Affiliation: Massachusetts Institute of Technology
- A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancerJustin Lamb
Departments of Medical Oncology and Medicine, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Cell 114:323-34. 2003..This work demonstrates that tumor gene expression databases can be used to study the function of a human oncogene in situ...
- The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and diseaseJustin Lamb
Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
Science 313:1929-35. 2006..These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project...
- Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulatorsHaley Hieronymus
The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Cancer Cell 10:321-30. 2006..Validating this prediction, we demonstrate that celastrol and gedunin inhibit HSP90 activity and HSP90 clients, including AR. Broadly, this work identifies new modes of HSP90 modulation through a gene expression-based strategy...
- The Connectivity Map: a new tool for biomedical researchJustin Lamb
Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA
Nat Rev Cancer 7:54-60. 2007....
- A method for high-throughput gene expression signature analysisDavid Peck
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Genome Biol 7:R61. 2006..Here, we describe a solution based on the combination of ligation-mediated amplification with an optically addressed microsphere and flow cytometric detection system...
- MicroRNA expression profiles classify human cancersJun Lu
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
Nature 435:834-8. 2005..These findings highlight the potential of miRNA profiling in cancer diagnosis...
- Cyclin D1 and molecular chaperones: implications for tumorigenesisJustin Lamb
Howard Hughes Medical Institute, Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts, USA
Cell Cycle 2:525-7. 2003..Many of the genes we found to be affected by cyclin D1 overexpression are recognized as molecular chaperones or their regulators. Might this provide insights to the role of the cyclin D1-C/EBPbeta axis in carcinogenesis?..
- Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistanceGuo Wei
Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Cell 10:331-42. 2006..Furthermore, this approach represents a strategy for identification of promising combination therapies for cancer...
- The activities of cyclin D1 that drive tumorigenesisMark E Ewen
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Trends Mol Med 10:158-62. 2004..Here, we describe the known functions of the cyclin D1 oncogene and delineate the evidence that cdk-independent actions are important for cyclin D1-mediated oncogenesis...
- Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elementsJosee Dostie
Program in Gene Function and Expression and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 0103, USA
Genome Res 16:1299-309. 2006..5C should be widely applicable for large-scale mapping of cis- and trans- interaction networks of genomic elements and for the study of higher-order chromosome structure...
- Positive and negative regulation of deltaN-p63 promoter activity by p53 and deltaN-p63-alpha contributes to differential regulation of p53 target genesDavid Christopher Harmes
Department of Pharmacology and Toxicology, Dartmouth Medical School, 7650 Remsen, Hanover, NH 03755, USA
Oncogene 22:7607-16. 2003..These studies also suggest that in response to genotoxic stress, deltaN-p63-alpha mediates the silencing of its own promoter thereby altering the pattern of p53-target gene expression...