C C Maley

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Selective instability: maternal effort and the evolution of gene activation and deactivation rates
    Carlo C Maley
    Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 98109 1024, USA
    Artif Life 9:317-26. 2003
  2. pmc NSAIDs modulate clonal evolution in Barrett's esophagus
    Rumen L Kostadinov
    Genomics and Computational Biology Graduate Program, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Genet 9:e1003553. 2013
  3. pmc Solving the puzzle of metastasis: the evolution of cell migration in neoplasms
    Jun Chen
    Genomics and Computational Biology Program, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e17933. 2011
  4. pmc Sequence space coverage, entropy of genomes and the potential to detect non-human DNA in human samples
    Zhandong Liu
    Genomics and Computational Biology Graduate Group, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Genomics 9:509. 2008
  5. pmc An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition
    Lauren M F Merlo
    The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA
    BMC Cancer 11:461. 2011
  6. ncbi request reprint Exploring the relationship between neutral and selective mutations in cancer
    C C Maley
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, N Seattle, WA 98109, USA
    Artif Life 6:325-45. 2000
  7. ncbi request reprint Multistage carcinogenesis in Barrett's esophagus
    Carlo C Maley
    The Wistar Institute, Cellular and Molecular Oncogenesis, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Cancer Lett 245:22-32. 2007
  8. ncbi request reprint Genetic clonal diversity predicts progression to esophageal adenocarcinoma
    Carlo C Maley
    The Wistar Institute, 3601 Spruce St, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 38:468-73. 2006
  9. ncbi request reprint Natural selection in neoplastic progression of Barrett's esophagus
    Carlo C Maley
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA
    Semin Cancer Biol 15:474-83. 2005
  10. ncbi request reprint Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus
    Carlo C Maley
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 64:3414-27. 2004

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Selective instability: maternal effort and the evolution of gene activation and deactivation rates
    Carlo C Maley
    Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 98109 1024, USA
    Artif Life 9:317-26. 2003
    ....
  2. pmc NSAIDs modulate clonal evolution in Barrett's esophagus
    Rumen L Kostadinov
    Genomics and Computational Biology Graduate Program, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Genet 9:e1003553. 2013
    ..Barrett's cells maintained relative equilibrium level of SGAs over time with occasional punctuations by expansion of clones having massive amount of SGAs...
  3. pmc Solving the puzzle of metastasis: the evolution of cell migration in neoplasms
    Jun Chen
    Genomics and Computational Biology Program, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e17933. 2011
    ..We suggest that resource heterogeneity within primary tumors selects for cell migration, and that cell emigration is a by-product of that selection...
  4. pmc Sequence space coverage, entropy of genomes and the potential to detect non-human DNA in human samples
    Zhandong Liu
    Genomics and Computational Biology Graduate Group, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Genomics 9:509. 2008
    ..Genomes store information for building and maintaining organisms. Complete sequencing of many genomes provides the opportunity to study and compare global information properties of those genomes...
  5. pmc An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition
    Lauren M F Merlo
    The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA
    BMC Cancer 11:461. 2011
    ..We have examined competition between normal and Barrett's esophagus cell lines, in the hopes of identifying a system that could screen for potential chemopreventive agents...
  6. ncbi request reprint Exploring the relationship between neutral and selective mutations in cancer
    C C Maley
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, N Seattle, WA 98109, USA
    Artif Life 6:325-45. 2000
    ..The model also suggests that selective mutations facilitate the development of cancer, so that the more selective mutations necessary for the development of cancer, the greater the chance of developing it...
  7. ncbi request reprint Multistage carcinogenesis in Barrett's esophagus
    Carlo C Maley
    The Wistar Institute, Cellular and Molecular Oncogenesis, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Cancer Lett 245:22-32. 2007
    ..The final events that lead to invasion and metastasis are unknown. Evolutionary biology provides important tools to understand clonal evolution in progression and cancer prevention...
  8. ncbi request reprint Genetic clonal diversity predicts progression to esophageal adenocarcinoma
    Carlo C Maley
    The Wistar Institute, 3601 Spruce St, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 38:468-73. 2006
    ..6) and ploidy abnormalities. Progression to cancer through accumulation of clonal diversity, on which natural selection acts, may be a fundamental principle of neoplasia with important clinical implications...
  9. ncbi request reprint Natural selection in neoplastic progression of Barrett's esophagus
    Carlo C Maley
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA
    Semin Cancer Biol 15:474-83. 2005
    ..Evolutionary analyses provide insights for clinical management, including rates of progression to cancer and emergence of resistance to interventions...
  10. ncbi request reprint Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus
    Carlo C Maley
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 64:3414-27. 2004
    ..Virtually all of the other lesion expansions, including microsatellite shifts, could be explained as hitchhikers on p16 lesion clonal expansions. These techniques can be applied to any neoplasm...
  11. ncbi request reprint Cancer prevention strategies that address the evolutionary dynamics of neoplastic cells: simulating benign cell boosters and selection for chemosensitivity
    Carlo C Maley
    Division of Human Biology, Fred Hutchinson Cancer Research Center, P O Box 19024, Mailstop C1 157, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 13:1375-84. 2004
    ..Effective therapeutic and prevention strategies will have to alter the competitive dynamics of a neoplasm to counter progression toward invasion, metastasis, and death...
  12. ncbi request reprint Genetic mechanisms of TP53 loss of heterozygosity in Barrett's esophagus: implications for biomarker validation
    V Jon Wongsurawat
    Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 15:509-16. 2006
    ..If an alternative biomarker assay, such as fluorescence in situ hybridization (FISH), provided equivalent results, then translation to the clinic might be accelerated, because LOH genotyping is presently limited to research centers...
  13. pmc Open questions in oesophageal adenocarcinogenesis
    Carlo C Maley
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Gut 56:897-8. 2007
  14. ncbi request reprint Extent of low-grade dysplasia is a risk factor for the development of esophageal adenocarcinoma in Barrett's esophagus
    Amitabh Srivastava
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 102:483-93; quiz 694. 2007
    ..The aim of this discovery study was to evaluate the hypothesis that extent of LGD and HGD are risk factors for progression to EA...
  15. pmc NSAIDs modulate CDKN2A, TP53, and DNA content risk for progression to esophageal adenocarcinoma
    Patricia C Galipeau
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 4:e67. 2007
    ..We aimed to evaluate somatic genetic abnormalities with NSAIDs as predictors of EA in a prospective cohort study of patients with BE...
  16. ncbi request reprint Cancer as an evolutionary and ecological process
    Lauren M F Merlo
    Cellular and Molecular Oncology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Cancer 6:924-35. 2006
    ..The tools of evolutionary biology and ecology are providing new insights into neoplastic progression and the clinical control of cancer...
  17. ncbi request reprint Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: a prospective analysis
    Dennis L Chao
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C1 157, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 15:1935-40. 2006
    ....
  18. ncbi request reprint The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma
    Carlo C Maley
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Res 64:7629-33. 2004
    ..This implies that interventions that limit expansion of genetically unstable clones may reduce risk of progression to cancer...
  19. ncbi request reprint Barrett's esophagus and its progression to adenocarcinoma
    Carlo C Maley
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Natl Compr Canc Netw 4:367-74. 2006
    ..However, most of these results should be confirmed in additional cohorts before they are used to change clinical practice...
  20. pmc Animal cell differentiation patterns suppress somatic evolution
    John W Pepper
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America
    PLoS Comput Biol 3:e250. 2007
    ..These results are relevant not only to understanding the evolutionary origins of multicellularity, but also the causes of pathologies such as cancer and senescence in extant metazoans, including humans...
  21. ncbi request reprint Biologic properties of columnar epithelium underneath reepithelialized squamous mucosa in Barrett's esophagus
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 29:372-80. 2005
    ..Prospective studies of large numbers of patients with BUSI will be required to determine the magnitude of its risk of progression to cancer...
  22. ncbi request reprint Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward
    Gary J Kelloff
    National Cancer Institute, Bethesda, Maryland 20852, USA
    Clin Cancer Res 12:3661-97. 2006
    ....