Elena Losina

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Pharmacologic regimens for knee osteoarthritis prevention: can they be cost-effective?
    E Losina
    Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopaedic Surgery, Brigham and Women s Hospital, Boston, MA, USA Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA Boston University School of Public Health, Boston, MA, USA Electronic address
    Osteoarthritis Cartilage 22:415-30. 2014
  2. doi request reprint The AViKA (Adding Value in Knee Arthroplasty) postoperative care navigation trial: rationale and design features
    Elena Losina
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    BMC Musculoskelet Disord 14:290. 2013
  3. pmc Reliability of medical record abstraction by non-physicians for orthopedic research
    Michael Y Mi
    Harvard Medical School, Harvard University, Boston, MA 02115, USA
    BMC Musculoskelet Disord 14:181. 2013
  4. pmc Impact of misspecifying the distribution of a prognostic factor on power and sample size for testing treatment interactions in clinical trials
    William M Reichmann
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA, USA
    BMC Med Res Methodol 13:21. 2013
  5. pmc The relationship between hand osteoarthritis and serum leptin concentration in participants of the Third National Health and Nutrition Examination Survey
    Mei Massengale
    Division of Rheumatology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Res Ther 14:R132. 2012
  6. pmc Studies of pain management in osteoarthritis: bedside to policy
    E Losina
    Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Osteoarthritis Cartilage 21:1264-71. 2013
  7. pmc Lifetime risk and age at diagnosis of symptomatic knee osteoarthritis in the US
    Elena Losina
    Brigham and Women s Hospital, Harvard University, and Boston University School of Public Health, Boston, MA 02115, USA
    Arthritis Care Res (Hoboken) 65:703-11. 2013
  8. pmc Disease-modifying drugs for knee osteoarthritis: can they be cost-effective?
    E Losina
    Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Osteoarthritis Cartilage 21:655-67. 2013
  9. pmc The dramatic increase in total knee replacement utilization rates in the United States cannot be fully explained by growth in population size and the obesity epidemic
    Elena Losina
    Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, 75 Francis Street, BC 4, Boston, MA 02115, USA
    J Bone Joint Surg Am 94:201-7. 2012
  10. pmc Empirical evaluation of the inter-relationship of articular elements involved in the pathoanatomy of knee osteoarthritis using magnetic resonance imaging
    Dennis S Meredith
    Department of Orthopedic Surgery, Hospital for Special Surgery, New York NY, USA
    BMC Musculoskelet Disord 10:133. 2009

Collaborators

Detail Information

Publications136 found, 100 shown here

  1. doi request reprint Pharmacologic regimens for knee osteoarthritis prevention: can they be cost-effective?
    E Losina
    Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopaedic Surgery, Brigham and Women s Hospital, Boston, MA, USA Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA Boston University School of Public Health, Boston, MA, USA Electronic address
    Osteoarthritis Cartilage 22:415-30. 2014
    ..We sought to determine the target populations and drug efficacy, toxicity, cost, and initiation age thresholds under which a pharmacologic regimen for knee osteoarthritis (OA) prevention could be cost-effective...
  2. doi request reprint The AViKA (Adding Value in Knee Arthroplasty) postoperative care navigation trial: rationale and design features
    Elena Losina
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    BMC Musculoskelet Disord 14:290. 2013
    ..Our objective was to design a randomized controlled trial to establish the efficacy of a motivational-interviewing-based telephone intervention aimed at improving patient outcomes and satisfaction following total knee arthroplasty...
  3. pmc Reliability of medical record abstraction by non-physicians for orthopedic research
    Michael Y Mi
    Harvard Medical School, Harvard University, Boston, MA 02115, USA
    BMC Musculoskelet Disord 14:181. 2013
    ..Furthermore, because medical record review is both technically demanding and time intensive, it is important to establish whether trained research staff with no clinical training can abstract medical records reliably...
  4. pmc Impact of misspecifying the distribution of a prognostic factor on power and sample size for testing treatment interactions in clinical trials
    William M Reichmann
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA, USA
    BMC Med Res Methodol 13:21. 2013
    ....
  5. pmc The relationship between hand osteoarthritis and serum leptin concentration in participants of the Third National Health and Nutrition Examination Survey
    Mei Massengale
    Division of Rheumatology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Arthritis Res Ther 14:R132. 2012
    ..However, this hypothesis has not been tested in large-scale hand OA cohorts. Our study aimed to determine whether there is a cross-sectional relationship between serum leptin levels and hand OA in a population-based sample of US adults...
  6. pmc Studies of pain management in osteoarthritis: bedside to policy
    E Losina
    Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Osteoarthritis Cartilage 21:1264-71. 2013
    ..Our objective was to characterize studies addressing management of OA-related pain with respect to the breadth of interventions, trial duration and size, outcome measures, and funding sources...
  7. pmc Lifetime risk and age at diagnosis of symptomatic knee osteoarthritis in the US
    Elena Losina
    Brigham and Women s Hospital, Harvard University, and Boston University School of Public Health, Boston, MA 02115, USA
    Arthritis Care Res (Hoboken) 65:703-11. 2013
    ..To estimate the incidence and lifetime risk of diagnosed symptomatic knee osteoarthritis (OA) and the age at diagnosis of knee OA based on self-reports in the US population...
  8. pmc Disease-modifying drugs for knee osteoarthritis: can they be cost-effective?
    E Losina
    Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Osteoarthritis Cartilage 21:655-67. 2013
    ..Disease-modifying osteoarthritis drugs (DMOADs) are under development. Our goal was to determine efficacy, toxicity, and cost thresholds under which DMOADs would be a cost-effective knee OA treatment...
  9. pmc The dramatic increase in total knee replacement utilization rates in the United States cannot be fully explained by growth in population size and the obesity epidemic
    Elena Losina
    Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, 75 Francis Street, BC 4, Boston, MA 02115, USA
    J Bone Joint Surg Am 94:201-7. 2012
    ..Our goal was to investigate whether the rapid increase in total knee replacement use over the past decade can be sufficiently attributed to changes in these two factors...
  10. pmc Empirical evaluation of the inter-relationship of articular elements involved in the pathoanatomy of knee osteoarthritis using magnetic resonance imaging
    Dennis S Meredith
    Department of Orthopedic Surgery, Hospital for Special Surgery, New York NY, USA
    BMC Musculoskelet Disord 10:133. 2009
    ..We assessed the association of pathological change in multiple articular structures involved in the pathoanatomy of osteoarthritis...
  11. pmc Decreasing medical complications for total knee arthroplasty: effect of critical pathways on outcomes
    M Elaine Husni
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    BMC Musculoskelet Disord 11:160. 2010
    ..However, pathway effectiveness is difficult to determine given methodological flaws, such as small or single center cohorts. We studied the effect of critical pathways on total knee replacement outcomes in a large population-based study...
  12. pmc Evaluation of exposure-specific risks from two independent samples: a simulation study
    William M Reichmann
    Department of Orthopedic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    BMC Med Res Methodol 11:1. 2011
    ..The goal of our study was to evaluate the existing methodology for calculating the ESR, propose an improved point estimator, and propose variance estimates that will allow the calculation of confidence intervals (CIs)...
  13. pmc Risk of venous thromboembolism after total hip and knee replacement in older adults with comorbidity and co-occurring comorbidities in the Nationwide Inpatient Sample (2003-2006)
    Alok Kapoor
    Hospital Medicine Unit, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    BMC Geriatr 10:63. 2010
    ..Identifying a high risk cohort such as older adults with comorbidities and co-occurring comorbidities who might benefit most from high potency prophylaxis would improve how we currently perform preoperative assessment...
  14. pmc Drug efficacy by direct and adjusted indirect comparison to placebo: An illustration by Mycobacterium avium complex prophylaxis in HIV
    Jennifer Chu
    Division of General Medicine, Department of Medicine, Massachusetts General Hospital, Boston, USA
    AIDS Res Ther 8:14. 2011
    ..abstract:..
  15. pmc Impact of obesity and knee osteoarthritis on morbidity and mortality in older Americans
    Elena Losina
    Brigham and Women s Hospital, Boston University School of Public Health, Massachusetts General Hospital, USA
    Ann Intern Med 154:217-26. 2011
    ..Obesity and knee osteoarthritis are among the most frequent chronic conditions affecting Americans aged 50 to 84 years...
  16. pmc Cost-effectiveness of total knee arthroplasty in the United States: patient risk and hospital volume
    Elena Losina
    Department of Orthopedic Surgery, Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Intern Med 169:1113-21; discussion 1121-2. 2009
    ..However, to our knowledge, the cost-effectiveness of TKA and the influences of hospital volume and patient risk on TKA cost-effectiveness have not been investigated in the United States...
  17. pmc Visual screening for malignant melanoma: a cost-effectiveness analysis
    Elena Losina
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Arch Dermatol 143:21-8. 2007
    ..To evaluate the cost-effectiveness of various melanoma screening strategies proposed in the United States...
  18. pmc Racial and sex disparities in life expectancy losses among HIV-infected persons in the united states: impact of risk behavior, late initiation, and early discontinuation of antiretroviral therapy
    Elena Losina
    Divisions of General Medicine, Department of Medicine, MA 02114, USA
    Clin Infect Dis 49:1570-8. 2009
    ....
  19. pmc The "ART" of linkage: pre-treatment loss to care after HIV diagnosis at two PEPFAR sites in Durban, South Africa
    Elena Losina
    Division of General Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 5:e9538. 2010
    ..Our objective was to determine PTLC in newly identified HIV-infected individuals in South Africa...
  20. pmc The independent effect of highly active antiretroviral therapy on severe opportunistic disease incidence and mortality in HIV-infected adults in Côte d'Ivoire
    Elena Losina
    Department of Biostatistics and Epidemiology, Boston University School of Public Health, Boston, MA, USA
    Antivir Ther 12:543-51. 2007
    ..Studies in developed countries have shown highly active antiretroviral therapy (HAART) decreases incidence of severe opportunistic diseases (ODs) in HIV-infected patients beyond that which is expected from changes in CD4+ T-cell count...
  21. pmc HIV morbidity and mortality in Jamaica: analysis of national surveillance data, 1993--2005
    Elena Losina
    Division of General Medicine and Infectious Diseases, Massachusetts General Hospital, 50 Staniford St, 9th Floor, Boston, Massachusetts 02114, USA
    Int J Infect Dis 12:132-8. 2008
    ..Using Jamaican national surveillance data, we estimated overall, AIDS-free, and AIDS survival, identified factors influencing HIV-related mortality, and examined factors associated with late HIV/AIDS identification...
  22. pmc When to start antiretroviral therapy in resource-limited settings
    Rochelle P Walensky
    Massachusetts General Hospital, Brigham and Women s Hospital, Harvard University Medical School, Harvard School of Public Health, and Boston University School of Public Health, Boston, Massachusetts 02114, USA
    Ann Intern Med 151:157-66. 2009
    ..The results of international clinical trials that are assessing when to initiate antiretroviral therapy (ART) will not be available for several years...
  23. pmc HIV drug resistance surveillance for prioritizing treatment in resource-limited settings
    Rochelle P Walensky
    Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    AIDS 21:973-82. 2007
    ..Sentinel testing programs for HIV drug resistance in resource-limited settings can inform policy on antiretroviral therapy (ART) and drug sequencing...
  24. ncbi request reprint Cost-effectiveness of HIV treatment in resource-poor settings--the case of Côte d'Ivoire
    Sue J Goldie
    Department of Health Policy and Management, Program in Health Decision Science, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 355:1141-53. 2006
    ..As antiretroviral therapy is increasingly used in settings with limited resources, key questions about the timing of treatment and use of diagnostic tests to guide clinical decisions must be addressed...
  25. pmc Depressive symptoms and their impact on health-seeking behaviors in newly-diagnosed HIV-infected patients in Durban, South Africa
    Lynn Ramirez-Avila
    Division of Infectious Diseases, Children s Hospital Boston, 333 Longwood Avenue, Boston, MA, 02139, USA
    AIDS Behav 16:2226-35. 2012
    ..Depression screening at the time of HIV diagnosis is critical for improving linkage to mental health and HIV services in South Africa...
  26. pmc Estimating the burden of total knee replacement in the United States
    Alexander M Weinstein
    Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Bone Joint Surg Am 95:385-92. 2013
    ..We are aware of no current estimates of the prevalence of total knee replacement among adults in the U.S...
  27. ncbi request reprint Projecting the cost-effectiveness of adherence interventions in persons with human immunodeficiency virus infection
    Sue J Goldie
    Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115 5924, USA
    Am J Med 115:632-41. 2003
    ..To explore the cost-effectiveness of interventions to improve adherence to combination antiretroviral therapy in patients with human immunodeficiency virus (HIV) infection...
  28. pmc Missed opportunities: refusal to confirm reactive rapid HIV tests in the emergency department
    Ishani Ganguli
    Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e53408. 2013
    ....
  29. pmc Drug-resistant tuberculosis among HIV-infected patients starting antiretroviral therapy in Durban, South Africa
    Jeffrey K Hom
    Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e43281. 2012
    ..To estimate the prevalence of drug-resistant tuberculosis (TB) and describe the resistance patterns in patients commencing antiretroviral therapy (ART) in an HIV clinic in Durban, South Africa...
  30. ncbi request reprint Neighborhoods matter: use of hospitals with worse outcomes following total knee replacement by patients from vulnerable populations
    Elena Losina
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Arch Intern Med 167:182-7. 2007
    ....
  31. ncbi request reprint Association of hospital and surgeon procedure volume with patient-centered outcomes of total knee replacement in a population-based cohort of patients age 65 years and older
    Jeffrey N Katz
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Rheum 56:568-74. 2007
    ..To study the association between procedure volume and patient-centered outcomes such as functional status...
  32. pmc Clinical impact and cost-effectiveness of antiretroviral therapy in India: starting criteria and second-line therapy
    Kenneth A Freedberg
    Divisions of General Medicine and Infectious Disease and the Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA, USA
    AIDS 21:S117-28. 2007
    ..India has more than 5.7 million people infected with human immunodeficiency virus (HIV). In 2004, the Indian government began providing antiretroviral therapy (ART), and there are now an estimated 56 500 people receiving ART...
  33. ncbi request reprint Cost-effectiveness implications of the timing of antiretroviral therapy in HIV-infected adults
    Bruce R Schackman
    Department of Health Policy and Management, Harvard School of Public Health, Boston, MA, USA
    Arch Intern Med 162:2478-86. 2002
    ....
  34. pmc Risk factors for revision of primary total hip arthroplasty: a systematic review
    Julian Jz Prokopetz
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Musculoskelet Disord 13:251. 2012
    ....
  35. pmc Factors associated with self-reported repeat HIV testing after a negative result in Durban, South Africa
    Susan Regan
    Division of General Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e62362. 2013
    ..Routine screening for HIV infection leads to early detection and treatment. We examined patient characteristics associated with repeated screening in a high prevalence country...
  36. pmc The clinical and economic impact of genotype testing at first-line antiretroviral therapy failure for HIV-infected patients in South Africa
    Julie H Levison
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 56:587-97. 2013
    ..After adherence counseling, these patients may safely and effectively continue first-line ART, thereby delaying more expensive second-line ART...
  37. pmc Acceptability of fingerstick versus oral fluid rapid HIV testing: results from the universal screening for HIV infection in the emergency room (USHER Phase II) randomized controlled trial
    Laurel A Donnell-Fink
    Division of Infectious Disease, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 61:588-92. 2012
    ..Patient preference for oral rapid HIV testing compared with more invasive whole blood fingerstick may influence the acceptance of rapid HIV testing...
  38. ncbi request reprint Cost-effectiveness of enfuvirtide in treatment-experienced patients with advanced HIV disease
    Paul E Sax
    Division of Infectious Disease and the Partners AIDS Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 39:69-77. 2005
    ..Because of the high cost of ENF compared with other antiretroviral agents, our objectives were to determine the potential long-term clinical impact and cost-effectiveness of ENF in these patients...
  39. ncbi request reprint Optimal frequency of CD4 cell count and HIV RNA monitoring prior to initiation of antiretroviral therapy in HIV-infected patients
    April D Kimmel
    Division of General Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Antivir Ther 10:41-52. 2005
    ..Guidelines regarding the frequency of CD4 cell count and HIV RNA monitoring in HIV-infected patients vary, with recommended strategies ranging from every 2 to every 6 months...
  40. pmc Factors associated with refusal of rapid HIV testing in an emergency department
    Mary L Pisculli
    Division of Infectious Disease, Brigham and Women s Hospital, Boston, MA, USA
    AIDS Behav 15:734-42. 2011
    ..Enrollment during morning hours was also associated with an increased risk of refusal. Increased educational efforts to convey the rationale and benefits of universal screening may improve testing uptake among these groups...
  41. doi request reprint Cumulative incidence of ACL reconstruction after ACL injury in adults: role of age, sex, and race
    Jamie E Collins
    Orthopedics and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Sports Med 41:544-9. 2013
    ..Anterior cruciate ligament (ACL) injuries are common and potentially disabling and frequently prompt surgical reconstruction. The utilization of ACL reconstruction among ACL-injured patients has not been examined rigorously...
  42. pmc The clinical impact and cost-effectiveness of routine, voluntary HIV screening in South Africa
    Rochelle P Walensky
    Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 56:26-35. 2011
    ..Although 900,000 HIV-infected South Africans receive antiretroviral therapy, the majority of South Africans with HIV remain undiagnosed...
  43. pmc Intensive tuberculosis screening for HIV-infected patients starting antiretroviral therapy in Durban, South Africa
    Ingrid V Bassett
    Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Infect Dis 51:823-9. 2010
    ..Our objective was to assess the yield and cost of a more intensive tuberculosis screening in HIV-infected patients starting antiretroviral therapy (ART) in Durban, South Africa...
  44. pmc Scaling up antiretroviral therapy in South Africa: the impact of speed on survival
    Rochelle P Walensky
    The Divisions of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Infect Dis 197:1324-32. 2008
    ..Only 33% of eligible human immunodeficiency virus (HIV)-infected patients in South Africa receive antiretroviral therapy (ART). We sought to estimate the impact of alternative ART scale-up scenarios on patient outcomes from 2007-2012...
  45. pmc Cost-effectiveness of preventing loss to follow-up in HIV treatment programs: a Côte d'Ivoire appraisal
    Elena Losina
    Division of General Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS Med 6:e1000173. 2009
    ..Our objective was to project the clinical impact and cost-effectiveness of interventions to prevent LTFU from HIV care in West Africa...
  46. pmc Test and treat DC: forecasting the impact of a comprehensive HIV strategy in Washington DC
    Rochelle P Walensky
    Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Infect Dis 51:392-400. 2010
    ..We forecast outcomes of this approach if implemented in Washington DC...
  47. ncbi request reprint Treatment for primary HIV infection: projecting outcomes of immediate, interrupted, or delayed therapy
    Rochelle P Walensky
    Division of Infectious Disease and the Partners AIDS Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    J Acquir Immune Defic Syndr 31:27-37. 2002
    ..These results can assist decision makers and those planning clinical trials in defining evidence-based performance measures for primary HIV infection treatment and future trials...
  48. doi request reprint Pain intensity and patients' acceptance of surgical complication risks with lumbar fusion
    Christopher M Bono
    Department of Orthopaedic Surgery and Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Spine (Phila Pa 1976) 38:140-7. 2013
    ..Cross-sectional study with prospective recruitment...
  49. pmc Barriers to care among people living with HIV in South Africa: contrasts between patient and healthcare provider perspectives
    Laura M Bogart
    Division of General Pediatrics, Department of Medicine, Boston Children s Hospital, Boston, MA, USA
    AIDS Care 25:843-53. 2013
    ..Better communication and understanding between patients and providers are needed to facilitate greater patient satisfaction and retention in HIV care...
  50. pmc Risk factors for revision of primary total hip replacement: results from a national case-control study
    Elizabeth A Wright
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arthritis Care Res (Hoboken) 64:1879-85. 2012
    ..To study the risk factors for revision of primary total hip replacement (THR) in a US population-based sample...
  51. ncbi request reprint Cost-effectiveness of an intervention to improve adherence to antiretroviral therapy in HIV-infected patients
    Kenneth A Freedberg
    Divisions of General Medicine and Infectious Diseases and the Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 43:S113-8. 2006
    ..Adherence interventions with modest effectiveness are likely to provide long-term survival benefit to patients and to be cost-effective compared with other uses of HIV care funds...
  52. pmc Predictive value of Medicare claims data for identifying revision of index hip replacement was modest
    Jeffrey N Katz
    Orthopedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston 02115, MA, USA
    J Clin Epidemiol 64:543-6. 2011
    ..To determine the positive predictive value of Medicare claims for identifying revision of total hip replacement (THR), a frequent marker of THR quality and outcome...
  53. ncbi request reprint Routine human immunodeficiency virus testing: an economic evaluation of current guidelines
    Rochelle P Walensky
    Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, and the Partners AIDS Research Center, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med 118:292-300. 2005
    ..Our objective was to evaluate the clinical effect and cost-effectiveness of current guidelines and of alternate HIV prevalence thresholds...
  54. ncbi request reprint Effectiveness of antiretroviral therapy after protease inhibitor failure: an analytic overview
    Elena Losina
    Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
    Clin Infect Dis 38:1613-22. 2004
    ..The best response was seen in NNRTI-naive patients receiving NNRTI- and boosted PI-containing regimens. New approaches are needed to achieve better suppression in pretreated HIV-infected patients...
  55. ncbi request reprint The survival benefits of AIDS treatment in the United States
    Rochelle P Walensky
    Division of Infectious Disease and General Medicine, Massachusetts General Hospital, Boston 02114, USA
    J Infect Dis 194:11-9. 2006
    ..As widespread adoption of potent combination antiretroviral therapy (ART) reaches its tenth year, our objective was to quantify the cumulative survival benefits of acquired immunodeficiency syndrome (AIDS) care in the United States...
  56. ncbi request reprint Association of hospital and surgeon volume of total hip replacement with functional status and satisfaction three years following surgery
    Jeffrey N Katz
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, B 3, Boston, MA 02115, USA
    Arthritis Rheum 48:560-8. 2003
    ..To evaluate whether hospital volume and surgeon volume of total hip replacements (THRs) are associated with patient-reported functional status and satisfaction with surgery 3 years postoperatively...
  57. pmc Clinical impact and cost-effectiveness of expanded voluntary HIV testing in India
    Kartik K Venkatesh
    Division of Infectious Disease, Department of Medicine, Alpert Medical School, Brown University Miriam Hospital, Providence, Rhode Island, United States of America
    PLoS ONE 8:e64604. 2013
    ..Despite expanding access to antiretroviral therapy (ART), most of the estimated 2.3 to 2.5 million HIV-infected individuals in India remain undiagnosed. The questions of whom to test for HIV and at what frequency remain unclear...
  58. pmc Determinants of self-reported health status in a population-based sample of persons with radiographic knee osteoarthritis
    William M Reichmann
    Brigham and Women s Hospital and Boston University School of Public Health, Boston, Massachusetts 02115, USA
    Arthritis Rheum 61:1046-53. 2009
    ..Our objective was to determine factors associated with self-reported health status in a national population-based sample with radiographic knee OA...
  59. pmc Risk factors for late-stage HIV disease presentation at initial HIV diagnosis in Durban, South Africa
    Paul K Drain
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e55305. 2013
    ..After observing persistently low CD4 counts at initial HIV diagnosis in South Africa, we sought to determine risk factors for late-stage HIV disease presentation among adults...
  60. pmc Type II odontoid fractures of the cervical spine: do treatment type and medical comorbidities affect mortality in elderly patients?
    Andrew J Schoenfeld
    Department of Orthopaedic Surgery, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Spine (Phila Pa 1976) 36:879-85. 2011
    ..Retrospective cohort study...
  61. pmc Resource utilization and cost-effectiveness of counselor- vs. provider-based rapid point-of-care HIV screening in the emergency department
    Rochelle P Walensky
    Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e25575. 2011
    ..Routine HIV screening in emergency department (ED) settings may require dedicated personnel. We evaluated the outcomes, costs and cost-effectiveness of HIV screening when offered by either a member of the ED staff or by an HIV counselor...
  62. pmc Loss to follow-up and mortality among HIV-infected people co-infected with TB at ART initiation in Durban, South Africa
    Ingrid V Bassett
    Division of Infectious Disease, Massachusetts General Hospital, Boston, USA
    J Acquir Immune Defic Syndr 59:25-30. 2012
    ..To quantify the impact of tuberculosis (TB) co-infection on death and loss to follow-up (LTFU) 12 months after entry into an ART program...
  63. pmc Who starts antiretroviral therapy in Durban, South Africa?... not everyone who should
    Ingrid V Bassett
    Division of Infectious Disease, Massachusetts General Hospital, Boston, MA 02114, USA
    AIDS 24:S37-44. 2010
    ..To evaluate rates of antiretroviral therapy (ART) initiation within 12 months of a new HIV diagnosis in Durban, South Africa...
  64. ncbi request reprint Survival following total hip replacement
    Jane Barrett
    Department of Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Evergreen Building, Suite 300, 46 Centerra Parkway, Lebanon, NH 03766, USA
    J Bone Joint Surg Am 87:1965-71. 2005
    ..The purpose of our investigation was to assess whether the association had the characteristics of a causal relationship or whether it might appear to be due to comorbidity or other factors...
  65. pmc Loss to care and death before antiretroviral therapy in Durban, South Africa
    Ingrid V Bassett
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 51:135-9. 2009
    ..To examine the loss to care and mortality rates before starting antiretroviral therapy (ART) among ART eligible HIV-infected patients in Durban, South Africa. Design: Retrospective cohort study...
  66. pmc Counselor- versus provider-based HIV screening in the emergency department: results from the universal screening for HIV infection in the emergency room (USHER) randomized controlled trial
    Rochelle P Walensky
    Division of Infectious Diseases and General Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Emerg Med 58:S126-32.e1-4. 2011
    ..We compare rates of rapid HIV testing, test offer, and acceptance in an urban emergency department (ED) when conducted by dedicated HIV counselors versus current members of the ED staff...
  67. ncbi request reprint Review of human immunodeficiency virus type 1-related opportunistic infections in sub-Saharan Africa
    Charles B Holmes
    Division of Infectious Disease, Partners AIDS Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Infect Dis 36:652-62. 2003
    ..Policies regarding the type and timing of opportunistic infection prophylaxis may be region specific and urgently require further study...
  68. pmc Predictors of mortality in patients initiating antiretroviral therapy in Durban, South Africa
    Bisola O Ojikutu
    Harvard Center for AIDS Research CFAR and Division of AIDS, Harvard Medical School, and Division of Infectious Disease, Massachusetts General Hospital, Boston, MA, USA
    S Afr Med J 98:204-8. 2008
    ..To identify predictors of mortality in patients initiating antiretroviral therapy (ART) in Durban, South Africa...
  69. pmc Routine voluntary HIV testing in Durban, South Africa: the experience from an outpatient department
    Ingrid V Bassett
    Division of Infectious Disease, Massachusetts General Hospital, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 46:181-6. 2007
    ..To evaluate the yield of a routine voluntary HIV testing program compared with traditional provider-referred voluntary counseling and testing (VCT) in a hospital-affiliated outpatient department (OPD) in Durban, South Africa...
  70. pmc The cost-effectiveness of pre-exposure prophylaxis for HIV infection in South African women
    Rochelle P Walensky
    Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Infect Dis 54:1504-13. 2012
    ..PrEP's long-term impact on patient outcomes, population-level transmission, and cost-effectiveness remains unknown...
  71. pmc Not all are lost: interrupted laboratory monitoring, early death, and loss to follow-up (LTFU) in a large South African treatment program
    Aima A Ahonkhai
    Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e32993. 2012
    ..Most studies have not distinguished between those who briefly interrupt, but return to care, and those more chronically lost to follow-up...
  72. pmc The cost-effectiveness of tuberculosis preventive therapy for HIV-infected individuals in southern India: a trial-based analysis
    Mai T Pho
    Section of Hospital Medicine, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois, USA
    PLoS ONE 7:e36001. 2012
    ..Further, the cost-effectiveness of IPT has not been studied in India...
  73. pmc Emergency provider attitudes and barriers to universal HIV testing in the emergency department
    Christian Arbelaez
    Department of Emergency Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Emerg Med 42:7-14. 2012
    ..The Centers for Disease Control and Prevention (CDC) recently published recommendations for routine, voluntary human immunodeficiency virus (HIV) testing of adults in all health care settings, including the emergency department (ED)...
  74. ncbi request reprint Should resistance testing be performed for treatment-naive HIV-infected patients? A cost-effectiveness analysis
    Paul E Sax
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Infect Dis 41:1316-23. 2005
    ..Our objective was to determine the clinical impact and cost-effectiveness of genotype resistance testing for treatment-naive patients with chronic HIV infection...
  75. ncbi request reprint Extent of followup care after elective total hip replacement
    Paola de Pablo
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Secion of Clinical Sciences, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Rheumatol 33:1159-66. 2006
    ..To estimate the extent of radiographic and orthopedic followup among recipients of total hip replacement (THR), and to identify patients who are less likely to have consistent followup over 6 years postoperatively...
  76. pmc Prevalence of HIV-1 drug resistance after failure of a first highly active antiretroviral therapy regimen in KwaZulu Natal, South Africa
    Vincent C Marconi
    Section of Retroviral Therapeutics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    Clin Infect Dis 46:1589-97. 2008
    ..The prevalence of resistance was assessed among patients from KwaZulu Natal, South Africa, following failure of their first highly active antiretroviral therapy (HAART) regimen...
  77. pmc Choice of hospital for revision total hip replacement
    Jeffrey N Katz
    Orthopedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, BC 4th floor, 75 Francis Street, Boston, MA 02115, USA
    J Bone Joint Surg Am 92:2829-34. 2010
    ..Little is known about how often patients have revision total hip replacement in the same hospital in which they had the primary procedure...
  78. pmc Early antiretroviral therapy for patients with acute aids-related opportunistic infections: a cost-effectiveness analysis of ACTG A5164
    Paul E Sax
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    HIV Clin Trials 11:248-59. 2010
    ..We project the life expectancies, costs, and incremental cost-effectiveness ratios (ICERs) of these strategies...
  79. pmc The cost-effectiveness of antiretroviral therapy for treating HIV disease in the Caribbean
    Lindsey L Wolf
    Division of General Medicine and the Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 46:463-71. 2007
    ..Antiretroviral therapy (ART) recently became available in the Organization of Eastern Caribbean States (OECS). Survival benefits and budgetary implications associated with universal access to ART have not been examined in the Caribbean...
  80. pmc Improving outcomes in state AIDS drug assistance programs
    Benjamin P Linas
    Divisions of General Medicine, Massachusetts General Hospital, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 51:513-21. 2009
    ..State AIDS Drug Assistance Programs (ADAPs) provide antiretroviral medications to patients with no access to medications. Resource constraints limit the ability of many ADAPs to meet demand for services...
  81. pmc Patient satisfaction with rapid HIV testing in the emergency department
    Laurel Donnell-Fink
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA 02114, USA
    Ann Emerg Med 58:S49-52. 2011
    ..This investigation assesses patient satisfaction with rapid HIV testing in the emergency department (ED) of an urban tertiary academic medical center...
  82. ncbi request reprint Prophylaxis for human immunodeficiency virus-related Pneumocystis carinii pneumonia: using simulation modeling to inform clinical guidelines
    Sue J Goldie
    Center for Risk Analysis, Department of Health Policy and Management, Harvard School of Public Health, 718 Huntington Ave, Second Floor, Boston, MA 02115 5924, USA
    Arch Intern Med 162:921-8. 2002
    ....
  83. ncbi request reprint The relationship of preventable opportunistic infections, HIV-1 RNA, and CD4 Cell counts to chronic mortality
    George R Seage
    Department of Epidemiology and Center for Risk Analysis, Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Acquir Immune Defic Syndr 30:421-8. 2002
    ....
  84. pmc The cost-effectiveness of routine tuberculosis screening with Xpert MTB/RIF prior to initiation of antiretroviral therapy: a model-based analysis
    Jason R Andrews
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, 02114, USA
    AIDS 26:987-95. 2012
    ..Such patients are usually screened by symptoms and sputum smear, which have poor sensitivity...
  85. pmc Medical decision-making among Hispanics and non-Hispanic Whites with chronic back and knee pain: a qualitative study
    Jeffrey N Katz
    Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    BMC Musculoskelet Disord 12:78. 2011
    ..Because these disorders are not life-threatening, decision-making is generally preference-based. Little is known about whether Hispanics in the U.S. differ from non-Hispanic Whites with respect to key decision making preferences...
  86. ncbi request reprint Early failures of total hip replacement: effect of surgeon volume
    Elena Losina
    Department of Biostatistics, Boston University School of Public Health and Robert B Brigham Arthritis and Musculoskeletal Clinical Research Center, Boston, Massachusetts 02118, USA
    Arthritis Rheum 50:1338-43. 2004
    ..To determine whether provider volume is associated with early failures following total hip replacement (THR) requiring revision...
  87. pmc Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa
    Zabrina Brumme
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, USA
    Clin Infect Dis 49:956-64. 2009
    ....
  88. pmc Loss to follow-up in a community clinic in South Africa--roles of gender, pregnancy and CD4 count
    Bingxia Wang
    Division of General Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Mass, USA
    S Afr Med J 101:253-7. 2011
    ..Faith-based organisations have expanded antiretroviral therapy (ART) in community clinics across South Africa. Loss to follow-up (LTFU), however, limits the potential individual and population treatment benefits and optimal care...
  89. ncbi request reprint Utilization of low-volume hospitals for total hip replacement
    Elena Losina
    Boston University School of Public Health and Robert B Brigham Arthritis Clinical Research Center, Boston, Massachusetts, USA
    Arthritis Rheum 51:836-42. 2004
    ..To identify factors associated with utilization of low-volume hospitals for total hip replacement (THR) and to estimate differences in the distances that Medicare beneficiaries had to travel to reach low- or high-volume hospitals...
  90. ncbi request reprint Comparison of health state utilities using community and patient preference weights derived from a survey of patients with HIV/AIDS
    Bruce R Schackman
    Center for Risk Analysis, Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts, USA
    Med Decis Making 22:27-38. 2002
    ....
  91. pmc HIV testing rates and outcomes in a South African community, 2001-2006: implications for expanded screening policies
    Michael D April
    Harvard Medical School, Boston, MA, USA
    J Acquir Immune Defic Syndr 51:310-6. 2009
    ..Revised World Health Organization recommendations seek to increase HIV testing. We assessed the need for expanded testing in South Africa by examining current testing and treatment trends among a high prevalence population...
  92. pmc Estimation of the prevalence of undiagnosed and diagnosed HIV in an urban emergency department
    William M Reichmann
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e27701. 2011
    ..We also sought to estimate these quantities within demographic and risk behavior subgroups...
  93. pmc Development and validation of an index of musculoskeletal functional limitations
    Jeffrey N Katz
    Department of Orthopaedic Surgery, Division of Rheumatology, Brigham and Womens Hospital, Department of Epidemiology, Harvard School of Public Health, Boston, USA
    BMC Musculoskelet Disord 10:62. 2009
    ..This paper reports on the development and preliminary validation of a self administered musculoskeletal functional limitations index...
  94. pmc Effectiveness of pediatric antiretroviral therapy in resource-limited settings: a systematic review and meta-analysis
    Andrea L Ciaranello
    The Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Infect Dis 49:1915-27. 2009
    ..We sought to derive pooled estimates of the 12-month rate of virologic suppression (HIV RNA, <400 copies/mL) and gain in CD4 cell percentage (DeltaCD4%) for children initiating ART in resource-limited settings...
  95. doi request reprint Cost effectiveness of venous thromboembolism pharmacological prophylaxis in total hip and knee replacement: a systematic review
    Alok Kapoor
    Hospital Medicine Unit, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Pharmacoeconomics 28:521-38. 2010
    ..Small numbers for other comparisons and absence of trials reporting symptomatic endpoints prohibit comprehensive conclusions...
  96. ncbi request reprint Offering patients the opportunity to choose their hospital for total knee replacement: impact on satisfaction with the surgery
    Elena Losina
    Boston University School of Public Health, and Robert Brigham Arthritis and Musculoskeletal Clinical Research Center, MA 02118, USA
    Arthritis Rheum 53:646-52. 2005
    ....
  97. ncbi request reprint Geographic diversity of low-volume hospitals in total knee replacement: implications for regionalization policies
    Elena Losina
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Med Care 44:637-45. 2006
    ....
  98. pmc The effect of antiretroviral therapy on secondary transmission of HIV among men who have sex with men
    Alethea W McCormick
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Clin Infect Dis 44:1115-22. 2007
    ..However, the potential reduction in secondary transmission associated with ART may be offset by the longer duration of infectiousness...
  99. ncbi request reprint CD4 decline and incidence of opportunistic infections in Cape Town, South Africa: implications for prophylaxis and treatment
    Charles B Holmes
    Divisions of Infectious Disease, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 42:464-9. 2006
    ..To determine the rate of CD4 decline and the incidence of opportunistic infections (OIs) among antiretroviral therapy-naive South African HIV-infected patients and inform timing of OI prophylaxis...
  100. ncbi request reprint Optimizing resource allocation in United States AIDS drug assistance programs
    Benjamin P Linas
    Division of General Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Infect Dis 43:1357-64. 2006
    ..We hypothesized that CD4 cell count-based ADAP eligibility would improve ADAP outcomes, allowing them to serve more-diverse patient populations and to prioritize persons who are at greatest risk of HIV-related mortality...
  101. ncbi request reprint Bilateral total knee replacement: staging and pulmonary embolism
    Jane Barrett
    Department of Medicine, Dartmouth Medical School, 46 Centerra Parkway, Evergreen Building, Suite 300, Lebanon, NH 03766, USA
    J Bone Joint Surg Am 88:2146-51. 2006
    ..A greater risk of pulmonary embolism after simultaneous total knee replacement has been reported by some authors, but little national data are available...

Research Grants7

  1. Knee OA: Setting Priorities for Care, Policy, Research
    Elena Losina; Fiscal Year: 2009
    ..This study will provide guidance to clinicians and policy makers on efforts to reduce pain and disability, and to improve quality of life for people with knee osteoarthritis. ..
  2. Modeling Sequential Antiretroviral Therapy in HIV
    Elena Losina; Fiscal Year: 2005
    ..Trained as a biostatistician, Elena Losina, Ph.D...
  3. Knee OA: Setting Priorities for Care, Policy, Research
    Elena Losina; Fiscal Year: 2007
    ..This study will provide guidance to clinicians and policy makers on efforts to reduce pain and disability, and to improve quality of life for people with knee osteoarthritis. ..
  4. Knee OA: Setting Priorities for Care, Policy, Research
    Elena Losina; Fiscal Year: 2010
    ..This study will provide guidance to clinicians and policy makers on efforts to reduce pain and disability, and to improve quality of life for people with knee osteoarthritis. ..