Michael Laub

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Phosphotransfer profiling: systematic mapping of two-component signal transduction pathways and phosphorelays
    Michael T Laub
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Methods Enzymol 423:531-48. 2007
  2. ncbi request reprint Specificity in two-component signal transduction pathways
    Michael T Laub
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Annu Rev Genet 41:121-45. 2007
  3. pmc Systematic dissection and trajectory-scanning mutagenesis of the molecular interface that ensures specificity of two-component signaling pathways
    Emily J Capra
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    PLoS Genet 6:e1001220. 2010
  4. ncbi request reprint Systems biology of Caulobacter
    Michael T Laub
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Annu Rev Genet 41:429-41. 2007
  5. ncbi request reprint A phosphorelay system controls stalk biogenesis during cell cycle progression in Caulobacter crescentus
    Emanuele G Biondi
    Bauer Center for Genomics Research, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Mol Microbiol 59:386-401. 2006
  6. ncbi request reprint Regulation of the bacterial cell cycle by an integrated genetic circuit
    Emanuele G Biondi
    FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 444:899-904. 2006
  7. pmc Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis
    Jeffrey M Skerker
    Bauer Center for Genomics Research, Harvard University, Cambridge, Massachusetts, USA
    PLoS Biol 3:e334. 2005
  8. pmc Dynamics of two Phosphorelays controlling cell cycle progression in Caulobacter crescentus
    Y Erin Chen
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Bacteriol 191:7417-29. 2009
  9. ncbi request reprint Cell-cycle progression and the generation of asymmetry in Caulobacter crescentus
    Jeffrey M Skerker
    Bauer Center for Genomics Research, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Rev Microbiol 2:325-37. 2004
  10. pmc Rewiring the specificity of two-component signal transduction systems
    Jeffrey M Skerker
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 133:1043-54. 2008

Research Grants

Collaborators

  • Harley H McAdams
  • Christine Jacobs
  • U Jenal
  • Jeffrey M Skerker
  • Emanuele G Biondi
  • Barrett S Perchuk
  • Emily J Capra
  • Emma A Lubin
  • Y Erin Chen
  • Orr Ashenberg
  • Ralf Paul
  • Jonathan H Badger
  • Muhammad Arif
  • Melanie S Prasol
  • Christos G Tsokos
  • Albert Siryaporn
  • Mark Goulian
  • Marc Folcher
  • Sören Abel
  • Irene Wiederkehr
  • Tina Jaeger
  • Yves V Brun
  • Hoda M Khouri
  • Karen E Nelson
  • Julia Sosa
  • Kathleen R Ryan
  • Ian T Paulsen
  • M J Rosovitz
  • Diana Radune
  • Ronald M Weiner
  • Tanja M Davidsen
  • Qi Yang
  • Gladys Alexandre
  • A Scott Durkin
  • Steven A Sullivan
  • Sean C Daugherty
  • Naomi L Ward
  • Robert J Dodson
  • Lauren M Brinkac
  • Sarah J Reisinger
  • Qinghu Ren
  • Timothy R Hoover
  • Jeremy D Selengut
  • Jan Mrazek
  • Nikhat Zafar
  • Daniel H Haft
  • Sagar P Kothari
  • Ramana Madupu
  • Liwei Zhou
  • Michelle Gwinn Giglio

Detail Information

Publications14

  1. ncbi request reprint Phosphotransfer profiling: systematic mapping of two-component signal transduction pathways and phosphorelays
    Michael T Laub
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Methods Enzymol 423:531-48. 2007
    ..The technique can be further extended to mapping phosphorelays and the cognate partners of histidine phosphotransferases. Here, we describe protocols and strategies for the successful implementation of this system-level technique...
  2. ncbi request reprint Specificity in two-component signal transduction pathways
    Michael T Laub
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Annu Rev Genet 41:121-45. 2007
    ....
  3. pmc Systematic dissection and trajectory-scanning mutagenesis of the molecular interface that ensures specificity of two-component signaling pathways
    Emily J Capra
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    PLoS Genet 6:e1001220. 2010
    ..Only some trajectories allow both the maintenance of phosphotransfer and the avoidance of unwanted cross-talk...
  4. ncbi request reprint Systems biology of Caulobacter
    Michael T Laub
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Annu Rev Genet 41:429-41. 2007
    ....
  5. ncbi request reprint A phosphorelay system controls stalk biogenesis during cell cycle progression in Caulobacter crescentus
    Emanuele G Biondi
    Bauer Center for Genomics Research, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Mol Microbiol 59:386-401. 2006
    ..This is the first example of a general method for identifying the connectivity of a phosphorelay and can be applied to any organism with two-component signal transduction systems...
  6. ncbi request reprint Regulation of the bacterial cell cycle by an integrated genetic circuit
    Emanuele G Biondi
    FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 444:899-904. 2006
    ..Our results define a single integrated circuit whose components and connectivity can account for the cell cycle oscillations of CtrA in Caulobacter...
  7. pmc Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis
    Jeffrey M Skerker
    Bauer Center for Genomics Research, Harvard University, Cambridge, Massachusetts, USA
    PLoS Biol 3:e334. 2005
    ..We propose that this system-wide selectivity insulates two-component pathways from one another, preventing unwanted cross-talk...
  8. pmc Dynamics of two Phosphorelays controlling cell cycle progression in Caulobacter crescentus
    Y Erin Chen
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Bacteriol 191:7417-29. 2009
    ..More generally, our results emphasize how the bifunctional nature of histidine kinases can help switch cells between mutually exclusive states...
  9. ncbi request reprint Cell-cycle progression and the generation of asymmetry in Caulobacter crescentus
    Jeffrey M Skerker
    Bauer Center for Genomics Research, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Rev Microbiol 2:325-37. 2004
  10. pmc Rewiring the specificity of two-component signal transduction systems
    Jeffrey M Skerker
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 133:1043-54. 2008
    ....
  11. pmc Comparative genomic evidence for a close relationship between the dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter crescentus
    Jonathan H Badger
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    J Bacteriol 188:6841-50. 2006
    ..neptunium genome will provide an important resource for the study of other interesting biological processes including chromosome segregation, polar growth, and cell aging...
  12. ncbi request reprint Functions of the CckA histidine kinase in Caulobacter cell cycle control
    Christine Jacobs
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Mol Microbiol 47:1279-90. 2003
    ..CtrA is more stable in the presence of CckA than it is absence, suggesting that CckA may also be involved, directly or indirectly, in the regulation of CtrA proteolysis...
  13. pmc Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate
    Ralf Paul
    Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Cell 133:452-61. 2008
    ..crescentus. Thus, single domain response regulators can facilitate crosstalk, feedback control, and long-range communication among members of the two-component network...
  14. pmc Genes directly controlled by CtrA, a master regulator of the Caulobacter cell cycle
    Michael T Laub
    Department of Developmental Biology, Stanford University School of Medicine, Beckman Center, B300, 279 Campus Drive, Palo Alto, CA 94304 5329, USA
    Proc Natl Acad Sci U S A 99:4632-7. 2002
    ..Identification of additional regulatory genes activated by CtrA will serve to directly connect new regulatory modules to the network controlling cell cycle progression...

Research Grants3

  1. Cell Cycle Regluation in Caulobacter crescentus
    Michael Laub; Fiscal Year: 2010
    ..Finally, a better understanding of how bacteria regulate the cell cycle may help guide the development of new antibiotics, a problem of increasing public-health relevance. ..
  2. Cell Cycle Regluation in Caulobacter crescentus
    Michael Laub; Fiscal Year: 2009
    ..Finally, a better understanding of how bacteria regulate the cell cycle may help guide the development of new antibiotics, a problem of increasing public-health relevance. ..