Janet Lo

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Increased epicardial adipose tissue volume in HIV-infected men and relationships to body composition and metabolic parameters
    Janet Lo
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    AIDS 24:2127-30. 2010
  2. pmc Increased prevalence of subclinical coronary atherosclerosis detected by coronary computed tomography angiography in HIV-infected men
    Janet Lo
    Massachusetts General Hospital and Harvard Medical School, USA
    AIDS 24:243-53. 2010
  3. pmc Relationship of peak growth hormone to cardiovascular parameters, waist circumference, lipids and glucose in HIV-infected patients and healthy adults
    Janet Lo
    Massachusetts General Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Endocrinol (Oxf) 71:815-22. 2009
  4. pmc Dyslipidemia and lipid management in HIV-infected patients
    Janet Lo
    Department of Medicine, Harvard Medical School, Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Endocrinol Diabetes Obes 18:144-7. 2011
  5. pmc Increased arterial inflammation relates to high-risk coronary plaque morphology in HIV-infected patients
    Ahmed Tawakol
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA and Cardiovascular Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA
    J Acquir Immune Defic Syndr 66:164-71. 2014
  6. pmc Low-dose physiological growth hormone in patients with HIV and abdominal fat accumulation: a randomized controlled trial
    Janet Lo
    Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    JAMA 300:509-19. 2008
  7. ncbi request reprint Relation of body composition to body mass index in HIV-infected patients with metabolic abnormalities
    Tisha Joy
    Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Acquir Immune Defic Syndr 47:174-84. 2008
  8. pmc Increased coronary artery calcium score and noncalcified plaque among HIV-infected men: relationship to metabolic syndrome and cardiac risk parameters
    Kathleen V Fitch
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, MA, USA
    J Acquir Immune Defic Syndr 55:495-9. 2010
  9. pmc Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers
    Florencia Pereyra
    Program in Nutritional Metabolism, Department of Radiology, Massachusetts General Hospital, Boston, USA
    AIDS 26:2409-12. 2012
  10. pmc Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men
    Markella V Zanni
    Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    AIDS 27:1263-72. 2013

Research Grants

Collaborators

Detail Information

Publications27

  1. pmc Increased epicardial adipose tissue volume in HIV-infected men and relationships to body composition and metabolic parameters
    Janet Lo
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    AIDS 24:2127-30. 2010
    ..0003). Relationships with glucose and insulin remained significant controlling for age, race, BMI, adiponectin, visceral adipose tissue and antiretroviral therapy. Epicardial fat may be an important fat depot in HIV-infected patients...
  2. pmc Increased prevalence of subclinical coronary atherosclerosis detected by coronary computed tomography angiography in HIV-infected men
    Janet Lo
    Massachusetts General Hospital and Harvard Medical School, USA
    AIDS 24:243-53. 2010
    ..We investigated the degree of subclinical atherosclerosis and the relationship of traditional and nontraditional risk factors to early atherosclerotic disease using coronary computed tomography angiography...
  3. pmc Relationship of peak growth hormone to cardiovascular parameters, waist circumference, lipids and glucose in HIV-infected patients and healthy adults
    Janet Lo
    Massachusetts General Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Endocrinol (Oxf) 71:815-22. 2009
    ..Relative growth hormone (GH) deficiency is highly prevalent in patients with HIV. The purpose of this study was to investigate relationships of GH to metabolic and anthropometric parameters in HIV patients and non-HIV controls...
  4. pmc Dyslipidemia and lipid management in HIV-infected patients
    Janet Lo
    Department of Medicine, Harvard Medical School, Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Endocrinol Diabetes Obes 18:144-7. 2011
    ..This review summarizes recent data investigating lipid abnormalities and its management in HIV-infected patients...
  5. pmc Increased arterial inflammation relates to high-risk coronary plaque morphology in HIV-infected patients
    Ahmed Tawakol
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA and Cardiovascular Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA
    J Acquir Immune Defic Syndr 66:164-71. 2014
    ..Mechanisms predisposing HIV-infected patients to increased cardiovascular disease (CVD) risk remain unclear...
  6. pmc Low-dose physiological growth hormone in patients with HIV and abdominal fat accumulation: a randomized controlled trial
    Janet Lo
    Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    JAMA 300:509-19. 2008
    ..Antiretroviral therapy can be associated with visceral adiposity and metabolic complications, increasing cardiovascular risk, and reduced growth hormone (GH) secretion may be a contributing factor...
  7. ncbi request reprint Relation of body composition to body mass index in HIV-infected patients with metabolic abnormalities
    Tisha Joy
    Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Acquir Immune Defic Syndr 47:174-84. 2008
    ..To determine visceral adiposity (VAT), subcutaneous adiposity (SAT), and regional body adipose differences between HIV-infected and non-HIV-infected subjects in relation to body mass index (BMI) and World Health Organization BMI categories...
  8. pmc Increased coronary artery calcium score and noncalcified plaque among HIV-infected men: relationship to metabolic syndrome and cardiac risk parameters
    Kathleen V Fitch
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, MA, USA
    J Acquir Immune Defic Syndr 55:495-9. 2010
    ....
  9. pmc Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers
    Florencia Pereyra
    Program in Nutritional Metabolism, Department of Radiology, Massachusetts General Hospital, Boston, USA
    AIDS 26:2409-12. 2012
    ..05) and compared with HIV-negative controls (P < 0.05). These data suggest a significant degree of coronary atherosclerosis and monocyte activation among elite controllers...
  10. pmc Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men
    Markella V Zanni
    Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    AIDS 27:1263-72. 2013
    ..Exploring potential underlying mechanisms, we used multidetector spiral coronary computed tomography angiography (coronary CTA) to compare atherosclerotic plaque morphology in HIV-infected patients and non-HIV-infected controls...
  11. pmc Increased aldosterone among HIV-infected women with visceral fat accumulation
    Janet Lo
    Program in Nutritional Metabolism, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    AIDS 23:2366-70. 2009
    ..Increased aldosterone may contribute to the detrimental effects of excess visceral adiposity on blood pressure and glucose homeostasis among HIV patients...
  12. doi request reprint The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetes
    Geoffrey A Walford
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America Diabetes Research Center, Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 10:e0121553. 2015
    ..We describe recruitment, enrollment, and phenotyping procedures and preliminary results for the first 668 of our planned 1,000 participants enriched for individuals at risk of requiring anti-diabetic therapy in the future...
  13. pmc Receptor activator of nuclear factor-κB ligand (RANKL) and its relationship to coronary atherosclerosis in HIV patients
    Janice J Hwang
    Program in Nutritional Metabolism, Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 61:359-63. 2012
    ..41, P < 0.001) and Agatston calcium score (ρ = -0.30, P < 0.01) in HIV-infected individuals even after adjusting for traditional cardiovascular risk factors...
  14. pmc Decreased respiratory quotient in relation to resting energy expenditure in HIV-infected and noninfected subjects
    Kathleen V Fitch
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, MA 02114, USA
    Metabolism 58:608-15. 2009
    ..Overall r(2) was equal to 0.825 and P was less than .0001 for the model. These data suggest that alterations in substrate metabolism may contribute to increased REE in HIV-infected patients compared with control subjects...
  15. doi request reprint 2013 American College of Cardiology/American Heart Association and 2004 Adult Treatment Panel III cholesterol guidelines applied to HIV-infected patients with/without subclinical high-risk coronary plaque
    Markella V Zanni
    aProgram in Nutritional Metabolism bBiostatistics Center cDepartment of Radiology, Cardiovascular Imaging Section dDivision of Cardiology, Massachusetts General Hospital and Harvard Medical School eHarvard School of Public Health, Boston, Massachusetts fDivision of Cardiology, Duke University School of Medicine, Durham, North Carolina, USA
    AIDS 28:2061-70. 2014
    ....
  16. pmc Soluble CD163 is associated with shortened telomere length in HIV-infected patients
    Suman Srinivasa
    Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA Department of Biology, Boston College, Chestnut Hill, MA and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC
    J Acquir Immune Defic Syndr 67:414-8. 2014
    ..06) and sCD163 (P = 0.05) remained predictors of TL controlling for age and smoking status. Our data demonstrate that increased immune activation relates to shorter TL in HIV...
  17. doi request reprint HDL redox activity is increased in HIV-infected men in association with macrophage activation and non-calcified coronary atherosclerotic plaque
    Markella V Zanni
    Massachusetts General Hospital, Program in Nutritional Metabolism, Harvard Medical School, Boston, MA, USA
    Antivir Ther 19:805-11. 2014
    ..In this study, we compare HRA in HIV-infected versus non-HIV-infected subjects and relate HRA to indices of macrophage activation and cardiovascular disease risk...
  18. pmc Arterial inflammation in patients with HIV
    Sharath Subramanian
    MR PET CT Program and Department of Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    JAMA 308:379-86. 2012
    ..Cardiovascular disease is increased in patients with human immunodeficiency virus (HIV), but the specific mechanisms are unknown...
  19. ncbi request reprint Dietary fat intake and relationship to serum lipid levels in HIV-infected patients with metabolic abnormalities in the HAART era
    Tisha Joy
    Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    AIDS 21:1591-600. 2007
    ..To evaluate dietary intake and its relationship to lipid parameters in HIV-infected patients with metabolic abnormalities...
  20. doi request reprint Plaque burden in HIV-infected patients is associated with serum intestinal microbiota-generated trimethylamine
    Suman Srinivasa
    aProgram in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA bINSERM UMRS1138, Cordeliers Research Centre, Paris cInstitute of Cardiometabolism and Nutrition, University Pierre and Marie Curie, Hospital Pitié Salpêtrière, Paris, France dUniversity of Rochester School of Medicine, Rochester, New York, New York eCardiothoracic Imaging Division, Department of Radiology, UTSW Medical Center, Dallas, Texas, USA fBiochimie et Hormonologie, Hôpital Tenon AP HP Paris, CdR Saint Antoine, INSERM UMR_S938, Universite Paris 6 UPMC, Institute of Cardiometabolism and Nutrition, Paris gDepartment of Cardiology, Saint Antoine Hospital, Inserm U938, Universite Paris 6 UPMC, Faculte de Medecine Pierre et Marie Curie, Paris, France
    AIDS 29:443-52. 2015
    ....
  21. pmc Effects of obesity, body composition, and adiponectin on carotid intima-media thickness in healthy women
    Janet Lo
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston 02114, USA
    J Clin Endocrinol Metab 91:1677-82. 2006
    ..Increased common carotid intima-media thickness (IMT) is predictive of coronary artery disease and stroke...
  22. pmc Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus
    Geoffrey A Walford
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114 Department of Medicine, Massachusetts General Hospital, Boston, MA 02114 Harvard Medical School, Boston, MA, 02115
    Metabolism 62:1772-8. 2013
    ..BCAA/AAAs decrease acutely during an oral glucose tolerance test (OGTT), a diagnostic test for T2D. It is unknown whether changes in BCAA/AAAs also signal an early response to commonly used medical therapies for T2D...
  23. pmc The biology of atherosclerosis: general paradigms and distinct pathogenic mechanisms among HIV-infected patients
    Janet Lo
    Program in Nutritional Metabolism, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    J Infect Dis 205:S368-74. 2012
    ..Key concepts in atherosclerosis are reviewed, including the evidence that inflammation and abnormal metabolism are major drivers of atherosclerosis, and connected to the current literature regarding atherosclerosis in the context of HIV...
  24. pmc Effects of TNF-alpha neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome
    Janet Lo
    Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit St, LON207, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 293:E102-9. 2007
    ..These findings may help to explain the lack of effect on insulin sensitivity and extend our knowledge of the biological effects of TNF-alpha neutralization in obesity...
  25. doi request reprint Adrenal function in HIV infection
    Janet Lo
    Program in Nutritional Metabolism and Neuroendocrine Clinic, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Endocrinol Diabetes Obes 17:205-9. 2010
    ..Adrenal dysfunction can increase morbidity and mortality among patients with HIV infection. Disorders and medications affecting cortisol, aldosterone or adrenal androgens in patients with HIV infection are reviewed...
  26. ncbi request reprint Cardiovascular disease in HIV-infected patients: does HIV infection in and of itself increase cardiovascular risk?
    Janet Lo
    Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin HIV AIDS 3:207-13. 2008
    ..The potential physiological mechanisms by which HIV might contribute to coronary artery disease are reviewed...
  27. doi request reprint Gender effects on cardiac valvular function in hyperprolactinaemic patients receiving cabergoline: a retrospective study
    Lisa B Nachtigall
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Clin Endocrinol (Oxf) 72:53-8. 2010
    ..Ergot-derived dopamine agonists are associated with increased risk of valvular dysfunction in Parkinson's disease. The risk of valvular disease associated with lower doses of cabergoline used to treat prolactinomas remains controversial...

Research Grants1

  1. Subclinical Coronary Atherosclerosis in HIV-Infected Patients
    Janet Lo; Fiscal Year: 2007
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