Harvey Lodish

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors
    Lingbo Zhang
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 499:92-6. 2013
  2. pmc Mir193b-365 is essential for brown fat differentiation
    Lei Sun
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Cell Biol 13:958-65. 2011
  3. pmc Adiponectin deficiency promotes tumor growth in mice by reducing macrophage infiltration
    Yutong Sun
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America
    PLoS ONE 5:e11987. 2010
  4. pmc Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis
    Wei Tong
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    J Exp Med 200:569-80. 2004
  5. pmc Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development
    Shawdee Eshghi
    Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Cell Biol 177:871-80. 2007
  6. pmc Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4
    J S Bogan
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Cell Biol 146:609-20. 1999
  7. ncbi request reprint Micromanagement of the immune system by microRNAs
    Harvey F Lodish
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Immunol 8:120-30. 2008
  8. pmc From stem cell to erythroblast: regulation of red cell production at multiple levels by multiple hormones
    Harvey Lodish
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    IUBMB Life 62:492-6. 2010
  9. pmc Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts
    Peng Ji
    Whitehead Institute for Biomedical Research, Cambridge, 9 Cambridge Center, Cambridge, MA, USA
    Haematologica 95:2013-21. 2010
  10. pmc Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
    Xiaohui Lu
    Whitehead Institute for Biomedical Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 102:18962-7. 2005

Collaborators

  • Lei Sun
  • Wei Tong
  • David Bartel
  • Marie Soleil Gauthier
  • Johan Flygare
  • Maroun Khoury
  • D Gary Gilliland
  • Chang Zheng Chen
  • Jianzhu Chen
  • Jing Zhang
  • Prakash K Rao
  • Huangming Xie
  • Bing Lim
  • Andreas Herrlich
  • Beiyan Zhou
  • Lingbo Zhang
  • Ryan Alexander
  • Adam C Drake
  • Michelle Dang
  • Qingqing Liu
  • Yutong Sun
  • Peng Ji
  • Song Chou
  • Ai Kotani
  • Minh T N Le
  • Shawdee Eshghi
  • Xiaohui Lu
  • Biao Luo
  • Prathapan Thiru
  • Violeta Rayon-Estrada
  • Lina Prak
  • Monika Hartmann
  • Maria Fragoso
  • Antonio D'Aiello
  • Bettina P Iliopoulou
  • Ilya Leskov
  • Karen Dubbin
  • Lauren Shields
  • Neil Ruderman
  • Victor Yeh
  • Tzutzuy Ramirez
  • Edoardo Missiaglia
  • Janet Shipley
  • Bingbing Yuan
  • Christopher J Shepherd
  • William Hwang
  • Greg Hyde
  • Pat Chu
  • Maki Murata-Hori
  • Yumiko Toyama
  • H Rosaria Chiang
  • Sumeet Gupta
  • Diana Schotte
  • Rudolf Jaenisch
  • Ronglih Liao
  • Ferenc Reinhardt
  • Scott A Armstrong
  • Robert Blelloch
  • Rostislav Medvid
  • Henry Yang
  • Michael Bauer
  • Monty Krieger
  • Pamela Rizk
  • Moonkyoung Um
  • Daon Ha
  • James Hsieh
  • Monique L den Boer
  • Poh Hui Chia
  • Gerald Udolph
  • Eva Klinman
  • Cameron Sadegh
  • J S Bogan
  • Jonathan Fu
  • Mariette G Vogelezang
  • Linda G Griffith
  • Richard O Hynes
  • Stephanie Wang
  • Christine Mayr
  • Mina Farkhondeh
  • Roshan M Kumar
  • Scott Baskerville
  • Yana Pikman
  • Sara Zarnegar
  • Gerlinde Wernig
  • Ross Levine
  • Amanda D Heard

Detail Information

Publications30

  1. pmc ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors
    Lingbo Zhang
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 499:92-6. 2013
    ..ZFP36L2 therefore functions as part of a molecular switch promoting BFU-E self-renewal and a subsequent increase in the total numbers of colony-forming unit-erythroid (CFU-E) progenitors and erythroid cells that are generated. ..
  2. pmc Mir193b-365 is essential for brown fat differentiation
    Lei Sun
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Cell Biol 13:958-65. 2011
    ..Mir193b-365 was upregulated by Prdm16 partially through Pparα. Our results demonstrate that Mir193b-365 serves as an essential regulator for brown fat differentiation, in part by repressing myogenesis...
  3. pmc Adiponectin deficiency promotes tumor growth in mice by reducing macrophage infiltration
    Yutong Sun
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America
    PLoS ONE 5:e11987. 2010
    ..Thus, we conclude that the enhanced tumor growth observed in adiponectin deficient mice is likely due to the reduction of macrophage infiltration rather than enhanced angiogenesis...
  4. pmc Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis
    Wei Tong
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    J Exp Med 200:569-80. 2004
    ..Thus, Lnk negatively modulates mpl signaling pathways and is important for Tpo-mediated megakaryocytopoiesis in vivo...
  5. pmc Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development
    Shawdee Eshghi
    Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Cell Biol 177:871-80. 2007
    ....
  6. pmc Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4
    J S Bogan
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Cell Biol 146:609-20. 1999
    ....
  7. ncbi request reprint Micromanagement of the immune system by microRNAs
    Harvey F Lodish
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Immunol 8:120-30. 2008
    ..Here, we provide an overview of the mechanisms by which miRNAs regulate gene expression, with specific focus on the role of miRNAs in regulating the development of immune cells and in modulating innate and adaptive immune responses...
  8. pmc From stem cell to erythroblast: regulation of red cell production at multiple levels by multiple hormones
    Harvey Lodish
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    IUBMB Life 62:492-6. 2010
    ....
  9. pmc Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts
    Peng Ji
    Whitehead Institute for Biomedical Research, Cambridge, 9 Cambridge Center, Cambridge, MA, USA
    Haematologica 95:2013-21. 2010
    ..However, it is not clear how chromatin condensation is achieved and whether it is required for enucleation...
  10. pmc Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
    Xiaohui Lu
    Whitehead Institute for Biomedical Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 102:18962-7. 2005
    ..Our results reveal the molecular basis for the prevalence of JAK2V617F in diseases of myeloid lineage cells that express these Type I cytokine receptors but not in lymphoid lineage cells that do not...
  11. pmc MicroRNAs in adipogenesis and as therapeutic targets for obesity
    Ryan Alexander
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Expert Opin Ther Targets 15:623-36. 2011
    ..Therefore, as with several other pathologies, miRNAs are emerging as feasible therapeutic targets for metabolic syndrome...
  12. pmc Epidermal growth factor (EGF) ligand release by substrate-specific a disintegrin and metalloproteases (ADAMs) involves different protein kinase C (PKC) isoenzymes depending on the stimulus
    Michelle Dang
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Biol Chem 286:17704-13. 2011
    ..Our results suggest a model in which substantial regulation of ectodomain cleavage occurs not only on the metalloprotease level but also on the level of the substrate or of a third protein...
  13. pmc Expansion of human cord blood hematopoietic stem cells for transplantation
    Song Chou
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell Stem Cell 7:427-8. 2010
    ..2010) by antagonizing the aryl hydrocarbon receptor. Major problems need to be overcome before ex vivo HSC expansion can be used clinically...
  14. pmc Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-beta, and TGF-alpha is specifically triggered by different stimuli and involves different PKC isoenzymes
    Andreas Herrlich
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    FASEB J 22:4281-95. 2008
    ..Employed in a high-throughput cloning strategy, our cleavage assay should allow the identification of candidate proteins involved in signal transduction of different extracellular stimuli into ectodomain cleavage...
  15. pmc Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rγ-/- (NSG) mice
    Adam C Drake
    Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e18382. 2011
    ..The ability to expand human HSCs in vitro should facilitate clinical use of HSCs and large-scale construction of humanized mice from the same donor for research applications...
  16. pmc Activation of AMP-activated protein kinase signaling pathway by adiponectin and insulin in mouse adipocytes: requirement of acyl-CoA synthetases FATP1 and Acsl1 and association with an elevation in AMP/ATP ratio
    Qingqing Liu
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    FASEB J 24:4229-39. 2010
    ..These studies demonstrate that a change in cellular energy state is associated with AMPK activation by both adiponectin and insulin, which requires the activity of FATP1 and Acsl1...
  17. pmc Cloning expeditions: risky but rewarding
    Harvey Lodish
    Whitehead Institute for Biomedical Research, Departments of Biology and Biological Engineering, MIT, Cambridge, Massachusetts, USA
    Mol Cell Biol 33:4620-7. 2013
    ..Unsurprisingly, all have gone on to become leaders in the fields of molecular cell biology and molecular medicine. ..
  18. ncbi request reprint MicroRNAs modulate hematopoietic lineage differentiation
    Chang Zheng Chen
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 303:83-6. 2004
    ..Our results indicate that microRNAs are components of the molecular circuitry that controls mouse hematopoiesis and suggest that other microRNAs have similar regulatory roles during other facets of vertebrate development...
  19. pmc Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure
    Prakash K Rao
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Circ Res 105:585-94. 2009
    ..To develop therapies aimed at rescuing the failing heart, it is important to understand the molecular mechanisms underlying cardiomyocyte structure and function...
  20. pmc Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells
    Chang Zheng Chen
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 99:15468-73. 2002
    ..Our overall strategy may be applicable for the identification of markers for other tissue-specific stem cells...
  21. pmc Small interfering RNA production by enzymatic engineering of DNA (SPEED)
    Biao Luo
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 101:5494-9. 2004
    ..Finally, cDNA-derived siRNA libraries can be readily generated from any cell type or species, enabling genome-wide functional screens in many biological systems...
  22. pmc Myogenic factors that regulate expression of muscle-specific microRNAs
    Prakash K Rao
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:8721-6. 2006
    ..Because miR-1 and miR-206 are predicted to repress similar mRNA targets, our work suggests that induction of these microRNAs is important in regulating the expression of muscle-specific proteins...
  23. pmc miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely
    Beiyan Zhou
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:7080-5. 2007
    ..Our results indicate that miR-150 most likely down-regulates mRNAs that are important for pre- and pro-B cell formation or function, and its ectopic expression in these cells blocks further development of B cells...
  24. pmc Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation
    Jing Zhang
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Blood 113:1304-14. 2009
    ..Our model might be also applicable to other solid tumors harboring oncogenic Kras mutations...
  25. pmc MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity
    Huangming Xie
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Diabetes 58:1050-7. 2009
    ..We investigated the regulation and involvement of microRNAs (miRNAs) in fat cell development and obesity...
  26. pmc MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets
    Minh T N Le
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Suite 601, Cambridge, MA 02142, USA
    Mol Cell Biol 29:5290-305. 2009
    ..We have further validated the binding of miR-125b to the miRNA response elements of 10 selected mRNA targets. Together, we report here for the first time the important role of miR-125b in human neuronal differentiation...
  27. pmc Distinct roles for miR-1 and miR-133a in the proliferation and differentiation of rhabdomyosarcoma cells
    Prakash K Rao
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    FASEB J 24:3427-37. 2010
    ..More important, these results point to the promise of enhancing rhabdomyosarcoma therapy using miRNAs as agents that mediate cytostasis and promote muscle differentiation...
  28. pmc miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221
    Ai Kotani
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Blood 114:4169-78. 2009
    ..These results demonstrate that down-regulation of miR-128b and miR-221 is implicated in glucocorticoid resistance and that restoration of their levels is a potentially promising therapeutic in MLL-AF4 ALL...
  29. pmc Targeting microRNAs in obesity
    Huangming Xie
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Expert Opin Ther Targets 13:1227-38. 2009
    ..In this review we summarize the current state of understanding of the roles of miRNAs in metabolic tissues under normal development and obese conditions, and discuss the potential use of miRNAs as therapeutic targets...
  30. ncbi request reprint MicroRNAs as regulators of mammalian hematopoiesis
    Chang Zheng Chen
    Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Institute for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, CA 94305 5175, USA
    Semin Immunol 17:155-65. 2005
    ..Here, we provide background on the biogenesis and function of miRNAs and discuss how miRNA-mediated post-transcriptional regulation may influence the development and function of blood cells...

Research Grants28

  1. MicorRNAs and hematopoietic differentiation
    Harvey Lodish; Fiscal Year: 2005
    ..Thus, these experiments will provide important insights for understanding the action of miRNAs in mammals and how their dysfunction might contribute to both hematological and other human diseases. ..
  2. Growth factors and engineered stroma for HSC expansion
    Harvey Lodish; Fiscal Year: 2006
    ..George Daley, we will test the ability of our novel growth factors/morphogens and genetically altered stromal cell lines to support the generation of transplantable HSCs from cultured human and mouse ES cell lines. ..
  3. MicorRNAs and hematopoietic differentiation
    Harvey Lodish; Fiscal Year: 2006
    ..Thus, these experiments will provide important insights for understanding the action of miRNAs in mammals and how their dysfunction might contribute to both hematological and other human diseases. ..
  4. ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION
    Harvey Lodish; Fiscal Year: 2007
    ..Functional studies and knock-out mice will be generated for each of these secreted proteins as warranted. ..
  5. MicroRNAs and hematopoietic differentiation
    Harvey Lodish; Fiscal Year: 2007
    ..Thus, these experiments will provide important insights for understanding the action of miRNAs in mammals and how their dysfunction might contribute to both hematological and other human diseases. ..
  6. Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansion
    Harvey Lodish; Fiscal Year: 2007
    ..The ability to expand HSCs ex vivo would greatly enhance these clinical applications, in the case of gene therapy allowing selection of those HSCs that have integrated a transgene in a specific chromosomal location. ..
  7. Adiponectin and CTRP9 signaling in muscle and liver
    Harvey Lodish; Fiscal Year: 2008
    ..Receptors for CTRP9 are unknown and thus we will use several approaches to identify and clone the CTRP9 receptor(s). ..
  8. Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansion
    Harvey Lodish; Fiscal Year: 2008
    ..The ability to expand HSCs ex vivo would greatly enhance these clinical applications, in the case of gene therapy allowing selection of those HSCs that have integrated a transgene in a specific chromosomal location. ..
  9. MicroRNAs and hematopoietic differentiation
    Harvey Lodish; Fiscal Year: 2008
    ..Thus, these experiments will provide important insights for understanding the action of miRNAs in mammals and how their dysfunction might contribute to both hematological and other human diseases. ..
  10. Adiponectin and CTRP9 signaling in muscle and liver
    Harvey Lodish; Fiscal Year: 2009
    ..Receptors for CTRP9 are unknown and thus we will use several approaches to identify and clone the CTRP9 receptor(s). ..
  11. Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansion
    Harvey Lodish; Fiscal Year: 2009
    ..The ability to expand HSCs ex vivo would greatly enhance these clinical applications, in the case of gene therapy allowing selection of those HSCs that have integrated a transgene in a specific chromosomal location. ..
  12. Adiponectin and CTRP9 signaling in muscle and liver
    Harvey F Lodish; Fiscal Year: 2010
    ..Receptors for CTRP9 are unknown and thus we will use several approaches to identify and clone the CTRP9 receptor(s). ..
  13. Growth factors and engineered stroma for HSC expansion
    Harvey Lodish; Fiscal Year: 2005
    ..George Daley, we will test the ability of our novel growth factors/morphogens and genetically altered stromal cell lines to support the generation of transplantable HSCs from cultured human and mouse ES cell lines. ..
  14. MicroRNAs and hematopoietic differentiation
    Harvey Lodish; Fiscal Year: 2004
    ..Thus, these experiments will provide important insights for understanding the action of miRNAs in mammals and how their dysfunction might contribute to both hematological and other human diseases. ..
  15. TGF-BETA RECEPTOR SIGNALING IN TRANSFORMED CELLS
    Harvey Lodish; Fiscal Year: 1999
    ..Most importantly, we will isolate and sequence full-length clones of these novel proteins, and determine their function in TGF-beta signaling. ..
  16. TGF-BETA RECEPTOR SIGNALING IN TRANSFORMED CELLS
    Harvey Lodish; Fiscal Year: 2000
    ..Most importantly, we will isolate and sequence full-length clones of these novel proteins, and determine their function in TGF-beta signaling. ..
  17. TGF-BETA RECEPTOR SIGNALING IN TRANSFORMED CELLS
    Harvey Lodish; Fiscal Year: 2001
    ..Most importantly, we will isolate and sequence full-length clones of these novel proteins, and determine their function in TGF-beta signaling. ..
  18. Growth factors and engineered stroma for HSC expansion
    Harvey Lodish; Fiscal Year: 2004
    ..George Daley, we will test the ability of our novel growth factors/morphogens and genetically altered stromal cell lines to support the generation of transplantable HSCs from cultured human and mouse ES cell lines. ..
  19. Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansion
    Harvey F Lodish; Fiscal Year: 2010
    ..The ability to expand HSCs ex vivo would greatly enhance these clinical applications, in the case of gene therapy allowing selection of those HSCs that have integrated a transgene in a specific chromosomal location. ..