Research Topics
| Daniel T LeungSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Memory B cell and other immune responses in children receiving two doses of an oral killed cholera vaccine compared to responses following natural cholera infection in BangladeshDaniel T Leung
Centre for Vaccine Sciences, Bangladesh, Dhaka, Bangladesh
Clin Vaccine Immunol 19:690-8. 2012..These findings may explain, in part, the lower efficacy of oral cholera vaccination in children...- Immune responses to cholera in childrenDaniel T Leung
Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
Expert Rev Anti Infect Ther 10:435-44. 2012..The impact of host factors such as malnutrition, genetics and coinfection with other pathogens also remains to be fully defined... - Factors associated with encephalopathy in patients with Salmonella enterica serotype Typhi bacteremia presenting to a diarrheal hospital in Dhaka, BangladeshDaniel T Leung
Division of Infectious Disease, Massachusetts General Hospital, Boston, 02114, USA
Am J Trop Med Hyg 86:698-702. 2012..Our findings suggest that age, severity of disease, and immune responses are associated with encephalopathy during Salmonella Typhi bacteremia, perhaps reflecting the impact of prominent inflammatory responses... - Comparison of memory B cell, antibody-secreting cell, and plasma antibody responses in young children, older children, and adults with infection caused by Vibrio cholerae O1 El Tor Ogawa in BangladeshDaniel T Leung
International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
Clin Vaccine Immunol 18:1317-25. 2011..cholerae O1, suggesting that under an optimal vaccination strategy, young children could achieve protective efficacy comparable to that induced in adults... - Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired choleraMohammad Arifuzzaman
Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh
Clin Vaccine Immunol 19:1304-11. 2012..These findings may explain the lower efficacy and shorter duration of protection afforded by OCV in young children... - Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with choleraRussell A Johnson
Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
Clin Vaccine Immunol 19:1712-21. 2012..Induction of anti-OSP responses may be associated with protection against cholera, and our results may support the development of a vaccine targeting V. cholerae OSP... - Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in BangladeshSweta M Patel
International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
Clin Vaccine Immunol 19:842-8. 2012..These results suggest that LPS-specific IgG memory B cells may be important in protection against infection with V. cholerae O1... - Frequency of reexposure to Vibrio cholerae O1 evaluated by subsequent vibriocidal titer rise after an episode of severe cholera in a highly endemic area in BangladeshAna A Weil
Department of Medicine, Harvard Medical School, Boston, MA, USA
Am J Trop Med Hyg 87:921-6. 2012..Repeated exposures to V. cholerae in endemic areas may be a necessary component for long-lasting protection against severe disease... - Identification of In Vivo-Induced Bacterial Proteins during Human Infection with Salmonella enterica Serotype Paratyphi AMohammad Murshid Alam
International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
Clin Vaccine Immunol 20:712-9. 2013..S. Paratyphi A antigens identified by IVIAT warrant further evaluation for their contributions to pathogenesis and might have diagnostic, therapeutic, or preventive relevance... - In vivo expression of Salmonella enterica serotype Typhi genes in the blood of patients with typhoid fever in BangladeshAlaullah Sheikh
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
PLoS Negl Trop Dis 5:e1419. 2011..Salmonella enterica serotype Typhi is the cause of typhoid fever. It is a human-restricted pathogen, and few data exist on S. Typhi gene expression in humans... 
Non-typhoidal Salmonella gastroenteritis at a diarrheal hospital in Dhaka, Bangladesh, 1996-2011Daniel T Leung
Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
Am J Trop Med Hyg 88:661-9. 2013..NTS patients had increased inflammatory cells in stool and required more fluid resuscitation...- Interferon-γ and proliferation responses to Salmonella enterica Serotype Typhi proteins in patients with S. Typhi Bacteremia in Dhaka, BangladeshAlaullah Sheikh
International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
PLoS Negl Trop Dis 5:e1193. 2011..Cellular immune responses are required to control and clear Salmonella infection. Despite this, there are limited data on cellular immune responses in humans infected with wild type S. Typhi... - Changing emergence of Shigella sero-groups in bangladesh: observation from four different diarrheal disease hospitalsSumon Kumar Das
Centre for Nutrition and Food Security CNFS, International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
PLoS ONE 8:e62029. 2013..Shigellosis continues to be a public health challenge for developing countries, including Bangladesh. The aim of the study is to demonstrate recent changes in Shigella sero-groups and their geographical diversity...