Gregory D Lewis

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Determinants of ventilatory efficiency in heart failure: the role of right ventricular performance and pulmonary vascular tone
    Gregory D Lewis
    Cardiology Division, Department of Medicine, and Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Circ Heart Fail 1:227-33. 2008
  2. pmc Metabolic signatures of exercise in human plasma
    Gregory D Lewis
    Cardiology Division and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Sci Transl Med 2:33ra37. 2010
  3. pmc Pulmonary vascular response patterns during exercise in left ventricular systolic dysfunction predict exercise capacity and outcomes
    Gregory D Lewis
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    Circ Heart Fail 4:276-85. 2011
  4. pmc Exercise oscillatory ventilation in systolic heart failure: an indicator of impaired hemodynamic response to exercise
    Ryan M Murphy
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circulation 124:1442-51. 2011
  5. pmc Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Clin Invest 121:1402-11. 2011
  6. ncbi request reprint Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension
    Gregory D Lewis
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circulation 116:1555-62. 2007
  7. doi request reprint Prolonged mean VO2 response time in systolic heart failure: an indicator of impaired right ventricular-pulmonary vascular function
    Neal A Chatterjee
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circ Heart Fail 6:499-507. 2013
  8. ncbi request reprint Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure
    Gregory D Lewis
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circulation 115:59-66. 2007
  9. pmc Metabolite profiling identifies pathways associated with metabolic risk in humans
    Susan Cheng
    Cardiology Division, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Circulation 125:2222-31. 2012
  10. doi request reprint Mechanisms of exercise intolerance in heart failure with preserved ejection fraction: the role of abnormal peripheral oxygen extraction
    Bishnu P Dhakal
    From the Cardiology Division B P D, R M, R M M, A L B, R B W, N E H, A S E, G D L and the Pulmonary and Critical Care Unit P P P, S S H, G D L, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston
    Circ Heart Fail 8:286-94. 2015

Detail Information

Publications32

  1. pmc Determinants of ventilatory efficiency in heart failure: the role of right ventricular performance and pulmonary vascular tone
    Gregory D Lewis
    Cardiology Division, Department of Medicine, and Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Circ Heart Fail 1:227-33. 2008
    ....
  2. pmc Metabolic signatures of exercise in human plasma
    Gregory D Lewis
    Cardiology Division and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Sci Transl Med 2:33ra37. 2010
    ..Plasma metabolic profiles obtained during exercise provide signatures of exercise performance and cardiovascular disease susceptibility, in addition to highlighting molecular pathways that may modulate the salutary effects of exercise...
  3. pmc Pulmonary vascular response patterns during exercise in left ventricular systolic dysfunction predict exercise capacity and outcomes
    Gregory D Lewis
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    Circ Heart Fail 4:276-85. 2011
    ..However, PAP response patterns to exercise in LVSD and their relationship to functional capacity and outcomes have not been characterized...
  4. pmc Exercise oscillatory ventilation in systolic heart failure: an indicator of impaired hemodynamic response to exercise
    Ryan M Murphy
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circulation 124:1442-51. 2011
    ..However, mechanistic insights into EOV have been limited by the absence of studies relating EOV to invasive hemodynamic measurements and blood gases performed during exercise...
  5. pmc Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Clin Invest 121:1402-11. 2011
    ..These studies identify a relationship between lipid acyl chain content and diabetes risk and demonstrate how lipid profiling could aid in clinical risk assessment...
  6. ncbi request reprint Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension
    Gregory D Lewis
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circulation 116:1555-62. 2007
    ..We tested the hypothesis that sildenafil, an effective therapy for pulmonary arterial hypertension, would lower pulmonary vascular resistance and improve exercise capacity in patients with HF complicated by PH...
  7. doi request reprint Prolonged mean VO2 response time in systolic heart failure: an indicator of impaired right ventricular-pulmonary vascular function
    Neal A Chatterjee
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circ Heart Fail 6:499-507. 2013
    ..To gain mechanistic insights into delayed VO2 kinetics in LVSD, we simultaneously assessed hemodynamic measurements, ventilatory parameters, and peripheral oxygen usage during exercise...
  8. ncbi request reprint Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure
    Gregory D Lewis
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circulation 115:59-66. 2007
    ..We tested the hypothesis that a single oral dose of sildenafil (50 mg) would improve exercise capacity and exercise hemodynamics in patients with chronic systolic HF through pulmonary vasodilation...
  9. pmc Metabolite profiling identifies pathways associated with metabolic risk in humans
    Susan Cheng
    Cardiology Division, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Circulation 125:2222-31. 2012
    ..Although metabolic risk factors are known to cluster in individuals who are prone to developing diabetes mellitus and cardiovascular disease, the underlying biological mechanisms remain poorly understood...
  10. doi request reprint Mechanisms of exercise intolerance in heart failure with preserved ejection fraction: the role of abnormal peripheral oxygen extraction
    Bishnu P Dhakal
    From the Cardiology Division B P D, R M, R M M, A L B, R B W, N E H, A S E, G D L and the Pulmonary and Critical Care Unit P P P, S S H, G D L, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston
    Circ Heart Fail 8:286-94. 2015
    ..We hypothesized that abnormally low peripheral o2 extraction (arterio-mixed venous o2 content difference, [C(a-v)o2]) during exercise significantly contributes to impaired exercise capacity in HFpEF...
  11. ncbi request reprint The emerging role for type 5 phosphodiesterase inhibition in heart failure
    Gregory D Lewis
    Cardiology Division, Bigelow 800, MassachusettsGeneral Hospital, 55 Fruit St, Boston, MA 02114, USA
    Curr Heart Fail Rep 3:123-8. 2006
    ..This review outlines both the underlying rationale and the results of initial studies of the therapeutic effects of PDE5 inhibition in HF...
  12. ncbi request reprint Pulmonary thromboembolism superimposed on a congenital ventricular septal defect in a 50-year-old man inhaled nitric oxide and sildenafil to the rescue
    Gregory D Lewis
    Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cardiol Rev 12:188-90. 2004
    ..To our knowledge, use of this combination therapy in patients with decompensated pulmonary arterial hypertension (PAH) and a predisposition to right-to-left shunting has not been previously reported...
  13. pmc Metabolite profiles and the risk of developing diabetes
    Thomas J Wang
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 17:448-53. 2011
    ..These findings underscore the potential key role of amino acid metabolism early in the pathogenesis of diabetes and suggest that amino acid profiles could aid in diabetes risk assessment...
  14. pmc β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors
    Lee D Roberts
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cell Metab 19:96-108. 2014
    ..In humans, plasma BAIBA concentrations are increased with exercise and inversely associated with metabolic risk factors. BAIBA may thus contribute to exercise-induced protection from metabolic diseases...
  15. ncbi request reprint Sildenafil improves coronary artery patency in a canine model of platelet-mediated cyclic coronary occlusion after thrombolysis
    Gregory D Lewis
    Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 47:1471-7. 2006
    ..We sought to assess the effect of sildenafil, a highly-specific type 5 phosphodiesterase (PDE5) inhibitor, on platelet-mediated cyclic coronary flow reductions occurring in a canine model of coronary thrombosis despite aspirin therapy...
  16. ncbi request reprint Type 5 phosphodiesterase inhibition in heart failure and pulmonary hypertension
    Gregory D Lewis
    Cardiology Division, Bigelow 800, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
    Curr Heart Fail Rep 1:183-9. 2004
    ..Inhibition of PDE5 has been shown to lower pulmonary vascular resistance in PAH and HF by augmenting local cGMP. This review outlines the therapeutic potential of PDE5 inhibition for the treatment of PAH and HF...
  17. doi request reprint Exercise oscillatory ventilation in heart failure
    Bishnu P Dhakal
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Trends Cardiovasc Med 22:185-91. 2012
    ..This article reviews the mechanistic basis of periodic breathing and the clinical utility of discerning patterns of irregular breathing in patients with heart failure...
  18. pmc Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training
    Aaron L Baggish
    Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
    J Physiol 589:3983-94. 2011
    ..73; P = 0.02). Although future work is required, these results suggest the potential value of c-miRNAs as exercise biomarkers and their possible roles as physiological mediators of exercise-induced cardiovascular adaptation...
  19. pmc Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury
    Gregory D Lewis
    Cardiology Division and Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Clin Invest 118:3503-12. 2008
    ..Our results identify a role for metabolic profiling in the early detection of myocardial injury and suggest that similar approaches may be used for detection or prediction of other disease states...
  20. doi request reprint Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction
    James L Januzzi
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 58:1881-9. 2011
    ..The aim of this study was to evaluate whether chronic heart failure (HF) therapy guided by concentrations of amino-terminal pro-B-type natriuretic peptide (NT-proBNP) is superior to standard of care (SOC) management...
  21. pmc Metabolite profiling identifies markers of uremia
    Eugene P Rhee
    Massachusetts General Hospital, 149 13th Street, 8th Floor, Boston, MA, USA
    J Am Soc Nephrol 21:1041-1051. 2010
    ..In summary, this study demonstrates the application of metabolite profiling to identify markers of ESRD, provide perspective on uremic dyslipidemia, and broaden our understanding of the biochemical effects of hemodialysis...
  22. doi request reprint ECG findings in competitive rowers: normative data and the prevalence of abnormalities using contemporary screening recommendations
    Meagan M Wasfy
    Cardiovascular Performance Program, Massachusetts General Hospital, Boston, Massachusetts, USA
    Br J Sports Med 49:200-6. 2015
    ..We therefore sought to describe normative ECG characteristics and to examine the prevalence of abnormal ECG findings as defined by contemporary athlete ECG interpretation criteria among competitive rowers...
  23. pmc Interpreting metabolomic profiles using unbiased pathway models
    Rahul C Deo
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Comput Biol 6:e1000692. 2010
    ..Given the involvement of transporters in human disease, metabolite profiling may contribute to improved disease classification via the interrogation of specific transporter activities...
  24. pmc Exercise blood pressure and the risk of incident cardiovascular disease (from the Framingham Heart Study)
    Gregory D Lewis
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 101:1614-20. 2008
    ..Our findings support the concept that dynamic BP provides incremental information to BP at rest and suggest that exercise diastolic BP may be a better predictor than exercise systolic BP in this age group...
  25. doi request reprint Myocardial adaptations to recreational marathon training among middle-aged men
    Jodi L Zilinski
    From the Cardiovascular Performance Program, Division of Cardiology, Department of Internal Medicine, Massachusetts General Hospital, Boston J L Z, M E C, S K I, J R D, G D L, R B W, A M H, A L B Sports Medicine Division, Boston Children s Hospital, Boston, MA P A d H Boston Athletic Association, MA P A d H, C T, K S D, A L B and Department of Emergency Medicine, Boston Medical Center, Boston, MA K S D
    Circ Cardiovasc Imaging 8:e002487. 2015
    ..To what degree cardiac remodeling occurs among recreational exercisers is unknown. We sought to evaluate the effect of recreational marathon training on myocardial structure and function comprehensively...
  26. pmc Application of metabolomics to cardiovascular biomarker and pathway discovery
    Gregory D Lewis
    Center for Immunology and Inflammatory Diseases and Cardiology Division, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Am Coll Cardiol 52:117-23. 2008
    ....
  27. pmc Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: insights from a coronary sinus sampling study
    Aslan T Turer
    Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75230 9047, USA
    J Am Coll Cardiol 57:2398-405. 2011
    ....
  28. pmc Effect of weight loss after weight loss surgery on plasma N-terminal pro-B-type natriuretic peptide levels
    Annabel Chen-Tournoux
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 106:1450-5. 2010
    ..These findings suggest a direct, reversible relation between obesity and reduced natriuretic peptide levels...
  29. pmc Resting ventricular-vascular function and exercise capacity in heart failure with preserved ejection fraction: a RELAX trial ancillary study
    Selma F Mohammed
    From the Division of Cardiovascular Diseases S F M, B A B, G L, R Z, M M R and Mayo Graduate School S F M, R Z, Mayo Clinic, Rochester, MN Duke Clinical Research Institute, Durham, NC S M, A F H Massachusetts General Hospital, Boston, MA G D L, M J S University of Vermont, Burlington, VT M L and Harvard Medical School, Boston, MA E B
    Circ Heart Fail 7:580-9. 2014
    ..We hypothesized that in heart failure with preserved ejection fraction, the severity of resting ventricular and vascular dysfunction are associated with impairment in exercise tolerance as assessed by peak oxygen consumption...
  30. pmc Effect of phosphodiesterase inhibition on insulin resistance in obese individuals
    Jennifer E Ho
    Cardiovascular Medicine Section, Department of Medicine, Boston University School of Medicine, Boston, MA J E H
    J Am Heart Assoc 3:e001001. 2014
    ..We sought to examine effects of phosphodiesterase-5 inhibition with tadalafil on IR in a pilot study of obese nondiabetic individuals...
  31. doi request reprint Exercise oscillatory ventilation in patients with fontan physiology
    Ashwin S Nathan
    From the Department of Medicine, Brigham and Women s Hospital, Boston, MA A S N, F W, D M S, K S, M J L, A R O Departments of Cardiology B L, L M, F W, J R, R H R, A U T, K S, M J L, A R O and Cardiovascular Surgery A U T, Boston Children s Hospital, MA and Department of Medicine, Massachusetts General Hospital, Boston G D L
    Circ Heart Fail 8:304-11. 2015
    ..Its presence correlates with heart failure severity and worse prognosis in adults with acquired heart failure. We evaluated the prevalence and predictive value of EOV in patients with single ventricle Fontan physiology...
  32. doi request reprint Pre-capillary pulmonary hypertension and right ventricular dilation predict clinical outcome in cardiac resynchronization therapy
    Neal A Chatterjee
    Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
    JACC Heart Fail 2:230-7. 2014
    ..This study examined the prognostic significance of pre- and post-capillary components of pulmonary hypertension (PH) in patients receiving cardiac resynchronization therapy (CRT)...