B D Levy

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury
    Caroline Bonnans
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 203:857-63. 2006
  2. pmc Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4
    A Planagumà
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mucosal Immunol 3:270-9. 2010
  3. pmc Resolvin D1 and Resolvin E1 Promote the Resolution of Allergic Airway Inflammation via Shared and Distinct Molecular Counter-Regulatory Pathways
    Bruce D Levy
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School Boston, MA, USA
    Front Immunol 3:390. 2012
  4. doi request reprint Resolution of acute inflammation in the lung
    Bruce D Levy
    Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115 email
    Annu Rev Physiol 76:467-92. 2014
  5. pmc 15-Epi-lipoxin A4 inhibits human neutrophil superoxide anion generation by regulating polyisoprenyl diphosphate phosphatase 1
    Troy Carlo
    Pulmonary and Critical Care Medicine Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    FASEB J 27:2733-41. 2013
  6. doi request reprint Lipoxins, resolvins and protectins: new leads for the treatment of asthma
    Oliver Haworth
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts, MA 02115, USA 1 617 525 8362 1 617 264 5133
    Expert Opin Drug Discov 3:1209-22. 2008
  7. pmc Resolution of inflammation in asthma
    Bruce D Levy
    Harvard Medical School, Department of Internal Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Chest Med 33:559-70. 2012
  8. pmc Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma
    Pankaj K Bhavsar
    Experimental Studies, Airways Disease Section, National Heart and Lung Institute, Imperial College London and Royal Brompton NHS Trust, London, UK
    Respir Res 11:71. 2010
  9. pmc The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection
    Bruce D Levy
    Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Prostaglandins Leukot Essent Fatty Acids 84:43-50. 2011
  10. ncbi request reprint Exploring new approaches to the treatment of asthma: potential roles for lipoxins and aspirin-triggered lipid mediators
    Bruce D Levy
    Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Drugs Today (Barc) 39:373-84. 2003

Collaborators

Detail Information

Publications45

  1. pmc Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury
    Caroline Bonnans
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 203:857-63. 2006
    ....
  2. pmc Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4
    A Planagumà
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mucosal Immunol 3:270-9. 2010
    ....
  3. pmc Resolvin D1 and Resolvin E1 Promote the Resolution of Allergic Airway Inflammation via Shared and Distinct Molecular Counter-Regulatory Pathways
    Bruce D Levy
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School Boston, MA, USA
    Front Immunol 3:390. 2012
    ..This article focuses on recent insights into the cellular and molecular mechanisms for resolvins that limit adaptive immune responses in healthy airways...
  4. doi request reprint Resolution of acute inflammation in the lung
    Bruce D Levy
    Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115 email
    Annu Rev Physiol 76:467-92. 2014
    ..This process appears to be defective in several common lung diseases that are characterized by excess or chronic inflammation. Here, we review the molecular and cellular effectors of resolution of acute inflammation in the lung. ..
  5. pmc 15-Epi-lipoxin A4 inhibits human neutrophil superoxide anion generation by regulating polyisoprenyl diphosphate phosphatase 1
    Troy Carlo
    Pulmonary and Critical Care Medicine Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    FASEB J 27:2733-41. 2013
    ..Together, these findings indicate that PDP1 serves an integral signaling role in neutrophil proinflammatory responses and as a target for counter-regulatory mediators...
  6. doi request reprint Lipoxins, resolvins and protectins: new leads for the treatment of asthma
    Oliver Haworth
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts, MA 02115, USA 1 617 525 8362 1 617 264 5133
    Expert Opin Drug Discov 3:1209-22. 2008
    ..Conclusion: These natural small molecules are rapidly inactivated, but serve as rationale templates for the design of stable analogues with protective actions that could serve as new therapeutic leads for asthma...
  7. pmc Resolution of inflammation in asthma
    Bruce D Levy
    Harvard Medical School, Department of Internal Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Chest Med 33:559-70. 2012
    ....
  8. pmc Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma
    Pankaj K Bhavsar
    Experimental Studies, Airways Disease Section, National Heart and Lung Institute, Imperial College London and Royal Brompton NHS Trust, London, UK
    Respir Res 11:71. 2010
    ..We measured leukotriene B4 (LTB4), and lipoxin A4 (LXA4) production by alveolar macrophages (AMs) and studied the impact of corticosteroids...
  9. pmc The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection
    Bruce D Levy
    Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Prostaglandins Leukot Essent Fatty Acids 84:43-50. 2011
    ..0 days with RvE1 and 37.5 days with a LXA(4) analog). Together, these results highlight the potential for pro-resolving mediators in prolonging survival of solid organ transplants...
  10. ncbi request reprint Exploring new approaches to the treatment of asthma: potential roles for lipoxins and aspirin-triggered lipid mediators
    Bruce D Levy
    Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Drugs Today (Barc) 39:373-84. 2003
    ....
  11. pmc Resolvins and protectins: natural pharmacophores for resolution biology
    Bruce D Levy
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Prostaglandins Leukot Essent Fatty Acids 82:327-32. 2010
    ..This review provides information on the biosynthesis and actions of these recently identified chemical mediators with particular reference to resolution of mucosal inflammatory responses...
  12. ncbi request reprint Lipoxins and lipoxin analogs in asthma
    B D Levy
    Pulmonary and Critical Care Medicine, Department of Internal Medicine and Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Prostaglandins Leukot Essent Fatty Acids 73:231-7. 2005
    ..Together, these findings indicate a pivotal role for LXs in mediating airway homeostasis...
  13. pmc Lipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism
    Bruce D Levy
    Department of Internal Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    FASEB J 21:3877-84. 2007
    ..Moreover, these results demonstrate these analogs' therapeutic potential as new agonists for the resolution of inflammation...
  14. pmc Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness
    Bruce D Levy
    Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 178:496-502. 2007
    ..Together, these findings provide evidence for endogenous PD1 as a pivotal counterregulatory signal in allergic airway inflammation and point to new therapeutic strategies for modulating inflammation in asthmatic lung...
  15. pmc Diminished lipoxin biosynthesis in severe asthma
    Bruce D Levy
    Pulmonary and Critical Care Medicine and Partners Asthma Center, Department of Internal Medicine, PBB Clinics 3, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 172:824-30. 2005
    ..Although arachidonic acid metabolism is well appreciated to regulate airway inflammation and reactivity, alterations in the biosynthetic capacity for both pro- and antiinflammatory eicosanoids in severe asthma have not been determined...
  16. ncbi request reprint Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation
    C B Clish
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 275:25372-80. 2000
    ..Moreover, they suggest that these eicosanoid oxidoreductases have multifaceted roles controlling the levels of specific eicosanoids involved in the regulation of inflammation...
  17. pmc Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury
    O Eickmeier
    Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mucosal Immunol 6:256-66. 2013
    ..Taken together, these findings indicate that AT-RvD1 displays potent mucosal protection and promotes catabasis after ALI...
  18. ncbi request reprint Lipid mediator class switching during acute inflammation: signals in resolution
    B D Levy
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Nat Immunol 2:612-9. 2001
    ....
  19. ncbi request reprint RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis
    H Hasturk
    Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston, Massachusetts, USA
    FASEB J 20:401-3. 2006
    ..Consistent with these potent actions, topical application of RvE1 in rabbit periodontitis conferred dramatic protection against inflammation induced tissue and bone loss associated with periodontitis...
  20. pmc Endogenous lipid mediators in the resolution of airway inflammation
    O Haworth
    Pulmonary and Critical Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur Respir J 30:980-92. 2007
    ..Roles are uncovered for these compounds, or their structural analogues, in regulating airway inflammation...
  21. ncbi request reprint Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4)
    Bruce D Levy
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 8:1018-23. 2002
    ..Moreover, our findings suggest that lipoxin and related pathways offer novel multi-pronged therapeutic approaches for human asthma...
  22. pmc Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation
    Oliver Haworth
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 9:873-9. 2008
    ....
  23. ncbi request reprint Polyisoprenyl phosphates: natural antiinflammatory lipid signals
    B D Levy
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 59:729-41. 2002
    ....
  24. ncbi request reprint Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury
    Koichi Fukunaga
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:5033-9. 2005
    ..Together, these findings indicate a protective role in ALI for COX-2-derived mediators, in part via enhanced lipoxin signaling, and carry potential therapeutic implications for this devastating clinical disorder...
  25. ncbi request reprint Lipoxins and aspirin-triggered lipoxins in airway responses
    Bruce D Levy
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Adv Exp Med Biol 525:19-23. 2003
    ..Moreover, these results indicate that LX's play pivotal and previously unappreciated roles in regulating allergy and pulmonary inflammation...
  26. ncbi request reprint Evaluation of a redesign initiative in an internal-medicine residency
    Graham T McMahon
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 362:1304-11. 2010
    ....
  27. pmc Molecular circuits of resolution in airway inflammation
    Troy Carlo
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    ScientificWorldJournal 10:1386-99. 2010
    ..This review will focus on the biosynthesis, receptors, cellular responses, and in vivo actions of lipoxins, resolvins, and protectins as exemplary molecular signaling circuits in the airway that are anti-inflammatory and proresolving...
  28. pmc Resolvins and protectins: mediating solutions to inflammation
    Payal Kohli
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Br J Pharmacol 158:960-71. 2009
    ..This review describes the discovery and synthesis of these novel lipid mediators, their receptors and mechanisms of action, and summarizes the studies to date that have uncovered roles for resolvins and protectins in disease states...
  29. pmc Chemical mediators and the resolution of airway inflammation
    Troy Carlo
    Brigham and Women s Hospital, Boston, MA, USA
    Allergol Int 57:299-305. 2008
    ..In this review, we describe the biosynthesis and bioactions of pro-resolving chemical mediators and provide examples of select mediators and their structural analogs with particular relevance to asthma...
  30. ncbi request reprint An initiative in mentoring to promote residents' and faculty members' careers
    Bruce D Levy
    Internal Medicine, PBB Clinics 3, Brigham and Women s Faulkner Hospital, 75 Francis Street, Boston, MA 02115, USA
    Acad Med 79:845-50. 2004
    ..The authors conclude that the formal mentoring program has ensured that all trainees are provided with a mentor, which has facilitated faculty-housestaff interactions and increased recognition of faculty contributions to mentoring...
  31. pmc Lipoxin A(4) regulates bronchial epithelial cell responses to acid injury
    Caroline Bonnans
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Pathol 168:1064-72. 2006
    ..Together, these findings indicate that injured bronchial epithelial cells up-regulate ALX in a COX-2-dependent manner to promote LXA(4)-mediated resolution of airway inflammation...
  32. ncbi request reprint Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death
    Kuniaki Ejima
    Brigham and Women s Hospital, Pulmonary and Critical Care Medicine, 75 Francis St, Boston, MA 02115, USA
    FASEB J 17:1325-7. 2003
    ..These beneficial effects occur, in part, by a compensatory increase in IL-10 that counterbalances the pro-inflammatory host response to endotoxemia...
  33. pmc Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma
    Anna Planagumà
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 178:574-82. 2008
    ..Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A(4) (LXA(4)) is an arachidonic acid-derived mediator that serves as an agonist for resolution of inflammation...
  34. pmc Resolution of Toll-like receptor 4-mediated acute lung injury is linked to eicosanoids and suppressor of cytokine signaling 3
    Jan N Hilberath
    Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    FASEB J 25:1827-35. 2011
    ..Together, these findings indicate pivotal roles for TLR4 in promoting sterile ALI and suggest downstream provocative roles for cysteinyl leukotrienes and protective roles for SOCS3 in the intensity and duration of host responses to ALI...
  35. ncbi request reprint Identification and functional characterization of a presqualene diphosphate phosphatase
    Koichi Fukunaga
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:9490-7. 2006
    ..Together, these findings indicate that PPAPDC2 in human PMN is the first lipid phosphate phosphohydrolase identified for PSDP. Regulation of this activity of the enzyme may have important roles for PMN activation in innate immunity...
  36. ncbi request reprint A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage
    Karsten Gronert
    Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 172:1856-61. 2004
    ..Moreover, they identify a potential molecular lesion in PMN signal transduction that may account for their aberrant responses and tissue destruction in this disease...
  37. pmc Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo
    Bruce D Levy
    Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Br J Pharmacol 146:344-51. 2005
    ..5%) and ROS generation (74.4%) 6 h later in peritoneal exudates. Together, these results provide new means to protect and control unchecked inflammatory responses that characterize many human diseases...
  38. pmc Activation of polyisoprenyl diphosphate phosphatase 1 remodels cellular presqualene diphosphate
    Troy Carlo
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Biochemistry 48:2997-3004. 2009
    ..Moreover, they provide evidence that PDP1 can serve as a new checkpoint for polyisoprenyl phosphate remodeling during cell activation...
  39. ncbi request reprint Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    Ronald L Sorkness
    Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    J Appl Physiol (1985) 104:394-403. 2008
    ..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component...
  40. ncbi request reprint Modulation of human airway smooth muscle migration by lipid mediators and Th-2 cytokines
    Krishnan Parameswaran
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, ON, L8N 4A6 Canada
    Am J Respir Cell Mol Biol 37:240-7. 2007
    ..IL-13 can promote airway smooth muscle migration through Src-kinase and leukotriene-dependent pathways. This may contribute to the accumulation of smooth muscle cells in remodeled airway submucosa...
  41. pmc Lipid mediators as agonists for the resolution of acute lung inflammation and injury
    Caroline Bonnans
    Department of Respiratory Disease, Arnaud de Villeneuve Hospital, Montpellier, France
    Am J Respir Cell Mol Biol 36:201-5. 2007
    ..LXA(4) and PSDP mimetics have been prepared with potent protective actions in murine models of asthma and acute lung injury...
  42. pmc Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 119:405-13. 2007
    ..Severe asthma causes the majority of asthma morbidity. Understanding mechanisms that contribute to the development of severe disease is important...
  43. ncbi request reprint Eicosanoids in scleroderma: lung disease hangs in the balance
    Bruce D Levy
    Arthritis Rheum 52:3693-7. 2005
  44. ncbi request reprint Myocardial 15-epi-lipoxin A4 generation provides a new mechanism for the immunomodulatory effects of statins and thiazolidinediones
    Bruce D Levy
    Circulation 114:873-5. 2006
  45. pmc Alterations of the arginine metabolome in asthma
    Abigail Lara
    Department of Pathobiology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Respir Crit Care Med 178:673-81. 2008
    ..As the sole nitrogen donor in nitric oxide (NO) synthesis and key intermediate in the urea cycle, arginine and its metabolic pathways are integrally linked to cellular respiration, metabolism, and inflammation...

Research Grants17

  1. Counter-regulatory Lipid Signals in Lung Disease
    Bruce Levy; Fiscal Year: 2002
    ..abstract_text> ..
  2. Counter-Regulatory Lipid Mediators in Lung Disease
    Bruce D Levy; Fiscal Year: 2010
    ....
  3. Counter-Regulatory Lipid Mediators in Lung Disease
    Bruce Levy; Fiscal Year: 2009
    ....
  4. Oxidative Stress and Anti-Inflammatory Lipids in Airway Disease
    Bruce Levy; Fiscal Year: 2009
    ..In this proposal, we seek to develop a better understanding of the natural biological processes invoked during airway infection and inflammation that dysregulate the natural homeostatic mechanisms. (End of Abstract) ..
  5. Oxidative Stress and Anti-Inflammatory Lipids in Airway Disease
    Bruce Levy; Fiscal Year: 2007
    ..In this proposal, we seek to develop a better understanding of the natural biological processes invoked during airway infection and inflammation that dysregulate the natural homeostatic mechanisms. (End of Abstract) ..
  6. Lipid Mediators in the Resolution of Asthma Exacerbations
    Bruce Levy; Fiscal Year: 2007
    ..This proposal's specific aims are directed towards uncovering basic mechanisms in the pathobiology of resolution from asthma exacerbation. ..
  7. Lipid Mediators in the Resolution of Asthma Exacerbatio*
    Bruce Levy; Fiscal Year: 2006
    ..This proposal's specific aims are directed towards uncovering basic mechanisms in the pathobiology of resolution from asthma exacerbation. ..
  8. Counter-regulatory Lipid Signals in Lung Disease
    Bruce Levy; Fiscal Year: 2006
    ..abstract_text> ..
  9. Lipid Mediators in Resolution of Asthma Exacerbations
    Bruce Levy; Fiscal Year: 2005
    ..This proposal's specific aims are directed towards uncovering basic mechanisms in the pathobiology of resolution from asthma exacerbation. ..
  10. Counter-regulatory Lipid Signals in Lung Disease
    Bruce Levy; Fiscal Year: 2005
    ..abstract_text> ..
  11. Counter-regulatory Lipid Signals in Lung Disease
    Bruce Levy; Fiscal Year: 2004
    ..abstract_text> ..
  12. Counter-regulatory Lipid Signals in Lung Disease
    Bruce Levy; Fiscal Year: 2003
    ..abstract_text> ..
  13. NOVEL LUNG DERIVED CHALONES--BIOSYNTHESIS AND BIOACTIONS
    Bruce Levy; Fiscal Year: 2002
    ..End of Abstract) ..
  14. Oxidative Stress and Anti-Inflammatory Lipids in Airway Disease
    Bruce D Levy; Fiscal Year: 2010
    ..In this proposal, we seek to develop a better understanding of the natural biological processes invoked during airway infection and inflammation that dysregulate the natural homeostatic mechanisms. (End of Abstract) ..