Research Topics
Genomes and Genes | Julie LinSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Associations of diet with albuminuria and kidney function declineJulie Lin
Renal Division, Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Clin J Am Soc Nephrol 5:836-43. 2010..Sparse longitudinal data exist on how diet influences microalbuminuria and estimated GFR (eGFR) decline in people with well-preserved kidney function...- Associations of dietary fat with albuminuria and kidney dysfunctionJulie Lin
Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Clin Nutr 92:897-904. 2010..Diet represents a potentially important target for intervention in nephropathy, yet data on this topic are scarce... - The association of serum lipids and inflammatory biomarkers with renal function in men with type II diabetes mellitusJ Lin
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Kidney Int 69:336-42. 2006.... - Genetic polymorphisms of angiotensin-2 type 1 receptor and angiotensinogen and risk of renal dysfunction and coronary heart disease in type 2 diabetes mellitusJulie Lin
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
BMC Nephrol 10:9. 2009.... - Associations of sugar and artificially sweetened soda with albuminuria and kidney function decline in womenJulie Lin
Channing Laboratory, Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Clin J Am Soc Nephrol 6:160-6. 2011..Sugar-sweetened soda is reported to be associated with increased risk for diabetes and albuminuria, but there are currently limited data on how sugar or artificially sweetened soda may be related to kidney function decline... 
Serum adiponectin and renal dysfunction in men with type 2 diabetesJulie Lin
Renal Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Diabetes Care 30:239-44. 2007..In contrast, serum levels of adiponectin are elevated in end-stage renal disease. We sought to investigate the relation between adiponectin and mild to moderate renal dysfunction in men with type 2 diabetes...- Association of dietary patterns with albuminuria and kidney function decline in older white women: a subgroup analysis from the Nurses' Health StudyJulie Lin
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Kidney Dis 57:245-54. 2011..Dietary patterns have been linked to such chronic diseases as cardiovascular disease, but sparse data currently are available for associations between dietary patterns and microalbuminuria or kidney function decline... - Membranous glomerulopathy associated with graft-versus-host disease following allogeneic stem cell transplantation. Report of 2 cases and review of the literatureJ Lin
Division of Nephrology, Department of Medicine, Columbia University, New York Presbyterian Hospital, New York, N Y, USA
Am J Nephrol 21:351-6. 2001..The close temporal association as well as evidence from murine models of GVHD support a pathogenetic association between GVHD and the development of MG... - Longitudinal trends and influence of BMI mismatch in living kidney donors and their recipientsJulie Lin
Renal Division and Division of Transplantation Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Int Urol Nephrol 43:891-7. 2011..Moreover, while deceased donor and recipient body size mismatch have been reported to influence allograft outcomes, how BMI mismatch in living kidney donor-recipient pairs affect graft survival is not well defined... - Kidney function decline and physical function in womenJulie Lin
Renal Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Nephrol Dial Transplant 23:2827-33. 2008..No data are currently available, however, on how kidney function decline may be associated with physical function... - Lipid and inflammatory biomarkers and kidney function decline in type 2 diabetesJ Lin
Renal Division, MRB 4, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Diabetologia 53:263-7. 2010..Potentially modifiable biomarkers may influence the decline in estimated GFR (eGFR), but few data are currently available in type 2 diabetic adults... - Kidney dysfunction and cognitive decline in womenImran Sajjad
Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Clin J Am Soc Nephrol 7:437-43. 2012..ESRD is associated with substantial cognitive deficits but whether earlier kidney dysfunction predicts cognitive decline is less well defined... - Inflammation and progressive nephropathy in type 1 diabetes in the diabetes control and complications trialJulie Lin
Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Diabetes Care 31:2338-43. 2008..Early albuminuria probably reflects vascular endothelial dysfunction, which may be mediated in part by chronic inflammation... - Hepatitis C, acute humoral rejection, and renal allograft survivalJohn P Forman
Department of Medicine, Brigham and Women's Hospital/Renal Division, 75 Francis Street, MRB-4, Boston, MA 02115, USA
J Am Soc Nephrol 15:3249-55. 2004..After adjusting for these confounding factors, the association between HCV Ab positivity and renal allograft loss was notably attenuated and no longer statistically significant... - Significance of anticardiolipin antibodies on short and long term allograft survival and function following kidney transplantationJohn P Forman
Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA
Am J Transplant 4:1786-91. 2004..A positive ACA titer prior to kidney transplantation was not associated with inferior renal outcomes after transplantation, although more research is required to address the prognostic significance of very high ACA titers... - Influence of albuminuria on cardiovascular risk in patients with stable coronary artery diseaseScott D Solomon
Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Circulation 116:2687-93. 2007..We assessed the association between albuminuria and the risks for death and cardiovascular events among patients with stable coronary disease... 
Erythropoietic response and outcomes in kidney disease and type 2 diabetesScott D Solomon
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02114, USA
N Engl J Med 363:1146-55. 2010..However, target-based strategies are confounded by each patient's individual hematopoietic response...- Predicting survival in patients requiring renal replacement therapy after cardiac surgeryMarzia Leacche
Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Ann Thorac Surg 81:1385-92. 2006.... - Glomerular tip lesion: a distinct entity within the minimal change disease/focal segmental glomerulosclerosis spectrumM Barry Stokes
Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 65:1690-702. 2004..0054). CONCLUSION: Within the MCD/FSGS spectrum, GTL is a distinctive and prognostically favorable clinical-pathologic entity whose presenting features and outcome more closely approximate those of MCD... - Hemoglobin Stability in Patients With Anemia, CKD, and Type 2 Diabetes: An Analysis of the TREAT (Trial to Reduce Cardiovascular Events With Aranesp Therapy) Placebo ArmHicham Skali
Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA Electronic address
Am J Kidney Dis 61:238-46. 2013..We intended to describe Hb level trends over time with no or minimal administration of erythropoiesis-stimulating agents... - Post-menopausal hormone use and albuminuriaEmily L Schopick
Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
Nephrol Dial Transplant 24:3739-44. 2009..Post-menopausal hormone use may influence the renin-angiotensin system and renal endothelial function, impacting albumin excretion. The association between post-menopausal hormone use and albuminuria is not well defined... - Angiotensin converting enzyme inhibition in chronic allograft nephropathyJulie Lin
Department of Medicine, Columbia University, New York, New York 10032, USA
Transplantation 73:783-8. 2002..It is associated with a trend of slowing renal insufficiency as well as a significant survival benefit in the combined endpoint of allograft failure or death... - A comparison of prediction equations for estimating glomerular filtration rate in adults without kidney diseaseJulie Lin
Renal Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Am Soc Nephrol 14:2573-80. 2003..Further studies are needed to derive and assess GFR prediction equations in people with normal or mildly impaired renal function... - Mycophenolate mofetil (MMF) vs placebo in patients with moderately advanced IgA nephropathy: a double-blind randomized controlled trialGershon Frisch
New York Presbyterian Hospital, Columbia University, New York, NY, USA
Nephrol Dial Transplant 20:2139-45. 2005..Currently, treatment is limited. We studied the use of mycophenolate mofetil (MMF) vs placebo in a group of North American IgAN patients at high risk for progressive disease... - Development of an outpatient native kidney biopsy service in low-risk patients: a multidisciplinary approachGearoid M McMahon
Renal Division, Brigham and Women s Hospital, Boston, Mass, USA
Am J Nephrol 35:321-6. 2012..In the US, native kidney biopsies are usually inpatient procedures. We developed an outpatient biopsy protocol for low-risk patients and assessed its safety and efficacy... - Idiopathic nodular glomerulosclerosis is a distinct clinicopathologic entity linked to hypertension and smokingGlen S Markowitz
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Hum Pathol 33:826-35. 2002..0007), degree of tubular atrophy and interstitial fibrosis (P =.0517), and degree of arteriosclerosis (P =.0096). In conclusion, ING is a progressive vasculopathic lesion linked to hypertension and cigarette smoking... - Outcomes in patients with normal serum creatinine and with artificial renal support for acute renal failure developing after coronary artery bypass graftingMarzia Leacche
Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA
Am J Cardiol 93:353-6. 2004.... - Regulation of kidney development by Shp2: an unbiased stereological analysisFrank S David
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
Anat Rec (Hoboken) 293:2147-53. 2010..12198 glomeruli, P = 0.22; 62.8 mm(3) vs. 66.0 mm(3) renal volume; P = 0.40). We conclude that loss of 50% gene/protein dosage of PTPN11/Shp2 is insufficient to affect glomerular (and thereby nephron) number in mouse kidneys in vivo... - Paroxysmal hypertension in a 48-year-old womanJennifer Hunt
Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Kidney Int 74:532-5. 2008 - Prevention of radiocontrast nephropathyJulie Lin
Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Curr Opin Nephrol Hypertens 14:105-10. 2005..Several clinical investigations have been published over the past 2 years that address potential prophylaxis against contrast nephropathy... - Refinement of survival prediction in patients undergoing lower extremity bypass surgery: stratification by chronic kidney disease classificationChristopher D Owens
Division of Vascular Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
J Vasc Surg 45:944-52. 2007..This study examined the prognostic significance of the chronic kidney disease (CKD) classification on survival, limb salvage, and graft patency in patients undergoing lower extremity arterial reconstruction... - Factors in career choice among US nephrologistsGearoid M McMahon
Division of Nephrology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Clin J Am Soc Nephrol 7:1786-92. 2012..There is a projected shortage of kidney specialists, and retention of trainees in nephrology is important. Determining factors that result in choosing a nephrology career could inform future strategies to attract nephrology fellows... - Hepatitis C, proteinuria, and renal insufficiencyWaichi Wong
Renal Unit, Massachusetts General Hospital, Boston, MA, USA
Am J Kidney Dis 44:924-9. 2004 - Genetic thrombophilias and preeclampsia: a meta-analysisJulie Lin
Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Obstet Gynecol 105:182-92. 2005.... - Combined angiotensin II receptor antagonism and angiotensin-converting enzyme inhibition further attenuates postinfarction left ventricular remodelingS Mankad
Division of Cardiology, Department of Medicine, Allegheny General Hospital, Pittsburgh, PA 15212, USA
Circulation 103:2845-50. 2001..Accordingly, we investigated the effects of AT(1) antagonism, ACEI, and their combination in a well-characterized ovine postinfarction model... - Renal monoclonal immunoglobulin deposition disease: the disease spectrumJ Lin
Division of Nephrology, Department of Medicine, Columbia University, New York-Presbyterian Hospital, 630 W. 168th Street, New York, NY 10032, USA
J Am Soc Nephrol 12:1482-92. 2001..0 mg/dl, emphasizing the importance of early detection. On multivariate analysis, initial creatinine was the only predictor of renal and patient survival in pure MIDD, underscoring the prognostic significance of the renal involvement... - Myocardial injury and left ventricular performance after subarachnoid hemorrhageS A Mayer
Department of Neurology, Columbia Presbyterian Medical Center, New York, NY, USA
Stroke 30:780-6. 1999..It is not known whether cardiac injury of this type adversely affects cardiovascular hemodynamic performance... - A trial of darbepoetin alfa in type 2 diabetes and chronic kidney diseaseMarc A Pfeffer
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 361:2019-32. 2009..Although darbepoetin alfa can effectively increase hemoglobin levels, its effect on clinical outcomes in these patients has not been adequately tested... - Vasopressin administration facilitates fluid removal during hemodialysisS van der Zee
Department of Medicine, Columbia University, New York, New York 10032, USA
Kidney Int 71:318-24. 2007..Inadequate vasopressin secretion during hemodialysis-induced fluid removal is a likely contributor to the intradialytic hypotension that limits fluid removal... - Obesity-related glomerulopathy: an emerging epidemicN Kambham
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Kidney Int 59:1498-509. 2001..The ten-fold increase in incidence over 15 years suggests a newly emerging epidemic. Heightened physician awareness of this entity is needed to ensure accurate diagnosis and appropriate therapy... - Mapping directions for the cardiorenal conundrum: where you end up depends upon where you started, so where do we go from here?Larry A Weinrauch
J Am Coll Cardiol 51:1275-6. 2008
Research Grants
- Predictors of Nephropathy in Type 2 DiabetesJulie Lin; Fiscal Year: 2007..The candidate for this K08 award is Julie Lin, M.D., M.P.H...
- Biomarkers in the progression of nephropathy in type 2DMJulie Lin; Fiscal Year: 2007..Data on how these modifiable biomarkers are related to kidney function decline could have an important and beneficial impact on treatment and monitoring of nephropathy in type 2 diabetes in the near future. ..
- Kidney function and cognitive and physical decline in older womenJulie Lin; Fiscal Year: 2009..Thus, findings from this longitudinal, prospective study of a large cohort of older women will meaningfully improve the quality of life and longevity of community-dwelling older citizens. ..
- Kidney function and cognitive and physical decline in older womenJulie Lin; Fiscal Year: 2010..Thus, findings from this longitudinal, prospective study of a large cohort of older women will meaningfully improve the quality of life and longevity of community-dwelling older citizens. ..