Harvey Lodish

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4
    J S Bogan
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Cell Biol 146:609-20. 1999
  2. pmc From stem cell to erythroblast: regulation of red cell production at multiple levels by multiple hormones
    Harvey Lodish
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    IUBMB Life 62:492-6. 2010
  3. doi request reprint Micromanagement of the immune system by microRNAs
    Harvey F Lodish
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Immunol 8:120-30. 2008
  4. pmc Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts
    Peng Ji
    Whitehead Institute for Biomedical Research, Cambridge, 9 Cambridge Center, Cambridge, MA, USA
    Haematologica 95:2013-21. 2010
  5. pmc Expansion of human cord blood hematopoietic stem cells for transplantation
    Song Chou
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell Stem Cell 7:427-8. 2010
  6. pmc MicroRNAs in adipogenesis and as therapeutic targets for obesity
    Ryan Alexander
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Expert Opin Ther Targets 15:623-36. 2011
  7. pmc Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rγ-/- (NSG) mice
    Adam C Drake
    Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e18382. 2011
  8. pmc Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
    Xiaohui Lu
    Whitehead Institute for Biomedical Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 102:18962-7. 2005
  9. ncbi request reprint MicroRNAs modulate hematopoietic lineage differentiation
    Chang Zheng Chen
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 303:83-6. 2004
  10. pmc miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely
    Beiyan Zhou
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:7080-5. 2007

Collaborators

  • David Bartel
  • Jianzhu Chen
  • Johan Flygare
  • Jing Zhang
  • Prakash K Rao
  • Huangming Xie
  • Chang Zheng Chen
  • Beiyan Zhou
  • Ryan Alexander
  • Adam C Drake
  • Peng Ji
  • Lei Sun
  • Song Chou
  • Bing Lim
  • Ai Kotani
  • Minh T N Le
  • Xiaohui Lu
  • Biao Luo
  • Maria Fragoso
  • Bettina P Iliopoulou
  • Ilya Leskov
  • Maroun Khoury
  • Lauren Shields
  • Victor Yeh
  • Tzutzuy Ramirez
  • Christopher J Shepherd
  • William Hwang
  • Greg Hyde
  • Edoardo Missiaglia
  • Janet Shipley
  • Bingbing Yuan
  • Pat Chu
  • Maki Murata-Hori
  • Monty Krieger
  • Yumiko Toyama
  • H Rosaria Chiang
  • Pamela Rizk
  • Sumeet Gupta
  • Diana Schotte
  • Rudolf Jaenisch
  • Moonkyoung Um
  • Ronglih Liao
  • Ferenc Reinhardt
  • Daon Ha
  • James Hsieh
  • Monique L den Boer
  • Scott A Armstrong
  • Robert Blelloch
  • Rostislav Medvid
  • Henry Yang
  • Michael Bauer
  • Poh Hui Chia
  • Gerald Udolph
  • J S Bogan
  • Christine Mayr
  • Stephanie Wang
  • Mina Farkhondeh
  • Scott Baskerville
  • Roshan M Kumar
  • Yana Pikman
  • D Gary Gilliland
  • Wei Tong
  • Sara Zarnegar
  • Gerlinde Wernig
  • Ross Levine
  • Ling Li
  • Amanda D Heard
  • Min Li
  • Anthony R Green
  • Maria Jose Sanchez
  • Stefano Monti
  • David de Graaf
  • Eric S Lander
  • Todd R Golub
  • Berthold Gottgens

Detail Information

Publications21

  1. pmc Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4
    J S Bogan
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Cell Biol 146:609-20. 1999
    ....
  2. pmc From stem cell to erythroblast: regulation of red cell production at multiple levels by multiple hormones
    Harvey Lodish
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    IUBMB Life 62:492-6. 2010
    ....
  3. doi request reprint Micromanagement of the immune system by microRNAs
    Harvey F Lodish
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Immunol 8:120-30. 2008
    ..Here, we provide an overview of the mechanisms by which miRNAs regulate gene expression, with specific focus on the role of miRNAs in regulating the development of immune cells and in modulating innate and adaptive immune responses...
  4. pmc Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts
    Peng Ji
    Whitehead Institute for Biomedical Research, Cambridge, 9 Cambridge Center, Cambridge, MA, USA
    Haematologica 95:2013-21. 2010
    ..However, it is not clear how chromatin condensation is achieved and whether it is required for enucleation...
  5. pmc Expansion of human cord blood hematopoietic stem cells for transplantation
    Song Chou
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell Stem Cell 7:427-8. 2010
    ..2010) by antagonizing the aryl hydrocarbon receptor. Major problems need to be overcome before ex vivo HSC expansion can be used clinically...
  6. pmc MicroRNAs in adipogenesis and as therapeutic targets for obesity
    Ryan Alexander
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Expert Opin Ther Targets 15:623-36. 2011
    ..Therefore, as with several other pathologies, miRNAs are emerging as feasible therapeutic targets for metabolic syndrome...
  7. pmc Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rγ-/- (NSG) mice
    Adam C Drake
    Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e18382. 2011
    ..The ability to expand human HSCs in vitro should facilitate clinical use of HSCs and large-scale construction of humanized mice from the same donor for research applications...
  8. pmc Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
    Xiaohui Lu
    Whitehead Institute for Biomedical Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 102:18962-7. 2005
    ..Our results reveal the molecular basis for the prevalence of JAK2V617F in diseases of myeloid lineage cells that express these Type I cytokine receptors but not in lymphoid lineage cells that do not...
  9. ncbi request reprint MicroRNAs modulate hematopoietic lineage differentiation
    Chang Zheng Chen
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 303:83-6. 2004
    ..Our results indicate that microRNAs are components of the molecular circuitry that controls mouse hematopoiesis and suggest that other microRNAs have similar regulatory roles during other facets of vertebrate development...
  10. pmc miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely
    Beiyan Zhou
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:7080-5. 2007
    ..Our results indicate that miR-150 most likely down-regulates mRNAs that are important for pre- and pro-B cell formation or function, and its ectopic expression in these cells blocks further development of B cells...
  11. pmc Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells
    Chang Zheng Chen
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 99:15468-73. 2002
    ..Our overall strategy may be applicable for the identification of markers for other tissue-specific stem cells...
  12. pmc Small interfering RNA production by enzymatic engineering of DNA (SPEED)
    Biao Luo
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 101:5494-9. 2004
    ..Finally, cDNA-derived siRNA libraries can be readily generated from any cell type or species, enabling genome-wide functional screens in many biological systems...
  13. pmc Distinct roles for miR-1 and miR-133a in the proliferation and differentiation of rhabdomyosarcoma cells
    Prakash K Rao
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    FASEB J 24:3427-37. 2010
    ..More important, these results point to the promise of enhancing rhabdomyosarcoma therapy using miRNAs as agents that mediate cytostasis and promote muscle differentiation...
  14. pmc miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221
    Ai Kotani
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Blood 114:4169-78. 2009
    ..These results demonstrate that down-regulation of miR-128b and miR-221 is implicated in glucocorticoid resistance and that restoration of their levels is a potentially promising therapeutic in MLL-AF4 ALL...
  15. pmc Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure
    Prakash K Rao
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Circ Res 105:585-94. 2009
    ..To develop therapies aimed at rescuing the failing heart, it is important to understand the molecular mechanisms underlying cardiomyocyte structure and function...
  16. pmc Targeting microRNAs in obesity
    Huangming Xie
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Expert Opin Ther Targets 13:1227-38. 2009
    ..In this review we summarize the current state of understanding of the roles of miRNAs in metabolic tissues under normal development and obese conditions, and discuss the potential use of miRNAs as therapeutic targets...
  17. pmc MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets
    Minh T N Le
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Suite 601, Cambridge, MA 02142, USA
    Mol Cell Biol 29:5290-305. 2009
    ..We have further validated the binding of miR-125b to the miRNA response elements of 10 selected mRNA targets. Together, we report here for the first time the important role of miR-125b in human neuronal differentiation...
  18. pmc Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation
    Jing Zhang
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Blood 113:1304-14. 2009
    ..Our model might be also applicable to other solid tumors harboring oncogenic Kras mutations...
  19. pmc Myogenic factors that regulate expression of muscle-specific microRNAs
    Prakash K Rao
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:8721-6. 2006
    ..Because miR-1 and miR-206 are predicted to repress similar mRNA targets, our work suggests that induction of these microRNAs is important in regulating the expression of muscle-specific proteins...
  20. pmc MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity
    Huangming Xie
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Diabetes 58:1050-7. 2009
    ..We investigated the regulation and involvement of microRNAs (miRNAs) in fat cell development and obesity...
  21. ncbi request reprint MicroRNAs as regulators of mammalian hematopoiesis
    Chang Zheng Chen
    Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Institute for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, CA 94305 5175, USA
    Semin Immunol 17:155-65. 2005
    ..Here, we provide background on the biogenesis and function of miRNAs and discuss how miRNA-mediated post-transcriptional regulation may influence the development and function of blood cells...

Research Grants28

  1. Growth factors and engineered stroma for HSC expansion
    Harvey Lodish; Fiscal Year: 2006
    ..George Daley, we will test the ability of our novel growth factors/morphogens and genetically altered stromal cell lines to support the generation of transplantable HSCs from cultured human and mouse ES cell lines. ..
  2. ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION
    Harvey Lodish; Fiscal Year: 2007
    ..Functional studies and knock-out mice will be generated for each of these secreted proteins as warranted. ..
  3. MicroRNAs and hematopoietic differentiation
    Harvey Lodish; Fiscal Year: 2007
    ..Thus, these experiments will provide important insights for understanding the action of miRNAs in mammals and how their dysfunction might contribute to both hematological and other human diseases. ..
  4. Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansion
    Harvey Lodish; Fiscal Year: 2007
    ..The ability to expand HSCs ex vivo would greatly enhance these clinical applications, in the case of gene therapy allowing selection of those HSCs that have integrated a transgene in a specific chromosomal location. ..
  5. Adiponectin and CTRP9 signaling in muscle and liver
    Harvey Lodish; Fiscal Year: 2009
    ..Receptors for CTRP9 are unknown and thus we will use several approaches to identify and clone the CTRP9 receptor(s). ..
  6. Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansion
    Harvey Lodish; Fiscal Year: 2009
    ..The ability to expand HSCs ex vivo would greatly enhance these clinical applications, in the case of gene therapy allowing selection of those HSCs that have integrated a transgene in a specific chromosomal location. ..
  7. Adiponectin and CTRP9 signaling in muscle and liver
    Harvey F Lodish; Fiscal Year: 2010
    ..Receptors for CTRP9 are unknown and thus we will use several approaches to identify and clone the CTRP9 receptor(s). ..
  8. TGF-BETA RECEPTOR SIGNALING IN TRANSFORMED CELLS
    Harvey Lodish; Fiscal Year: 2001
    ..Most importantly, we will isolate and sequence full-length clones of these novel proteins, and determine their function in TGF-beta signaling. ..
  9. Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansion
    Harvey F Lodish; Fiscal Year: 2010
    ..The ability to expand HSCs ex vivo would greatly enhance these clinical applications, in the case of gene therapy allowing selection of those HSCs that have integrated a transgene in a specific chromosomal location. ..