G Y Lauwers

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Long term survivors with metastatic pancreatic adenocarcinoma treated with gemcitabine: a retrospective analysis
    Bernardo H L Goulart
    Division of Hematology Oncology, Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Hematol Oncol 2:13. 2009
  2. pmc Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor
    Tsutomu Fujii
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA
    BMC Gastroenterol 10:79. 2010
  3. pmc Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma
    Vikram Deshpande
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    BMC Cancer 11:60. 2011
  4. doi request reprint Novel endoscopic therapeutic modalities for superficial neoplasms arising in Barrett's esophagus: a primer for surgical pathologists
    Gregory Y Lauwers
    Gastrointestinal Pathology Unit, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 USA
    Mod Pathol 22:489-98. 2009
  5. ncbi request reprint Endoscopic mucosal resection for gastric epithelial neoplasms: a study of 39 cases with emphasis on the evaluation of specimens and recommendations for optimal pathologic analysis
    Gregory Y Lauwers
    Department of Pathology, Gastrointestinal Pathology Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Mod Pathol 17:2-8. 2004
  6. ncbi request reprint Gastric preneoplastic lesions and epithelial dysplasia
    Gregory Y Lauwers
    Department of Pathology, Massachusetts General Hospital, Gastrointestinal Pathology Service, 55 Fruit Street, Warren 2, Boston, MA 02114 2696, USA
    Gastroenterol Clin North Am 36:813-29, vi. 2007
  7. doi request reprint Pathology of non-Helicobacter pylori gastritis: extending the histopathologic horizons
    Gregory Y Lauwers
    Gastrointestinal Pathology Service, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street WRN 2, Boston, MA 02114 2696, USA
    J Gastroenterol 45:131-45. 2010
  8. ncbi request reprint Defining the pathologic diagnosis of metaplasia, atrophy, dysplasia, and gastric adenocarcinoma
    Gregory Y Lauwers
    Department of Pathology, Massachusetts General Hospital WRN 2, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Gastroenterol 36:S37-43; discussion S61-2. 2003
  9. ncbi request reprint Prognostic histologic indicators of curatively resected hepatocellular carcinomas: a multi-institutional analysis of 425 patients with definition of a histologic prognostic index
    Gregory Y Lauwers
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Surg Pathol 26:25-34. 2002
  10. ncbi request reprint Cytoskeletal and kinetic epithelial differences between NSAID gastropathy and Helicobacter pylori gastritis: an immunohistochemical determination
    G Y Lauwers
    James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Histopathology 39:133-40. 2001

Detail Information

Publications99

  1. pmc Long term survivors with metastatic pancreatic adenocarcinoma treated with gemcitabine: a retrospective analysis
    Bernardo H L Goulart
    Division of Hematology Oncology, Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Hematol Oncol 2:13. 2009
    ..However, a subgroup of patients survives more than 1 year. We analyzed the survival outcomes of this subgroup and evaluated clinical and pathological factors that might affect survival durations...
  2. pmc Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor
    Tsutomu Fujii
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA
    BMC Gastroenterol 10:79. 2010
    ..The carbon tetrachloride (CCl4)-induced mouse model has been historically relied upon to study liver injury and regeneration. We exposed mice to CCl4 to assess whether EGF and CD133+ HSCs are up-regulated in chronically injured liver...
  3. pmc Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma
    Vikram Deshpande
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    BMC Cancer 11:60. 2011
    ..The genetics of advanced biliary tract cancers (BTC), which encompass intra- and extra-hepatic cholangiocarcinomas as well as gallbladder carcinomas, are heterogeneous and remain to be fully defined...
  4. doi request reprint Novel endoscopic therapeutic modalities for superficial neoplasms arising in Barrett's esophagus: a primer for surgical pathologists
    Gregory Y Lauwers
    Gastrointestinal Pathology Unit, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 USA
    Mod Pathol 22:489-98. 2009
    ....
  5. ncbi request reprint Endoscopic mucosal resection for gastric epithelial neoplasms: a study of 39 cases with emphasis on the evaluation of specimens and recommendations for optimal pathologic analysis
    Gregory Y Lauwers
    Department of Pathology, Gastrointestinal Pathology Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Mod Pathol 17:2-8. 2004
    ..Based on our experience, we offer some recommendations in order to provide optimal pathologic analysis of endoscopic mucosal resection specimens...
  6. ncbi request reprint Gastric preneoplastic lesions and epithelial dysplasia
    Gregory Y Lauwers
    Department of Pathology, Massachusetts General Hospital, Gastrointestinal Pathology Service, 55 Fruit Street, Warren 2, Boston, MA 02114 2696, USA
    Gastroenterol Clin North Am 36:813-29, vi. 2007
    ..This article describes gastric preneoplastic lesions and epithelial dysplasia. The possible role of Helicobacter pylori infection is emphasized...
  7. doi request reprint Pathology of non-Helicobacter pylori gastritis: extending the histopathologic horizons
    Gregory Y Lauwers
    Gastrointestinal Pathology Service, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street WRN 2, Boston, MA 02114 2696, USA
    J Gastroenterol 45:131-45. 2010
    ..pylori) gastritis. In this review, we present major clinico-pathological entities, based on either the salient morphological features or the underlying etiologies...
  8. ncbi request reprint Defining the pathologic diagnosis of metaplasia, atrophy, dysplasia, and gastric adenocarcinoma
    Gregory Y Lauwers
    Department of Pathology, Massachusetts General Hospital WRN 2, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Gastroenterol 36:S37-43; discussion S61-2. 2003
    ..We review the histopathologic steps that predate the development of gastric cancer and evaluate the risks of transformation that they confer...
  9. ncbi request reprint Prognostic histologic indicators of curatively resected hepatocellular carcinomas: a multi-institutional analysis of 425 patients with definition of a histologic prognostic index
    Gregory Y Lauwers
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Surg Pathol 26:25-34. 2002
    ..The combination of these histologic parameters provides adequate prognostic stratification...
  10. ncbi request reprint Cytoskeletal and kinetic epithelial differences between NSAID gastropathy and Helicobacter pylori gastritis: an immunohistochemical determination
    G Y Lauwers
    James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Histopathology 39:133-40. 2001
    ..In an attempt to clarify this question we investigated the differences in the structural cytoskeleton and proliferative activity of these two gastropathies...
  11. ncbi request reprint Cytokeratins 7 and 20 and mucin core protein expression in esophageal cervical inlet patch
    Gregory Y Lauwers
    Gastrointestinal Pathology Service, Department of Pathology, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 29:437-42. 2005
    ..Two pathogenetic pathways can be entertained: focal upper esophageal mucosal misdevelopment in pediatric population and patchy metaplastic replacement of squamous mucosa in adults with gastroesophageal reflux disease...
  12. doi request reprint Gastric hyperplastic polyps: a heterogeneous clinicopathologic group including a distinct subset best categorized as mucosal prolapse polyp
    Elvira Gonzalez-Obeso
    Department, Hospital General de Ciudad Real, Ciudad Real, Spain
    Am J Surg Pathol 35:670-7. 2011
    ..Gastric hyperplastic polyps are the second most common subtype of gastric polyps. There has been an ongoing debate about their precise diagnostic criteria and etiological associations...
  13. ncbi request reprint Dysplasia as a predictive marker for invasive carcinoma in Barrett esophagus: a follow-up study based on 138 cases from a diagnostic variability study
    E Montgomery
    Department of Pathology, The Johns Hopkins University, Baltimore, MD 21205, USA
    Hum Pathol 32:379-88. 2001
    ..Rebiopsy of ulcerated areas should be considered because they may harbor malignancy. Histologic grading of dysplasia using established criteria is a powerful prognosticator in BE. HUM PATHOL 32:379-388...
  14. ncbi request reprint Histopathology of Barrett's esophagus after ablation and endoscopic mucosal resection therapy
    R D Odze
    Gastrointestinal Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Endoscopy 40:1008-15. 2008
    ..On the other hand, anecdotal reports have suggested that buried dysplasia may progress to cancer in some instances...
  15. doi request reprint Gastric epithelial dysplasia: the Western perspective
    A Srivastava
    Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Dig Liver Dis 40:641-9. 2008
    ..However, the novel imaging and endoscopic modalities have modified management strategies with mucosal lesions amenable to endoscopic resection, while surgical resection is reserved to invasive adenocarcinoma with submucosal invasion...
  16. doi request reprint Effect of tumor characteristics and duplication of the muscularis mucosae on the endoscopic staging of superficial Barrett esophagus-related neoplasia
    Rajni V Mandal
    Department of Pathology, Gastrointestinal Pathology Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 33:620-5. 2009
    ..EUS alone is not sufficient for staging these neoplasms precisely, and to accurately stratify patients into different treatment arms, EMR should play a role as a complementary staging modality...
  17. ncbi request reprint Loss of cell polarity protein Lgl2 in foveolar-type gastric dysplasia: correlation with expression of the apical marker aPKC-zeta
    Mikhail Lisovsky
    Department of Pathology, UMassMemorial Medical Center and University of Massachusetts Medical School, Worcester, MA, USA
    Virchows Arch 457:635-42. 2010
    ..aPKC-zeta had moderate sensitivity as a marker of gastric dysplasia and additional studies are needed to establish its role in the diagnosis of dysplasia...
  18. pmc Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer
    Lei Xu
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 69:7905-10. 2009
    ..These data show that VEGF blockade up-regulates inflammatory pathways and NRP1, which should be evaluated as potential targets for improving anti-VEGF therapy...
  19. ncbi request reprint Autoimmune pancreatitis-related cholecystitis: a morphologically and immunologically distinctive form of lymphoplasmacytic sclerosing cholecystitis
    Wei Lia Wang
    The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Histopathology 54:829-36. 2009
    ..The aim was to identify unique morphological and immunological features that could help distinguish gallbladders of AIP from those associated with PSC and PDACs...
  20. ncbi request reprint IgG4+ to IgG+ plasma cells ratio of ampulla can help differentiate autoimmune pancreatitis from other "mass forming" pancreatic lesions
    Alireza Sepehr
    Department of Pathology, Gastrointestinal Pathology Service, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 32:1770-9. 2008
    ..In conclusion, evaluation of ampullary histology and IgG4/IgG ratio might be proven beneficial in discriminating AIP from other mass forming pancreatic lesions...
  21. doi request reprint Adenomatous and foveolar gastric dysplasia: distinct patterns of mucin expression and background intestinal metaplasia
    Do Youn Park
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Am J Surg Pathol 32:524-33. 2008
    ..4%) of GED (P = 0.005 for both comparisons). In conclusion, our study indicates that foveolar and adenomatous types of GED have distinct clinicopathologic features, mucin profiles, and association with different types of IM...
  22. ncbi request reprint EMR for Barrett's esophagus-related superficial neoplasms offers better diagnostic reproducibility than mucosal biopsy
    Mari Mino-Kenudson
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Gastrointest Endosc 66:660-6; quiz 767, 769. 2007
    ..It also allows for better pathologic grading compared with mucosal biopsy specimens. However, the interobserver variation in the interpretation of EMR specimens has not been tested...
  23. ncbi request reprint Autoimmune pancreatitis: a systemic immune complex mediated disease
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 30:1537-45. 2006
    ..Documentation of increased numbers of tissue IgG4 positive plasma cells, although not an entirely specific marker for AIP, may provide ancillary evidence for the diagnosis of a IgG4-related systemic disease...
  24. ncbi request reprint Endoscopic mucosal resection: an improved diagnostic procedure for early gastroesophageal epithelial neoplasms
    Mindy J Hull
    Department of Pathology, Gastrointestinal Pathology Service, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 30:114-8. 2006
    ..EMR can substantially modify the diagnostic grade of a lesion and therefore facilitate optimal therapeutic decisions by avoiding undertreatment and overtreatment based on inaccurate grading and staging...
  25. pmc The Cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer
    Do Youn Park
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Pathol 171:1509-19. 2007
    ..Loss of Cables expression in 65% of CRCs suggests that it is a common event in colonic carcinogenesis, with promoter methylation and LOH appearing to be important mechanisms of Cables gene inactivation...
  26. ncbi request reprint Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagus
    Marie E Robert
    Department of Pathology, Yale University, New Haven, CT 06520, USA
    Am J Clin Pathol 124:519-27. 2005
    ..Rab11a immunoreactivity did not enhance the diagnostic assessment of dysplasia in Barrett esophagus. The previously reported positive correlation of p53 immunoreactivity with the presence of dysplasia in Barrett esophagus was confirmed...
  27. ncbi request reprint Cellular kinetics in Barrett's epithelium carcinogenic sequence: roles of apoptosis, bcl-2 protein, and cellular proliferation
    G Y Lauwers
    Department of Pathology, University of Florida College of Medicine, Gainesville 32610 0275, USA
    Mod Pathol 10:1201-8. 1997
    ..We confirm the upward shift of cellular proliferation in dysplastic epithelia. Apoptosis that is increased in dysplasia might play a significant role in carcinogenesis by restraining increased cellular proliferation...
  28. ncbi request reprint Buried dysplasia and early adenocarcinoma arising in barrett esophagus after porfimer-photodynamic therapy
    Mari Mino-Kenudson
    Department of Pathology, Gastrointestinal Pathology Service, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Am J Surg Pathol 31:403-9. 2007
    ..Thorough endoscopic surveillance with extensive biopsies, especially of the sites previously positive for neoplasia is important to avoid overlooking buried neoplasms that may progress...
  29. pmc Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia
    Oliver Strobel
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 138:1166-77. 2010
    ..A majority of PanIN are thought to arise from ducts. We identified a novel ductal compartment that is gathered in gland-like outpouches (pancreatic duct glands [PDG]) of major ducts and characterized its role in injury and metaplasia...
  30. ncbi request reprint Alpha-CTLA-4 mAb-associated panenteritis: a histologic and immunohistochemical analysis
    Darryl A Oble
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Am J Surg Pathol 32:1130-7. 2008
    ....
  31. ncbi request reprint Case records of the Massachusetts General Hospital. Case 10-2006. A 66-year-old woman with Barrett's esophagus with high-grade dysplasia
    Norman S Nishioka
    Gastrointestinal Unit, Massachusetts General Hospital, USA
    N Engl J Med 354:1403-9. 2006
  32. doi request reprint Serous cystadenoma of the pancreas: limitations and pitfalls of endoscopic ultrasound-guided fine-needle aspiration biopsy
    Nicole A Belsley
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer 114:102-10. 2008
    ..In the current study, the authors evaluated the diagnostic sensitivity of endoscopic ultrasound (EUS)-guided fine-needle aspiration biopsy (FNAB) and cross-sectional imaging for SCA...
  33. ncbi request reprint Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 29:381-9. 2005
    ..Although p63 and AMACR are also specific for pancreatic adenocarcinoma, their low sensitivity limits their use in clinical practice...
  34. doi request reprint CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance
    Do Youn Park
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Mod Pathol 23:54-61. 2010
    ....
  35. ncbi request reprint Detection of high-grade dysplasia in Barrett's esophagus by spectroscopy measurement of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence
    Stephan Brand
    Gastrointestinal Unit, Wellman Laboratories of Photomedicine, Boston, Massachusetts, USA
    Gastrointest Endosc 56:479-87. 2002
    ..This study used quantitative methods to determine whether aminolevulinic acid-induced protoporphyrin IX fluorescence can differentiate between Barrett's mucosa with and without dysplasia...
  36. doi request reprint The rectal tonsil: a reactive lymphoid proliferation that may mimic lymphoma
    Alton B Farris
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 32:1075-9. 2008
    ..In conclusion, RT, with its distinctive features, is an important entity to recognize. Familiarity with the range of histologic features characteristic of the RT is critical in avoiding misinterpretation as lymphoma...
  37. pmc Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
    Christopher G Willett
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Med 10:145-7. 2004
    ..These data indicate that VEGF blockade has a direct and rapid antivascular effect in human tumors...
  38. pmc Branch-duct intraductal papillary mucinous neoplasms: observations in 145 patients who underwent resection
    J Ruben Rodriguez
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 133:72-9; quiz 309-10. 2007
    ..This study describes the combined experience of 2 tertiary centers with branch-duct IPMNs aiming to validate these recommendations...
  39. ncbi request reprint Gastrointestinal manifestations of dermatologic disorders
    Helen M Shields
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    Clin Gastroenterol Hepatol 5:1010-7; quiz 1005-6. 2007
    ..Advances in molecular genetics that provide insight into the underlying pathophysiology and histopathology of these lesions are highlighted...
  40. pmc Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine
    Melissa J Suter
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastrointest Endosc 71:346-53. 2010
    ..When deployed through a balloon-centering catheter, OFDI can automatically image the entire distal esophagus (6.0 cm length) in approximately 2 minutes...
  41. ncbi request reprint Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with autoimmune pancreatocentric disease
    Lynn D Cornell
    Departments of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 31:1586-97. 2007
    ....
  42. ncbi request reprint Autoimmune pancreatitis: imaging features
    Dushyant V Sahani
    Department of Radiology, Massachusetts General Hospital, White Bldg 270F, 55 Fruit St, Boston MA 02114, USA
    Radiology 233:345-52. 2004
    ..To retrospectively determine imaging findings in patients with autoimmune pancreatitis...
  43. ncbi request reprint Cystic neoplasms of the pancreas
    William R Brugge
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 351:1218-26. 2004
  44. pmc Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
    Dawang Zhou
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Cell 16:425-38. 2009
    ..Approximately 30% of human HCCs show low Yap1(Ser127) phosphorylation and a majority exhibit loss of cleaved, activated Mst1. Mst1/2 inhibition of Yap1 is an important pathway for tumor suppression in liver relevant to human HCC...
  45. ncbi request reprint Morphologic features are useful in distinguishing Barrett esophagus from carditis with intestinal metaplasia
    Amitabh Srivastava
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 31:1733-41. 2007
    ..Larger prospective studies need to be performed to validate these findings and evaluate the reproducibility of this approach in routine clinical practice...
  46. pmc Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    Sarah P Thayer
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 425:851-6. 2003
    ..These data suggest that this pathway may have an early and critical role in the genesis of this cancer, and that maintenance of hedgehog signalling is important for aberrant proliferation and tumorigenesis...
  47. ncbi request reprint Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study
    Mikhail Lisovsky
    Department of Pathology, UMass Memorial Medical Center, University of Massachusetts Medical School, Worcester, MA, USA
    Mod Pathol 22:977-84. 2009
    ..However, the consistently negative anti-Lgl2 immunoreactivity seen in intestinal metaplasia does not allow differentiation of dysplasia from intestinal metaplasia with reactive change...
  48. pmc Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging
    Melissa J Suter
    Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital Boston, Massachusetts 02114, USA
    Gastrointest Endosc 68:745-53. 2008
    ..The clinical utility of OCT has been limited, however, by its inability to acquire images over large areas...
  49. ncbi request reprint Defective mismatch repair in the pathogenesis of low-grade appendiceal mucinous neoplasms and adenocarcinomas
    Joseph Misdraji
    James Homer Wright Pathology Laboratories at the Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mod Pathol 17:1447-54. 2004
    ..Defective DNA mismatch was found in 11% of invasive carcinomas, likely due to a germline mutation. These findings suggest that sporadic appendiceal neoplasia rarely arises through the defective DNA mismatch repair (mutator) pathway...
  50. doi request reprint IgG4-associated cholangitis: a comparative histological and immunophenotypic study with primary sclerosing cholangitis on liver biopsy material
    Vikram Deshpande
    The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Mod Pathol 22:1287-95. 2009
    ..On a liver biopsy, the histological features of IgG4-associated cholangitis may be distinctive, and in conjunction with IgG4 immunohistochemical stain, may help distinguish this disease from primary sclerosing cholangitis...
  51. ncbi request reprint Gastric epithelial dysplasia
    Joseph Misdraji
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Semin Diagn Pathol 19:20-30. 2002
    ..We also discuss new classifications of gastric epithelial dysplasia designed to develop equivalence between grading schemes worldwide...
  52. ncbi request reprint Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis
    Kenneth K Tanabe
    Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
    JAMA 299:53-60. 2008
    ..Overexpression of epidermal growth factor (EGF) in the liver induces transformation to hepatocellular carcinoma in animal models. Polymorphisms in the EGF gene modulate EGF levels...
  53. doi request reprint En bloc esophageal mucosectomy for concentric circumferential mucosal resection (with video)
    Field F Willingham
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastrointest Endosc 69:147-51. 2009
    ..With conventional EMR, specimens are fragmented, metaplasia may be left behind, and invasive lesions could be missed because of incomplete sampling. Concentric subtotal esophageal mucosectomy would address these limitations...
  54. pmc Comprehensive imaging of gastroesophageal biopsy samples by spectrally encoded confocal microscopy
    DongKyun Kang
    Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastrointest Endosc 71:35-43. 2010
    ....
  55. ncbi request reprint Iatrogenic Trichuris suis infection in a patient with Crohn disease
    Richard L Kradin
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Pathol Lab Med 130:718-20. 2006
    ..This report examines the morphology of the immature and adult T suis, the effects of this intervention on the immunophenotype of the bowel mucosa, and it also raises the possibility of persistent active infection in man...
  56. pmc Optical coherence tomography to identify intramucosal carcinoma and high-grade dysplasia in Barrett's esophagus
    John A Evans
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Clin Gastroenterol Hepatol 4:38-43. 2006
    ..The purpose of this study was to establish OCT image characteristics of IMC and HGD in Barrett's esophagus...
  57. ncbi request reprint Endoscopic ultrasound guided fine needle aspiration biopsy of autoimmune pancreatitis: diagnostic criteria and pitfalls
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
    Am J Surg Pathol 29:1464-71. 2005
    ....
  58. ncbi request reprint The Cables gene on chromosome 18Q regulates colon cancer progression in vivo
    Sandra D Kirley
    Department of Urology, Massachusetts General Hospital, Boston 02114, USA
    Cancer Biol Ther 4:861-3. 2005
    ..These data coupled with previous observations support the hypothesis that Cables is a relevant target of the chromosome 18q deletions frequently seen in human colorectal cancer...
  59. ncbi request reprint Intraductal papillary mucinous neoplasm of pancreas: multi-detector row CT with 2D curved reformations--correlation with MRCP
    Dushyant V Sahani
    Department of Abdominal Imaging and Interventions, Massachusetts General Hospital, 55 Fruit St, White 270, Boston, MA 02114, USA
    Radiology 238:560-9. 2006
    ....
  60. doi request reprint Subclassification of autoimmune pancreatitis: a histologic classification with clinical significance
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Am J Surg Pathol 35:26-35. 2011
    ..On the basis of these significant differences between the 2 types of AIP, we advocate the position that all subsequent studies attempt to substratify their patients into these 2 groups...
  61. ncbi request reprint Autoimmune pancreatitis: more than just a pancreatic disease? A contemporary review of its pathology
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Pathol Lab Med 129:1148-54. 2005
    ..Autoimmune pancreatitis (AIP) is a chronic inflammatory condition of the pancreas constituting one quarter of Whipple resections performed for benign conditions in North America...
  62. ncbi request reprint Case records of the Massachusetts General Hospital. Case 23-2005. A 57-year-old man with a mass in the liver
    Kenneth K Tanabe
    Department of Surgical Oncology, Massachusetts General Hospital, USA
    N Engl J Med 353:401-10. 2005
  63. ncbi request reprint Management of superficial Barrett's epithelium-related neoplasms by endoscopic mucosal resection: clinicopathologic analysis of 27 cases
    Mari Mino-Kenudson
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 29:680-6. 2005
    ..This is a significant advantage since it can modify patients' management. However, frequent incompleteness of resection and high persistence/recurrence are significant pitfalls that dictate continued endoscopic surveillance...
  64. ncbi request reprint Are ulcers a marker for invasive carcinoma in Barrett's esophagus? Data from a diagnostic variability study with clinical follow-up
    Elizabeth Montgomery
    Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Gastroenterol 97:27-31. 2002
    ..We correlated follow-up information from 138 patients with Barrett's esophagus and varying degrees of dysplasia with the presence of ulcers...
  65. ncbi request reprint The clinical significance of incidental chronic colitis: a study of 17 cases
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Am J Surg Pathol 34:463-9. 2010
    ..In this study, we report the clinical, histologic, and follow-up data on 17 cases of histologically documented cases of chronic colitis in which a definitive etiologic factor could not be identified...
  66. ncbi request reprint Cystic pancreatic endocrine tumor: a variant commonly confused with cystic adenocarcinoma
    Vikram Deshpande
    Department of Pathology, Cytology and Gastrointestinal Pathology Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer 111:47-53. 2007
    ..In the authors' experience, FNAB of cystic pancreatic endocrine tumors (PETs) frequently causes diagnostic difficulties, partly because of unexpected overlapping features with cystic ductal adenocarcinomas...
  67. ncbi request reprint Histopathologic aspects of photodynamic therapy for dysplasia and early adenocarcinoma arising in Barrett's esophagus
    Shinichi Ban
    Department of Pathology, Gastrointestinal Pathology Service, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    Am J Surg Pathol 28:1466-73. 2004
    ..The higher than expected incidence of buried residual neoplastic epithelium should also be emphasized since it represents a risk for undetected growth of malignancy...
  68. ncbi request reprint Protocol for the examination of specimens from patients with invasive carcinomas of the appendix
    Joseph Misdraji
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Pathol Lab Med 130:1433-9. 2006
  69. ncbi request reprint Eosinophilic gastroenteritis associated with systemic lupus erythematosus
    David A Barbie
    Department of Internal Medicine, Massachusetts General Hospital, Boston, MA, USA
    J Clin Gastroenterol 38:883-6. 2004
    ..This is the first report to our knowledge of an individual with eosinophilic gastroenteritis and systemic lupus erythematosus...
  70. pmc Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
    Nabeel Bardeesy
    Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 20:3130-46. 2006
    ....
  71. pmc Identifying intestinal metaplasia at the squamocolumnar junction by using optical coherence tomography
    John A Evans
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastrointest Endosc 65:50-6. 2007
    ..The accuracy of OCT for differentiating tissue types at the squamocolumnar junction (SCJ) has not been established...
  72. ncbi request reprint Chronic sclerosing sialadenitis (K├╝ttner tumor) is an IgG4-associated disease
    Julia Turbiner Geyer
    Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 34:202-10. 2010
    ....
  73. pmc Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations
    David C Wilbur
    Department of Pathology, James Homer Wright Pathology Laboratories, Massachusetts General Hospital, and the Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
    Arch Pathol Lab Med 133:1949-53. 2009
    ..Before implementation, technical issues, pathologist adaptability, and morphologic pitfalls must be well characterized...
  74. pmc Co-registered spectrally encoded confocal microscopy and optical frequency domain imaging system
    D K Kang
    Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Microsc 239:87-91. 2010
    ....
  75. ncbi request reprint Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation
    H Beppu
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Oncogene 27:1063-70. 2008
    ..These results demonstrate that genetic mutations altering the BMP signaling pathway in the stromal microenvironment can lead to epithelial tumors in the colon...
  76. ncbi request reprint Pathological aspects of hepatocellular carcinoma: a critical review of prognostic factors
    G Y Lauwers
    Department of Pathology, University of Florida, Gainesville, USA
    Hepatogastroenterology 45:1197-202. 1998
    ..We review herein the pathological factors that are currently recorded at specialized centers and analyze their value as prognostic indicators for patients with HCC...
  77. ncbi request reprint Pathology of non-infective gastritis
    A Srivastava
    Department of Pathology, Dartmouth Hitchcock Medical Center and Dartmouth Medical School, Lebanon, NH, USA
    Histopathology 50:15-29. 2007
    ..e. iatrogenic, autoimmune, vascular or idiopathic...
  78. ncbi request reprint Reproducibility of the diagnosis of dysplasia in Barrett esophagus: a reaffirmation
    E Montgomery
    Department of Pathology, The Johns Hopkins University, Baltimore, MD 21205, USA
    Hum Pathol 32:368-78. 2001
    ..The criteria used by the group are presented. HUM PATHOL 32:368-978...
  79. ncbi request reprint Natural orifice transesophageal mediastinoscopy and thoracoscopy
    F F Willingham
    Department of Medicine, Gastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114 3117, USA
    Surg Endosc 22:1042-7. 2008
    ..In addition NOTES esophageal access routes also have the potential to replace conventional thoracoscopic approaches for medial or hilar lesions...
  80. ncbi request reprint Pathologic spectrum and prognostic significance of underlying liver disease in hepatocellular carcinoma
    Mari Mino
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Surg Oncol Clin N Am 12:13-24. 2003
    ..Finally, the importance of vascular invasion, number of tumors, and tumor size of HCCs in addition to the effect of fibrosis has led Vauthey et al [20] to propose a simplified staging of HCC with better prognostication of survival...
  81. ncbi request reprint Surgically resected hepatocellular carcinoma: protean yet predictable
    Jean Nicolas Vauthey
    Ann Surg Oncol 12:270-2. 2005
  82. pmc Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas
    Eunice L Kwak
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Clin Cancer Res 12:4283-7. 2006
    ..Given recent reports of TKI-responsive cases of esophageal and pancreatic cancer, this study was designed to determine the prevalence of EGFR mutations in these gastrointestinal cancers...
  83. ncbi request reprint Intraepithelial lymphocytosis in architecturally preserved proximal small intestinal mucosa: an increasing diagnostic problem with a wide differential diagnosis
    Ian Brown
    Sullivan Nicolaides Pathology, Taringa, Queensland, Australia
    Arch Pathol Lab Med 130:1020-5. 2006
    ..A wide variety of immunologic stimuli can raise intraepithelial lymphocyte numbers. Among the other common associations are enteric infection, autoimmune disease, drugs, and gastric Helicobacter infection...
  84. ncbi request reprint Post-gastric endoscopic mucosal resection surveillance biopsies: evaluation of mucosal changes and recognition of potential mimics of residual adenocarcinoma
    Tomoko Mitsuhashi
    Department of Pathology, Saitama Medical School, Saitama, Japan
    Am J Surg Pathol 30:650-6. 2006
    ..Mimics of residual adenocarcinoma, namely clear cell degeneration and signet-ring cell-like change should be judiciously assessed to avoid unnecessary surgery...
  85. ncbi request reprint Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
    Ben Z Stanger
    Howard Hughes Medical Institute and the Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Cancer Cell 8:185-95. 2005
    ....
  86. ncbi request reprint Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: results of a multicenter study
    Timothy M Pawlik
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Surgery 137:403-10. 2005
    ..We evaluated the efficacy of hepatic resection and the factors affecting survival after resection in such patients...
  87. ncbi request reprint Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma
    Timothy M Pawlik
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    Liver Transpl 11:1086-92. 2005
    ....
  88. ncbi request reprint Is hepatic resection for large or multinodular hepatocellular carcinoma justified? Results from a multi-institutional database
    Kelvin K Ng
    Centre for the Study of Liver Disease, Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    Ann Surg Oncol 12:364-73. 2005
    ..This study evaluated the long-term outcome of patients with hepatic resection for large (>5 cm in diameter) or multinodular (more than three nodules) HCC by using a multi-institutional database...
  89. ncbi request reprint Dysplasia arising in barrett's esophagus: diagnostic pitfalls and natural history
    John R Goldblum
    Cleveland Clinic Foundation, OH 44195, USA
    Semin Diagn Pathol 19:12-9. 2002
    ..However, no biomarker has yet proven to be superior to the histologic recognition of dysplasia in identifying these high-risk patients...
  90. ncbi request reprint Intraductal papillary mucinous neoplasm (IPMN) of the pancreas: its histopathologic difference between 2 major types
    Shinichi Ban
    Department of Pathology, Saitama Medical School, Saitama, Japan
    Am J Surg Pathol 30:1561-9. 2006
    ..05). In conclusion, gastric and intestinal types of IPMNs have distinct histopathologic features and mucin profiles, suggesting that they may follow different biologic pathways...
  91. ncbi request reprint Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation
    Nestor F Esnaola
    Department of Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Gastrointest Surg 6:224-32; discussion 232. 2002
    ..3; 95% CI, 2.0 to 19.9). Tumor size and grade are strong predictors of microvascular invasion. A tumor biopsy with pathologic grading at the time of pretransplantation ablative therapy could improve selection of patients with HCC for OLT...
  92. pmc Comparison of clinicopathologic characteristics and outcomes after resection in patients with hepatocellular carcinoma treated in the United States, France, and Japan
    Nestor F Esnaola
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Ann Surg 238:711-9. 2003
    ..To compare the clinicopathologic characteristics and outcomes after resection of patients with hepatocellular carcinoma (HCC) treated in the United States, France, and Japan...
  93. pmc Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer
    Christopher G Willett
    Duke University Medical Center, Durham, NC 27710, USA
    Nat Clin Pract Oncol 4:316-21. 2007
    ..The case presented here is a complete pathological response seen in a patient with extensive and locally invasive carcinoma after receiving this combined treatment...
  94. pmc Preoperative predictors of survival after resection of small hepatocellular carcinomas
    Jeffrey D Wayne
    International Cooperative Study Group on Hepatocellular Carcinoma Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Ann Surg 235:722-30; discussion 730-1. 2002
    ..To determine preoperative predictors of survival that can guide the choice of treatment for patients with small hepatocellular cancers (HCCs)...
  95. ncbi request reprint Hepatocellular lymphoepithelioma-like carcinoma associated with epstein barr virus: a hitherto unrecognized entity
    Michael W Si
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Diagn Mol Pathol 13:183-9. 2004
    ..We report a unique case of hepatocellular LELC arising in a cirrhotic liver with EBV demonstrated in the tumor cells...
  96. pmc Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients
    Stefano Crippa
    Department of Surgery, University of Verona, Verona, Italy
    Ann Surg 247:571-9. 2008
    ..We evaluated the clinicopathologic characteristics, prevalence of cancer, and prognosis of a large series of well-characterized MCNs in 2 tertiary centers...
  97. ncbi request reprint Pneumatosis intestinalis: a challenging biopsy diagnosis
    Aashiyana Koreishi
    James Homer Wright Pathology Laboratory at the Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 31:1469-75. 2007
    ..In biopsy material, though, the diagnosis is more challenging, as giant cells and histiocytes can be interpreted as granulomatous inflammation indicative of other conditions such as infection or Crohn disease...
  98. ncbi request reprint Mucin expression in reactive gastropathy: an immunohistochemical analysis
    Mari Mino-Kenudson
    Massachusetts General Hospital Department of Pathology, Boston, MA 02114 2696, USA
    Arch Pathol Lab Med 131:86-90. 2007
    ..However, the evaluation of mucins, important components of the protective mucosal mucous layer, has not been reported...
  99. doi request reprint Gastroduodenitis associated with yttrium 90-microsphere selective internal radiation: an iatrogenic complication in need of recognition
    Fumihiro Ogawa
    Gastrointestinal Pathology Service, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, MA 02114 2696, USA
    Arch Pathol Lab Med 132:1734-8. 2008
    ..During administration of microspheres via the hepatic artery branches, some may on occasion be misdirected and be caught in the capillary bed of the duodenal and/or stomach...