Adam Lacy Hulbert

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins
    Adam Lacy-Hulbert
    Medical Research Council University of Edinburgh Centre for Inflammation Research, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Proc Natl Acad Sci U S A 104:15823-8. 2007
  2. ncbi Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation
    Lynda M Stuart
    Medical Research Council Center for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    J Immunol 168:1627-35. 2002
  3. ncbi Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion
    Mark Lucas
    University of Edinburgh MRC Center for Inflammation Research, University of Edinburgh, College of Medicine and Veterinary Medicine, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    J Immunol 171:2610-5. 2003
  4. ncbi Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
    Joseph H McCarty
    Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17 227, Cambridge, MA 02139, USA
    Development 132:165-76. 2005
  5. pmc Persistence of apoptotic cells without autoimmune disease or inflammation in CD14-/- mice
    Andrew Devitt
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, UK
    J Cell Biol 167:1161-70. 2004
  6. ncbi Designer macrophages: oxidative metabolism fuels inflammation repair
    Adam Lacy-Hulbert
    Centre for Inflammation Research, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom
    Cell Metab 4:7-8. 2006
  7. ncbi Requirements for apoptotic cell contact in regulation of macrophage responses
    Mark Lucas
    Medical Research Council University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Immunol 177:4047-54. 2006
  8. pmc Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma
    Joseph H McCarty
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Am J Pathol 172:1740-7. 2008

Collaborators

  • John Savill
  • L M Stuart
  • Christopher D Gregory
  • Jurgen Roes
  • Adam Lacy-Hulbert
  • Joseph H McCarty
  • Mark Lucas
  • Denise Crowley
  • Richard O Hynes
  • Roderick T Bronson
  • Marc Barry
  • Andrew Devitt
  • Hamid Tissire
  • Aileen M Smith
  • Ailiang Zhang
  • Kairbaan Hodivala-Dilke
  • Roy Silverstein
  • Maria Febbraio
  • Kathryn J Moore
  • Alain Charest
  • David Housman
  • Michael F Clay
  • Christopher O Bellamy
  • Sanna M Goyert
  • Lynsey A Melville
  • Sophie C Gangloff
  • Kate G Parker
  • Carol Anne Ogden
  • Ceri Oldreive

Detail Information

Publications8

  1. pmc Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins
    Adam Lacy-Hulbert
    Medical Research Council University of Edinburgh Centre for Inflammation Research, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Proc Natl Acad Sci U S A 104:15823-8. 2007
    ..Our results identify a vital role for myeloid alphav integrins in generating mucosal Treg cells and emphasize the importance of antigen-presenting cells in establishing immune tolerance...
  2. ncbi Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation
    Lynda M Stuart
    Medical Research Council Center for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    J Immunol 168:1627-35. 2002
    ....
  3. ncbi Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion
    Mark Lucas
    University of Edinburgh MRC Center for Inflammation Research, University of Edinburgh, College of Medicine and Veterinary Medicine, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    J Immunol 171:2610-5. 2003
    ....
  4. ncbi Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
    Joseph H McCarty
    Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17 227, Cambridge, MA 02139, USA
    Development 132:165-76. 2005
    ....
  5. pmc Persistence of apoptotic cells without autoimmune disease or inflammation in CD14-/- mice
    Andrew Devitt
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, UK
    J Cell Biol 167:1161-70. 2004
    ..We conclude that CD14 plays a broad tethering role in apoptotic cell clearance in vivo and that apoptotic cells can persist in the absence of proinflammatory consequences...
  6. ncbi Designer macrophages: oxidative metabolism fuels inflammation repair
    Adam Lacy-Hulbert
    Centre for Inflammation Research, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom
    Cell Metab 4:7-8. 2006
    ..provide insight into the mechanisms by which reparative macrophages are generated and reveal a previously unappreciated link between this anti-inflammatory axis and mitochondrial oxidative metabolism (Vats el al., 2006)...
  7. ncbi Requirements for apoptotic cell contact in regulation of macrophage responses
    Mark Lucas
    Medical Research Council University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Immunol 177:4047-54. 2006
    ..We conclude that the profound suppression of LPS-driven TNF-alpha release by macrophage populations requires hitherto obscure contact-dependent licensing of macrophage responsiveness to TGF-beta by apoptotic cells...
  8. pmc Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma
    Joseph H McCarty
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Am J Pathol 172:1740-7. 2008
    ....