Daniel T Leung

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Factors associated with encephalopathy in patients with Salmonella enterica serotype Typhi bacteremia presenting to a diarrheal hospital in Dhaka, Bangladesh
    Daniel T Leung
    Division of Infectious Disease, Massachusetts General Hospital, Boston, 02114, USA
    Am J Trop Med Hyg 86:698-702. 2012
  2. pmc Immune responses to the O-specific polysaccharide antigen in children who received a killed oral cholera vaccine compared to responses following natural cholera infection in Bangladesh
    Daniel T Leung
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Clin Vaccine Immunol 20:780-8. 2013
  3. pmc Memory B cell and other immune responses in children receiving two doses of an oral killed cholera vaccine compared to responses following natural cholera infection in Bangladesh
    Daniel T Leung
    Centre for Vaccine Sciences, Bangladesh, Dhaka, Bangladesh
    Clin Vaccine Immunol 19:690-8. 2012
  4. pmc Immune responses to cholera in children
    Daniel T Leung
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Expert Rev Anti Infect Ther 10:435-44. 2012
  5. pmc Comparison of memory B cell, antibody-secreting cell, and plasma antibody responses in young children, older children, and adults with infection caused by Vibrio cholerae O1 El Tor Ogawa in Bangladesh
    Daniel T Leung
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Clin Vaccine Immunol 18:1317-25. 2011
  6. pmc Immune responses to O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 Ogawa in adult Bangladeshi recipients of an oral killed cholera vaccine and comparison to responses in patients with cholera
    Taher Uddin
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh NIDDK, LBC, National Institutes of Health, Bethesda, Maryland Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts Departments of Medicine and Pediatrics, Harvard Medical School, Boston, Massachusetts Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts
    Am J Trop Med Hyg 90:873-81. 2014
  7. pmc Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera
    Russell A Johnson
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Clin Vaccine Immunol 19:1712-21. 2012
  8. pmc Identification of immunogenic Salmonella enterica serotype Typhi antigens expressed in chronic biliary carriers of S. Typhi in Kathmandu, Nepal
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS Negl Trop Dis 7:e2335. 2013
  9. pmc Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera
    Mohammad Arifuzzaman
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh
    Clin Vaccine Immunol 19:1304-11. 2012
  10. pmc Antibody avidity in humoral immune responses in Bangladeshi children and adults following administration of an oral killed cholera vaccine
    Mohammad Murshid Alam
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Clin Vaccine Immunol 20:1541-8. 2013

Collaborators

  • Jason B Harris
  • Richelle C Charles
  • Alaullah Sheikh
  • Sean M Rollins
  • Ana A Weil
  • Joshua Labaer
  • Atiqur Rahman
  • Tran Vu Thieu Nga
  • Buddha Basnyat
  • Steffen Porwollik
  • James E Graham
  • Stephen Baker
  • Mohammod Jobayer Chisti
  • Albrecht Ludwig
  • Jeremy Farrar
  • Rubhana Raqib
  • Mohammad Murshid Alam
  • Stephen B Calderwood
  • Edward T Ryan
  • Firdausi Qadri
  • Regina C LaRocque
  • Taher Uddin
  • Taufiqur Rahman Bhuiyan
  • Farhana Khanam
  • PAVOL KOVAC
  • Peng Xu
  • Yanan Yu
  • Ying Wu-Freeman
  • Russell A Johnson
  • Amena Aktar
  • Fahima Chowdhury
  • Saruar Bhuiyan
  • Tania Sultana
  • Anuj Kalsy
  • Ashraful I Khan
  • John D Clements
  • Sumon Kumar Das
  • Rasheduzzaman Rashu
  • Meagan Kelly Bufano
  • Mohammad Nazim
  • Sweta M Patel
  • M Mohasin
  • Mohammad Arif Rahman
  • Mohammad Arifuzzaman
  • Ishaan Desai
  • Marcin Pacek
  • Y Yu
  • Meagan K Bufano
  • Megan Kelly Bufano
  • M Arifur Rahman
  • W F Vann
  • Abu Sayeed
  • Grace Eckhoff
  • Umme Salma
  • Md Rasheduzzaman Rashu
  • Aklima Akter
  • Y Wu Freeman
  • Sadia Afrin
  • Deena Al Mahbuba
  • Sarmin Akter
  • Mohammad Abdul Malek
  • Abu Syed Golam Faruque
  • Fahmida Dil Farzana
  • Mohammed Abdus Salam
  • Nusrat Jahan
  • W Abdullah Brooks
  • Shaikh Meshbahuddin Ahmad
  • Kaisar Ali Talukder
  • Farzana Ferdous
  • M Abu Sayeed
  • Lillian L Tsai
  • Shahnawaz Ahmed
  • Pradip Kumar Bardhan
  • Marjahan Akhtar
  • David Sarracino
  • Amit Saha
  • Bryan Krastins
  • M Asrafuzzaman Riyadh
  • M Saruar Bhuiyan
  • M Ismail Hosen
  • Randall K Holmes

Detail Information

Publications21

  1. pmc Factors associated with encephalopathy in patients with Salmonella enterica serotype Typhi bacteremia presenting to a diarrheal hospital in Dhaka, Bangladesh
    Daniel T Leung
    Division of Infectious Disease, Massachusetts General Hospital, Boston, 02114, USA
    Am J Trop Med Hyg 86:698-702. 2012
    ..Our findings suggest that age, severity of disease, and immune responses are associated with encephalopathy during Salmonella Typhi bacteremia, perhaps reflecting the impact of prominent inflammatory responses...
  2. pmc Immune responses to the O-specific polysaccharide antigen in children who received a killed oral cholera vaccine compared to responses following natural cholera infection in Bangladesh
    Daniel T Leung
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Clin Vaccine Immunol 20:780-8. 2013
    ....
  3. pmc Memory B cell and other immune responses in children receiving two doses of an oral killed cholera vaccine compared to responses following natural cholera infection in Bangladesh
    Daniel T Leung
    Centre for Vaccine Sciences, Bangladesh, Dhaka, Bangladesh
    Clin Vaccine Immunol 19:690-8. 2012
    ..These findings may explain, in part, the lower efficacy of oral cholera vaccination in children...
  4. pmc Immune responses to cholera in children
    Daniel T Leung
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Expert Rev Anti Infect Ther 10:435-44. 2012
    ..The impact of host factors such as malnutrition, genetics and coinfection with other pathogens also remains to be fully defined...
  5. pmc Comparison of memory B cell, antibody-secreting cell, and plasma antibody responses in young children, older children, and adults with infection caused by Vibrio cholerae O1 El Tor Ogawa in Bangladesh
    Daniel T Leung
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Clin Vaccine Immunol 18:1317-25. 2011
    ..cholerae O1, suggesting that under an optimal vaccination strategy, young children could achieve protective efficacy comparable to that induced in adults...
  6. pmc Immune responses to O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 Ogawa in adult Bangladeshi recipients of an oral killed cholera vaccine and comparison to responses in patients with cholera
    Taher Uddin
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh NIDDK, LBC, National Institutes of Health, Bethesda, Maryland Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts Departments of Medicine and Pediatrics, Harvard Medical School, Boston, Massachusetts Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts
    Am J Trop Med Hyg 90:873-81. 2014
    ..The markedly lower ASC and MBC responses to OSP and LPS observed among vaccinees might explain, in part, the lower protection of an OCV compared with natural infection...
  7. pmc Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera
    Russell A Johnson
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Clin Vaccine Immunol 19:1712-21. 2012
    ..Induction of anti-OSP responses may be associated with protection against cholera, and our results may support the development of a vaccine targeting V. cholerae OSP...
  8. pmc Identification of immunogenic Salmonella enterica serotype Typhi antigens expressed in chronic biliary carriers of S. Typhi in Kathmandu, Nepal
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS Negl Trop Dis 7:e2335. 2013
    ..Little is known about the interaction between the host and pathogen in the biliary tract of chronic carriers, and there is currently no reliable diagnostic assay to identify asymptomatic S. Typhi carriage...
  9. pmc Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera
    Mohammad Arifuzzaman
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh
    Clin Vaccine Immunol 19:1304-11. 2012
    ..These findings may explain the lower efficacy and shorter duration of protection afforded by OCV in young children...
  10. pmc Antibody avidity in humoral immune responses in Bangladeshi children and adults following administration of an oral killed cholera vaccine
    Mohammad Murshid Alam
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Clin Vaccine Immunol 20:1541-8. 2013
    ....
  11. pmc Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in Bangladesh
    Sweta M Patel
    International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Clin Vaccine Immunol 19:842-8. 2012
    ..These results suggest that LPS-specific IgG memory B cells may be important in protection against infection with V. cholerae O1...
  12. pmc Impact of Ramadan on clinical and microbiologic parameters of patients seen at a diarrheal hospital in urban Dhaka, Bangladesh, 1996-2012
    Daniel T Leung
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts Department of Medicine, Harvard Medical School, Boston, Massachusetts Centre for Nutrition and Food Security, Dhaka, Bangladesh Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts
    Am J Trop Med Hyg 90:294-8. 2014
    ..Our findings suggest that Ramadan has few effects on the profile of enteric pathogens and clinical features of adults seeking medical care for diarrhea...
  13. pmc Identification of in vivo-induced bacterial proteins during human infection with Salmonella enterica serotype Paratyphi A
    Mohammad Murshid Alam
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    Clin Vaccine Immunol 20:712-9. 2013
    ..S. Paratyphi A antigens identified by IVIAT warrant further evaluation for their contributions to pathogenesis and might have diagnostic, therapeutic, or preventive relevance...
  14. pmc Frequency of reexposure to Vibrio cholerae O1 evaluated by subsequent vibriocidal titer rise after an episode of severe cholera in a highly endemic area in Bangladesh
    Ana A Weil
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Am J Trop Med Hyg 87:921-6. 2012
    ..Repeated exposures to V. cholerae in endemic areas may be a necessary component for long-lasting protection against severe disease...
  15. pmc Non-typhoidal Salmonella gastroenteritis at a diarrheal hospital in Dhaka, Bangladesh, 1996-2011
    Daniel T Leung
    Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Am J Trop Med Hyg 88:661-9. 2013
    ..NTS patients had increased inflammatory cells in stool and required more fluid resuscitation...
  16. pmc In vivo expression of Salmonella enterica serotype Typhi genes in the blood of patients with typhoid fever in Bangladesh
    Alaullah Sheikh
    International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
    PLoS Negl Trop Dis 5:e1419. 2011
    ..Salmonella enterica serotype Typhi is the cause of typhoid fever. It is a human-restricted pathogen, and few data exist on S. Typhi gene expression in humans...
  17. pmc Cellular and Cytokine Responses to Salmonella enterica Serotype Typhi Proteins in Patients with Typhoid Fever in Bangladesh
    Saruar Bhuiyan
    Division of Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, ICDDR, B, Dhaka, Bangladesh Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts Department of Medicine, Harvard Medical School, Boston, Massachusetts Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts Virginia G Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts
    Am J Trop Med Hyg 90:1024-30. 2014
    ..These results suggest that S. Typhi antigens induce a predominantly Th1 response, but that elevations in other cytokines may be modulatory. ..
  18. pmc Immunoproteomic analysis of antibody in lymphocyte supernatant in patients with typhoid fever in Bangladesh
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Vaccine Immunol 21:280-5. 2014
    ..These observations suggest that purified antigens could be used with ALS and corresponding acute-phase activated B lymphocytes in diagnostic platforms to identify acutely infected patients, even in areas where enteric fever is endemic. ..
  19. pmc Evaluation in mice of a conjugate vaccine for cholera made from Vibrio cholerae O1 (Ogawa) O-specific polysaccharide
    Mohammad Murshid Alam
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America International Centre for Diarrheal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    PLoS Negl Trop Dis 8:e2683. 2014
    ..Serogroup specificity in Vibrio cholerae is determined by the O-specific polysaccharide (OSP) of lipopolysaccharide (LPS). Generally, polysaccharides are poorly immunogenic, especially in young children...
  20. pmc Interferon-γ and proliferation responses to Salmonella enterica Serotype Typhi proteins in patients with S. Typhi Bacteremia in Dhaka, Bangladesh
    Alaullah Sheikh
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    PLoS Negl Trop Dis 5:e1193. 2011
    ..Cellular immune responses are required to control and clear Salmonella infection. Despite this, there are limited data on cellular immune responses in humans infected with wild type S. Typhi...
  21. pmc Changing emergence of Shigella sero-groups in Bangladesh: observation from four different diarrheal disease hospitals
    Sumon Kumar Das
    Centre for Nutrition and Food Security CNFS, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    PLoS ONE 8:e62029. 2013
    ..Shigellosis continues to be a public health challenge for developing countries, including Bangladesh. The aim of the study is to demonstrate recent changes in Shigella sero-groups and their geographical diversity...