Research Topics
Genomes and GenesSpecies | Mathias LichterfeldSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Antiretroviral drug toxicity -- a challenge for the hepatologist?Ulrich Spengler
Department of General Internal Medicine I, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
J Hepatol 36:283-94. 2002- HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversityMathias Lichterfeld
Partners AIDS Research Center and Howard Hughes Medical Institute, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02129, USA
AIDS 18:1383-92. 2004..Later diversification of responses to other proteins during prolonged antigen exposure provides evidence of the initial preferential immunogenicity of Nef epitopes compared to similarly conserved regions within other viral proteins... 
Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllersJinghe Huang
Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, 149 13th Street, Room 5219, Boston, MA 02129, USA
J Virol 84:9463-71. 2010..These data reveal previously unrecognized innate components of immune protection against HIV-1 in elite controllers and offer novel perspectives for the manipulation of host immunity for the prevention and treatment of HIV-1 infection...- CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21Huabiao Chen
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts, USA
J Clin Invest 121:1549-60. 2011..These data demonstrate a mechanism of host resistance to HIV-1 in elite controllers and may open novel perspectives for clinical strategies to prevent or treat HIV-1 infection... - Inhibition of HIV-1 integration in ex vivo-infected CD4 T cells from elite controllersMaria J Buzon
Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114
J Virol 85:9646-50. 2011..These data contribute to increasing evidence that intrinsic inhibition of specific HIV-1 replication steps plays an important role in the ability of elite controllers to maintain undetectable viral loads... - Treatment of HIV-1-associated Kaposi's sarcoma with pegylated liposomal doxorubicin and HAART simultaneously induces effective tumor remission and CD4+ T cell recoveryM Lichterfeld
Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
Infection 33:140-7. 2005.... - Liver histopathology in human immunodeficiency virus-hepatitis C virus co-infected patients with fatal liver diseaseMathias Lichterfeld
Department of General Internal Medicine, Universitatsklinikum Bonn, Germany
J Gastroenterol Hepatol 20:739-45. 2005..Here, histopathological features of fatal liver disease in HIV-HCV co-infected patients were comparatively assessed... - The tandem-repeat polymorphism of the DC-SIGNR gene does not affect the susceptibility to HIV infection and the progression to AIDSMathias Lichterfeld
Department of General Internal Medicine, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
Clin Immunol 107:55-9. 2003..Thus, the DC-SIGNR tandem-repeat polymorphism in exon 4 does not have a significant impact on the host's susceptibility to HIV and the clinical progression to AIDS... - Clinical outcomes of HIV-HCV co-infection in a large cohort of hemophiliac patientsMathias Lichterfeld
Department of General Internal Medicine, Rheinische Friedrich Wilhelms Universitat, 53105 Bonn, Germany
J Infect 50:221-8. 2005..To determine the disease progression of HIV-HCV co-infected hemophiliacs in a large cohort of patients (n = 288) cared for at a single medical institution... - T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamilyMathias Lichterfeld
Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA, USA
Int Immunol 18:1179-88. 2006..Thus, despite distinct TCR recognition of HLA-A3 or HLA-A11 presented HIV-1 peptides in the vast majority of cases, specific TCRs can cross-recognize their antigen in the context of both HLA-A3 and HLA-A11... - Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopesNicole Frahm
Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 7:173-8. 2006..These data suggest that subdominant responses can contribute to in vivo viral control and that high HLA allele frequencies may drive the elimination of subdominant yet effective epitopes from circulating viral populations... - Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infectionHendrik Streeck
Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital, Charlestown, MA, 02129, USA
J Infect Dis 194:734-9. 2006..However, despite these immunological changes, no differences in viremia or in the CD4+ T cell count were found 6 months after HAART was stopped, when treated subjects were compared with untreated subjects... - De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infectionTodd M Allen
Partners AIDS Research Center, Massachusetts General Hospital, Boston, 02129, USA
J Virol 79:12952-60. 2005.... - Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypesXu G Yu
Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Room 5212, Charlestown, MA 02129, USA
J Virol 81:1619-31. 2007..These data show the influence of HLA allele subtypes on TCR selection and indicate that extensive TCR diversity is not a prerequisite to prevention of allowable viral mutations... 
CD4 T-cell regeneration in HIV-1 elite controllersYue Yang
Infectious Disease Division, Massachusetts General Hospital, Boston, USA
AIDS 26:701-6. 2012..Here, we assessed mechanisms of CD4 T-cell homeostasis in elite controllers with progressive vs. nonprogressive HIV-1 disease courses...- Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infectionGalit Alter
Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, USA
Blood 106:3366-9. 2005..Taken together, these studies demonstrate a sequential impairment of NK cell function with persistent viral replication resulting from a progressive deregulation of NK cell subsets with distinct functional properties... - Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infectionTodd M Allen
Howard Hughes Medical Institute, Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital, and Division of AIDS, Harvard Medical School, Boston, MA, USA
J Virol 78:7069-78. 2004..Moreover, reversion of these mutations in the absence of the original immune pressure reveals the potential plasticity of immunologically selected evolutionary changes... - Limited sequence evolution within persistently targeted CD8 epitopes in chronic human immunodeficiency virus type 1 infectionTomohiko Koibuchi
Partners AIDS Research Center, Massachusetts General Hospital, and Division of AIDS, Harvard Medical School, Boston, USA
J Virol 79:8171-81. 2005.... - The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine designMarcus Altfeld
Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Boston, MA 02129, USA
J Virol 79:5000-5. 2005.... - Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infectionMathias Lichterfeld
Partners AIDS Research Center, Massachusetts General Hospital, and Division of AIDS, Harvard Medical School, Boston, MA 02129, USA
J Virol 81:4199-214. 2007..These data suggest that high-avidity HIV-1-specific CD8+ T-cell clones are recruited during early infection but are subsequently lost in the presence of persistent high-level viral replication... - Systemic inhibition of myeloid dendritic cells by circulating HLA class I molecules in HIV-1 infectionJinghe Huang
Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA
Retrovirology 9:11. 2012..Here, we investigated the expression of soluble HLA class I isoforms during HIV-1 infection and assessed their functional impact on antigen-presenting characteristics of dendritic cells... - Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2Jinghe Huang
Ragon Institute of MGH, Harvard, MIT, 149, 13th Street, Charlestown, MA 02129, USA
J Virol 84:10784-91. 2010.... - Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cellsMathias Lichterfeld
Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Boston, MA 02129, USA
J Exp Med 200:701-12. 2004..This identification of a reversible defect in cell-mediated immunity in chronic HIV-1 infection has important implications for immunotherapeutic interventions... - Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressorsMathias Lichterfeld
Partners AIDS Research Center and Harvard University Center for AIDS Research, Massachusetts General Hospital, Boston, MA, USA
Blood 112:3679-87. 2008.... - HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus loadNicole Frahm
Partners AIDS Research Center, Massachusetts General Hospital, No. 5214, 149 13th Street, Charlestown, MA 02129, USA
J Virol 79:10218-25. 2005..The data support an important role of the presented epitope in mediating relative control of HIV replication and help to better define immune correlates of controlled HIV infection... - Dendritic cell dysfunction during primary HIV-1 infectionJinghe Huang
Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA
J Infect Dis 204:1557-62. 2011..These data indicate that key functional properties of dendritic cells are compromised during primary HIV-1 infection... 
A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cellsMathias Lichterfeld
Partners AIDS Research Center, Massachusetts General Hospital, and Harvard University Center for AIDS Research, Boston, MA 02129, USA
J Exp Med 204:2813-24. 2007....- High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide levelXu G Yu
Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA
AIDS 19:1449-56. 2005.... - Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunctionDiana M Brainard
Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
J Virol 81:8439-50. 2007..These data suggest that both CXCR3(+) CD8 T cells and LN CXCR3 ligands decrease as HIV infection progresses, resulting in reduced homing of CTL into LNs and contributing to immune dysfunction... - Limited durability of viral control following treated acute HIV infectionDaniel E Kaufmann
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
PLoS Med 1:e36. 2004..These data may be relevant to current efforts to develop an HIV-1 vaccine designed to retard disease progression rather than prevent infection since they indicate that durable maintenance of low-level viremia may be difficult to achieve... - Induction of strong HIV-1-specific CD4+ T-cell responses using an HIV-1 gp120/NefTat vaccine adjuvanted with AS02A in antiretroviral-treated HIV-1-infected individualsMathias Lichterfeld
Ragon Institute of Massachusetts General Hospital, Boston, USA
J Acquir Immune Defic Syndr 59:1-9. 2012..Induction of HIV-1-specific CD4(+) T-cell responses by therapeutic vaccination represents an attractive intervention to potentially increase immune control of HIV-1... - Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasiansXu G Yu
Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02129, USA
AIDS Res Hum Retroviruses 20:557-64. 2004.... - Increased natural killer cell activity in viremic HIV-1 infectionGalit Alter
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA
J Immunol 173:5305-11. 2004..Taken together, these data demonstrate that viremic HIV-1 infection is associated with a reduction in NK cell numbers and a perturbation of NK cell subsets, but increased overall NK cell activity... - Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cellsKatie Williams
Ragon Institute of MGH, Harvard, Massachusetts Institute of Technology, Boston, Massachusetts 02114, USA
AIDS 24:1964-6. 2010..These data suggest distinct epigenetic signatures in HIV-1-specific T cells in progressors and controllers... - Random T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strainXu G Yu
Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
J Virol 81:12666-9. 2007.... - Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I allelesHendrik Streeck
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
J Virol 81:7725-31. 2007.... - Rapid determination of the Delta32 deletion in the human CC-chemokine receptor 5 (CCR5) gene without DNA extraction by lightcycler real-time polymerase chain reactionHans Dieter Nischalke
Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat, D 53105 Bonn, Germany
AIDS Res Hum Retroviruses 20:750-4. 2004..We have established a new real-time PCR protocol, which enables fast, cost-saving, and reliable CCR5 genotyping... - Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptidesDaniel E Kaufmann
Partners AIDS Research Center and Infectious Disease Unit, Howard Hughes Medical Institute, Massachusetts General Hospital, and Division of AIDS, Boston, Massachusetts 02114, USA
J Virol 78:4463-77. 2004..These findings have implications for the design of immunotherapeutic strategies and for testing candidate HIV vaccines... - Shelterin dysfunction and p16(INK4a)-mediated growth inhibition in HIV-1-specific CD8 T cellsMathias Lichterfeld
Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA
J Virol 86:5533-40. 2012..These data suggest that shelterin dysfunction and ensuing upregulation of the tumor suppressor p16(INK4a) promote accelerated aging of HIV-1-specific T cells during progressive HIV-1 infection... - Immunodominance of HIV-1-specific CD8(+) T-cell responses in acute HIV-1 infection: at the crossroads of viral and host geneticsMathias Lichterfeld
Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
Trends Immunol 26:166-71. 2005.... - Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllersFrancois Vigneault
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
J Virol 85:3015-9. 2011..Thus, these data identify a specific subgroup of elite controllers whose immunological and gene expression characteristics approximate those of HIV-1-negative persons... - Loss of HIV-1-specific T cell proliferation in chronic HIV-1 infection: cause or consequence of viral replication?Mathias Lichterfeld
Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
AIDS 19:1225-7. 2005 - The emerging role of leukocyte immunoglobulin-like receptors (LILRs) in HIV-1 infectionMathias Lichterfeld
Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA
J Leukoc Biol 91:27-33. 2012..Obtaining a more complete understanding of LILR-mediated immune regulation during HIV-1 infection may ultimately allow for improved strategies to treat or prevent HIV-1-associated disease manifestations... - Reduced CC chemokine receptor (CCR) 1 and CCR5 surface expression on peripheral blood T lymphocytes from patients with chronic hepatitis C infectionMathias Lichterfeld
Department of General Internal Medicine, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
J Infect Dis 185:1803-7. 2002..Thus, chronic hepatitis C, but not hepatitis B, infection alters surface expression of distinct CCRs, resulting in lower CC chemokine responsiveness... - HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alphaMathias Lichterfeld
Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Rm 6613, Boston, MA 02129, USA
Blood 104:487-94. 2004..These results suggest that HIV-1-specific cytotoxicity of CD8(+) T cells is preferentially mediated by a subset of CD8(+) T cells secreting both interferon-gamma and TNF-alpha... - Mutational escape in HIV-1 CTL epitopes leads to increased binding to inhibitory myelomonocytic MHC class I receptorsYue Yang
Ragon Institute of Massachusetts General Hospital, Harvard and MIT, Boston, Massachusetts, United States of America
PLoS ONE 5:e15084. 2010.... - [Antiretroviral treatment of HIV infected patients]Mathias Lichterfeld
Immunologische Ambulanz, Medizinische Klinik I, , Sigmund-Freud-Strasse 25, 53105 Bonn
Med Monatsschr Pharm 26:111-21; quiz 121-2. 2003 - HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1Marcus Altfeld
PLoS Med 3:e403. 2006.... - Pilot study of interferon alpha high-dose induction therapy in combination with ribavirin for chronic hepatitis C in HIV-co-infected patientsJürgen Kurt Rockstroh
Department of Medicine I, University of Bonn, Germany
AIDS 16:2083-5. 2002..In HIV/HCV-co-infected patients, the therapeutic benefit of high-dose IFN-alpha therefore seems to be limited by its poor tolerability...