Justin Lamb

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer
    Justin Lamb
    Departments of Medical Oncology and Medicine, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 114:323-34. 2003
  2. ncbi The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
    Justin Lamb
    Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Science 313:1929-35. 2006
  3. ncbi Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators
    Haley Hieronymus
    The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Cancer Cell 10:321-30. 2006
  4. ncbi The Connectivity Map: a new tool for biomedical research
    Justin Lamb
    Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA
    Nat Rev Cancer 7:54-60. 2007
  5. ncbi A method for high-throughput gene expression signature analysis
    David Peck
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Genome Biol 7:R61. 2006
  6. ncbi MicroRNA expression profiles classify human cancers
    Jun Lu
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Nature 435:834-8. 2005
  7. ncbi Cyclin D1 and molecular chaperones: implications for tumorigenesis
    Justin Lamb
    Howard Hughes Medical Institute, Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts, USA
    Cell Cycle 2:525-7. 2003
  8. ncbi Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
    Guo Wei
    Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Cell 10:331-42. 2006
  9. ncbi The activities of cyclin D1 that drive tumorigenesis
    Mark E Ewen
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Trends Mol Med 10:158-62. 2004
  10. ncbi Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements
    Josee Dostie
    Program in Gene Function and Expression and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 0103, USA
    Genome Res 16:1299-309. 2006

Collaborators

Detail Information

Publications11

  1. ncbi A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer
    Justin Lamb
    Departments of Medical Oncology and Medicine, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 114:323-34. 2003
    ..This work demonstrates that tumor gene expression databases can be used to study the function of a human oncogene in situ...
  2. ncbi The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
    Justin Lamb
    Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Science 313:1929-35. 2006
    ..These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project...
  3. ncbi Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators
    Haley Hieronymus
    The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Cancer Cell 10:321-30. 2006
    ..Validating this prediction, we demonstrate that celastrol and gedunin inhibit HSP90 activity and HSP90 clients, including AR. Broadly, this work identifies new modes of HSP90 modulation through a gene expression-based strategy...
  4. ncbi The Connectivity Map: a new tool for biomedical research
    Justin Lamb
    Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA
    Nat Rev Cancer 7:54-60. 2007
    ....
  5. ncbi A method for high-throughput gene expression signature analysis
    David Peck
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Genome Biol 7:R61. 2006
    ..Here, we describe a solution based on the combination of ligation-mediated amplification with an optically addressed microsphere and flow cytometric detection system...
  6. ncbi MicroRNA expression profiles classify human cancers
    Jun Lu
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Nature 435:834-8. 2005
    ..These findings highlight the potential of miRNA profiling in cancer diagnosis...
  7. ncbi Cyclin D1 and molecular chaperones: implications for tumorigenesis
    Justin Lamb
    Howard Hughes Medical Institute, Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts, USA
    Cell Cycle 2:525-7. 2003
    ..Many of the genes we found to be affected by cyclin D1 overexpression are recognized as molecular chaperones or their regulators. Might this provide insights to the role of the cyclin D1-C/EBPbeta axis in carcinogenesis?..
  8. ncbi Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
    Guo Wei
    Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Cell 10:331-42. 2006
    ..Furthermore, this approach represents a strategy for identification of promising combination therapies for cancer...
  9. ncbi The activities of cyclin D1 that drive tumorigenesis
    Mark E Ewen
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Trends Mol Med 10:158-62. 2004
    ..Here, we describe the known functions of the cyclin D1 oncogene and delineate the evidence that cdk-independent actions are important for cyclin D1-mediated oncogenesis...
  10. ncbi Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements
    Josee Dostie
    Program in Gene Function and Expression and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 0103, USA
    Genome Res 16:1299-309. 2006
    ..5C should be widely applicable for large-scale mapping of cis- and trans- interaction networks of genomic elements and for the study of higher-order chromosome structure...
  11. ncbi Positive and negative regulation of deltaN-p63 promoter activity by p53 and deltaN-p63-alpha contributes to differential regulation of p53 target genes
    David Christopher Harmes
    Department of Pharmacology and Toxicology, Dartmouth Medical School, 7650 Remsen, Hanover, NH 03755, USA
    Oncogene 22:7607-16. 2003
    ..These studies also suggest that in response to genotoxic stress, deltaN-p63-alpha mediates the silencing of its own promoter thereby altering the pattern of p53-target gene expression...