A S Lundberg
Affiliation: Massachusetts Institute of Technology
- Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexesA S Lundberg
The Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Mol Cell Biol 18:753-61. 1998..Complete phosphorylation of pRb, inactivation of E2F binding, and activation of E2F transcription occur only after sequential action of at least two distinct G1 cyclin kinase complexes...
- Genes involved in senescence and immortalizationA S Lundberg
Whitehead Institute, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Curr Opin Cell Biol 12:705-9. 2000..Significant progress continues to be made in our understanding of cellular senescence and immortalization...
- Regulation of cyclin E transcription by E2Fs and retinoblastoma proteinY Geng
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Oncogene 12:1173-80. 1996..The activity of this promoter can be regulated negatively by pRB. Our results suggest the operation of a positive-feedback loop in late G1 that functions to ensure continued cyclin E expression and pRB inactivation...