Thomas Kupper

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors
    Kazuki Hirahara
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Immunol 177:4488-94. 2006
  2. pmc Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells
    Rahul Purwar
    Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 18:1248-53. 2012
  3. pmc Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity
    Xiaodong Jiang
    Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 483:227-31. 2012
  4. pmc Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity
    Rahul Purwar
    Department of Dermatology, Brigham and Women s Hospital, Harvard Skin Disease Research Center, Boston, Massachusetts, United States of America
    PLoS ONE 6:e16245. 2011
  5. pmc Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity
    Luzheng Liu
    Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Harvard Skin Disease Research Center, Boston, Massachusetts, USA
    Nat Med 16:224-7. 2010
  6. pmc Old and new: recent innovations in vaccine biology and skin T cells
    Thomas S Kupper
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02493, USA
    J Invest Dermatol 132:829-34. 2012
  7. pmc Impact of specialist consultations on inpatient admissions for dermatology-specific and related DRGs
    Lissy Hu
    Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    J Gen Intern Med 28:1477-82. 2013
  8. pmc CD43 is a ligand for E-selectin on CLA+ human T cells
    Robert C Fuhlbrigge
    Department of Dermatology, Brigham and Women s Hospital, Harvard Institutes of Medicine, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Blood 107:1421-6. 2006
  9. ncbi request reprint A novel method for the isolation of skin resident T cells from normal and diseased human skin
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and the Harvard Skin Disease Research Center, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Invest Dermatol 126:1059-70. 2006
  10. ncbi request reprint The vast majority of CLA+ T cells are resident in normal skin
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and Harvard Skin Disease Research Center, Boston, MA 02115, USA
    J Immunol 176:4431-9. 2006

Research Grants

  1. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 2004
  2. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 2005
  3. SPORE in Skin Cancer
    Thomas Kupper; Fiscal Year: 2005
  4. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 2006
  5. IMMUNOPHYSIOLOGY OF KERATINOCYTE CYTOKINES
    Thomas Kupper; Fiscal Year: 2007
  6. DERMATOLOGY TRAINING GRANT
    Thomas Kupper; Fiscal Year: 2007
  7. SPORE in Skin Cancer
    Thomas Kupper; Fiscal Year: 2007
  8. Skin Homing T Cells -- Molecular Characterization of CLA
    Thomas Kupper; Fiscal Year: 2009
  9. IL-1 RECEPTORS AND CUTANEOUS DISEASE
    Thomas Kupper; Fiscal Year: 2003
  10. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 2003

Collaborators

Detail Information

Publications37

  1. ncbi request reprint The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors
    Kazuki Hirahara
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Immunol 177:4488-94. 2006
    ..Therefore, the majority of true circulating Treg express functional skin-homing receptors, and human Treg may regulate local immune responses in normal human skin...
  2. pmc Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells
    Rahul Purwar
    Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 18:1248-53. 2012
    ..These results suggest a role for IL-9 in tumor immunity and offer insight into potential therapeutic strategies. ..
  3. pmc Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity
    Xiaodong Jiang
    Department of Dermatology and Harvard Skin Disease Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 483:227-31. 2012
    ..These findings have important implications for our understanding of protective immune memory at epithelial interfaces with the environment, and suggest novel strategies for vaccines that protect against tissue tropic organisms...
  4. pmc Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity
    Rahul Purwar
    Department of Dermatology, Brigham and Women s Hospital, Harvard Skin Disease Research Center, Boston, Massachusetts, United States of America
    PLoS ONE 6:e16245. 2011
    ..This population of T cells may contribute to the pathogenesis of asthma and other T cell mediated lung diseases...
  5. pmc Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity
    Luzheng Liu
    Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Harvard Skin Disease Research Center, Boston, Massachusetts, USA
    Nat Med 16:224-7. 2010
    ..m.) injection as used in MVA clinical trials. Thus, delivery of rVACV-based vaccines, including MVA vaccines, through physically disrupted epidermis has clear-cut advantages over conventional vaccination via hypodermic injection...
  6. pmc Old and new: recent innovations in vaccine biology and skin T cells
    Thomas S Kupper
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02493, USA
    J Invest Dermatol 132:829-34. 2012
    ....
  7. pmc Impact of specialist consultations on inpatient admissions for dermatology-specific and related DRGs
    Lissy Hu
    Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    J Gen Intern Med 28:1477-82. 2013
    ..Identifying patients based on DRG codes includes all patients admitted for skin conditions and therefore allows for a more comprehensive analysis of the dermatologic care delivered...
  8. pmc CD43 is a ligand for E-selectin on CLA+ human T cells
    Robert C Fuhlbrigge
    Department of Dermatology, Brigham and Women s Hospital, Harvard Institutes of Medicine, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Blood 107:1421-6. 2006
    ..The identification and characterization of CD43 as a T-cell E-selectin ligand distinct from PSGL-1 expands the role of CD43 in the regulation of T-cell trafficking and provides new targets for the modulation of immune functions in skin...
  9. ncbi request reprint A novel method for the isolation of skin resident T cells from normal and diseased human skin
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and the Harvard Skin Disease Research Center, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Invest Dermatol 126:1059-70. 2006
    ..This method also allowed efficient isolation of malignant T cells from the skin lesions of cutaneous T cell lymphoma and the isolation of tumor-infiltrating lymphocytes from primary squamous cell carcinomas and melanoma metastases...
  10. ncbi request reprint The vast majority of CLA+ T cells are resident in normal skin
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and Harvard Skin Disease Research Center, Boston, MA 02115, USA
    J Immunol 176:4431-9. 2006
    ..These findings demonstrate that there is a large pool of memory T cells in normal skin that can initiate and perpetuate immune reactions in the absence of T cell recruitment from the blood...
  11. pmc IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin
    Rachael A Clark
    Department of Dermatology, Brigham and Women s Hospital and the Harvard Skin Disease Research Center, Boston, MA 02115, USA
    Blood 109:194-202. 2007
    ....
  12. pmc Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression
    Kei Ichi Yamanaka
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 121:148-157.e3. 2008
    ....
  13. pmc Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells
    Rachael A Clark
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 205:2221-34. 2008
    ..TLR7 agonists neutralized both of these strategies, supporting their use in SCCs and other tumors with similar immune defects...
  14. pmc Human skin cells support thymus-independent T cell development
    Rachael A Clark
    Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women s Hospital, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    J Clin Invest 115:3239-49. 2005
    ..Skin and bone marrow biopsies can thus be used to generate de novo functional and diverse T cell populations for potential therapeutic use in immunosuppressed patients...
  15. ncbi request reprint Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1
    Gunther G Pendl
    Institute of Cell Biology, ZMBE, University of Munster, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Blood 99:946-56. 2002
    ..Thus, fucosylated ligands of the endothelial selectins, determined in part by Fuc-TIV, and independent of PSGL-1, are required for extravasation of DCs into sites of cutaneous inflammation...
  16. ncbi request reprint Immunologic targets in psoriasis
    Thomas S Kupper
    Department of Dermatology, Brigham and Women s Hospital, Boston, USA
    N Engl J Med 349:1987-90. 2003
  17. ncbi request reprint E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system
    Benjamin F Chong
    Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 172:1575-81. 2004
    ..Coexpression of these molecules on blood vessels in noninflamed skin provides the basis for a model of cutaneous immunosurveillance system active in the absence of pathologic inflammation...
  18. pmc Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen
    Charles J Dimitroff
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 112:1008-18. 2003
    ..These data indicate that 4-F-GlcNAc prevents CHS by inhibiting selectin ligand activity and the capacity of effector T cells to enter antigen-challenged skin without affecting the afferent phase of CHS...
  19. ncbi request reprint Immune surveillance in the skin: mechanisms and clinical consequences
    Thomas S Kupper
    Department of Dermatology, Brigham and Women s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 4:211-22. 2004
  20. ncbi request reprint Identification of autoantigens in psoriatic plaques using expression cloning
    David A Jones
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 123:93-100. 2004
    ....
  21. ncbi request reprint Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model
    Jeff S Friedman
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Blood Marrow Transplant 10:448-60. 2004
    ..We suggest that the lack of effector activity demonstrated by old T cells in vivo is a reflection of a cell-autonomous defect downstream of signals required for antigen-driven proliferation...
  22. ncbi request reprint IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity
    Tamara Kopp
    Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, University of Vienna Medical School, Vienna International Research Cooperation Center, Vienna, Austria
    J Immunol 170:5438-44. 2003
    ..7 days, p < 0.01). Based on these results we propose that IL-23-induced changes of LC may be an important mechanism in directing the outcome of cutaneous immune responses...
  23. ncbi request reprint Increased CCR4 expression in cutaneous T cell lymphoma
    Katalin Ferenczi
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 119:1405-10. 2002
    ..These data may explain, in part, why these T cells accumulate in the skin, a diagnostic feature of cutaneous T cell lymphomas...
  24. ncbi request reprint Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots
    Robert C Fuhlbrigge
    Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 168:5645-51. 2002
    ....
  25. ncbi request reprint Monitoring the decrease of circulating malignant T cells in cutaneous T-cell lymphoma during photopheresis and interferon therapy
    Katalin Ferenczi
    Harvard Skin Disease Research Center, Boston, MA 02115, USA
    Arch Dermatol 139:909-13. 2003
    ..Treatment of advanced-stage CTCL is aimed at suppressing the dominant T-cell clone, which is typically present in the skin, peripheral blood, and lymph nodes...
  26. ncbi request reprint IL-1 alpha, innate immunity, and skin carcinogenesis: the effect of constitutive expression of IL-1 alpha in epidermis on chemical carcinogenesis
    Jo Ellen Murphy
    Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 170:5697-703. 2003
    ..These mice may provide a mechanism to investigate the validity of these models of human skin tumorigenesis...
  27. pmc Identification of cells initiating human melanomas
    Tobias Schatton
    Transplantation Research Center, Children s Hospital Boston and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 451:345-9. 2008
    ..Identification of tumour-initiating cells with enhanced abundance in more advanced disease but susceptibility to specific targeting through a defining chemoresistance determinant has important implications for cancer therapy...
  28. ncbi request reprint Imiquimod: a topically applied link between innate and acquired immunity
    Daniel J Hurwitz
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Dermatol 139:1347-50. 2003
  29. ncbi request reprint T-cell distribution and adhesion receptor expression in metastatic melanoma
    Carsten Weishaupt
    Department of Dermatology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Clin Cancer Res 13:2549-56. 2007
    ..To kill tumor, antigen-specific CTL must efficiently target and enter tumor tissue. The purpose of this study was to examine the pathway of leukocyte migration to metastatic melanoma...
  30. ncbi request reprint Dynamic programming of CD8+ T cell trafficking after live viral immunization
    Luzheng Liu
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Immunity 25:511-20. 2006
    ..These observations demonstrate a mechanism by which T cells provide both immediate tissue-specific immune control at the pathogen entry site and a more flexible systemic protection against pathogen dissemination...
  31. pmc Misbehaving macrophages in the pathogenesis of psoriasis
    Rachael A Clark
    Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 116:2084-7. 2006
    ..Strikingly, both groups report an important contribution by macrophages, implying that macrophages can contribute to both epithelial-based and T cell-mediated pathways of inflammation...
  32. pmc Skin-derived interleukin-7 contributes to the proliferation of lymphocytes in cutaneous T-cell lymphoma
    Kei Ichi Yamanaka
    Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 107:2440-5. 2006
    ..These observations led us to postulate that IL-7 produced by skin cells contributes to the survival and proliferation of T cells within skin lesions and is likely the source of elevated circulating IL-7 in CTCL...
  33. ncbi request reprint Activation of neutrophils in cutaneous T-cell lymphoma
    Deborah S Goddard
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Cancer Res 11:8243-9. 2005
    ..In working with blood from CTCL patients, we noticed frequent activation of neutrophils; therefore, we tested the hypothesis that neutrophils are activated in CTCL subjects compared with normal healthy controls...
  34. pmc Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion
    Luzheng Liu
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Suite 672, Boston, MA 02115, USA
    J Virol 79:7363-70. 2005
    ....
  35. ncbi request reprint Complete remission in a patient with angiosarcoma by the combination of OK-432, rhIL-2, and radiotherapy
    Tomoko Inaba
    Eur J Dermatol 15:411-3. 2005
  36. ncbi request reprint Decreased T-cell receptor excision circles in cutaneous T-cell lymphoma
    Kei Ichi Yamanaka
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 023115, USA
    Clin Cancer Res 11:5748-55. 2005
    ..Their concentration is therefore a measure of unexpanded naïve T cells relative to T cells that have undergone expansion...
  37. ncbi request reprint Counter-regulation of interleukin-1alpha (IL-1alpha) and IL-1 receptor antagonist in murine keratinocytes
    John B Mee
    Dermatology Section, Division of Medicine, Imperial College London, UK
    J Invest Dermatol 124:1267-74. 2005
    ..Taken together, these observations provide the first demonstration of mutual counter-regulation of IL-1 receptor ligands in keratinocytes...

Research Grants33

  1. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 2004
    ..This should add to our fundamental understanding of both normal immunosurveillance as well as T cell mediated organ specific inflammatory disease. ..
  2. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 2005
    ..This should add to our fundamental understanding of both normal immunosurveillance as well as T cell mediated organ specific inflammatory disease. ..
  3. SPORE in Skin Cancer
    Thomas Kupper; Fiscal Year: 2005
    ..An administrative structure is in place that will assure oversight, integration, planning, didactic activities, and most importantly, the growth and evolution of the SPORE over the next five years. ..
  4. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 2006
    ..This should add to our fundamental understanding of both normal immunosurveillance as well as T cell mediated organ specific inflammatory disease. ..
  5. IMMUNOPHYSIOLOGY OF KERATINOCYTE CYTOKINES
    Thomas Kupper; Fiscal Year: 2007
    ..These questions, which can only be answered in our transgenic system, will provide important insights into the relationship between keratinocytes, T cells, and skin disease...
  6. DERMATOLOGY TRAINING GRANT
    Thomas Kupper; Fiscal Year: 2007
    ..Given the unsettled future of NIH funding, we believe that this investment in the future has never been more pressing. ..
  7. SPORE in Skin Cancer
    Thomas Kupper; Fiscal Year: 2007
    ..This proposed work is facilitated through substantial supplemental institutional commitments from each participating DFHCC hospital. ..
  8. Skin Homing T Cells -- Molecular Characterization of CLA
    Thomas Kupper; Fiscal Year: 2009
    ..Knowledge generated from this grant application over the next five years will have a significant impact on both areas. ..
  9. IL-1 RECEPTORS AND CUTANEOUS DISEASE
    Thomas Kupper; Fiscal Year: 2003
    ..Recognition of antigen in skin by recruited T cells leads to T cell cytokine production, and, ultimately, elimination of the pathogen. ..
  10. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 2003
    ..This should add to our fundamental understanding of both normal immunosurveillance as well as T cell mediated organ specific inflammatory disease. ..
  11. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 2002
    ..This should add to our fundamental understanding of both normal immunosurveillance as well as T cell mediated organ specific inflammatory disease. ..
  12. IL-1 RECEPTORS AND CUTANEOUS DISEASE
    Thomas Kupper; Fiscal Year: 1999
    ..Recognition of antigen in skin by recruited T cells leads to T cell cytokine production, and, ultimately, elimination of the pathogen. ..
  13. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 1999
    ....
  14. ROLE OF IL-1 RECEPTORS IN CUTANEOUS DISEASE
    Thomas Kupper; Fiscal Year: 1993
    ..We propose that inflammatory skin diseases, including psoriasis, reflect disequilibrium in the balance of this highly conserved relationship between IL-1 and the IL-1R in epidermis,..
  15. ROLE OF IL-1 RECEPTORS IN CUTANEOUS DISEASE
    Thomas Kupper; Fiscal Year: 1992
    ..We propose that inflammatory skin diseases, including psoriasis, reflect disequilibrium in the balance of this highly conserved relationship between IL-1 and the IL-1R in epidermis,..
  16. IL-1 RECEPTORS AND CUTANEOUS DISEASE
    Thomas Kupper; Fiscal Year: 2000
    ..Recognition of antigen in skin by recruited T cells leads to T cell cytokine production, and, ultimately, elimination of the pathogen. ..
  17. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 2000
    ....
  18. IL-1 RECEPTORS AND CUTANEOUS DISEASE
    Thomas Kupper; Fiscal Year: 2001
    ..Recognition of antigen in skin by recruited T cells leads to T cell cytokine production, and, ultimately, elimination of the pathogen. ..
  19. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 2001
    ....
  20. IL-1 RECEPTORS AND CUTANEOUS DISEASE
    Thomas Kupper; Fiscal Year: 2002
    ..Recognition of antigen in skin by recruited T cells leads to T cell cytokine production, and, ultimately, elimination of the pathogen. ..
  21. Skin Homing T Cells -- Molecular Characterization of CLA
    Thomas S Kupper; Fiscal Year: 2010
    ..Knowledge generated from this grant application over the next five years will have a significant impact on both areas. ..