Shannon M Macdonald

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Proton radiotherapy for pediatric central nervous system ependymoma: clinical outcomes for 70 patients
    Shannon M Macdonald
    This paper was presented at the International Symposium on Pediatric Neuro Oncology on June 24, 2012, in Toronto, Canada Corresponding Author Shannon MacDonald, MD, Massachusetts General Hospital, Department of Radiation Oncology, Yawkey 112, 30 Fruit Street, Boston, MA 02114
    Neuro Oncol 15:1552-9. 2013
  2. doi request reprint Proton therapy for breast cancer after mastectomy: early outcomes of a prospective clinical trial
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 86:484-90. 2013
  3. pmc Proton radiotherapy for chest wall and regional lymphatic radiation; dose comparisons and treatment delivery
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA
    Radiat Oncol 8:71. 2013
  4. doi request reprint Proton beam therapy following resection for childhood ependymoma
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Cox 340, 100 Blossom Street, Boston, MA 02114, USA
    Childs Nerv Syst 26:285-91. 2010
  5. doi request reprint Nanoparticle-enhanced MRI to evaluate radiation delivery to the regional lymphatics for patients with breast cancer
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 77:1098-104. 2010
  6. doi request reprint ACR appropriateness criteria® locally advanced breast cancer
    Shannon M Macdonald
    Massachusetts General Hospital, Boston, Massachusetts, USA
    Breast J 17:579-85. 2011
  7. doi request reprint Proton radiotherapy for pediatric central nervous system germ cell tumors: early clinical outcomes
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 79:121-9. 2011
  8. ncbi request reprint Proton radiotherapy for childhood ependymoma: initial clinical outcomes and dose comparisons
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 71:979-86. 2008
  9. ncbi request reprint Partial-breast irradiation: towards a replacement for whole-breast irradiation?
    Shannon M Macdonald
    Harvard Medical School, Massachusetts General Hospital, Department of Radiation Oncology, Boston, MA 02114, USA
    Expert Rev Anticancer Ther 7:123-34. 2007
  10. ncbi request reprint Natural history and role of radiation in patients with supratentorial and infratentorial WHO grade II ependymomas: results from a population-based study
    Ayal A Aizer
    Harvard Radiation Oncology Program, Department of Radiation Oncology, Massachusetts General Hospital, 55 Fruit Street, Lunder LL3, Boston, MA, 02114, USA
    J Neurooncol 115:411-9. 2013

Collaborators

Detail Information

Publications34

  1. pmc Proton radiotherapy for pediatric central nervous system ependymoma: clinical outcomes for 70 patients
    Shannon M Macdonald
    This paper was presented at the International Symposium on Pediatric Neuro Oncology on June 24, 2012, in Toronto, Canada Corresponding Author Shannon MacDonald, MD, Massachusetts General Hospital, Department of Radiation Oncology, Yawkey 112, 30 Fruit Street, Boston, MA 02114
    Neuro Oncol 15:1552-9. 2013
    ..Proton radiotherapy (PRT) spares healthy tissues outside the target region, but reports of clinical outcomes are scarce. We report outcomes for 70 patients treated with PRT for intracranial ependymoma...
  2. doi request reprint Proton therapy for breast cancer after mastectomy: early outcomes of a prospective clinical trial
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 86:484-90. 2013
    ..We report acute toxicities and feasibility of proton delivery for 12 women treated with postmastectomy proton radiation with or without reconstruction...
  3. pmc Proton radiotherapy for chest wall and regional lymphatic radiation; dose comparisons and treatment delivery
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA
    Radiat Oncol 8:71. 2013
    ..This study investigates the use of protons for PMRT in selected patients with unfavorable cardiac anatomy. We also report the first clinical application of protons for these patients...
  4. doi request reprint Proton beam therapy following resection for childhood ependymoma
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Cox 340, 100 Blossom Street, Boston, MA 02114, USA
    Childs Nerv Syst 26:285-91. 2010
    ..Proton radiation therapy is a form of radiation with physical properties that can provide an advantage in normal tissue sparing compared to the more commonly used photon therapy...
  5. doi request reprint Nanoparticle-enhanced MRI to evaluate radiation delivery to the regional lymphatics for patients with breast cancer
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 77:1098-104. 2010
    ..Lymphotrophic nanoparticle-enhanced MRI (LN-MRI) allows for accurate identification of malignant and benign lymph nodes. We sought to evaluate RT delivery to lymphatics for breast cancer using LN-MRI...
  6. doi request reprint ACR appropriateness criteria® locally advanced breast cancer
    Shannon M Macdonald
    Massachusetts General Hospital, Boston, Massachusetts, USA
    Breast J 17:579-85. 2011
    ..In those instances where evidence is either lacking or not definitive, expert opinion may be used to recommend imaging or treatment...
  7. doi request reprint Proton radiotherapy for pediatric central nervous system germ cell tumors: early clinical outcomes
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 79:121-9. 2011
    ....
  8. ncbi request reprint Proton radiotherapy for childhood ependymoma: initial clinical outcomes and dose comparisons
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 71:979-86. 2008
    ....
  9. ncbi request reprint Partial-breast irradiation: towards a replacement for whole-breast irradiation?
    Shannon M Macdonald
    Harvard Medical School, Massachusetts General Hospital, Department of Radiation Oncology, Boston, MA 02114, USA
    Expert Rev Anticancer Ther 7:123-34. 2007
    ..Although relatively new, its use is growing rapidly and many institutional and cooperative group trials are quickly enlisting patients, while physicians are gaining experience in a variety of partial-breast irradiation techniques...
  10. ncbi request reprint Natural history and role of radiation in patients with supratentorial and infratentorial WHO grade II ependymomas: results from a population-based study
    Ayal A Aizer
    Harvard Radiation Oncology Program, Department of Radiation Oncology, Massachusetts General Hospital, 55 Fruit Street, Lunder LL3, Boston, MA, 02114, USA
    J Neurooncol 115:411-9. 2013
    ..Observation, with radiation reserved as a salvage option, may be a reasonable postoperative strategy in this population...
  11. doi request reprint Proton radiotherapy for high-risk pediatric neuroblastoma: early outcomes and dose comparison
    Jona A Hattangadi
    Harvard Radiation Oncology Program, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 83:1015-22. 2012
    ....
  12. doi request reprint ACR Appropriateness Criteria® conservative surgery and radiation--stage I and II breast carcinoma: expert panel on radiation oncology: breast
    Jennifer R Bellon
    Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Breast J 17:448-55. 2011
    ..Several randomized studies are ongoing to determine the efficacy, safety, and appropriate patients for these shorter treatments...
  13. doi request reprint Proton radiation therapy for pediatric medulloblastoma and supratentorial primitive neuroectodermal tumors: outcomes for very young children treated with upfront chemotherapy
    Rachel B Jimenez
    Harvard Radiation Oncology Program, Boston, Massachusetts, USA
    Int J Radiat Oncol Biol Phys 87:120-6. 2013
    ..To report the early outcomes for very young children with medulloblastoma or supratentorial primitive neuroectodermal tumor (SPNET) treated with upfront chemotherapy followed by 3-dimensional proton radiation therapy (3D-CPT)...
  14. doi request reprint Patterns of failure after proton therapy in medulloblastoma; linear energy transfer distributions and relative biological effectiveness associations for relapses
    Roshan V Sethi
    Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts
    Int J Radiat Oncol Biol Phys 88:655-63. 2014
    ..Here we report the patterns of failure after the use of protons, compare it to that in the available photon literature, and determine the LET and RBE values in areas of recurrence...
  15. ncbi request reprint Chest wall radiotherapy: middle ground for treatment of patients with one to three positive lymph nodes after mastectomy
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 75:1297-303. 2009
    ....
  16. doi request reprint Early clinical outcomes using proton radiation for children with central nervous system atypical teratoid rhabdoid tumors
    Karen De Amorim Bernstein
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Int J Radiat Oncol Biol Phys 86:114-20. 2013
    ..Irradiation improves survival but has traditionally been avoided in patients under the age of 3 due to the increasing risk of neurocognitive side effects. We report the first cohort of AT/RT patients treated with proton therapy...
  17. pmc Accelerated partial breast irradiation with low-dose-rate interstitial implant brachytherapy after wide local excision: 12-year outcomes from a prospective trial
    Jona A Hattangadi
    Harvard Radiation Oncology Program, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 83:791-800. 2012
    ..To evaluate the long-term toxicity, cosmesis, and local control of accelerated partial breast irradiation with implant brachytherapy after wide local excision for Stage T1N0 breast cancer (BCa)...
  18. pmc Second nonocular tumors among survivors of retinoblastoma treated with contemporary photon and proton radiotherapy
    Roshan V Sethi
    Harvard Medical School, Boston, Massachusetts
    Cancer 120:126-33. 2014
    ..Proton RT allows for significant sparing of nontarget tissue. The current study compared the risk of second malignancy in patients with retinoblastoma who were treated with photon and proton RT...
  19. pmc Bifocal intracranial tumors of nongerminomatous germ cell etiology: diagnostic and therapeutic implications
    Ayal A Aizer
    Harvard Radiation Oncology Program, Boston, Massachusetts, USA
    Neuro Oncol 15:955-60. 2013
    ..We sought to characterize the association between bifocal intracranial tumors and NGGCT histology...
  20. pmc Proton radiotherapy for parameningeal rhabdomyosarcoma: clinical outcomes and late effects
    Stephanie K Childs
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 82:635-42. 2012
    ..To report the clinical outcome and late side effect profile of proton radiotherapy in the treatment of children with parameningeal rhabdomyosarcoma (PM-RMS)...
  21. doi request reprint Intensity modulated proton therapy for postmastectomy radiation of bilateral implant reconstructed breasts: a treatment planning study
    Rachel B Jimenez
    Harvard Radiation Oncology Program, Brigham and Women s Hospital, Department of Radiation Oncology, 75 Francis Street, Boston, MA 02215, USA
    Radiother Oncol 107:213-7. 2013
    ..The purpose of this study was to compare IMPT to three-dimensional (3D) conformal radiation following bilateral mastectomy and reconstruction...
  22. ncbi request reprint Intensity modulated radiation therapy versus three-dimensional conformal radiation therapy for the treatment of high grade glioma: a dosimetric comparison
    Shannon M Macdonald
    Massachusetts General Hospital, Boston, Massachusetts, USA
    J Appl Clin Med Phys 8:47-60. 2007
    ..With the availability of new cancer imaging tools and more effective systemic agents, IMRT may be used to intensify tumor doses while minimizing toxicity, therefore potentially improving outcomes in patients with high-grade glioma...
  23. doi request reprint Delayed diagnosis in children with intracranial germ cell tumors
    Roshan V Sethi
    Harvard Medical School, Massachusetts General Hospital, Boston, MA
    J Pediatr 163:1448-53. 2013
    ..To review symptoms and provider history in a large cohort of patients with germ cell tumors (GCTs) to highlight the variety of manifestations and assess the effect of delayed diagnosis on outcomes...
  24. pmc Prospective study of health-related quality of life for children with brain tumors treated with proton radiotherapy
    Karen A Kuhlthau
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Oncol 30:2079-86. 2012
    ..We describe the health-related quality of life (HRQoL) of a cohort of children with brain tumors treated with proton radiotherapy...
  25. ncbi request reprint A phase I study of lapatinib with whole brain radiotherapy in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer brain metastases
    Nancy U Lin
    Harvard Medical School, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA
    Breast Cancer Res Treat 142:405-14. 2013
    ..Given the high ORR, concurrent lapatinib-WBRT could still be considered for future study with careful safety monitoring. ..
  26. doi request reprint Proton radiotherapy for pediatric bladder/prostate rhabdomyosarcoma: clinical outcomes and dosimetry compared to intensity-modulated radiation therapy
    Shane E Cotter
    Harvard Radiation Oncology Program, Boston, Massachusetts 02114, USA
    Int J Radiat Oncol Biol Phys 81:1367-73. 2011
    ....
  27. pmc The impact of radiation therapy on the risk of lymphedema after treatment for breast cancer: a prospective cohort study
    Laura E G Warren
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts
    Int J Radiat Oncol Biol Phys 88:565-71. 2014
    ..Lymphedema after breast cancer treatment can be an irreversible condition with a negative impact on quality of life. The goal of this study was to identify radiation therapy-related risk factors for lymphedema...
  28. ncbi request reprint Clinical outcomes and late endocrine, neurocognitive, and visual profiles of proton radiation for pediatric low-grade gliomas
    Benjamin A Greenberger
    Harvard Medical School, Boston, Massachusetts
    Int J Radiat Oncol Biol Phys 89:1060-8. 2014
    ..Increased conformality of RT could decrease the incidence and severity of late effects. We report our experience with 32 pediatric patients treated with proton RT...
  29. doi request reprint Radiation therapy: retinal tumors
    Roshan V Sethi
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Dev Ophthalmol 52:58-74. 2013
    ....
  30. ncbi request reprint Is it time to use protons for breast cancer?
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cancer J 13:84-6. 2007
  31. ncbi request reprint Cardiac blood biomarkers in patients receiving thoracic (chemo)radiation
    Kevin R Kozak
    Harvard Radiation Oncology Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Lung Cancer 62:351-5. 2008
    ..Thus, contemporary thoracic (chemo)radiation does not commonly result in elevations of serum TnT, CK-MB or NT-proBNP. Elevations in these markers during treatment merit further evaluation...
  32. ncbi request reprint Standard fractionation low-dose proton radiotherapy for diffuse choroidal hemangiomas in pediatric Sturge-Weber syndrome
    Yoshihiro Yonekawa
    Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    J AAPOS 17:318-22. 2013
    ..Treatment techniques for young children who cannot cooperate with conventional radiation protocols are also described. ..
  33. ncbi request reprint MRI changes in the "normal" pineal gland following chemotherapy for suprasellar germ cell tumors
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Pediatr Hematol Oncol 25:5-15. 2008
    ....
  34. ncbi request reprint Proton beam radiation therapy
    Shannon M Macdonald
    New York University Cancer Center, New York University Medical Center, New York, USA
    Cancer Invest 24:199-208. 2006