John E Landers

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint New VAPB deletion variant and exclusion of VAPB mutations in familial ALS
    J E Landers
    Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, Charlestown, MA, USA
    Neurology 70:1179-85. 2008
  2. ncbi request reprint Motoneuron-specific NR3B gene: no association with ALS and evidence for a common null allele
    S Niemann
    RIKEN MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
    Neurology 70:666-76. 2008
  3. doi request reprint Paraoxonase 1 (PON1) organophosphate hydrolysis is not reduced in ALS
    A M Wills
    Day Neuromuscular Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 70:929-34. 2008
  4. pmc A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS
    A M Wills
    Cecil B Day Neuromuscular Research Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neurology 73:16-24. 2009
  5. ncbi request reprint Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
    T J Kwiatkowski
    Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
    Science 323:1205-8. 2009
  6. doi request reprint High-throughput mutation screening using a single amplification condition
    Lijia Shi
    Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, Charlestown, MA, USA
    Methods Mol Biol 520:195-204. 2009
  7. pmc Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis
    John E Landers
    Cecil B Day Neuromuscular Research Laboratory, Massachusetts General Hospital East, Building 114, Navy Yard, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 106:9004-9. 2009
  8. ncbi request reprint Using high-throughput SNP technologies to study cancer
    L J Engle
    Cetek Corporation, Marlborough, MA, USA
    Oncogene 25:1594-601. 2006
  9. pmc A common haplotype within the PON1 promoter region is associated with sporadic ALS
    John E Landers
    Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, Charlestown, MA, USA
    Amyotroph Lateral Scler 9:306-14. 2008
  10. pmc A simple, bead-based approach for multi-SNP molecular haplotyping
    James D Hurley
    PolyGenyx, Inc, 100 Barber Avenue, Worcester, MA 01606, USA
    Nucleic Acids Res 32:e186. 2004

Detail Information

Publications11

  1. doi request reprint New VAPB deletion variant and exclusion of VAPB mutations in familial ALS
    J E Landers
    Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, Charlestown, MA, USA
    Neurology 70:1179-85. 2008
    ..No additional mutations have been identified...
  2. ncbi request reprint Motoneuron-specific NR3B gene: no association with ALS and evidence for a common null allele
    S Niemann
    RIKEN MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
    Neurology 70:666-76. 2008
    ..We tested whether genetic dysfunction of GRIN3B is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS)...
  3. doi request reprint Paraoxonase 1 (PON1) organophosphate hydrolysis is not reduced in ALS
    A M Wills
    Day Neuromuscular Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 70:929-34. 2008
    ..We tested the hypothesis that this association correlates with functional changes in paraoxonase 1 (PON1, MIM 168820)...
  4. pmc A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS
    A M Wills
    Cecil B Day Neuromuscular Research Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neurology 73:16-24. 2009
    ..However, several other large studies, including five genome-wide association studies, have not duplicated this finding...
  5. ncbi request reprint Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
    T J Kwiatkowski
    Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
    Science 323:1205-8. 2009
    ..Neuronal cytoplasmic protein aggregation and defective RNA metabolism thus appear to be common pathogenic mechanisms involved in ALS and possibly in other neurodegenerative disorders...
  6. doi request reprint High-throughput mutation screening using a single amplification condition
    Lijia Shi
    Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, Charlestown, MA, USA
    Methods Mol Biol 520:195-204. 2009
    ..This combination of a single amplification condition, single-step purification, and sequencing setup using universal primers all contribute to a simple and high-throughput mutation screen...
  7. pmc Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis
    John E Landers
    Cecil B Day Neuromuscular Research Laboratory, Massachusetts General Hospital East, Building 114, Navy Yard, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 106:9004-9. 2009
    ..These findings support the view that genetic factors modify phenotypes in this disease and that cellular motor proteins are determinants of motor neuron viability...
  8. ncbi request reprint Using high-throughput SNP technologies to study cancer
    L J Engle
    Cetek Corporation, Marlborough, MA, USA
    Oncogene 25:1594-601. 2006
    ....
  9. pmc A common haplotype within the PON1 promoter region is associated with sporadic ALS
    John E Landers
    Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, Charlestown, MA, USA
    Amyotroph Lateral Scler 9:306-14. 2008
    ..75E-05). We conclude that a common haplotype within the PON1 promoter region is associated with susceptibility to sporadic ALS...
  10. pmc A simple, bead-based approach for multi-SNP molecular haplotyping
    James D Hurley
    PolyGenyx, Inc, 100 Barber Avenue, Worcester, MA 01606, USA
    Nucleic Acids Res 32:e186. 2004
    ..This assay has applications in diagnostic testing, promoter analysis, association studies and pharmacogenetic analysis...
  11. pmc Genome complexity reduction for SNP genotyping analysis
    Barbara Jordan
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:2942-7. 2002
    ..Finally, we describe an in silico approach that can effectively predict the SNP loci amplified in a given DOP-PCR, permitting the design of an efficient set of reactions for large-scale, genome-wide SNP studies...

Research Grants3

  1. An Innovative, High-Throughput Method of SNP Haplotyping
    John Landers; Fiscal Year: 2004
    ....
  2. Mannose-Binding Lectin Haplotypes and Infection Risk
    John Landers; Fiscal Year: 2004
    ..Patients with a haplotypic configuration predicting increased risk of disease/infection could undergo several steps to reduce this risk, improve their quality of life, and reduce the total economic impact to society. ..
  3. Characterization of KIFAP3, a Modifier of Survival in Sporadic ALS
    John E Landers; Fiscal Year: 2010
    ..The purpose of this proposal is to understand how this gene influences survival, which will aid in the development of treatment strategies to extend the lifespan of patients afflicted with ALS. ..