Michael LaubSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
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Publications
Phosphotransfer profiling: systematic mapping of two-component signal transduction pathways and phosphorelaysMichael T Laub
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
Methods Enzymol 423:531-48. 2007..The technique can be further extended to mapping phosphorelays and the cognate partners of histidine phosphotransferases. Here, we describe protocols and strategies for the successful implementation of this system-level technique...- Specificity in two-component signal transduction pathwaysMichael T Laub
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Annu Rev Genet 41:121-45. 2007.... - Systems biology of CaulobacterMichael T Laub
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Annu Rev Genet 41:429-41. 2007.... - A phosphorelay system controls stalk biogenesis during cell cycle progression in Caulobacter crescentusEmanuele G Biondi
Bauer Center for Genomics Research, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
Mol Microbiol 59:386-401. 2006..This is the first example of a general method for identifying the connectivity of a phosphorelay and can be applied to any organism with two-component signal transduction systems... 
Dynamics of two Phosphorelays controlling cell cycle progression in Caulobacter crescentusY Erin Chen
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Bacteriol 191:7417-29. 2009..More generally, our results emphasize how the bifunctional nature of histidine kinases can help switch cells between mutually exclusive states...- Regulation of the bacterial cell cycle by an integrated genetic circuitEmanuele G Biondi
FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Nature 444:899-904. 2006..Our results define a single integrated circuit whose components and connectivity can account for the cell cycle oscillations of CtrA in Caulobacter... - Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysisJeffrey M Skerker
Bauer Center for Genomics Research, Harvard University, Cambridge, Massachusetts, USA
PLoS Biol 3:e334. 2005..We propose that this system-wide selectivity insulates two-component pathways from one another, preventing unwanted cross-talk... - Cell-cycle progression and the generation of asymmetry in Caulobacter crescentusJeffrey M Skerker
Bauer Center for Genomics Research, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Nat Rev Microbiol 2:325-37. 2004 - Rewiring the specificity of two-component signal transduction systemsJeffrey M Skerker
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 133:1043-54. 2008.... - Comparative genomic evidence for a close relationship between the dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter crescentusJonathan H Badger
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
J Bacteriol 188:6841-50. 2006..neptunium genome will provide an important resource for the study of other interesting biological processes including chromosome segregation, polar growth, and cell aging... - Functions of the CckA histidine kinase in Caulobacter cell cycle controlChristine Jacobs
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
Mol Microbiol 47:1279-90. 2003..CtrA is more stable in the presence of CckA than it is absence, suggesting that CckA may also be involved, directly or indirectly, in the regulation of CtrA proteolysis... - Allosteric regulation of histidine kinases by their cognate response regulator determines cell fateRalf Paul
Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
Cell 133:452-61. 2008..crescentus. Thus, single domain response regulators can facilitate crosstalk, feedback control, and long-range communication among members of the two-component network... - Genes directly controlled by CtrA, a master regulator of the Caulobacter cell cycleMichael T Laub
Department of Developmental Biology, Stanford University School of Medicine, Beckman Center, B300, 279 Campus Drive, Palo Alto, CA 94304-5329, USA
Proc Natl Acad Sci U S A 99:4632-7. 2002..Identification of additional regulatory genes activated by CtrA will serve to directly connect new regulatory modules to the network controlling cell cycle progression...
Research Grants
- Cell Cycle Regluation in Caulobacter crescentusMichael Laub; Fiscal Year: 2010..Finally, a better understanding of how bacteria regulate the cell cycle may help guide the development of new antibiotics, a problem of increasing public-health relevance. ..