Mathias Lichterfeld

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Antiretroviral drug toxicity -- a challenge for the hepatologist?
    Ulrich Spengler
    Department of General Internal Medicine I, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    J Hepatol 36:283-94. 2002
  2. ncbi request reprint HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity
    Mathias Lichterfeld
    Partners AIDS Research Center and Howard Hughes Medical Institute, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02129, USA
    AIDS 18:1383-92. 2004
  3. pmc Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers
    Jinghe Huang
    Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, 149 13th Street, Room 5219, Boston, MA 02129, USA
    J Virol 84:9463-71. 2010
  4. pmc CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21
    Huabiao Chen
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts, USA
    J Clin Invest 121:1549-60. 2011
  5. pmc Inhibition of HIV-1 integration in ex vivo-infected CD4 T cells from elite controllers
    Maria J Buzon
    Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114
    J Virol 85:9646-50. 2011
  6. ncbi request reprint Clinical outcomes of HIV-HCV co-infection in a large cohort of hemophiliac patients
    Mathias Lichterfeld
    Department of General Internal Medicine, Rheinische Friedrich Wilhelms Universitat, 53105 Bonn, Germany
    J Infect 50:221-8. 2005
  7. ncbi request reprint Treatment of HIV-1-associated Kaposi's sarcoma with pegylated liposomal doxorubicin and HAART simultaneously induces effective tumor remission and CD4+ T cell recovery
    M Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
    Infection 33:140-7. 2005
  8. ncbi request reprint The tandem-repeat polymorphism of the DC-SIGNR gene does not affect the susceptibility to HIV infection and the progression to AIDS
    Mathias Lichterfeld
    Department of General Internal Medicine, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Clin Immunol 107:55-9. 2003
  9. ncbi request reprint Liver histopathology in human immunodeficiency virus-hepatitis C virus co-infected patients with fatal liver disease
    Mathias Lichterfeld
    Department of General Internal Medicine, Universitatsklinikum Bonn, Germany
    J Gastroenterol Hepatol 20:739-45. 2005
  10. ncbi request reprint Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes
    Nicole Frahm
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:173-8. 2006

Detail Information

Publications50

  1. ncbi request reprint Antiretroviral drug toxicity -- a challenge for the hepatologist?
    Ulrich Spengler
    Department of General Internal Medicine I, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    J Hepatol 36:283-94. 2002
  2. ncbi request reprint HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity
    Mathias Lichterfeld
    Partners AIDS Research Center and Howard Hughes Medical Institute, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02129, USA
    AIDS 18:1383-92. 2004
    ....
  3. pmc Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers
    Jinghe Huang
    Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, 149 13th Street, Room 5219, Boston, MA 02129, USA
    J Virol 84:9463-71. 2010
    ..These data reveal previously unrecognized innate components of immune protection against HIV-1 in elite controllers and offer novel perspectives for the manipulation of host immunity for the prevention and treatment of HIV-1 infection...
  4. pmc CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21
    Huabiao Chen
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts, USA
    J Clin Invest 121:1549-60. 2011
    ..These data demonstrate a mechanism of host resistance to HIV-1 in elite controllers and may open novel perspectives for clinical strategies to prevent or treat HIV-1 infection...
  5. pmc Inhibition of HIV-1 integration in ex vivo-infected CD4 T cells from elite controllers
    Maria J Buzon
    Infectious Disease Division, Massachusetts General Hospital, Boston, MA 02114
    J Virol 85:9646-50. 2011
    ..These data contribute to increasing evidence that intrinsic inhibition of specific HIV-1 replication steps plays an important role in the ability of elite controllers to maintain undetectable viral loads...
  6. ncbi request reprint Clinical outcomes of HIV-HCV co-infection in a large cohort of hemophiliac patients
    Mathias Lichterfeld
    Department of General Internal Medicine, Rheinische Friedrich Wilhelms Universitat, 53105 Bonn, Germany
    J Infect 50:221-8. 2005
    ..To determine the disease progression of HIV-HCV co-infected hemophiliacs in a large cohort of patients (n = 288) cared for at a single medical institution...
  7. ncbi request reprint Treatment of HIV-1-associated Kaposi's sarcoma with pegylated liposomal doxorubicin and HAART simultaneously induces effective tumor remission and CD4+ T cell recovery
    M Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
    Infection 33:140-7. 2005
    ....
  8. ncbi request reprint The tandem-repeat polymorphism of the DC-SIGNR gene does not affect the susceptibility to HIV infection and the progression to AIDS
    Mathias Lichterfeld
    Department of General Internal Medicine, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Clin Immunol 107:55-9. 2003
    ..Thus, the DC-SIGNR tandem-repeat polymorphism in exon 4 does not have a significant impact on the host's susceptibility to HIV and the clinical progression to AIDS...
  9. ncbi request reprint Liver histopathology in human immunodeficiency virus-hepatitis C virus co-infected patients with fatal liver disease
    Mathias Lichterfeld
    Department of General Internal Medicine, Universitatsklinikum Bonn, Germany
    J Gastroenterol Hepatol 20:739-45. 2005
    ..Here, histopathological features of fatal liver disease in HIV-HCV co-infected patients were comparatively assessed...
  10. ncbi request reprint Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes
    Nicole Frahm
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:173-8. 2006
    ..These data suggest that subdominant responses can contribute to in vivo viral control and that high HLA allele frequencies may drive the elimination of subdominant yet effective epitopes from circulating viral populations...
  11. pmc Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes
    Xu G Yu
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Room 5212, Charlestown, MA 02129, USA
    J Virol 81:1619-31. 2007
    ..These data show the influence of HLA allele subtypes on TCR selection and indicate that extensive TCR diversity is not a prerequisite to prevention of allowable viral mutations...
  12. pmc De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection
    Todd M Allen
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, 02129, USA
    J Virol 79:12952-60. 2005
    ....
  13. pmc Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infection
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, and Division of AIDS, Harvard Medical School, Boston, MA 02129, USA
    J Virol 81:4199-214. 2007
    ..These data suggest that high-avidity HIV-1-specific CD8+ T-cell clones are recruited during early infection but are subsequently lost in the presence of persistent high-level viral replication...
  14. pmc Limited durability of viral control following treated acute HIV infection
    Daniel E Kaufmann
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Med 1:e36. 2004
    ..However, the durability of such control remains unclear. Here we present longitudinal follow-up of a single-arm, open-label study assessing the impact of STI in the setting of acute HIV-1 infection...
  15. pmc Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Boston, MA 02129, USA
    J Exp Med 200:701-12. 2004
    ..This identification of a reversible defect in cell-mediated immunity in chronic HIV-1 infection has important implications for immunotherapeutic interventions...
  16. pmc Limited sequence evolution within persistently targeted CD8 epitopes in chronic human immunodeficiency virus type 1 infection
    Tomohiko Koibuchi
    Partners AIDS Research Center, Massachusetts General Hospital, and Division of AIDS, Harvard Medical School, Boston, USA
    J Virol 79:8171-81. 2005
    ....
  17. ncbi request reprint T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA, USA
    Int Immunol 18:1179-88. 2006
    ..Thus, despite distinct TCR recognition of HLA-A3 or HLA-A11 presented HIV-1 peptides in the vast majority of cases, specific TCRs can cross-recognize their antigen in the context of both HLA-A3 and HLA-A11...
  18. pmc CD4 T-cell regeneration in HIV-1 elite controllers
    Yue Yang
    Infectious Disease Division, Massachusetts General Hospital, Boston, USA
    AIDS 26:701-6. 2012
    ..Here, we assessed mechanisms of CD4 T-cell homeostasis in elite controllers with progressive vs. nonprogressive HIV-1 disease courses...
  19. ncbi request reprint Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection
    Hendrik Streeck
    Partners AIDS Research Center, Infectious Disease Unit, Massachusetts General Hospital, Charlestown, MA, 02129, USA
    J Infect Dis 194:734-9. 2006
    ..However, despite these immunological changes, no differences in viremia or in the CD4+ T cell count were found 6 months after HAART was stopped, when treated subjects were compared with untreated subjects...
  20. pmc The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design
    Marcus Altfeld
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Boston, MA 02129, USA
    J Virol 79:5000-5. 2005
    ....
  21. pmc Systemic inhibition of myeloid dendritic cells by circulating HLA class I molecules in HIV-1 infection
    Jinghe Huang
    Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA
    Retrovirology 9:11. 2012
    ..Here, we investigated the expression of soluble HLA class I isoforms during HIV-1 infection and assessed their functional impact on antigen-presenting characteristics of dendritic cells...
  22. pmc Dendritic cell dysfunction during primary HIV-1 infection
    Jinghe Huang
    Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA
    J Infect Dis 204:1557-62. 2011
    ..These data indicate that key functional properties of dendritic cells are compromised during primary HIV-1 infection...
  23. pmc Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2
    Jinghe Huang
    Ragon Institute of MGH, Harvard, MIT, 149, 13th Street, Charlestown, MA 02129, USA
    J Virol 84:10784-91. 2010
    ....
  24. pmc Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors
    Mathias Lichterfeld
    Partners AIDS Research Center and Harvard University Center for AIDS Research, Massachusetts General Hospital, Boston, MA, USA
    Blood 112:3679-87. 2008
    ....
  25. ncbi request reprint Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection
    Galit Alter
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, USA
    Blood 106:3366-9. 2005
    ..Taken together, these studies demonstrate a sequential impairment of NK cell function with persistent viral replication resulting from a progressive deregulation of NK cell subsets with distinct functional properties...
  26. pmc Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles
    Hendrik Streeck
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Virol 81:7725-31. 2007
    ....
  27. pmc Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction
    Diana M Brainard
    Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    J Virol 81:8439-50. 2007
    ..These data suggest that both CXCR3(+) CD8 T cells and LN CXCR3 ligands decrease as HIV infection progresses, resulting in reduced homing of CTL into LNs and contributing to immune dysfunction...
  28. pmc A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, and Harvard University Center for AIDS Research, Boston, MA 02129, USA
    J Exp Med 204:2813-24. 2007
    ....
  29. ncbi request reprint High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level
    Xu G Yu
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA
    AIDS 19:1449-56. 2005
    ....
  30. ncbi request reprint Increased natural killer cell activity in viremic HIV-1 infection
    Galit Alter
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA
    J Immunol 173:5305-11. 2004
    ..Taken together, these data demonstrate that viremic HIV-1 infection is associated with a reduction in NK cell numbers and a perturbation of NK cell subsets, but increased overall NK cell activity...
  31. pmc Induction of strong HIV-1-specific CD4+ T-cell responses using an HIV-1 gp120/NefTat vaccine adjuvanted with AS02A in antiretroviral-treated HIV-1-infected individuals
    Mathias Lichterfeld
    Ragon Institute of Massachusetts General Hospital, Boston, USA
    J Acquir Immune Defic Syndr 59:1-9. 2012
    ..Induction of HIV-1-specific CD4(+) T-cell responses by therapeutic vaccination represents an attractive intervention to potentially increase immune control of HIV-1...
  32. pmc Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells
    Katie Williams
    Ragon Institute of MGH, Harvard, Massachusetts Institute of Technology, Boston, Massachusetts 02114, USA
    AIDS 24:1964-6. 2010
    ..These data suggest distinct epigenetic signatures in HIV-1-specific T cells in progressors and controllers...
  33. ncbi request reprint Rapid determination of the Delta32 deletion in the human CC-chemokine receptor 5 (CCR5) gene without DNA extraction by lightcycler real-time polymerase chain reaction
    Hans Dieter Nischalke
    Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universitat, D 53105 Bonn, Germany
    AIDS Res Hum Retroviruses 20:750-4. 2004
    ..We have established a new real-time PCR protocol, which enables fast, cost-saving, and reliable CCR5 genotyping...
  34. pmc Random T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain
    Xu G Yu
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Virol 81:12666-9. 2007
    ....
  35. doi request reprint Susceptibility to CD8 T-Cell-Mediated Killing Influences the Reservoir of Latently HIV-1-Infected CD4 T Cells
    Maria J Buzon
    Infectious Disease Division, Massachusetts General Hospital, Boston, MA Ragon Institute of MGH, MIT, and Harvard, Boston, MA Laboratory of AIDS Immunology, The First Affiliated Hospital of China Medical University, Shenyang, People s Republic of China and Infectious Disease Division, Brigham and Women s Hospital, Boston, MA
    J Acquir Immune Defic Syndr 65:1-9. 2014
    ..Cell-intrinsic characteristics of CD4 T cells, the main target cells for HIV-1, may affect the composition of the latent viral reservoir by altering the susceptibility to CD8 T-cell-mediated killing...
  36. pmc HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load
    Nicole Frahm
    Partners AIDS Research Center, Massachusetts General Hospital, No 5214, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 79:10218-25. 2005
    ..The data support an important role of the presented epitope in mediating relative control of HIV replication and help to better define immune correlates of controlled HIV infection...
  37. pmc Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection
    Todd M Allen
    Howard Hughes Medical Institute, Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital, and Division of AIDS, Harvard Medical School, Boston, MA, USA
    J Virol 78:7069-78. 2004
    ..Moreover, reversion of these mutations in the absence of the original immune pressure reveals the potential plasticity of immunologically selected evolutionary changes...
  38. pmc Shelterin dysfunction and p16(INK4a)-mediated growth inhibition in HIV-1-specific CD8 T cells
    Mathias Lichterfeld
    Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Virol 86:5533-40. 2012
    ..These data suggest that shelterin dysfunction and ensuing upregulation of the tumor suppressor p16(INK4a) promote accelerated aging of HIV-1-specific T cells during progressive HIV-1 infection...
  39. ncbi request reprint Immunodominance of HIV-1-specific CD8(+) T-cell responses in acute HIV-1 infection: at the crossroads of viral and host genetics
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02129, USA
    Trends Immunol 26:166-71. 2005
    ....
  40. pmc Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides
    Daniel E Kaufmann
    Partners AIDS Research Center and Infectious Disease Unit, Howard Hughes Medical Institute, Massachusetts General Hospital, and Division of AIDS, Boston, Massachusetts 02114, USA
    J Virol 78:4463-77. 2004
    ..These findings have implications for the design of immunotherapeutic strategies and for testing candidate HIV vaccines...
  41. ncbi request reprint Loss of HIV-1-specific T cell proliferation in chronic HIV-1 infection: cause or consequence of viral replication?
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    AIDS 19:1225-7. 2005
  42. pmc Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers
    Francois Vigneault
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 85:3015-9. 2011
    ..Thus, these data identify a specific subgroup of elite controllers whose immunological and gene expression characteristics approximate those of HIV-1-negative persons...
  43. ncbi request reprint Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians
    Xu G Yu
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02129, USA
    AIDS Res Hum Retroviruses 20:557-64. 2004
    ....
  44. pmc The emerging role of leukocyte immunoglobulin-like receptors (LILRs) in HIV-1 infection
    Mathias Lichterfeld
    Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Leukoc Biol 91:27-33. 2012
    ..Obtaining a more complete understanding of LILR-mediated immune regulation during HIV-1 infection may ultimately allow for improved strategies to treat or prevent HIV-1-associated disease manifestations...
  45. ncbi request reprint Reduced CC chemokine receptor (CCR) 1 and CCR5 surface expression on peripheral blood T lymphocytes from patients with chronic hepatitis C infection
    Mathias Lichterfeld
    Department of General Internal Medicine, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Infect Dis 185:1803-7. 2002
    ..Thus, chronic hepatitis C, but not hepatitis B, infection alters surface expression of distinct CCRs, resulting in lower CC chemokine responsiveness...
  46. pmc Mutational escape in HIV-1 CTL epitopes leads to increased binding to inhibitory myelomonocytic MHC class I receptors
    Yue Yang
    Ragon Institute of Massachusetts General Hospital, Harvard and MIT, Boston, Massachusetts, United States of America
    PLoS ONE 5:e15084. 2010
    ....
  47. ncbi request reprint HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Rm 6613, Boston, MA 02129, USA
    Blood 104:487-94. 2004
    ..These results suggest that HIV-1-specific cytotoxicity of CD8(+) T cells is preferentially mediated by a subset of CD8(+) T cells secreting both interferon-gamma and TNF-alpha...
  48. ncbi request reprint [Antiretroviral treatment of HIV infected patients]
    Mathias Lichterfeld
    Immunologische Ambulanz, Medizinische Klinik I, Rheinischen Friedrich Wilhelms Universität, Sigmund Freud Strasse 25, 53105 Bonn
    Med Monatsschr Pharm 26:111-21; quiz 121-2. 2003
  49. pmc HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1
    Marcus Altfeld
    PLoS Med 3:e403. 2006
    ..Very little is known about the immunodominance patterns of HIV-1-specific T cell responses during primary HIV-1 infection and the reasons for human lymphocyte antigen (HLA) modulation of disease progression...
  50. ncbi request reprint Pilot study of interferon alpha high-dose induction therapy in combination with ribavirin for chronic hepatitis C in HIV-co-infected patients
    Jürgen Kurt Rockstroh
    Department of Medicine I, University of Bonn, Germany
    AIDS 16:2083-5. 2002
    ..In HIV/HCV-co-infected patients, the therapeutic benefit of high-dose IFN-alpha therefore seems to be limited by its poor tolerability...