B Magasanik

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc The transduction of the nitrogen regulation signal in Saccharomyces cerevisiae
    Boris Magasanik
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 102:16537-8. 2005
  2. ncbi request reprint Origins
    Boris Magasanik
    Department of Biochemistry, Massachusetts Institute of Technology, Cambridge, 02139 4307, USA
    J Biol Chem 280:22557-9. 2005
  3. pmc Ammonia assimilation by Saccharomyces cerevisiae
    Boris Magasanik
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Eukaryot Cell 2:827-9. 2003
  4. ncbi request reprint Nitrogen regulation in Saccharomyces cerevisiae
    Boris Magasanik
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Gene 290:1-18. 2002
  5. pmc Transcriptional and posttranslational regulation of the general amino acid permease of Saccharomyces cerevisiae
    M Stanbrough
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    J Bacteriol 177:94-102. 1995
  6. pmc Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes
    M Stanbrough
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Proc Natl Acad Sci U S A 92:9450-4. 1995
  7. pmc Sequence and expression of GLN3, a positive nitrogen regulatory gene of Saccharomyces cerevisiae encoding a protein with a putative zinc finger DNA-binding domain
    P L Minehart
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Mol Cell Biol 11:6216-28. 1991
  8. pmc Recognition of nitrogen-responsive upstream activation sequences of Saccharomyces cerevisiae by the product of the GLN3 gene
    D Blinder
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Bacteriol 177:4190-3. 1995
  9. pmc Interaction of the GATA factor Gln3p with the nitrogen regulator Ure2p in Saccharomyces cerevisiae
    D Blinder
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Bacteriol 178:4734-6. 1996
  10. pmc Activation of the dephosphorylation of nitrogen regulator I-phosphate of Escherichia coli
    J Liu
    Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139
    J Bacteriol 177:926-31. 1995

Collaborators

Detail Information

Publications20

  1. pmc The transduction of the nitrogen regulation signal in Saccharomyces cerevisiae
    Boris Magasanik
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 102:16537-8. 2005
    ..As a consequence of the drop in glutamine concentration, Gln3p is able to enter the nucleus and to activate the transcription of nitrogen-regulated genes...
  2. ncbi request reprint Origins
    Boris Magasanik
    Department of Biochemistry, Massachusetts Institute of Technology, Cambridge, 02139 4307, USA
    J Biol Chem 280:22557-9. 2005
  3. pmc Ammonia assimilation by Saccharomyces cerevisiae
    Boris Magasanik
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Eukaryot Cell 2:827-9. 2003
  4. ncbi request reprint Nitrogen regulation in Saccharomyces cerevisiae
    Boris Magasanik
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Gene 290:1-18. 2002
    ..A second focus of the review is the nitrogen regulation of the general amino acid permease, Gap1p, and the proline permease, Put4p, by ubiquitin mediated intracellular protein sorting in the secretory and endosomal pathways...
  5. pmc Transcriptional and posttranslational regulation of the general amino acid permease of Saccharomyces cerevisiae
    M Stanbrough
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    J Bacteriol 177:94-102. 1995
    ..These results suggest that inactivation of the permease results from its dephosphorylation...
  6. pmc Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes
    M Stanbrough
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Proc Natl Acad Sci U S A 92:9450-4. 1995
    ..The results further indicate that Gln3p is inactivated by an increase in the intracellular concentration of glutamine and that Nil1p is inactivated by an increase in intracellular glutamate...
  7. pmc Sequence and expression of GLN3, a positive nitrogen regulatory gene of Saccharomyces cerevisiae encoding a protein with a putative zinc finger DNA-binding domain
    P L Minehart
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Mol Cell Biol 11:6216-28. 1991
    ..Neither control of transcription nor control of initiation of translation of GLN3 is important for regulation in response to glutamine availability...
  8. pmc Recognition of nitrogen-responsive upstream activation sequences of Saccharomyces cerevisiae by the product of the GLN3 gene
    D Blinder
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Bacteriol 177:4190-3. 1995
    ..We then demonstrated the specific binding of the more than 90% pure Gln3p to the UASN by gel shift and footprinting methods...
  9. pmc Interaction of the GATA factor Gln3p with the nitrogen regulator Ure2p in Saccharomyces cerevisiae
    D Blinder
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Bacteriol 178:4734-6. 1996
    ..Our results indicate that Ure2p probably does not interfere with the binding of the GATA factor Gln3p to GATAAG sites but acts directly on Gln3p to block its ability to activate transcription...
  10. pmc Activation of the dephosphorylation of nitrogen regulator I-phosphate of Escherichia coli
    J Liu
    Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139
    J Bacteriol 177:926-31. 1995
    ..This effect of glutamate appears to be a backup control that becomes effective when the normal regulation of PII activity is disabled...
  11. pmc The URE2 gene product of Saccharomyces cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione s-transferases
    P W Coschigano
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Mol Cell Biol 11:822-32. 1991
    ..The predicted URE2 gene product has homology to glutathione S-transferases. The gene has been mapped to chromosome XIV, 5.9 map units from petX and 3.4 map units from kex2...
  12. ncbi request reprint Regulation of transcription of the glnALG operon of Escherichia coli by protein phosphorylation
    B Magasanik
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Biochimie 71:1005-12. 1989
    ..The signal is transduced to the modulator by means of 2 additional proteins: uridylytransferase and PII...
  13. pmc The glnB region of the Escherichia coli chromosome
    J Liu
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    J Bacteriol 175:7441-9. 1993
    ..On the other hand, the product of hmpA, a gene located on the other side of glnB and transcribed in the opposite direction, appears to play an auxiliary role in this process...
  14. pmc Two transcription factors, Gln3p and Nil1p, use the same GATAAG sites to activate the expression of GAP1 of Saccharomyces cerevisiae
    M Stanbrough
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Bacteriol 178:2465-8. 1996
    ..The fact that both Gln3p and Nil1p utilize GATAAG sites to activate transcription is reflected in the high homology of the zinc finger regions of the two proteins...
  15. ncbi request reprint Activation of transcription at sigma 54-dependent promoters on linear templates requires intrinsic or induced bending of the DNA
    M Carmona
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Mol Biol 261:348-56. 1996
    ..Computer simulation of the shape of the DNA suggests that in the case of glnAp2, but not of glnHp2 or the altered glnAp2, this segment has an intrinsic curvature of 70 degrees...
  16. pmc Role of NAD-linked glutamate dehydrogenase in nitrogen metabolism in Saccharomyces cerevisiae
    S M Miller
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    J Bacteriol 172:4927-35. 1990
    ....
  17. pmc Role of GATA factor Nil2p in nitrogen regulation of gene expression in Saccharomyces cerevisiae
    D W Rowen
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Bacteriol 179:3761-6. 1997
    ..Apparently, the principal role of Nil2p is to prevent activation of transcription by Nil1p unless Nil1p has been converted to a more active state by the absence of glutamine and glutamate...
  18. pmc Phosphorylation of nitrogen regulator I (NRI) of Escherichia coli
    V Weiss
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Proc Natl Acad Sci U S A 85:8919-23. 1988
    ..In turn, NRII-phosphate transfers its phosphate reversibly to an aspartic residue of NRI. NRI-phosphate is hydrolyzed to NRI and inorganic phosphate in a divalent cation-requiring autocatalytic reaction...
  19. pmc Phosphorylation of nitrogen regulator I of Escherichia coli induces strong cooperative binding to DNA essential for activation of transcription
    V Weiss
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Proc Natl Acad Sci U S A 89:5088-92. 1992
    ..We propose that not the phosphorylation of NRI itself but rather the tetramerization of NRI-phosphate on DNA binding induces the conformational change of the central domain to the active conformation...
  20. pmc Sequence of the GLN1 gene of Saccharomyces cerevisiae: role of the upstream region in regulation of glutamine synthetase expression
    P L Minehart
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139 4307
    J Bacteriol 174:1828-36. 1992
    ..cis-acting sites required for the increased transcription in response to purine starvation also have been localized...