Research Topics
Genomes and Genes | Harvey LodishSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
Research Grants
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Publications
Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4J S Bogan
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
J Cell Biol 146:609-20. 1999....- From stem cell to erythroblast: regulation of red cell production at multiple levels by multiple hormonesHarvey Lodish
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
IUBMB Life 62:492-6. 2010.... 
Micromanagement of the immune system by microRNAsHarvey F Lodish
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Rev Immunol 8:120-30. 2008..Here, we provide an overview of the mechanisms by which miRNAs regulate gene expression, with specific focus on the role of miRNAs in regulating the development of immune cells and in modulating innate and adaptive immune responses...- Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblastsPeng Ji
Whitehead Institute for Biomedical Research, Cambridge, 9 Cambridge Center, Cambridge, MA, USA
Haematologica 95:2013-21. 2010..However, it is not clear how chromatin condensation is achieved and whether it is required for enucleation... - Expansion of human cord blood hematopoietic stem cells for transplantationSong Chou
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Cell Stem Cell 7:427-8. 2010..2010) by antagonizing the aryl hydrocarbon receptor. Major problems need to be overcome before ex vivo HSC expansion can be used clinically... - MicroRNAs in adipogenesis and as therapeutic targets for obesityRyan Alexander
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Expert Opin Ther Targets 15:623-36. 2011..Additionally, miRNAs can be used as prognosis markers for disease onset and progression. Ultimately, miRNAs are prime therapeutic targets for obesity and its consequent pathologies in other metabolic tissues... - Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rγ-/- (NSG) miceAdam C Drake
Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
PLoS ONE 6:e18382. 2011..The ability to expand human HSCs in vitro should facilitate clinical use of HSCs and large-scale construction of humanized mice from the same donor for research applications... - Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformationXiaohui Lu
Whitehead Institute for Biomedical Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 102:18962-7. 2005..Our results reveal the molecular basis for the prevalence of JAK2V617F in diseases of myeloid lineage cells that express these Type I cytokine receptors but not in lymphoid lineage cells that do not... 
MicroRNAs modulate hematopoietic lineage differentiationChang Zheng Chen
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Science 303:83-6. 2004..Our results indicate that microRNAs are components of the molecular circuitry that controls mouse hematopoiesis and suggest that other microRNAs have similar regulatory roles during other facets of vertebrate development...- miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurelyBeiyan Zhou
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 104:7080-5. 2007..Our results indicate that miR-150 most likely down-regulates mRNAs that are important for pre- and pro-B cell formation or function, and its ectopic expression in these cells blocks further development of B cells... - Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cellsChang Zheng Chen
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 99:15468-73. 2002..Our overall strategy may be applicable for the identification of markers for other tissue-specific stem cells... - Small interfering RNA production by enzymatic engineering of DNA (SPEED)Biao Luo
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 101:5494-9. 2004..Finally, cDNA-derived siRNA libraries can be readily generated from any cell type or species, enabling genome-wide functional screens in many biological systems... - Distinct roles for miR-1 and miR-133a in the proliferation and differentiation of rhabdomyosarcoma cellsPrakash K Rao
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
FASEB J 24:3427-37. 2010..More important, these results point to the promise of enhancing rhabdomyosarcoma therapy using miRNAs as agents that mediate cytostasis and promote muscle differentiation... - miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221Ai Kotani
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Blood 114:4169-78. 2009..These results demonstrate that down-regulation of miR-128b and miR-221 is implicated in glucocorticoid resistance and that restoration of their levels is a potentially promising therapeutic in MLL-AF4 ALL... - Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failurePrakash K Rao
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
Circ Res 105:585-94. 2009..To develop therapies aimed at rescuing the failing heart, it is important to understand the molecular mechanisms underlying cardiomyocyte structure and function... - Targeting microRNAs in obesityHuangming Xie
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Expert Opin Ther Targets 13:1227-38. 2009..In this review we summarize the current state of understanding of the roles of miRNAs in metabolic tissues under normal development and obese conditions, and discuss the potential use of miRNAs as therapeutic targets... - MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targetsMinh T N Le
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Suite 601, Cambridge, MA 02142, USA
Mol Cell Biol 29:5290-305. 2009..We have further validated the binding of miR-125b to the miRNA response elements of 10 selected mRNA targets. Together, we report here for the first time the important role of miR-125b in human neuronal differentiation... - Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformationJing Zhang
Whitehead Institute for Biomedical Research, Cambridge, MA, USA
Blood 113:1304-14. 2009..Our model might be also applicable to other solid tumors harboring oncogenic Kras mutations... - Myogenic factors that regulate expression of muscle-specific microRNAsPrakash K Rao
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 103:8721-6. 2006..Because miR-1 and miR-206 are predicted to repress similar mRNA targets, our work suggests that induction of these microRNAs is important in regulating the expression of muscle-specific proteins... - MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesityHuangming Xie
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
Diabetes 58:1050-7. 2009..We investigated the regulation and involvement of microRNAs (miRNAs) in fat cell development and obesity... - MicroRNAs as regulators of mammalian hematopoiesisChang Zheng Chen
Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Institute for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, CA 94305 5175, USA
Semin Immunol 17:155-65. 2005..Here, we provide background on the biogenesis and function of miRNAs and discuss how miRNA-mediated post-transcriptional regulation may influence the development and function of blood cells...
Research Grants
- Growth factors and engineered stroma for HSC expansionHarvey Lodish; Fiscal Year: 2006..George Daley, we will test the ability of our novel growth factors/morphogens and genetically altered stromal cell lines to support the generation of transplantable HSCs from cultured human and mouse ES cell lines. ..
- ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTIONHarvey Lodish; Fiscal Year: 2007..Functional studies and knock-out mice will be generated for each of these secreted proteins as warranted. ..
- MicroRNAs and hematopoietic differentiationHarvey Lodish; Fiscal Year: 2007..Thus, these experiments will provide important insights for understanding the action of miRNAs in mammals and how their dysfunction might contribute to both hematological and other human diseases. ..
- Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansionHarvey Lodish; Fiscal Year: 2007..The ability to expand HSCs ex vivo would greatly enhance these clinical applications, in the case of gene therapy allowing selection of those HSCs that have integrated a transgene in a specific chromosomal location. ..
- Adiponectin and CTRP9 signaling in muscle and liverHarvey Lodish; Fiscal Year: 2009..Receptors for CTRP9 are unknown and thus we will use several approaches to identify and clone the CTRP9 receptor(s). ..
- Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansionHarvey Lodish; Fiscal Year: 2009..The ability to expand HSCs ex vivo would greatly enhance these clinical applications, in the case of gene therapy allowing selection of those HSCs that have integrated a transgene in a specific chromosomal location. ..
- Adiponectin and CTRP9 signaling in muscle and liverHarvey F Lodish; Fiscal Year: 2010..Receptors for CTRP9 are unknown and thus we will use several approaches to identify and clone the CTRP9 receptor(s). ..
- TGF-BETA RECEPTOR SIGNALING IN TRANSFORMED CELLSHarvey Lodish; Fiscal Year: 2001..Most importantly, we will isolate and sequence full-length clones of these novel proteins, and determine their function in TGF-beta signaling. ..
- Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansionHarvey F Lodish; Fiscal Year: 2010..The ability to expand HSCs ex vivo would greatly enhance these clinical applications, in the case of gene therapy allowing selection of those HSCs that have integrated a transgene in a specific chromosomal location. ..