Hua Jenny Lu

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Differential, phosphorylation dependent trafficking of AQP2 in LLC-PK1 cells
    William L Rice
    Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e32843. 2012
  2. pmc A zebrafish model of conditional targeted podocyte ablation and regeneration
    Jianmin Huang
    Center for Systems Biology, Program in Membrane Biology, Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 83:1193-200. 2013
  3. pmc Aquaporin 2 promotes cell migration and epithelial morphogenesis
    Ying Chen
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA
    J Am Soc Nephrol 23:1506-17. 2012
  4. pmc The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells
    Hua Jenny Lu
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 295:F290-4. 2008
  5. pmc AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cells
    Naofumi Yui
    Massachusetts General Hospital Center for Systems Biology, Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Open 1:101-8. 2012
  6. pmc Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase
    Wei Li
    Center for Systems Biology, Program in Membrane Biology, Division of Nephrology, Dept of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 301:F309-18. 2011

Collaborators

  • Dennis Brown
  • Richard Bouley
  • Yan Zhang
  • Udo Hasler
  • Robert A Fenton
  • Ying Chen
  • Jianmin Huang
  • Naofumi Yui
  • William L Rice
  • Toshiyuki Matsuzaki
  • Wei Li
  • Mary McKee
  • Alan J Davidson
  • Alice Xiang
  • Hong D Huang
  • Zhizhan Gu
  • Gregg G Gundersen
  • Michael B Brenner
  • William Rice
  • Jim C Norman
  • Alfred Van Hoek
  • Jian Li
  • Jianping Xiong
  • Victor W Hsu
  • Paula Nunes

Detail Information

Publications6

  1. pmc Differential, phosphorylation dependent trafficking of AQP2 in LLC-PK1 cells
    William L Rice
    Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e32843. 2012
    ..Overall, our data provide evidence supporting the role of S256 and S269 in the maintenance of AQP2 at the cell surface and reveal the dynamics of internalization and recycling of differentially phosphorylated AQP2 in cell culture...
  2. pmc A zebrafish model of conditional targeted podocyte ablation and regeneration
    Jianmin Huang
    Center for Systems Biology, Program in Membrane Biology, Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 83:1193-200. 2013
    ..Thus, our studies show that zebrafish podocytes are capable of regenerating following depletion, and establish the Tg(podocin:NTR-GFP) fish as a new model to study podocyte injury and repair...
  3. pmc Aquaporin 2 promotes cell migration and epithelial morphogenesis
    Ying Chen
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA
    J Am Soc Nephrol 23:1506-17. 2012
    ..In summary, these data suggest that the water channel AQP2 interacts with integrins to promote renal epithelial cell migration, contributing to the structural and functional integrity of the mammalian kidney...
  4. pmc The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cells
    Hua Jenny Lu
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 295:F290-4. 2008
    ..The potential role of S261 phosphorylation/dephosphorylation in vasopressin action remains to be determined...
  5. pmc AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cells
    Naofumi Yui
    Massachusetts General Hospital Center for Systems Biology, Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Open 1:101-8. 2012
    ..This is the first report showing that VP/FK mediated F-actin depolymerization is dependent on AQP2 protein expression in renal epithelial cells, and that this is not dependent on the polarity of AQP2 membrane insertion...
  6. pmc Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase
    Wei Li
    Center for Systems Biology, Program in Membrane Biology, Division of Nephrology, Dept of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 301:F309-18. 2011
    ..Our study provides an alternative mechanism to regulate AQP2 trafficking, bypassing the VP-vasopressin receptor signaling pathway...

Research Grants3

  1. Characterization of AQP2 interacting proteins and novel functions of AQP2
    Hua Lu; Fiscal Year: 2007
    ..Multidisciplinary approaches and powerful technologies will be used to carry out these studies that will shed light on the mechanism of AQP2 trafficking and function. ..