Affiliation: Massachusetts General Hospital
- Claudin-4 overexpression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using a C-terminal fragment of Clostridium perfringens enterotoxinBabak Litkouhi
Department of Obstetrics, Gynecology and Reproductive Biology, Division of Gynecologic Oncology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Neoplasia 9:304-14. 2007..We sought to correlate claudin-4 overexpression in EOC with clinical outcomes and TJ barrier function, investigate DNA methylation as a mechanism for overexpression, and evaluate the effect of C-CPE on the TJ...
- C terminus of Clostridium perfringens enterotoxin downregulates CLDN4 and sensitizes ovarian cancer cells to Taxol and CarboplatinZhijian Gao
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Clin Cancer Res 17:1065-74. 2011..The purpose of this study was to determine the potential clinical applications of C-CPE and its effects on CLDN4 expression in EOC...
- Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancerMichael J Callahan
Laboratory of Gynecologic Oncology, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Boston, Massachusetts, USA
Clin Cancer Res 14:7667-73. 2008..To evaluate the possible mechanisms influencing the infiltration of CD8 T lymphocytes into the tumor epithelium of advanced-stage serous ovarian cancers...
- Overexpression of CEACAM6 in borderline and invasive mucinous ovarian neoplasmsBehrang Litkouhi
Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA
Gynecol Oncol 109:234-9. 2008..Microarray analysis previously demonstrated high CEACAM6 overexpression in MON's and this study sought to validate this finding...