David E Leaf

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery
    David E Leaf
    Division of Renal Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA Electronic address
    Kidney Int 89:939-48. 2016
  2. doi Excessive diagnostic testing in acute kidney injury
    David E Leaf
    Division of Renal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    BMC Nephrol 17:9. 2016
  3. pmc Cathelicidin antimicrobial protein, vitamin D, and risk of death in critically ill patients
    David E Leaf
    Division of Renal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    Crit Care 19:80. 2015
  4. doi Cathelicidin antimicrobial protein, vitamin D, and risk of death in critically ill patients
    David E Leaf
    Division of Renal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    Crit Care 19:812. 2015
  5. pmc Plasma catalytic iron, AKI, and death among critically ill patients
    David E Leaf
    Division of Renal Medicine, Brigham and Women s Hospital, Boston, Massachusetts and
    Clin J Am Soc Nephrol 9:1849-56. 2014
  6. pmc Dysregulated mineral metabolism in patients with acute kidney injury and risk of adverse outcomes
    David E Leaf
    Division of Nephrology, Columbia University Medical Center, New York, NY, USA
    Clin Endocrinol (Oxf) 79:491-8. 2013
  7. pmc FGF-23 levels in patients with AKI and risk of adverse outcomes
    David E Leaf
    Division of Nephrology, Columbia University, New York, New York, USA
    Clin J Am Soc Nephrol 7:1217-23. 2012
  8. doi Effect of vitamin D repletion on urinary calcium excretion among kidney stone formers
    David E Leaf
    Department of Medicine, Columbia University, New York, New York, USA
    Clin J Am Soc Nephrol 7:829-34. 2012
  9. pmc Plasma FGF23 levels increase rapidly after acute kidney injury
    Marta Christov
    1 Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA 2 Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Kidney Int 84:776-85. 2013
  10. doi Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury
    David E Leaf
    Department of Medicine, Columbia University, New York, NY, USA
    Nephrol Dial Transplant 25:1335-7. 2010

Detail Information

Publications17

  1. doi Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery
    David E Leaf
    Division of Renal Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA Electronic address
    Kidney Int 89:939-48. 2016
    ..Thus, cFGF23 levels rise early in AKI following cardiac surgery and are independently associated with adverse postoperative outcomes. ..
  2. doi Excessive diagnostic testing in acute kidney injury
    David E Leaf
    Division of Renal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    BMC Nephrol 17:9. 2016
    ..The patterns, performance characteristics, and yield of diagnostic tests ordered for the evaluation of acute kidney injury (AKI) have not been rigorously evaluated...
  3. pmc Cathelicidin antimicrobial protein, vitamin D, and risk of death in critically ill patients
    David E Leaf
    Division of Renal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    Crit Care 19:80. 2015
    ..However, few studies in humans have directly assessed plasma hCAP18 levels, and no study has evaluated the association between hCAP18 levels and adverse outcomes among critically ill patients...
  4. doi Cathelicidin antimicrobial protein, vitamin D, and risk of death in critically ill patients
    David E Leaf
    Division of Renal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    Crit Care 19:812. 2015
    ..However, few studies in humans have directly assessed plasma hCAP18 levels, and no study has evaluated the association between hCAP18 levels and adverse outcomes among critically ill patients...
  5. pmc Plasma catalytic iron, AKI, and death among critically ill patients
    David E Leaf
    Division of Renal Medicine, Brigham and Women s Hospital, Boston, Massachusetts and
    Clin J Am Soc Nephrol 9:1849-56. 2014
    ..Catalytic iron has been hypothesized to be a key mediator of AKI. However, the association between plasma catalytic iron levels and AKI has not been well studied in humans...
  6. pmc Dysregulated mineral metabolism in patients with acute kidney injury and risk of adverse outcomes
    David E Leaf
    Division of Nephrology, Columbia University Medical Center, New York, NY, USA
    Clin Endocrinol (Oxf) 79:491-8. 2013
    ..We evaluated the association between vitamin D metabolites and clinical outcomes among patients with AKI...
  7. pmc FGF-23 levels in patients with AKI and risk of adverse outcomes
    David E Leaf
    Division of Nephrology, Columbia University, New York, New York, USA
    Clin J Am Soc Nephrol 7:1217-23. 2012
    ..Whether fibroblast growth factor 23 levels are elevated and associated with adverse outcomes in patients with AKI has not been studied...
  8. doi Effect of vitamin D repletion on urinary calcium excretion among kidney stone formers
    David E Leaf
    Department of Medicine, Columbia University, New York, New York, USA
    Clin J Am Soc Nephrol 7:829-34. 2012
    ..This study examined the effect of vitamin D repletion on urinary calcium excretion among stone formers...
  9. pmc Plasma FGF23 levels increase rapidly after acute kidney injury
    Marta Christov
    1 Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA 2 Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Kidney Int 84:776-85. 2013
    ..Thus, circulating FGF23 levels rise rapidly during AKI in rodents and humans. In mice, this increase is independent of established modulators of FGF23 secretion. ..
  10. doi Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury
    David E Leaf
    Department of Medicine, Columbia University, New York, NY, USA
    Nephrol Dial Transplant 25:1335-7. 2010
    ..Here, we document, for the first time, elevated levels of FGF-23 in a patient with rhabdomyolysis-induced AKI...
  11. doi Increased plasma catalytic iron in patients may mediate acute kidney injury and death following cardiac surgery
    David E Leaf
    Division of Renal Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Kidney Int 87:1046-54. 2015
    ..Interventions aimed at reducing plasma catalytic iron levels as a strategy for preventing AKI in humans are warranted. ..
  12. pmc Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma
    David E Leaf
    Division of Renal Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 98:887-91. 2013
    ..Most cases of oncogenic osteomalacia have been associated with benign tumors of bone or soft tissue; however, whether malignant neoplasms can also produce and secrete FGF23 is currently unknown...
  13. pmc Randomized controlled trial of calcitriol in severe sepsis
    David E Leaf
    1 Division of Renal Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    Am J Respir Crit Care Med 190:533-41. 2014
    ..Vitamin D and its metabolites have potent immunomodulatory effects in vitro, including up-regulation of cathelicidin, a critical antimicrobial protein...
  14. doi Relationship between ICU design and mortality
    David E Leaf
    7 Dazian, Beth Israel Hospital, 1st Ave at 16th St, New York, NY 10003, USA
    Chest 137:1022-7. 2010
    ..Architectural design of health-care facilities can influence patient safety; however, it is unknown whether patient outcomes are significantly affected by ICU design...
  15. doi Impact of nonphysician staffing on outcomes in a medical ICU
    Hayley B Gershengorn
    Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Medical Center, New York, NY 10003, USA
    Chest 139:1347-53. 2011
    ..In our study, we compare outcomes of nonphysician provider-based teams to those of medical house staff-based teams in the MICU...
  16. doi Laxative abuse, eating disorders, and kidney stones: a case report and review of the literature
    David E Leaf
    Division of Renal Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Kidney Dis 60:295-8. 2012
    ..However, patients with underlying idiopathic hypercalciuria who develop eating disorders may be at increased risk of stone formation in the setting of low urine volume and therefore high supersaturation of calcium oxalate and phosphate...
  17. doi A physiologic-based approach to the evaluation of a patient with hyperphosphatemia
    David E Leaf
    Division of Renal Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Kidney Dis 61:330-6. 2013
    ..Finally, we illustrate how measurement of fibroblast growth factor 23 could be integrated in the future when the test becomes more widely available...