Thomas Kuntzen

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Intrahepatic mRNA expression in hepatitis C virus and HIV/hepatitis C virus co-infection: infiltrating cells, cytokines, and influence of HAART
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    AIDS 22:203-10. 2008
  2. pmc Temporal dynamics of a predominant protease inhibitor-resistance mutation in a treatment-naive, hepatitis C virus-infected individual
    Arthur Y Kim
    Partners AIDS Research Center, Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Infect Dis 199:737-41. 2009
  3. pmc Viral sequence evolution in acute hepatitis C virus infection
    Thomas Kuntzen
    Massachusetts General Hospital, Infectious Disease, 13th Street, Charlestown, MA 02129, USA
    J Virol 81:11658-68. 2007
  4. pmc High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome
    Victoria Kasprowicz
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 82:3154-60. 2008
  5. pmc Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Hepatology 48:1769-78. 2008
  6. pmc Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes
    Arthur Y Kim
    Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, GRB 504, Boston, Massachusetts 02114, USA
    Gastroenterology 140:686-696.e1. 2011
  7. pmc Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
    Victoria Kasprowicz
    Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Virol 84:1656-63. 2010
  8. pmc Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 82:5594-605. 2008
  9. pmc Transmission and long-term stability of compensated CD8 escape mutations
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA, USA
    J Virol 83:3993-7. 2009
  10. pmc A set of reference sequences for the hepatitis C genotypes 4d, 4f, and 4k covering the full open reading frame
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Med Virol 80:1370-8. 2008

Detail Information

Publications14

  1. ncbi request reprint Intrahepatic mRNA expression in hepatitis C virus and HIV/hepatitis C virus co-infection: infiltrating cells, cytokines, and influence of HAART
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    AIDS 22:203-10. 2008
    ..This accelerated pathogenesis is probably influenced by differences in the composition of infiltrating inflammatory cells and the local release of inflammatory and profibrogenic cytokines...
  2. pmc Temporal dynamics of a predominant protease inhibitor-resistance mutation in a treatment-naive, hepatitis C virus-infected individual
    Arthur Y Kim
    Partners AIDS Research Center, Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Infect Dis 199:737-41. 2009
    ..The persistence of drug-resistance mutations argues for baseline resistance genotyping at the time therapy is initiated to accurately predict the efficacy of treatment...
  3. pmc Viral sequence evolution in acute hepatitis C virus infection
    Thomas Kuntzen
    Massachusetts General Hospital, Infectious Disease, 13th Street, Charlestown, MA 02129, USA
    J Virol 81:11658-68. 2007
    ....
  4. pmc High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome
    Victoria Kasprowicz
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 82:3154-60. 2008
    ..Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection...
  5. pmc Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Hepatology 48:1769-78. 2008
    ....
  6. pmc Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes
    Arthur Y Kim
    Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, GRB 504, Boston, Massachusetts 02114, USA
    Gastroenterology 140:686-696.e1. 2011
    ..We aimed to determine the correlations between these alleles and natural outcomes of HCV and determine associated key T-cell responses...
  7. pmc Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
    Victoria Kasprowicz
    Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Virol 84:1656-63. 2010
    ..Our data indicate that most CD8 T-cell responses in chronic HCV infection do not target the circulating virus and that the appearance of HCV-specific CD127(+) T cells is driven by viral variation...
  8. pmc Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 82:5594-605. 2008
    ....
  9. pmc Transmission and long-term stability of compensated CD8 escape mutations
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA, USA
    J Virol 83:3993-7. 2009
    ..Herein, we illustrate the long-term stability of stereotypic escape mutations in the immunodominant HLA-B27-restricted epitope KK10 in p24/Gag following transmission when accompanied by a specific compensatory mutation...
  10. pmc A set of reference sequences for the hepatitis C genotypes 4d, 4f, and 4k covering the full open reading frame
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Med Virol 80:1370-8. 2008
    ..Reference sequences for accurate HCV genotyping are required for optimized treatment, and a better knowledge of the global viral sequence diversity is needed to guide vaccines or new drugs effective in the world wide epidemic...
  11. ncbi request reprint Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution
    Joerg Timm
    Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Hepatology 46:339-49. 2007
    ....
  12. pmc Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non-genotype 1 infection
    Julian Schulze zur Wiesch
    Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Blood 110:1559-69. 2007
    ....
  13. pmc Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Virol 81:12382-93. 2007
    ....
  14. pmc Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection
    Arthur Y Kim
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 3:e492. 2006
    ..Here we examined the effect of a lymphotropic virus, HIV-1, on the ability of coinfected patients to maintain spontaneous control of HCV infection...