Adam Lacy Hulbert

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins
    Adam Lacy-Hulbert
    Medical Research Council University of Edinburgh Centre for Inflammation Research, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Proc Natl Acad Sci U S A 104:15823-8. 2007
  2. ncbi Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation
    Lynda M Stuart
    Medical Research Council Center for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    J Immunol 168:1627-35. 2002
  3. ncbi Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion
    Mark Lucas
    University of Edinburgh/MRC Center for Inflammation Research, University of Edinburgh, College of Medicine and Veterinary Medicine, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    J Immunol 171:2610-5. 2003
  4. ncbi Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
    Joseph H McCarty
    Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17 227, Cambridge, MA 02139, USA
    Development 132:165-76. 2005
  5. ncbi Persistence of apoptotic cells without autoimmune disease or inflammation in CD14-/- mice
    Andrew Devitt
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, UK
    J Cell Biol 167:1161-70. 2004
  6. ncbi Designer macrophages: oxidative metabolism fuels inflammation repair
    Adam Lacy-Hulbert
    Centre for Inflammation Research, University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom
    Cell Metab 4:7-8. 2006
  7. ncbi Requirements for apoptotic cell contact in regulation of macrophage responses
    Mark Lucas
    Medical Research Council/University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom
    J Immunol 177:4047-54. 2006
  8. ncbi Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma
    Joseph H McCarty
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Am J Pathol 172:1740-7. 2008

Collaborators

  • John Savill
  • L M Stuart
  • Christopher D Gregory
  • Jurgen Roes
  • Adam Lacy-Hulbert
  • Joseph H McCarty
  • Mark Lucas
  • Richard O Hynes
  • Denise Crowley
  • Roderick T Bronson
  • Marc Barry
  • Andrew Devitt
  • Aileen M Smith
  • Hamid Tissire
  • Kairbaan Hodivala-Dilke
  • Roy Silverstein
  • Ailiang Zhang
  • Maria Febbraio
  • Kathryn J Moore
  • David Housman
  • Alain Charest
  • Lynsey A Melville
  • Ceri Oldreive
  • Michael F Clay
  • Christopher O Bellamy
  • Sanna M Goyert
  • Sophie C Gangloff
  • Kate G Parker
  • Carol Anne Ogden

Detail Information

Publications8

  1. ncbi Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins
    Adam Lacy-Hulbert
    Medical Research Council University of Edinburgh Centre for Inflammation Research, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Proc Natl Acad Sci U S A 104:15823-8. 2007
    ..Our results identify a vital role for myeloid alphav integrins in generating mucosal Treg cells and emphasize the importance of antigen-presenting cells in establishing immune tolerance...
  2. ncbi Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation
    Lynda M Stuart
    Medical Research Council Center for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    J Immunol 168:1627-35. 2002
    ....
  3. ncbi Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion
    Mark Lucas
    University of Edinburgh/MRC Center for Inflammation Research, University of Edinburgh, College of Medicine and Veterinary Medicine, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    J Immunol 171:2610-5. 2003
    ....
  4. ncbi Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
    Joseph H McCarty
    Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street, E17 227, Cambridge, MA 02139, USA
    Development 132:165-76. 2005
    ....
  5. ncbi Persistence of apoptotic cells without autoimmune disease or inflammation in CD14-/- mice
    Andrew Devitt
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, Scotland, UK
    J Cell Biol 167:1161-70. 2004
    ..We conclude that CD14 plays a broad tethering role in apoptotic cell clearance in vivo and that apoptotic cells can persist in the absence of proinflammatory consequences...
  6. ncbi Designer macrophages: oxidative metabolism fuels inflammation repair
    Adam Lacy-Hulbert
    Centre for Inflammation Research, University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom
    Cell Metab 4:7-8. 2006
    ..provide insight into the mechanisms by which reparative macrophages are generated and reveal a previously unappreciated link between this anti-inflammatory axis and mitochondrial oxidative metabolism (Vats el al., 2006)...
  7. ncbi Requirements for apoptotic cell contact in regulation of macrophage responses
    Mark Lucas
    Medical Research Council/University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom
    J Immunol 177:4047-54. 2006
    ..We conclude that the profound suppression of LPS-driven TNF-alpha release by macrophage populations requires hitherto obscure contact-dependent licensing of macrophage responsiveness to TGF-beta by apoptotic cells...
  8. ncbi Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma
    Joseph H McCarty
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Am J Pathol 172:1740-7. 2008
    ....