Research Topics
Species | Elena LosinaSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Lifetime Risk and Age at Diagnosis of Symptomatic Knee Osteoarthritis in the USElena Losina
Brigham and Women s Hospital, Harvard University, and Boston University School of Public Health, Boston, Massachusetts
Arthritis Care Res (Hoboken) 65:703-11. 2013..To estimate the incidence and lifetime risk of diagnosed symptomatic knee osteoarthritis (OA) and the age at diagnosis of knee OA based on self-reports in the US population...- Disease-modifying drugs for knee osteoarthritis: can they be cost-effective?E Losina
Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA, USA Section of Clinical Sciences, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA Boston University School of Public Health, Boston, MA, USA Electronic address
Osteoarthritis Cartilage 21:655-67. 2013..Disease-modifying osteoarthritis drugs (DMOADs) are under development. Our goal was to determine efficacy, toxicity, and cost thresholds under which DMOADs would be a cost-effective knee OA treatment... 
The dramatic increase in total knee replacement utilization rates in the United States cannot be fully explained by growth in population size and the obesity epidemicElena Losina
Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, 75 Francis Street, BC 4, Boston, MA 02115, USA
J Bone Joint Surg Am 94:201-7. 2012..Our goal was to investigate whether the rapid increase in total knee replacement use over the past decade can be sufficiently attributed to changes in these two factors...- Empirical evaluation of the inter-relationship of articular elements involved in the pathoanatomy of knee osteoarthritis using magnetic resonance imagingDennis S Meredith
Department of Orthopedic Surgery, Hospital for Special Surgery, New York NY, USA
BMC Musculoskelet Disord 10:133. 2009..We assessed the association of pathological change in multiple articular structures involved in the pathoanatomy of osteoarthritis... - Decreasing medical complications for total knee arthroplasty: effect of critical pathways on outcomesM Elaine Husni
Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
BMC Musculoskelet Disord 11:160. 2010..However, pathway effectiveness is difficult to determine given methodological flaws, such as small or single center cohorts. We studied the effect of critical pathways on total knee replacement outcomes in a large population-based study... - Evaluation of exposure-specific risks from two independent samples: a simulation studyWilliam M Reichmann
Department of Orthopedic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
BMC Med Res Methodol 11:1. 2011..The goal of our study was to evaluate the existing methodology for calculating the ESR, propose an improved point estimator, and propose variance estimates that will allow the calculation of confidence intervals (CIs)... - Risk of venous thromboembolism after total hip and knee replacement in older adults with comorbidity and co-occurring comorbidities in the Nationwide Inpatient Sample (2003-2006)Alok Kapoor
Hospital Medicine Unit, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
BMC Geriatr 10:63. 2010..Identifying a high risk cohort such as older adults with comorbidities and co-occurring comorbidities who might benefit most from high potency prophylaxis would improve how we currently perform preoperative assessment... - Drug efficacy by direct and adjusted indirect comparison to placebo: An illustration by Mycobacterium avium complex prophylaxis in HIVJennifer Chu
Division of General Medicine, Department of Medicine, Massachusetts General Hospital, Boston, USA
AIDS Res Ther 8:14. 2011..abstract:.. - Racial and sex disparities in life expectancy losses among HIV-infected persons in the united states: impact of risk behavior, late initiation, and early discontinuation of antiretroviral therapyElena Losina
Divisions of General Medicine, Department of Medicine, MA 02114, USA
Clin Infect Dis 49:1570-8. 2009.... - Cost-effectiveness of total knee arthroplasty in the United States: patient risk and hospital volumeElena Losina
Department of Orthopedic Surgery, Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women s Hospital, Boston, MA 02115, USA
Arch Intern Med 169:1113-21; discussion 1121-2. 2009..However, to our knowledge, the cost-effectiveness of TKA and the influences of hospital volume and patient risk on TKA cost-effectiveness have not been investigated in the United States... - Impact of obesity and knee osteoarthritis on morbidity and mortality in older AmericansElena Losina
Brigham and Women s Hospital, Boston University School of Public Health, Massachusetts General Hospital, USA
Ann Intern Med 154:217-26. 2011..Obesity and knee osteoarthritis are among the most frequent chronic conditions affecting Americans aged 50 to 84 years... - HIV morbidity and mortality in Jamaica: analysis of national surveillance data, 1993--2005Elena Losina
Division of General Medicine and Infectious Diseases, Massachusetts General Hospital, 50 Staniford St, 9th Floor, Boston, Massachusetts 02114, USA
Int J Infect Dis 12:132-8. 2008..Using Jamaican national surveillance data, we estimated overall, AIDS-free, and AIDS survival, identified factors influencing HIV-related mortality, and examined factors associated with late HIV/AIDS identification... - The "ART" of linkage: pre-treatment loss to care after HIV diagnosis at two PEPFAR sites in Durban, South AfricaElena Losina
Division of General Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 5:e9538. 2010..Our objective was to determine PTLC in newly identified HIV-infected individuals in South Africa... - The independent effect of highly active antiretroviral therapy on severe opportunistic disease incidence and mortality in HIV-infected adults in Côte d'IvoireElena Losina
Department of Biostatistics and Epidemiology, Boston University School of Public Health, Boston, MA, USA
Antivir Ther 12:543-51. 2007..Studies in developed countries have shown highly active antiretroviral therapy (HAART) decreases incidence of severe opportunistic diseases (ODs) in HIV-infected patients beyond that which is expected from changes in CD4+ T-cell count... - Visual screening for malignant melanoma: a cost-effectiveness analysisElena Losina
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
Arch Dermatol 143:21-8. 2007..To evaluate the cost-effectiveness of various melanoma screening strategies proposed in the United States... - When to start antiretroviral therapy in resource-limited settingsRochelle P Walensky
Massachusetts General Hospital, Brigham and Women s Hospital, Harvard University Medical School, Harvard School of Public Health, and Boston University School of Public Health, Boston, Massachusetts 02114, USA
Ann Intern Med 151:157-66. 2009..The results of international clinical trials that are assessing when to initiate antiretroviral therapy (ART) will not be available for several years... - HIV drug resistance surveillance for prioritizing treatment in resource-limited settingsRochelle P Walensky
Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
AIDS 21:973-82. 2007..Sentinel testing programs for HIV drug resistance in resource-limited settings can inform policy on antiretroviral therapy (ART) and drug sequencing... - Depressive symptoms and their impact on health-seeking behaviors in newly-diagnosed HIV-infected patients in Durban, South AfricaLynn Ramirez-Avila
Division of Infectious Diseases, Children s Hospital Boston, 333 Longwood Avenue, Boston, MA, 02139, USA
AIDS Behav 16:2226-35. 2012..Depression screening at the time of HIV diagnosis is critical for improving linkage to mental health and HIV services in South Africa... 
Cost-effectiveness of HIV treatment in resource-poor settings--the case of Côte d'IvoireSue J Goldie
Department of Health Policy and Management, Program in Health Decision Science, Harvard School of Public Health, Boston, MA 02115, USA
N Engl J Med 355:1141-53. 2006..As antiretroviral therapy is increasingly used in settings with limited resources, key questions about the timing of treatment and use of diagnostic tests to guide clinical decisions must be addressed...- Estimating the burden of total knee replacement in the United StatesAlexander M Weinstein
Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women s Hospital, Boston, MA 02115, USA
J Bone Joint Surg Am 95:385-92. 2013..We are aware of no current estimates of the prevalence of total knee replacement among adults in the U.S... - Projecting the cost-effectiveness of adherence interventions in persons with human immunodeficiency virus infectionSue J Goldie
Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115 5924, USA
Am J Med 115:632-41. 2003..To explore the cost-effectiveness of interventions to improve adherence to combination antiretroviral therapy in patients with human immunodeficiency virus (HIV) infection... - Drug-resistant tuberculosis among HIV-infected patients starting antiretroviral therapy in Durban, South AfricaJeffrey K Hom
Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 7:e43281. 2012..To estimate the prevalence of drug-resistant tuberculosis (TB) and describe the resistance patterns in patients commencing antiretroviral therapy (ART) in an HIV clinic in Durban, South Africa... - Association of hospital and surgeon procedure volume with patient-centered outcomes of total knee replacement in a population-based cohort of patients age 65 years and olderJeffrey N Katz
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arthritis Rheum 56:568-74. 2007..To study the association between procedure volume and patient-centered outcomes such as functional status... - Cost-effectiveness implications of the timing of antiretroviral therapy in HIV-infected adultsBruce R Schackman
Department of Health Policy and Management, Harvard School of Public Health, Boston, MA, USA
Arch Intern Med 162:2478-86. 2002.... - Clinical impact and cost-effectiveness of antiretroviral therapy in India: starting criteria and second-line therapyKenneth A Freedberg
Divisions of General Medicine and Infectious Disease and the Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA, USA
AIDS 21:S117-28. 2007..India has more than 5.7 million people infected with human immunodeficiency virus (HIV). In 2004, the Indian government began providing antiretroviral therapy (ART), and there are now an estimated 56 500 people receiving ART... - Neighborhoods matter: use of hospitals with worse outcomes following total knee replacement by patients from vulnerable populationsElena Losina
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
Arch Intern Med 167:182-7. 2007.... - Acceptability of fingerstick versus oral fluid rapid HIV testing: results from the universal screening for HIV infection in the emergency room (USHER Phase II) randomized controlled trialLaurel A Donnell-Fink
Division of Infectious Disease, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 61:588-92. 2012..Patient preference for oral rapid HIV testing compared with more invasive whole blood fingerstick may influence the acceptance of rapid HIV testing... - Optimal frequency of CD4 cell count and HIV RNA monitoring prior to initiation of antiretroviral therapy in HIV-infected patientsApril D Kimmel
Division of General Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Antivir Ther 10:41-52. 2005..Guidelines regarding the frequency of CD4 cell count and HIV RNA monitoring in HIV-infected patients vary, with recommended strategies ranging from every 2 to every 6 months... - Cost-effectiveness of enfuvirtide in treatment-experienced patients with advanced HIV diseasePaul E Sax
Division of Infectious Disease and the Partners AIDS Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 39:69-77. 2005..Because of the high cost of ENF compared with other antiretroviral agents, our objectives were to determine the potential long-term clinical impact and cost-effectiveness of ENF in these patients... - Cost-effectiveness of preventing loss to follow-up in HIV treatment programs: a Côte d'Ivoire appraisalElena Losina
Division of General Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS Med 6:e1000173. 2009..Our objective was to project the clinical impact and cost-effectiveness of interventions to prevent LTFU from HIV care in West Africa... - Treatment for primary HIV infection: projecting outcomes of immediate, interrupted, or delayed therapyRochelle P Walensky
Division of Infectious Disease and the Partners AIDS Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
J Acquir Immune Defic Syndr 31:27-37. 2002..These results can assist decision makers and those planning clinical trials in defining evidence-based performance measures for primary HIV infection treatment and future trials... - Intensive tuberculosis screening for HIV-infected patients starting antiretroviral therapy in Durban, South AfricaIngrid V Bassett
Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
Clin Infect Dis 51:823-9. 2010..Our objective was to assess the yield and cost of a more intensive tuberculosis screening in HIV-infected patients starting antiretroviral therapy (ART) in Durban, South Africa... - Scaling up antiretroviral therapy in South Africa: the impact of speed on survivalRochelle P Walensky
The Divisions of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
J Infect Dis 197:1324-32. 2008..Only 33% of eligible human immunodeficiency virus (HIV)-infected patients in South Africa receive antiretroviral therapy (ART). We sought to estimate the impact of alternative ART scale-up scenarios on patient outcomes from 2007-2012... - The clinical impact and cost-effectiveness of routine, voluntary HIV screening in South AfricaRochelle P Walensky
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
J Acquir Immune Defic Syndr 56:26-35. 2011..Although 900,000 HIV-infected South Africans receive antiretroviral therapy, the majority of South Africans with HIV remain undiagnosed... - Test and treat DC: forecasting the impact of a comprehensive HIV strategy in Washington DCRochelle P Walensky
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Clin Infect Dis 51:392-400. 2010..We forecast outcomes of this approach if implemented in Washington DC... - Risk factors for revision of primary total hip replacement: results from a national case-control studyElizabeth A Wright
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arthritis Care Res (Hoboken) 64:1879-85. 2012..To study the risk factors for revision of primary total hip replacement (THR) in a US population-based sample... - Cost-effectiveness of an intervention to improve adherence to antiretroviral therapy in HIV-infected patientsKenneth A Freedberg
Divisions of General Medicine and Infectious Diseases and the Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
J Acquir Immune Defic Syndr 43:S113-8. 2006..Adherence interventions with modest effectiveness are likely to provide long-term survival benefit to patients and to be cost-effective compared with other uses of HIV care funds... - Factors associated with refusal of rapid HIV testing in an emergency departmentMary L Pisculli
Division of Infectious Disease, Brigham and Women s Hospital, Boston, MA, USA
AIDS Behav 15:734-42. 2011..Enrollment during morning hours was also associated with an increased risk of refusal. Increased educational efforts to convey the rationale and benefits of universal screening may improve testing uptake among these groups... - Predictive value of Medicare claims data for identifying revision of index hip replacement was modestJeffrey N Katz
Orthopedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston 02115, MA, USA
J Clin Epidemiol 64:543-6. 2011..To determine the positive predictive value of Medicare claims for identifying revision of total hip replacement (THR), a frequent marker of THR quality and outcome... - Effectiveness of antiretroviral therapy after protease inhibitor failure: an analytic overviewElena Losina
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
Clin Infect Dis 38:1613-22. 2004..The best response was seen in NNRTI-naive patients receiving NNRTI- and boosted PI-containing regimens. New approaches are needed to achieve better suppression in pretreated HIV-infected patients... - The survival benefits of AIDS treatment in the United StatesRochelle P Walensky
Division of Infectious Disease and General Medicine, Massachusetts General Hospital, Boston 02114, USA
J Infect Dis 194:11-9. 2006..As widespread adoption of potent combination antiretroviral therapy (ART) reaches its tenth year, our objective was to quantify the cumulative survival benefits of acquired immunodeficiency syndrome (AIDS) care in the United States... - Routine human immunodeficiency virus testing: an economic evaluation of current guidelinesRochelle P Walensky
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, and the Partners AIDS Research Center, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med 118:292-300. 2005..Our objective was to evaluate the clinical effect and cost-effectiveness of current guidelines and of alternate HIV prevalence thresholds... - Type II odontoid fractures of the cervical spine: do treatment type and medical comorbidities affect mortality in elderly patients?Andrew J Schoenfeld
Department of Orthopaedic Surgery, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
Spine (Phila Pa 1976) 36:879-85. 2011..Retrospective cohort study... - Resource utilization and cost-effectiveness of counselor- vs. provider-based rapid point-of-care HIV screening in the emergency departmentRochelle P Walensky
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 6:e25575. 2011..Routine HIV screening in emergency department (ED) settings may require dedicated personnel. We evaluated the outcomes, costs and cost-effectiveness of HIV screening when offered by either a member of the ED staff or by an HIV counselor... - Loss to follow-up and mortality among HIV-infected people co-infected with TB at ART initiation in Durban, South AfricaIngrid V Bassett
Division of Infectious Disease, Massachusetts General Hospital, Boston, USA
J Acquir Immune Defic Syndr 59:25-30. 2012..To quantify the impact of tuberculosis (TB) co-infection on death and loss to follow-up (LTFU) 12 months after entry into an ART program... - Routine voluntary HIV testing in Durban, South Africa: the experience from an outpatient departmentIngrid V Bassett
Division of Infectious Disease, Massachusetts General Hospital, Boston, MA 02114, USA
J Acquir Immune Defic Syndr 46:181-6. 2007..To evaluate the yield of a routine voluntary HIV testing program compared with traditional provider-referred voluntary counseling and testing (VCT) in a hospital-affiliated outpatient department (OPD) in Durban, South Africa... - Counselor- versus provider-based HIV screening in the emergency department: results from the universal screening for HIV infection in the emergency room (USHER) randomized controlled trialRochelle P Walensky
Division of Infectious Diseases and General Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Ann Emerg Med 58:S126-32.e1-4. 2011..We compare rates of rapid HIV testing, test offer, and acceptance in an urban emergency department (ED) when conducted by dedicated HIV counselors versus current members of the ED staff... - Review of human immunodeficiency virus type 1-related opportunistic infections in sub-Saharan AfricaCharles B Holmes
Division of Infectious Disease, Partners AIDS Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Clin Infect Dis 36:652-62. 2003..Policies regarding the type and timing of opportunistic infection prophylaxis may be region specific and urgently require further study... - Predictors of mortality in patients initiating antiretroviral therapy in Durban, South AfricaBisola O Ojikutu
Harvard Center for AIDS Research CFAR and Division of AIDS, Harvard Medical School, and Division of Infectious Disease, Massachusetts General Hospital, Boston, MA, USA
S Afr Med J 98:204-8. 2008..To identify predictors of mortality in patients initiating antiretroviral therapy (ART) in Durban, South Africa... - Loss to care and death before antiretroviral therapy in Durban, South AfricaIngrid V Bassett
Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
J Acquir Immune Defic Syndr 51:135-9. 2009..To examine the loss to care and mortality rates before starting antiretroviral therapy (ART) among ART eligible HIV-infected patients in Durban, South Africa. Design: Retrospective cohort study... - Survival following total hip replacementJane Barrett
Department of Medicine, Section of Biostatistics and Epidemiology, Dartmouth Medical School, Evergreen Building, Suite 300, 46 Centerra Parkway, Lebanon, NH 03766, USA
J Bone Joint Surg Am 87:1965-71. 2005..The purpose of our investigation was to assess whether the association had the characteristics of a causal relationship or whether it might appear to be due to comorbidity or other factors... - Who starts antiretroviral therapy in Durban, South Africa?... not everyone who shouldIngrid V Bassett
Division of Infectious Disease, Massachusetts General Hospital, Boston, MA 02114, USA
AIDS 24:S37-44. 2010..To evaluate rates of antiretroviral therapy (ART) initiation within 12 months of a new HIV diagnosis in Durban, South Africa... - Not all are lost: interrupted laboratory monitoring, early death, and loss to follow-up (LTFU) in a large South African treatment programAima A Ahonkhai
Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 7:e32993. 2012..Most studies have not distinguished between those who briefly interrupt, but return to care, and those more chronically lost to follow-up... - The cost-effectiveness of tuberculosis preventive therapy for HIV-infected individuals in southern India: a trial-based analysisMai T Pho
Section of Hospital Medicine, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois, USA
PLoS ONE 7:e36001. 2012..Further, the cost-effectiveness of IPT has not been studied in India... - Emergency provider attitudes and barriers to universal HIV testing in the emergency departmentChristian Arbelaez
Department of Emergency Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Emerg Med 42:7-14. 2012..The Centers for Disease Control and Prevention (CDC) recently published recommendations for routine, voluntary human immunodeficiency virus (HIV) testing of adults in all health care settings, including the emergency department (ED)... - Determinants of self-reported health status in a population-based sample of persons with radiographic knee osteoarthritisWilliam M Reichmann
Brigham and Women s Hospital and Boston University School of Public Health, Boston, Massachusetts 02115, USA
Arthritis Rheum 61:1046-53. 2009..Our objective was to determine factors associated with self-reported health status in a national population-based sample with radiographic knee OA... - Early antiretroviral therapy for patients with acute aids-related opportunistic infections: a cost-effectiveness analysis of ACTG A5164Paul E Sax
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
HIV Clin Trials 11:248-59. 2010..We project the life expectancies, costs, and incremental cost-effectiveness ratios (ICERs) of these strategies... - The cost-effectiveness of antiretroviral therapy for treating HIV disease in the CaribbeanLindsey L Wolf
Division of General Medicine and the Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
J Acquir Immune Defic Syndr 46:463-71. 2007..Antiretroviral therapy (ART) recently became available in the Organization of Eastern Caribbean States (OECS). Survival benefits and budgetary implications associated with universal access to ART have not been examined in the Caribbean... - Prevalence of HIV-1 drug resistance after failure of a first highly active antiretroviral therapy regimen in KwaZulu Natal, South AfricaVincent C Marconi
Section of Retroviral Therapeutics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
Clin Infect Dis 46:1589-97. 2008..The prevalence of resistance was assessed among patients from KwaZulu Natal, South Africa, following failure of their first highly active antiretroviral therapy (HAART) regimen... - Improving outcomes in state AIDS drug assistance programsBenjamin P Linas
Divisions of General Medicine, Massachusetts General Hospital, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 51:513-21. 2009..State AIDS Drug Assistance Programs (ADAPs) provide antiretroviral medications to patients with no access to medications. Resource constraints limit the ability of many ADAPs to meet demand for services... - Choice of hospital for revision total hip replacementJeffrey N Katz
Orthopedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women s Hospital, BC 4th floor, 75 Francis Street, Boston, MA 02115, USA
J Bone Joint Surg Am 92:2829-34. 2010..Little is known about how often patients have revision total hip replacement in the same hospital in which they had the primary procedure... - Association of hospital and surgeon volume of total hip replacement with functional status and satisfaction three years following surgeryJeffrey N Katz
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, 75 Francis Street, B 3, Boston, MA 02115, USA
Arthritis Rheum 48:560-8. 2003..To evaluate whether hospital volume and surgeon volume of total hip replacements (THRs) are associated with patient-reported functional status and satisfaction with surgery 3 years postoperatively... - Prophylaxis for human immunodeficiency virus-related Pneumocystis carinii pneumonia: using simulation modeling to inform clinical guidelinesSue J Goldie
Center for Risk Analysis, Department of Health Policy and Management, Harvard School of Public Health, 718 Huntington Ave, Second Floor, Boston, MA 02115-5924, USA
Arch Intern Med 162:921-8. 2002..quot; In TMP/SMX-intolerant patients, dapsone is more cost-effective than atovaquone... - The relationship of preventable opportunistic infections, HIV-1 RNA, and CD4 Cell counts to chronic mortalityGeorge R Seage
Department of Epidemiology and Center for Risk Analysis, Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Acquir Immune Defic Syndr 30:421-8. 2002.... - Extent of followup care after elective total hip replacementPaola de Pablo
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Secion of Clinical Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA
J Rheumatol 33:1159-66. 2006..These population groups can serve as targets for interventions to improve followup after elective THR... - Patient satisfaction with rapid HIV testing in the emergency departmentLaurel Donnell-Fink
Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA 02114, USA
Ann Emerg Med 58:S49-52. 2011..This investigation assesses patient satisfaction with rapid HIV testing in the emergency department (ED) of an urban tertiary academic medical center... - Should resistance testing be performed for treatment-naive HIV-infected patients? A cost-effectiveness analysisPaul E Sax
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
Clin Infect Dis 41:1316-23. 2005..Our objective was to determine the clinical impact and cost-effectiveness of genotype resistance testing for treatment-naive patients with chronic HIV infection... - The cost-effectiveness of routine tuberculosis screening with Xpert MTB/RIF prior to initiation of antiretroviral therapy: a model-based analysisJason R Andrews
Division of Infectious Diseases, Massachusetts General Hospital, Boston, 02114, USA
AIDS 26:987-95. 2012..Such patients are usually screened by symptoms and sputum smear, which have poor sensitivity... - Medical decision-making among Hispanics and non-Hispanic Whites with chronic back and knee pain: a qualitative studyJeffrey N Katz
Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
BMC Musculoskelet Disord 12:78. 2011..Because these disorders are not life-threatening, decision-making is generally preference-based. Little is known about whether Hispanics in the U.S. differ from non-Hispanic Whites with respect to key decision making preferences... - Comparison of health state utilities using community and patient preference weights derived from a survey of patients with HIV/AIDSBruce R Schackman
Center for Risk Analysis, Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts, USA
Med Decis Making 22:27-38. 2002.... - Loss to follow-up in a community clinic in South Africa--roles of gender, pregnancy and CD4 countBingxia Wang
Division of General Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Mass, USA
S Afr Med J 101:253-7. 2011..Faith-based organisations have expanded antiretroviral therapy (ART) in community clinics across South Africa. Loss to follow-up (LTFU), however, limits the potential individual and population treatment benefits and optimal care... - Utilization of low-volume hospitals for total hip replacementElena Losina
Boston University School of Public Health and Robert B Brigham Arthritis Clinical Research Center, Boston, Massachusetts, USA
Arthritis Rheum 51:836-42. 2004..To identify factors associated with utilization of low-volume hospitals for total hip replacement (THR) and to estimate differences in the distances that Medicare beneficiaries had to travel to reach low- or high-volume hospitals... - Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South AfricaZabrina Brumme
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, USA
Clin Infect Dis 49:956-64. 2009.... - HIV testing rates and outcomes in a South African community, 2001-2006: implications for expanded screening policiesMichael D April
Harvard Medical School, Boston, MA, USA
J Acquir Immune Defic Syndr 51:310-6. 2009..Revised World Health Organization recommendations seek to increase HIV testing. We assessed the need for expanded testing in South Africa by examining current testing and treatment trends among a high prevalence population... - Early failures of total hip replacement: effect of surgeon volumeElena Losina
Department of Biostatistics, Boston University School of Public Health and Robert B Brigham Arthritis and Musculoskeletal Clinical Research Center, Boston, Massachusetts 02118, USA
Arthritis Rheum 50:1338-43. 2004..To determine whether provider volume is associated with early failures following total hip replacement (THR) requiring revision... - Estimation of the prevalence of undiagnosed and diagnosed HIV in an urban emergency departmentWilliam M Reichmann
Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS ONE 6:e27701. 2011..We also sought to estimate these quantities within demographic and risk behavior subgroups... - Development and validation of an index of musculoskeletal functional limitationsJeffrey N Katz
Department of Orthopaedic Surgery, Division of Rheumatology, Brigham and Womens Hospital, Department of Epidemiology, Harvard School of Public Health, Boston, USA
BMC Musculoskelet Disord 10:62. 2009..This paper reports on the development and preliminary validation of a self administered musculoskeletal functional limitations index... - Cost effectiveness of venous thromboembolism pharmacological prophylaxis in total hip and knee replacement: a systematic reviewAlok Kapoor
Hospital Medicine Unit, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Pharmacoeconomics 28:521-38. 2010..Small numbers for other comparisons and absence of trials reporting symptomatic endpoints prohibit comprehensive conclusions... - Geographic diversity of low-volume hospitals in total knee replacement: implications for regionalization policiesElena Losina
Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
Med Care 44:637-45. 2006.... - Effectiveness of pediatric antiretroviral therapy in resource-limited settings: a systematic review and meta-analysisAndrea L Ciaranello
The Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Clin Infect Dis 49:1915-27. 2009..We sought to derive pooled estimates of the 12-month rate of virologic suppression (HIV RNA, <400 copies/mL) and gain in CD4 cell percentage (DeltaCD4%) for children initiating ART in resource-limited settings... - Offering patients the opportunity to choose their hospital for total knee replacement: impact on satisfaction with the surgeryElena Losina
Boston University School of Public Health, and Robert Brigham Arthritis and Musculoskeletal Clinical Research Center, MA 02118, USA
Arthritis Rheum 53:646-52. 2005.... - The effect of antiretroviral therapy on secondary transmission of HIV among men who have sex with menAlethea W McCormick
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Clin Infect Dis 44:1115-22. 2007..However, the potential reduction in secondary transmission associated with ART may be offset by the longer duration of infectiousness... - CD4 decline and incidence of opportunistic infections in Cape Town, South Africa: implications for prophylaxis and treatmentCharles B Holmes
Divisions of Infectious Disease, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Acquir Immune Defic Syndr 42:464-9. 2006..To determine the rate of CD4 decline and the incidence of opportunistic infections (OIs) among antiretroviral therapy-naive South African HIV-infected patients and inform timing of OI prophylaxis... - Bilateral total knee replacement: staging and pulmonary embolismJane Barrett
Department of Medicine, Dartmouth Medical School, 46 Centerra Parkway, Evergreen Building, Suite 300, Lebanon, NH 03766, USA
J Bone Joint Surg Am 88:2146-51. 2006..A greater risk of pulmonary embolism after simultaneous total knee replacement has been reported by some authors, but little national data are available... - Optimizing resource allocation in United States AIDS drug assistance programsBenjamin P Linas
Division of General Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Clin Infect Dis 43:1357-64. 2006..We hypothesized that CD4 cell count-based ADAP eligibility would improve ADAP outcomes, allowing them to serve more-diverse patient populations and to prioritize persons who are at greatest risk of HIV-related mortality... - Incidence rates of dislocation, pulmonary embolism, and deep infection during the first six months after elective total hip replacementCharlotte B Phillips
Robert Breck Brigham Multipurpose Arthritis and Musculoskeletal Diseases Center, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
J Bone Joint Surg Am 85:20-6. 2003..LEVEL OF EVIDENCE: Prognostic study, Level II-1 (retrospective study). See p. 2 for complete description of levels of evidence... - Association between hospital and surgeon procedure volume and the outcomes of total knee replacementJeffrey N Katz
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
J Bone Joint Surg Am 86:1909-16. 2004..The relationship between hospital and surgeon volume and perioperative outcomes following total knee replacement has received little study... - Does modality of survey administration impact data quality: audio computer assisted self interview (ACASI) versus self-administered pen and paper?William M Reichmann
Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS ONE 5:e8728. 2010..In the context of a randomized controlled trial (RCT) on HIV testing in the emergency department (ED) setting, we evaluated preferences for survey modality and data quality arising from each modality... - Complications for racial and ethnic minority groups after total hip and knee replacement: a review of the literatureBenedict U Nwachukwu
Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Bone Joint Surg Am 92:338-45. 2010..It has been shown that racial and ethnic minority groups underutilize these procedures; however, little information exists on postoperative outcomes for ethnic minorities... - Acute human immunodeficiency virus infection in patients presenting to an urban urgent care centerJonathan M Pincus
Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Clin Infect Dis 37:1699-704. 2003..Given the importance of this diagnosis, testing for acute HIV infection using RNA and antibody assays should be offered to all patients in similar settings with viral symptoms and any risk factors for HIV infection... - The economics of improving medication adherence in osteoporosis: validation and application of a simulation modelAmanda R Patrick
Brigham and Women s Hospital Division of Pharmacoepidemiology, 1620 Tremont Street, Suite 3030, Boston, Massachusetts 02120
J Clin Endocrinol Metab 96:2762-70. 2011..Adherence to osteoporosis treatment is low. Although new therapies and behavioral interventions may improve medication adherence, questions are likely to arise regarding their cost-effectiveness... - Contribution of hospital characteristics to the volume-outcome relationship: dislocation and infection following total hip replacement surgeryDaniel H Solomon
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 46:2436-44. 2002..We evaluated the contribution of hospital structural characteristics to the volume-outcome relationship in THR by examining the rates and predictors of postoperative complications... - Differences in self-reported health in the Osteoarthritis Initiative (OAI) and Third National Health and Nutrition Examination Survey (NHANES-III)William M Reichmann
Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS ONE 6:e17345. 2011..To assess self-reported health status (SRHS) in two cohorts of participants with radiographic knee osteoarthritis (OA) and examine the extent that differences in SRHS are due to study design... - Development of a preliminary index that predicts adverse events after total knee replacementDaniel H Solomon
Division of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
Arthritis Rheum 54:1536-42. 2006.... - Early outcomes and the virological effect of delayed treatment switching to second-line therapy in an antiretroviral roll-out programme in South AfricaJulie H Levison
Division of General Medicine, Massachusetts General Hospital, Boston, MA, USA
Antivir Ther 16:853-61. 2011..We aimed to describe predictors of lack of virological suppression in HIV-infected patients on second-line ART in a roll-out programme in South Africa... - Assessing the impact of federal HIV prevention spending on HIV testing and awarenessBenjamin P Linas
Massachusetts General Hospital, 50 Staniford St, Ninth Floor, Boston, MA 02114, USA
Am J Public Health 96:1038-43. 2006..The United States allocates more than $900 million annually for the prevention of HIV infection. We assessed the impact of this funding on HIV testing and knowledge... - Mortality in elderly patients after cervical spine fracturesMitchel B Harris
Department of Orthopedic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
J Bone Joint Surg Am 92:567-74. 2010..The purposes of this study were to determine the three-month and one-year mortality associated with cervical spine fractures in patients sixty-five years of age or older and to evaluate potential factors that may influence mortality... - Effective HIV case identification through routine HIV screening at urgent care centers in MassachusettsRochelle P Walensky
Division of General Medicine, Massachusetts General Hospital, 50 Staniford St, 9th Floor, Boston, MA 02114, USA
Am J Public Health 95:71-3. 2005..Urgent care center-based routine HIV counseling, testing, and referral programs are feasible, can have high positive diagnosis yields, and should be the standard of care in high HIV prevalence areas... - Departures from community equipoise may lead to incorrect inference in randomized trialsJeffrey N Katz
Department of Orthopaedic Surgery, Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women s Hospital, Boston, MA 02115, USA
J Clin Epidemiol 64:280-5. 2011..To assess the impact of selective enrollment on the results of randomized controlled trials (RCTs)... - Determinants of work absence following surgery for carpal tunnel syndromeJeffrey N Katz
Robert Brigham Arthritis and Musculoskeletal Clinical Research Center, Section of Clinical Sciences, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Ind Med 47:120-30. 2005..The objective was to identify factors across multiple domains associated with return to work in a community-based cohort of workers with carpal tunnel syndrome... - Identifying undiagnosed human immunodeficiency virus: the yield of routine, voluntary inpatient testingRochelle P Walensky
Division of Infectious Disease and Partners AIDS Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, 50 Staniford St, Ninth Floor, Boston, MA 02114, USA
Arch Intern Med 162:887-92. 2002....
Research Grants
- Modeling Sequential Antiretroviral Therapy in HIVElena Losina; Fiscal Year: 2005..Trained as a biostatistician, Elena Losina, Ph.D...
- Knee OA: Setting Priorities for Care, Policy, ResearchElena Losina; Fiscal Year: 2007..This study will provide guidance to clinicians and policy makers on efforts to reduce pain and disability, and to improve quality of life for people with knee osteoarthritis. ..
- Knee OA: Setting Priorities for Care, Policy, ResearchElena Losina; Fiscal Year: 2009..This study will provide guidance to clinicians and policy makers on efforts to reduce pain and disability, and to improve quality of life for people with knee osteoarthritis. ..
- Knee OA: Setting Priorities for Care, Policy, ResearchElena Losina; Fiscal Year: 2010..This study will provide guidance to clinicians and policy makers on efforts to reduce pain and disability, and to improve quality of life for people with knee osteoarthritis. ..