal airway, in combination with a sleep induced fall in upper airway muscle activity...
  39. pmc Control of upper airway muscle activity in younger versus older men during sleep onset
    Robert B Fogel
    Harvard Medical School and Division of Sleep Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    J Physiol 553:533-44. 2003
    ..Sleep onset per se does not appear to have a greater effect on upper airway muscle activity as one ages...
  40. pmc Within-breath control of genioglossal muscle activation in humans: effect of sleep-wake state
    Robert B Fogel
    Harvard Medical School and Division of Sleep Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    J Physiol 550:899-910. 2003
    ..The loss of this protective mechanism during sleep suggests that an airway dependent upon such mechanisms (as in the patient with sleep apnoea) will be prone to collapse during sleep...
  41. ncbi request reprint Anatomic and physiologic predictors of apnea severity in morbidly obese subjects
    Robert B Fogel
    Divisions of Sleep Medicine and Pulmonary Critical Care, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston MA, USA
    Sleep 26:150-5. 2003
    ..We thus attempted to identify anatomic and physiologic predictors of apnea severity...
  42. pmc Obstructive sleep apnea and aging effects on macrovascular and microcirculatory function
    Susie Yim-Yeh
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Sleep 33:1177-83. 2010
    ..We hypothesize that OSA, independent of obesity, contributes to abnormal vascular function...
  43. pmc Aging and sleep: physiology and pathophysiology
    Bradley A Edwards
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Semin Respir Crit Care Med 31:618-33. 2010
    ....
  44. pmc Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function
    Matthias Eikermann
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Anesthesiology 107:621-9. 2007
    ..The authors hypothesized that cholinesterase inhibition when given the in absence of neuromuscular blockade (NB) would decrease upper airway dilatory muscle activity and consequently upper airway volume...
  45. doi request reprint Differential effects of isoflurane and propofol on upper airway dilator muscle activity and breathing
    Matthias Eikermann
    Department of Anesthesia, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    Anesthesiology 108:897-906. 2008
    ..The authors sought to understand which anesthetics increase or decrease upper airway dilator muscle activity and to study the mechanisms mediating the effect...
  46. pmc Pentobarbital dose-dependently increases respiratory genioglossus muscle activity while impairing diaphragmatic function in anesthetized rats
    Matthias Eikermann
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114 2696, USA
    Anesthesiology 110:1327-34. 2009
    ..The authors assessed the effects of pentobarbital on upper airway dilator and respiratory pump muscle function in rats and compared these results with the effects of normal sleep...
  47. pmc Potential therapeutic targets in obstructive sleep apnoea
    Julian P Saboisky
    Brigham and Women s Hospital, Harvard Medical School, Division of Sleep Medicine, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Expert Opin Ther Targets 13:795-809. 2009
    ....
  48. doi request reprint Obstructive sleep apnea and the risk for cardiovascular disease
    Puja Kohli
    Brigham and Women s Hospital, Brookline, MA 02446, USA
    Curr Atheroscler Rep 13:138-46. 2011
    ..This chapter reviews these epidemiologic studies, the current understanding of the mechanisms by which OSA may contribute to the progression of cardiovascular diseases, and the effects of OSA treatment on cardiovascular disease outcomes...
  49. pmc Sleep-disordered breathing and COPD: the overlap syndrome
    Robert L Owens
    Sleep Disorders Research Program, Brigham and Women s Hospital, Boston, MA 02115, USA
    Respir Care 55:1333-44; discussion 1344-6. 2010
    ..Treatment currently consists of continuous positive airway pressure, and oxygen as needed. Noninvasive ventilation may be helpful in overlap syndrome patients, but this has not yet been well studied...
  50. pmc Ventilatory control and airway anatomy in obstructive sleep apnea
    Andrew Wellman
    Sleep Disorders Program at BI, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 170:1225-32. 2004
    ..88, p = 0.0016). We conclude that loop gain has a substantial impact on apnea severity in certain patients with sleep apnea, particularly those with a pharyngeal closing pressure near atmospheric...
  51. pmc Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea
    Raphael C Heinzer
    Division of Sleep Medicine, Sleep Disorders Program BI, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 172:114-7. 2005
    ..These results demonstrate that relatively small changes in lung volume have an important effect on the upper airway in subjects with sleep apnea during non-REM sleep...
  52. pmc Obstructive airway disease and obstructive sleep apnea: effect of pulmonary function
    Bhavneesh Sharma
    Division of Sleep Medicine, Harvard Medical School Brigham and Women s Hospital, Boston, MA 02115, USA
    Lung 189:37-41. 2011
    ..However, the high prevalence of OSA in OAD patients appears to be due to obesity, and reduced pulmonary function is not an independent risk factor for OSA...
  53. pmc Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea
    Amy S Jordan
    Harvard Medical School and Division of Sleep Medicine, Brigham and Women s Hospital, Sleep Disorders Research Program, Boston, MA 02115, USA
    J Appl Physiol (1985) 99:2020-7. 2005
    ..38 +/- 0.02 vs. 0.33 +/- 0.03; P = 0.14). These results suggest that women may be protected from developing OSA by having a less collapsible upper airway for any given degree of obesity...
  54. pmc Pathophysiology & genetics of obstructive sleep apnoea
    Lisa Campana
    Brigham and Women s Hospital, Division of Sleep Medicine, Sleep Disorders Program and Harvard Medical School Boston, MA, USA
    Indian J Med Res 131:176-87. 2010
    ..We briefly review the state-of-the-art knowledge regarding OSA pathogenesis in adults and highlight the potential role of genetics in influencing key OSA pathophysiological traits...
  55. pmc Upper airway function in the pathogenesis of obstructive sleep apnea: a review of the current literature
    Robert L Owens
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Pulm Med 14:519-24. 2008
    ..However, recent work has focused on the function, rather than structure alone, of the upper airway...
  56. pmc Influence of wakefulness on pharyngeal airway muscle activity
    Yu Lun Lo
    Brigham and Women s Hospital, Sleep Disorders Research Program, 75 Francis Street, Boston, Massachusetts 02115, USA
    Thorax 62:799-805. 2007
    ..A study was therefore undertaken to assess the isolated impact of sleep on upper airway muscle activity after minimising respiratory/mechanical inputs...
  57. ncbi request reprint The role of open-lung biopsy in ARDS
    Sanjay R Patel
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, MA 02115, USA
    Chest 125:197-202. 2004
    ..The goals of this study were to better define the frequency of unexpected diagnoses made by open-lung biopsy, the frequency biopsy results lead to a change in clinical management, and the frequency of procedural complications...
  58. pmc Recruitment and rate-coding strategies of the human genioglossus muscle
    Julian P Saboisky
    Division of Sleep Medicine, Sleep Disorders Program, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 109:1939-49. 2010
    ..Understanding upper airway muscle recruitment/derecruitment may yield therapeutic targets for maintenance of pharyngeal patency...
  59. pmc The influence of end-expiratory lung volume on measurements of pharyngeal collapsibility
    Robert L Owens
    Sleep Disorders Research Program, Div of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Appl Physiol (1985) 108:445-51. 2010
    ..Changes in lung volume alter Pcrit substantially. This work supports a role for lung volume in the pathogenesis of OSA, and lung volume changes should be a consideration during assessment of pharyngeal mechanics...
  60. pmc Genioglossal muscle response to CO2 stimulation during NREM sleep
    Yu Lun Lo
    Department of Thoracic Medicine, Chang Gang Memorial Hospital, Taipei, Taiwan
    Sleep 29:470-7. 2006
    ..The objective was to evaluate the responsiveness of upper airway muscles to hypercapnia with and without intrapharyngeal negative pressure during non-rapid eye movement (NREM) sleep and wakefulness...
  61. pmc Mechanical ventilation and air leaks after lung biopsy for acute respiratory distress syndrome
    Michael H Cho
    Division of Pulmonary, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Ann Thorac Surg 82:261-6. 2006
    ..Persistent air leak is the most common postoperative complication. Risk factors in this setting are not known...
  62. pmc Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea
    R C Heinzer
    Sleep Medicine Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Thorax 61:435-9. 2006
    ..We sought to determine the effect of a constant lung volume increase on sleep disordered breathing during non-REM sleep...
  63. pmc Phase-rectified signal averaging as a sensitive index of autonomic changes with aging
    L M Campana
    Boston University, Department of Biomedical Engineering, and Brigham and Women s Hospital, 44 Cummington St, Boston, MA 02215, USA
    J Appl Physiol (1985) 108:1668-73. 2010
    ..We propose that the decrease in DC and AC may be a sensitive marker for autonomic changes with aging. Further work will be required to determine whether the observed changes predict poorer cardiac health prognosis...
  64. doi request reprint Effect of the chest wall on pressure-volume curve analysis of acute respiratory distress syndrome lungs
    Robert L Owens
    Departments of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Crit Care Med 36:2980-5. 2008
    ..We sought to quantify the effect of the chest wall by considering the chest wall and lung in series...
  65. pmc Pulmonary characteristics in COPD and mechanisms of increased work of breathing
    Stephen H Loring
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol (1985) 107:309-14. 2009
    ..Extrinsic restriction, in which the chest wall fails to achieve and maintain abnormally high lung volumes in COPD, can limit ventilatory function and contribute to disability...
  66. ncbi request reprint Assessment of automated scoring of polysomnographic recordings in a population with suspected sleep-disordered breathing
    Stephen D Pittman
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Mass 02115 5817, USA
    Sleep 27:1394-403. 2004
    ..To assess the accuracy of an automated system (Morpheus I Sleep Scoring System) for analyzing and quantifying polysomnographic data from a population with sleep-disordered breathing...
  67. pmc Genioglossus premotoneurons and the negative pressure reflex in rats
    Nancy L Chamberlin
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 579:515-26. 2007
    ..These results suggest that perihypoglossal GG premotoneurons near the obex mediate the NPR and those caudal to the obex are important mediators of respiratory-related GG activity but are not involved in the NPR...
  68. pmc The pharyngeal lumen: both length and size matter
    Amy Jordan
    Brigham and Women s Hospital, Boston, MA 02115, USA
    J Clin Sleep Med 1:264-5. 2005
  69. pmc Using a wrist-worn device based on peripheral arterial tonometry to diagnose obstructive sleep apnea: in-laboratory and ambulatory validation
    Stephen D Pittman
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115 5817, USA
    Sleep 27:923-33. 2004
    ..To assess the accuracy of a wrist-worn device (Watch_PAT 100) to diagnose obstructive sleep apnea in the home...
  70. pmc Gas exchange impairment induced by open suctioning in acute respiratory distress syndrome: impact of permissive hypercapnia
    Maria Paula Caramez
    Department of Anesthesia and Critical Care, and Respiratory Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Crit Care Med 36:560-4. 2008
    ..To determine whether hypercarbia occurs following the use of open suctioning in lung lavage injured sheep and whether the baseline PaCO2 and duration of suctioning affect gas exchange...
  71. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 12-2003. An 82-year-old man with dyspnea and pulmonary abnormalities
    Atul Malhotra
    Pulmonary and Critical Care Unit, Brigham and Women s Hospital and Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School, Boston, USA
    N Engl J Med 348:1574-85. 2003
  72. pmc The impact of anatomic manipulations on pharyngeal collapse: results from a computational model of the normal human upper airway
    Yaqi Huang
    Sleep Medicine Division and Pulmonary Critical Care Division, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Chest 128:1324-30. 2005
    ..We believe that, in the future, finite element modeling will provide a useful tool to help advance our understanding of OSA and its response to various therapies...
  73. pmc Pathophysiology of adult obstructive sleep apnea
    Danny J Eckert
    Division of Sleep Medicine, Sleep Disorders Program, Brigham and Women s Hospital, and Havard Medical School, Boston, MA 02115, USA
    Proc Am Thorac Soc 5:144-53. 2008
    ..Finally, the potential for novel treatment strategies, based on an improved understanding of the underlying pathophysiology, is also discussed with the ultimate aim of stimulating research ideas in areas where knowledge is lacking...
  74. ncbi request reprint Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing
    M Eikermann
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Br J Anaesth 101:344-9. 2008
    ..Sugammadex reverses neuromuscular block by encapsulating rocuronium. However, its effects on upper airway integrity and breathing are unknown...
  75. ncbi request reprint Telomerase activity in rat cardiac myocytes is age and gender dependent
    A Leri
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    J Mol Cell Cardiol 32:385-90. 2000
    ..The greater growth potential of female myocytes may be critical for the longer lifespan and decreased incidence of heart failure in women...
  76. pmc Central sleep apnea: Pathophysiology and treatment
    Danny J Eckert
    Division of Sleep Medicine, Sleep Disorders Program, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 131:595-607. 2007
    ..The clinical implications of improved CSA pathophysiology knowledge and the potential for novel therapeutic treatment approaches are also discussed...
  77. pmc A secondary reflex suppression phase is present in genioglossus but not tensor palatini in response to negative upper airway pressure
    Danny J Eckert
    Sleep Disorders Program, Div of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 108:1619-24. 2010
    ..These differential responses support the hypothesis that GG reflex suppression may be mediated via inhibition of respiratory-related premotor input...
  78. pmc Sleep in congestive heart failure
    Bhavneesh Sharma
    Division of Sleep Medicine, Harvard Medical School, Brigham and Women s Hospital, 75 Francis Street Asb1, Boston, MA 02115 6106, USA
    Med Clin North Am 94:447-64. 2010
    ..Periodic limb movements are also common in CHF...
  79. pmc The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans
    Amy S Jordan
    Brigham and Women s Hospital, Sleep Disorders Research Program BIDMC, 75 Francis Street, Boston, MA 02115, USA
    J Physiol 558:993-1004. 2004
    ..These results demonstrate that the ventilatory response to arousal is influenced by pre-arousal airway resistance and gender. Whether this contributes to the perpetuation of respiratory events and the pathogenesis of OSA is unclear...
  80. ncbi request reprint Follow-up assessment of CPAP efficacy in patients with obstructive sleep apnea using an ambulatory device based on peripheral arterial tonometry
    Stephen D Pittman
    Division of Sleep Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115 5817, USA
    Sleep Breath 10:123-31. 2006
    ..The Watch_PAT device accurately identified participants with moderate-severe SDB while using CPAP in the attended setting of a sleep laboratory...
  81. pmc Esophageal and transpulmonary pressures in acute respiratory failure
    Daniel Talmor
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Crit Care Med 34:1389-94. 2006
    ..By measuring esophageal pressure (Pes), we sought to characterize influence of the chest wall on Ppl and transpulmonary pressure (PL) in patients with acute respiratory failure...
  82. ncbi request reprint Regulation of contractile proteins in diabetic heart
    A Malhotra
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cardiovasc Res 34:34-40. 1997
    ..The focus of this review has been the explication of a biochemical defect which underlies cardiac contractile dysfunction in experimental models of diabetes...
  83. ncbi request reprint Negative pressure pulmonary hemorrhage
    D R Schwartz
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston 02114 2696, USA
    Chest 115:1194-7. 1999
    ..We describe a case of negative pressure pulmonary hemorrhage, and we propose that its etiology is stress failure, the mechanical disruption of the alveolar-capillary membrane...
  84. pmc The impact of endotracheal suctioning on gas exchange and hemodynamics during lung-protective ventilation in acute respiratory distress syndrome
    Maria Paula Caramez
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, and with Harvard Medical School, Boston Massachusetts 02114, USA
    Respir Care 51:497-502. 2006
    ....
  85. pmc Cytokine release following recruitment maneuvers
    Daniel Talmor
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Rd, CC 470, Boston MA 02215, USA
    Chest 132:1434-9. 2007
    ..There are reports of rigors and/or clinical deterioration following recruitment maneuvers (RMs), leading us to question whether the use of sustained high-pressure inflation could lead to release of inflammatory mediators...
  86. ncbi request reprint Prone positioning of patients in acute respiratory failure
    Atul Malhotra
    N Engl J Med 346:295-7. 2002
  87. ncbi request reprint Awake negative pressure reflex response of the genioglossus in OSA patients and normal subjects
    Richard B Berry
    Medical Health Care Group, Long Beach Veterans Affairs Medical Center, University of California, Irvine, California 90822, USA
    J Appl Physiol (1985) 94:1875-82. 2003
    ..05) at a suction pressure of approximately 13 cmH(2)O. We conclude that the response of the genioglossus to NPA during wakefulness is not impaired in OSA patients compared with normal subjects and is greater at low suction pressures...
  88. ncbi request reprint Interactions between hypoglycemia and sleep architecture in children with type 1 diabetes mellitus
    Giora Pillar
    Pediatrics Department A, Rambam Medical Center, and Technion Israel Institute of Technology, Haifa, Israel
    J Pediatr 142:163-8. 2003
    ..To assess the interactions between nocturnal hypoglycemia and sleep in children with type 1 diabetes mellitus (DM)...
  89. pmc Discharge patterns of human genioglossus motor units during sleep onset
    Vanessa Wilkinson
    Department of Psychology, University of Melbourne, Parkville, Australia
    Sleep 31:525-33. 2008
    ..The aim of the present study was to determine the effect of sleep onset on the activity of individual motor units as a function of their particular discharge pattern...
  90. ncbi request reprint The debate about gender differences in obstructive sleep apnea
    Kelly Carden
    Sleep Med 4:485-7. 2003
  91. pmc Influence of gender and age on upper-airway length during development
    Ohad Ronen
    Department of Otolaryngology, Head and Neck Surgery, Carmel Medical Center, Haifa, Israel
    Pediatrics 120:e1028-34. 2007
    ....
  92. pmc The impact of cardiac resynchronization therapy on obstructive sleep apnea in heart failure patients: a pilot study
    Michael L Stanchina
    Pulmonary, Critical Care, and Sleep Medicine Division, Rhode Island Hospital, 1285 South County Trail, East Greenwich, RI 02818, USA
    Chest 132:433-9. 2007
    ..We hypothesized that through increased cardiac output CRT/pacing would reduce obstructive events and daytime symptoms of sleepiness...
  93. pmc Muscle weakness after administration of neuromuscular blocking agents: do not immobilize the diaphragm unnecessarily
    Matthias Eikermann
    Crit Care Med 35:1634-5; author reply 1635. 2007
  94. pmc Treatment adherence and outcomes in flexible vs standard continuous positive airway pressure therapy
    Mark S Aloia
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence RI, USA
    Chest 127:2085-93. 2005
    ..To compare adherence and clinical outcomes between flexible positive airway pressure (PAP) [C-Flex; Respironics; Murraysville, PA] and standard PAP therapy (ie, continuous positive airway pressure [CPAP])...
  95. pmc Use of computational modeling to predict responses to upper airway surgery in obstructive sleep apnea
    Yaqi Huang
    Sleep Medicine Division, Pulmonary and Critical Care Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Laryngoscope 117:648-53. 2007
    ..Computational models of the upper airway using finite element analysis to simulate the effects of various anatomic and physiologic manipulations on pharyngeal mechanics could be helpful in predicting surgical success...
  96. pmc Inspiratory efforts during mechanical ventilation: is there risk of barotrauma?
    Stephen H Loring
    Chest 131:646-8. 2007
  97. pmc Association between reduced sleep and weight gain in women
    Sanjay R Patel
    Division of Pulmonary and Critical Care Medicine, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Epidemiol 164:947-54. 2006
    ..These data suggest that short sleep duration is associated with a modest increase in future weight gain and incident obesity. Further research is needed to understand the mechanisms by which sleep duration may affect weight...
  98. pmc Risk factors for ARDS in patients receiving mechanical ventilation for > 48 h
    Xiaoming Jia
    Massachusetts Institute of Technology, Cambridge, MA, USA
    Chest 133:853-61. 2008
    ..However, controversy persists regarding the optimal ventilator settings for patients without ARDS receiving mechanical ventilation. This study tested the hypothesis that ventilator settings influence the development of new ARDS...
  99. ncbi request reprint Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: results of a meta-analysis
    Najib T Ayas
    Department of Medicine, University of British Colombia
    Sleep 27:249-53. 2004
    ....
  100. pmc Paradoxical responses to positive end-expiratory pressure in patients with airway obstruction during controlled ventilation
    Maria Paula Caramez
    Respiratory and Emergency Intensive Care Unit, Emergency Department, Hospital das Clinicas, University of Sao Paulo Medical School, Brazil
    Crit Care Med 33:1519-28. 2005
    ..The controversial occurrence of a paradoxic lung deflation promoted by PEEP was scrutinized...
  101. ncbi request reprint Profile of neonates admitted in pediatric ICU and validation of Score for Neonatal Acute Physiology (SNAP)
    Anil Vasudevan
    Department of Pediatrics, All India Institute of Medical Science, Ansari Nagar, New Delhi 110 029, India
    Indian Pediatr 43:344-8. 2006
    ..8 +/- 9.8 and 10.1 +/- 6.4 in survivors (P<0.001). There was no correlation between SNAP score and mean length of stay in hospital (P=0.5). We conclude that SNAP correlates well with mortality in neonates admitted to the PICU...

Research Grants10

  1. Sleep Apnea and Obesity: Cardiovascular Risk Assessment
    Atul Malhotra; Fiscal Year: 2003
    ..This data may have important implications for the diagnosis and treatment of these abnormalities. ..
  2. Mechanisms Underlying the Aging Predisposition to Obstructive Sleep Apnea
    Atul Malhotra; Fiscal Year: 2010
    ..We plan to characterize many of the variables important in causing sleep apnea so that we can develop a better understanding of why the elderly develop this disease, and how best to prevent or minimize its complications. ..
  3. Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea Pathogenesis
    Atul Malhotra; Fiscal Year: 2009
    ....
  4. Mechanisms Underlying the Aging Predisposition to Obstructive Sleep Apnea
    Atul Malhotra; Fiscal Year: 2009
    ..We plan to characterize many of the variables important in causing sleep apnea so that we can develop a better understanding of why the elderly develop this disease, and how best to prevent or minimize its complications. ..
  5. Aging Influence on the Development of Sleep Apnea
    Atul Malhotra; Fiscal Year: 2007
    ..abstract_text> ..
  6. Sleep Apnea and Obesity: Cardiovascular Risk Assessment
    Atul Malhotra; Fiscal Year: 2007
    ..This data may have important implications for the diagnosis and treatment of these abnormalities. ..
  7. Sleep Apnea and Obesity: Cardiovascular Risk Assessment
    Atul Malhotra; Fiscal Year: 2006
    ..This data may have important implications for the diagnosis and treatment of these abnormalities. ..
  8. Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea Pathogenesis
    Atul Malhotra; Fiscal Year: 2010
    ....