A Leaf

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Adenoviral gene transfer of Caenorhabditis elegans n--3 fatty acid desaturase optimizes fatty acid composition in mammalian cells
    Z B Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 98:4050-4. 2001
  2. ncbi request reprint Inhibitory effect of n-3 fish oil fatty acids on cardiac Na+/Ca2+ exchange currents in HEK293t cells
    Yong Fu Xiao
    Harvard Medical School, Boston, MA 02215, USA
    Biochem Biophys Res Commun 321:116-23. 2004
  3. ncbi request reprint Historical overview of n-3 fatty acids and coronary heart disease
    Alexander Leaf
    Massachusetts General Hospital and the Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 87:1978S-80S. 2008
  4. ncbi request reprint Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils
    Alexander Leaf
    Departments of Medicine, Massachusetts General Hospital, Boston, Mass, USA
    Circulation 107:2646-52. 2003
  5. ncbi request reprint Interactions of n-3 fatty acids with ion channels in excitable tissues
    A Leaf
    Department of Medicine, Massachusetts General Hospital, Charleston, MA 02129, USA
    Prostaglandins Leukot Essent Fatty Acids 67:113-20. 2002
  6. ncbi request reprint Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake
    Alexander Leaf
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 112:2762-8. 2005
  7. ncbi request reprint Membrane effects of the n-3 fish oil fatty acids, which prevent fatal ventricular arrhythmias
    A Leaf
    Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Membr Biol 206:129-39. 2005
  8. ncbi request reprint The electrophysiologic basis for the antiarrhythmic and anticonvulsant effects of n-3 polyunsaturated fatty acids: heart and brain
    A Leaf
    Department of Medicine, Massachusetts General Hospital, Boston 02129, USA
    Lipids 36:S107-10. 2001
  9. ncbi request reprint Diet and sudden cardiac death
    A Leaf
    Department of Medicine, Massachusetts General Hospital and the Harvard Medical School, Boston, MA, USA
    J Nutr Health Aging 5:173-8. 2001
  10. ncbi request reprint Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids
    Alexander Leaf
    Departments of Medicine, Massachusetts General Hospital and the Harvard Medical School, Boston, MA 02114, USA
    Fundam Clin Pharmacol 20:525-38. 2006

Research Grants

Detail Information

Publications30

  1. pmc Adenoviral gene transfer of Caenorhabditis elegans n--3 fatty acid desaturase optimizes fatty acid composition in mammalian cells
    Z B Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 98:4050-4. 2001
    ..This study demonstrates an effective approach to modifying fatty acid composition of mammalian cells and also provides a basis for potential applications of this gene transfer in experimental and clinical settings...
  2. ncbi request reprint Inhibitory effect of n-3 fish oil fatty acids on cardiac Na+/Ca2+ exchange currents in HEK293t cells
    Yong Fu Xiao
    Harvard Medical School, Boston, MA 02215, USA
    Biochem Biophys Res Commun 321:116-23. 2004
    ..Our data demonstrate that the n-3 PUFAs significantly suppress cardiac I(NCX1), which is probably one of their protective effects against lethal arrhythmias...
  3. ncbi request reprint Historical overview of n-3 fatty acids and coronary heart disease
    Alexander Leaf
    Massachusetts General Hospital and the Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 87:1978S-80S. 2008
    ..033). These studies demonstrate that fish oil fatty acids have beneficial effects on coronary heart disease...
  4. ncbi request reprint Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils
    Alexander Leaf
    Departments of Medicine, Massachusetts General Hospital, Boston, Mass, USA
    Circulation 107:2646-52. 2003
  5. ncbi request reprint Interactions of n-3 fatty acids with ion channels in excitable tissues
    A Leaf
    Department of Medicine, Massachusetts General Hospital, Charleston, MA 02129, USA
    Prostaglandins Leukot Essent Fatty Acids 67:113-20. 2002
    ..Our preliminary data seem to support this membrane tension hypothesis...
  6. ncbi request reprint Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake
    Alexander Leaf
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 112:2762-8. 2005
    ..Therefore, we hypothesized that these n-3 fatty acids might prevent potentially fatal ventricular arrhythmias in high-risk patients...
  7. ncbi request reprint Membrane effects of the n-3 fish oil fatty acids, which prevent fatal ventricular arrhythmias
    A Leaf
    Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Membr Biol 206:129-39. 2005
    ..Others and we have demonstrated that these membrane effects on the heart can prevent fatal cardiac arrhythmias in humans...
  8. ncbi request reprint The electrophysiologic basis for the antiarrhythmic and anticonvulsant effects of n-3 polyunsaturated fatty acids: heart and brain
    A Leaf
    Department of Medicine, Massachusetts General Hospital, Boston 02129, USA
    Lipids 36:S107-10. 2001
    ..Evidence of important beneficial neurological effects of dietary n-3 PUFA are emerging with more likely to be discovered...
  9. ncbi request reprint Diet and sudden cardiac death
    A Leaf
    Department of Medicine, Massachusetts General Hospital and the Harvard Medical School, Boston, MA, USA
    J Nutr Health Aging 5:173-8. 2001
    ..With some 250,000 deaths occurring within one hour of the onset of acute myocardial infarctions annually in the USA alone and millions more in the whole world, the potential large public health benefit from this understanding is evident...
  10. ncbi request reprint Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids
    Alexander Leaf
    Departments of Medicine, Massachusetts General Hospital and the Harvard Medical School, Boston, MA 02114, USA
    Fundam Clin Pharmacol 20:525-38. 2006
    ..The results of this study and the mechanisms by which the n-3 fish oil fatty acids prevent fatal cardiac arrhythmias will be the subject of this review...
  11. ncbi request reprint Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids
    Alexander Leaf
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Pharmacol Ther 98:355-77. 2003
    ..An attempt to show the place of the PUFAs in human nutrition during the 2-4 million years of our evolution will conclude the review...
  12. ncbi request reprint Omega-3 fatty acids and prevention of arrhythmias
    Alexander Leaf
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Lipidol 18:31-4. 2007
    ..There is now a considerable factual basis from laboratory and clinical trials that omega-3 fatty acids of fish oil will prevent fatal arrhythmias in animals and humans and this is the focus of the review...
  13. ncbi request reprint Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids
    Alexander Leaf
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Cardiovasc Med (Hagerstown) 8:S27-9. 2007
    ..The results of this study and the mechanisms by which n-3 fish oil fatty acids prevent fatal cardiac arrhythmias will be the subject of this review...
  14. ncbi request reprint Fish oil fatty acids as cardiovascular drugs
    Alexander Leaf
    Departments of Medicine, aMassachusetts General Hospital, Boston, MA, USA
    Curr Vasc Pharmacol 6:1-12. 2008
    ..The bold, underlined abbreviation will appear in the text to identify the fatty acid being discussed...
  15. ncbi request reprint Coexpression with beta(1)-subunit modifies the kinetics and fatty acid block of hH1(alpha) Na(+) channels
    Y F Xiao
    Charles A Dana Research Institute and Harvard Thorndike Laboratory, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Am J Physiol Heart Circ Physiol 279:H35-46. 2000
    ..Our data demonstrate that functional association of beta(1)-subunit with hH1(alpha) modifies the kinetics and fatty acid block of the Na(+) channel...
  16. pmc Regulation of sodium channel gene expression by class I antiarrhythmic drugs and n - 3 polyunsaturated fatty acids in cultured neonatal rat cardiac myocytes
    J X Kang
    Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston 02114, USA
    Proc Natl Acad Sci U S A 94:2724-8. 1997
    ..These data demonstrate that chronic EPA treatment not only does not up-regulate the cardiac sodium channel expression but also reduces the mexiletine-induced increase in the cardiac sodium channel expression...
  17. ncbi request reprint Point mutations in alpha-subunit of human cardiac Na+ channels alter Na+ current kinetics
    Y F Xiao
    Charles A Dana Research Institute and Harvard Thorndike Laboratory, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Biochem Biophys Res Commun 281:45-52. 2001
    ..The effects of PUFAs on these mutant channels will be the subject of subsequent reports...
  18. ncbi request reprint Partitioning of polyunsaturated fatty acids, which prevent cardiac arrhythmias, into phospholipid cell membranes
    E M Pound
    Department of Medicine, Massachusetts General Hospital and the Harvard Medical School, Boston, MA 02114, USA
    J Lipid Res 42:346-51. 2001
    ..Pound, E. M., J. X. Kang, and A. Leaf. Partitioning of polyunsaturated fatty acids, which prevent cardiac arrhythmias, into phospholipid cell membranes. J. Lipid Res. 2001. 42: 346--351...
  19. pmc Evidence that free polyunsaturated fatty acids modify Na+ channels by directly binding to the channel proteins
    J X Kang
    Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 93:3542-6. 1996
    ....
  20. pmc Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acid
    J X Kang
    Medical Services, Massachusetts General Hospital East, 149 13th Street, Fourth Floor, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 94:13671-6. 1997
    ....
  21. ncbi request reprint Omega-3 fatty acids and ventricular arrhythmias
    Alexander Leaf
    Department of Medicine, Massachusetts General Hospital, Boston, Mass, USA
    World Rev Nutr Diet 94:129-38. 2005
  22. pmc Retinoic acid alters the intracellular trafficking of the mannose-6-phosphate/insulin-like growth factor II receptor and lysosomal enzymes
    J X Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 95:13687-91. 1998
    ..Therefore, our observations may have important implications for the understanding of the diverse biological effects of retinoids...
  23. ncbi request reprint Electrophysiologic properties of lidocaine, cocaine, and n-3 fatty-acids block of cardiac Na+ channels
    Yong Fu Xiao
    Department of Medicine, Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Eur J Pharmacol 485:31-41. 2004
    ....
  24. pmc Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels
    Y F Xiao
    The Charles A. Dana Research Institute and Harvard-Thorndike Laboratory, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 98:3606-11. 2001
    ..Therefore, asparagine at the 406 site in hH1(alpha) may be important for the inhibition by the PUFAs of cardiac voltage-gated Na(+) currents, which play a significant role in the antiarrhythmic actions of PUFAs...
  25. ncbi request reprint Prevention of fatal cardiac arrhythmias by polyunsaturated fatty acids
    Alexander Leaf
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    Nutr Health 16:47-9. 2002
  26. ncbi request reprint Potent block of inactivation-deficient Na+ channels by n-3 polyunsaturated fatty acids
    Yong Fu Xiao
    Charles A Dana Research Institute and Harvard Thorndike Laboratory, and Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, USA
    Am J Physiol Cell Physiol 290:C362-70. 2006
    ..Our data demonstrate that the double mutations at the 409 and 410 sites in the D1-S6 region of hH1(alpha) induce inactivation-deficient I(Na) and that n-3 PUFAs inhibit mutant I(Na)...
  27. ncbi request reprint On the reanalysis of the GISSI-Prevenzione
    Alexander Leaf
    Circulation 105:1874-5. 2002
  28. ncbi request reprint Why the omega-3 piggy should go to market
    Jing X Kang
    Nat Biotechnol 25:505-6; author reply 506. 2007
  29. ncbi request reprint Omega-3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research: a report from the National Heart, Lung, and Blood Institute and Office Of Dietary Supplements Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesi
    Barry London
    Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S 572, 200 Lothrop St, Pittsburgh, PA 15213 2582, USA
    Circulation 116:e320-35. 2007
  30. ncbi request reprint Conclusions and recommendations from the symposium, Beyond Cholesterol: Prevention and Treatment of Coronary Heart Disease with n-3 Fatty Acids
    Richard J Deckelbaum
    Institute of Human Nutrition, Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA
    Am J Clin Nutr 87:2010S-2S. 2008
    ..Additional references for these conclusions can be found in the articles included in the supplement...

Research Grants3

  1. HOW DIETARY N-3 FATTY ACIDS PREVENT FATAL ARRHYTHMIAS
    Alexander Leaf; Fiscal Year: 1999
    ..abstract_text> ..
  2. HOW DIETARY N-3 FATTY ACIDS PREVENT FATAL ARRHYTHMIAS
    Alexander Leaf; Fiscal Year: 2000
    ..abstract_text> ..
  3. HOW DIETARY N-3 FATTY ACIDS PREVENT FATAL ARRHYTHMIAS
    Alexander Leaf; Fiscal Year: 2001
    ..abstract_text> ..