R C Larocque

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc High depth, whole-genome sequencing of cholera isolates from Haiti and the Dominican Republic
    Rachel Sealfon
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
    BMC Genomics 13:468. 2012
  2. pmc Pre-travel health care of immigrants returning home to visit friends and relatives
    Regina C LaRocque
    Travelers Advice and Immunization Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Trop Med Hyg 88:376-80. 2013
  3. doi Global TravEpiNet: a national consortium of clinics providing care to international travelers--analysis of demographic characteristics, travel destinations, and pretravel healthcare of high-risk US international travelers, 2009-2011
    Regina C LaRocque
    Travelers Advice and Immunization Center, Massachusetts General Hospital, Boston, USA
    Clin Infect Dis 54:455-62. 2012
  4. doi Health recommendations for international travel: a review of the evidence base of travel medicine
    Regina C LaRocque
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Infect Dis 24:403-9. 2011
  5. doi Pre-travel health advice-seeking behavior among US international travelers departing from Boston Logan International Airport
    Regina C LaRocque
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    J Travel Med 17:387-91. 2010
  6. pmc A variant in long palate, lung and nasal epithelium clone 1 is associated with cholera in a Bangladeshi population
    R C Larocque
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA
    Genes Immun 10:267-72. 2009
  7. ncbi The utility of sputum induction for diagnosis of Pneumocystis pneumonia in immunocompromised patients without human immunodeficiency virus
    Regina C LaRocque
    Division of Infectious Diseases, Brigham Women s Hospital Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Clin Infect Dis 37:1380-3. 2003
  8. pmc Proteomic analysis of Vibrio cholerae in human stool
    Regina C LaRocque
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Infect Immun 76:4145-51. 2008
  9. ncbi Postgenomic approaches to cholera vaccine development
    Regina C LaRocque
    Division of Infectious Diseases, Massachusetts General Hospital, GRJ 504, 55 Fruit Street, Boston, MA 02114, USA
    Expert Rev Vaccines 5:337-46. 2006
  10. pmc Leptospirosis during dengue outbreak, Bangladesh
    Regina C LaRocque
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Emerg Infect Dis 11:766-9. 2005

Collaborators

Detail Information

Publications27

  1. pmc High depth, whole-genome sequencing of cholera isolates from Haiti and the Dominican Republic
    Rachel Sealfon
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
    BMC Genomics 13:468. 2012
    ..cholerae isolates to a high depth of coverage (>2000x); four of the seven isolates were previously sequenced...
  2. pmc Pre-travel health care of immigrants returning home to visit friends and relatives
    Regina C LaRocque
    Travelers Advice and Immunization Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Trop Med Hyg 88:376-80. 2013
    ..Making pre-travel health care available in primary care settings may be one step to this goal...
  3. doi Global TravEpiNet: a national consortium of clinics providing care to international travelers--analysis of demographic characteristics, travel destinations, and pretravel healthcare of high-risk US international travelers, 2009-2011
    Regina C LaRocque
    Travelers Advice and Immunization Center, Massachusetts General Hospital, Boston, USA
    Clin Infect Dis 54:455-62. 2012
    ..Despite this, little is known about the health characteristics and pretravel healthcare of US international travelers, particularly those at higher risk of travel-associated illness...
  4. doi Health recommendations for international travel: a review of the evidence base of travel medicine
    Regina C LaRocque
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Infect Dis 24:403-9. 2011
    ..This review will describe the evidence base underlying travel medicine, highlight recently updated travel medicine guidelines, and outline future research priorities...
  5. doi Pre-travel health advice-seeking behavior among US international travelers departing from Boston Logan International Airport
    Regina C LaRocque
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    J Travel Med 17:387-91. 2010
    ..Despite this, data about sources of health information used by international travelers are limited...
  6. pmc A variant in long palate, lung and nasal epithelium clone 1 is associated with cholera in a Bangladeshi population
    R C Larocque
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA
    Genes Immun 10:267-72. 2009
    ..Our results suggest that variation in host innate immune responses may influence the outcome of exposure to V. cholerae in an endemic setting...
  7. ncbi The utility of sputum induction for diagnosis of Pneumocystis pneumonia in immunocompromised patients without human immunodeficiency virus
    Regina C LaRocque
    Division of Infectious Diseases, Brigham Women s Hospital Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Clin Infect Dis 37:1380-3. 2003
    ..However, this retrospective review of the experience at a tertiary referral center suggests that sputum induction has clinical utility for diagnosing PCP in immunocompromised patients without HIV infection...
  8. pmc Proteomic analysis of Vibrio cholerae in human stool
    Regina C LaRocque
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Infect Immun 76:4145-51. 2008
    ..We identified a number of these in vivo expressed proteins as immunogenic during human infection. To our knowledge, this is the first characterization of the proteome of a pathogenic bacteria recovered from a natural host...
  9. ncbi Postgenomic approaches to cholera vaccine development
    Regina C LaRocque
    Division of Infectious Diseases, Massachusetts General Hospital, GRJ 504, 55 Fruit Street, Boston, MA 02114, USA
    Expert Rev Vaccines 5:337-46. 2006
    ..This work holds promise for the identification of bacterial targets of protective human immune responses and may contribute to the development of a new generation of cholera vaccines...
  10. pmc Leptospirosis during dengue outbreak, Bangladesh
    Regina C LaRocque
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Emerg Infect Dis 11:766-9. 2005
    ..A total of 18% of dengue-negative patients tested positive for leptospirosis. The case-fatality rate among leptospirosis patients (5%) was higher than among dengue fever patients (1.2%)...
  11. pmc Transcriptional profiling of Vibrio cholerae recovered directly from patient specimens during early and late stages of human infection
    Regina C LaRocque
    Division of Infectious Diseases, Gray Jackson 504, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Infect Immun 73:4488-93. 2005
    ..These findings provide a more detailed assessment of the transcriptome of V. cholerae in the human host than previous studies of organisms in stool alone and have implications for cholera control and the design of improved vaccines...
  12. pmc Complexity of rice-water stool from patients with Vibrio cholerae plays a role in the transmission of infectious diarrhea
    Eric J Nelson
    Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 104:19091-6. 2007
    ..cholerae. If lytic phage are present, viable counts of V. cholerae drop, stools become DF(-), other microorganisms bloom, and cholera transmission is reduced...
  13. pmc Transcutaneous immunization with toxin-coregulated pilin A induces protective immunity against Vibrio cholerae O1 El Tor challenge in mice
    Julianne E Rollenhagen
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Infect Immun 74:5834-9. 2006
    ..001). Our results suggest that transcutaneous immunization with TcpA and an immunoadjuvant induces protective anti-TcpA immune responses. Anti-TcpA responses may contribute to an optimal cholera vaccine...
  14. pmc A systems biology approach to modeling vibrio cholerae gene expression under virulence-inducing conditions
    Sanjat Kanjilal
    Harvard MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 192:4300-10. 2010
    ..This study applies systems biology tools to analysis of gene expression of V. cholerae in vitro and provides an important comparator for future studies done in vivo...
  15. pmc Transcutaneous immunization with a Vibrio cholerae O1 Ogawa synthetic hexasaccharide conjugate following oral whole-cell cholera vaccination boosts vibriocidal responses and induces protective immunity in mice
    A A Tarique
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Vaccine Immunol 19:594-602. 2012
    ..Our results suggest that transcutaneous and subcutaneous boosting with a neoglycoconjugate following oral cholera vaccination may be an effective strategy to prolong protective immune responses against V. cholerae...
  16. pmc Identification of in vivo-induced bacterial protein antigens during human infection with Salmonella enterica serovar Typhi
    Jason B Harris
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Infect Immun 74:5161-8. 2006
    ..Serovar Typhi antigens identified by IVIAT warrant further evaluation for their contributions to pathogenesis, and they may have diagnostic, therapeutic, or preventive uses...
  17. pmc Characterization of anti-Salmonella enterica serotype Typhi antibody responses in bacteremic Bangladeshi patients by an immunoaffinity proteomics-based technology
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Clin Vaccine Immunol 17:1188-95. 2010
    ..Typhi-infected patients and detected anti-HlyE responses at the time of clinical presentation in patients but not in controls. These findings could assist in the development of improved diagnostic assays...
  18. pmc Clinical outcomes in household contacts of patients with cholera in Bangladesh
    Ana A Weil
    International Centre for Diarrhoeal Disease Research Dhaka, Bangladesh
    Clin Infect Dis 49:1473-9. 2009
    ..cholerae infection and associated clinical symptoms in household contacts of patients with cholera and to identify risk factors for development of severe dehydration in this cohort...
  19. pmc Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium
    Richelle C Charles
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS ONE 4:e6994. 2009
    ..The PhoP regulon is a well studied two component (PhoP/Q) coordinately regulated network of genes whose expression is required for intracellular survival of S. enterica...
  20. pmc Immunologic responses to Vibrio cholerae in patients co-infected with intestinal parasites in Bangladesh
    Jason B Harris
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS Negl Trop Dis 3:e403. 2009
    ..However, the immunomodulatory effects of concomitant intestinal parasitic infection in cholera patients have not been systematically evaluated...
  21. pmc Blood group, immunity, and risk of infection with Vibrio cholerae in an area of endemicity
    Jason B Harris
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Infect Immun 73:7422-7. 2005
    ..Based on this epidemiologic evidence, we propose a hypothesis for understanding the association between blood group O and the risk of infection with V. cholerae O1 and O139 as well as the risk of developing severe symptoms once infected...
  22. pmc Diarrheal epidemics in Dhaka, Bangladesh, during three consecutive floods: 1988, 1998, and 2004
    Brian S Schwartz
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, USA
    Am J Trop Med Hyg 74:1067-73. 2006
    ..Our findings suggest that cholera is the predominant cause of flood-associated diarrheal epidemics in Dhaka, but that other organisms spread by the fecal-oral route also contribute...
  23. pmc Susceptibility to Vibrio cholerae infection in a cohort of household contacts of patients with cholera in Bangladesh
    Jason B Harris
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS Negl Trop Dis 2:e221. 2008
    ..Despite recent progress in understanding the molecular basis of Vibrio cholerae pathogenesis, there is relatively little knowledge of the factors that determine the variability in human susceptibility to V. cholerae infection...
  24. pmc Leptospirosis as a cause of fever in urban Bangladesh
    Emily A Kendall
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA
    Am J Trop Med Hyg 82:1127-30. 2010
    ..Persons with leptospirosis were older than those with undifferentiated fever in this population. The dominant infecting serogroups in Bangladesh differed from serogroups commonly reported in nearby regions...
  25. pmc Hyperinfectivity of human-passaged Vibrio cholerae can be modeled by growth in the infant mouse
    Ashfaqul Alam
    International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Infect Immun 73:6674-9. 2005
    ..cholerae as well as the contribution of three type IV pili to the phenotype...
  26. ncbi Incomplete correlation of serum vibriocidal antibody titer with protection from Vibrio cholerae infection in urban Bangladesh
    Debasish Saha
    International Centre for Diarrheal Disease Research, Bangladesh
    J Infect Dis 189:2318-22. 2004
    ..No association between baseline vibriocidal titer and protection from V. cholerae O139 infection was found. Our findings suggest that the vibriocidal antibody is an incomplete predictor of protection from V. cholerae infection...
  27. pmc Cholera toxin-specific memory B cell responses are induced in patients with dehydrating diarrhea caused by Vibrio cholerae O1
    Channa R Jayasekera
    International Centre for Diarrhoeal Disease Research, Bangladesh
    J Infect Dis 198:1055-61. 2008
    ..The presence of antigen-specific memory B cells may therefore be a more direct measure of protection than serum antibody responses...