L Kruglyak

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Parametric and nonparametric linkage analysis: a unified multipoint approach
    L Kruglyak
    Whitehead Institute for Biomedical Research, Cambridge
    Am J Hum Genet 58:1347-63. 1996
  2. ncbi request reprint The use of a genetic map of biallelic markers in linkage studies
    L Kruglyak
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02139, USA
    Nat Genet 17:21-4. 1997
  3. ncbi request reprint Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome
    D G Wang
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 280:1077-82. 1998
  4. ncbi request reprint Sib-pair collection strategies for complex diseases
    M I McCarthy
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Genet Epidemiol 15:317-40. 1998
  5. pmc Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion
    K Ardlie
    Center for Genome Research, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    Am J Hum Genet 69:582-9. 2001
  6. ncbi request reprint Building human genome maps with radiation hybrids
    D Slonim
    Whitehead MIT Center for Genome Research, Cambridge 02139, USA
    J Comput Biol 4:487-504. 1997
  7. ncbi request reprint Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families
    M M Mahtani
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nat Genet 14:90-4. 1996
  8. ncbi request reprint The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression
    B A Hamilton
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Neuron 18:711-22. 1997
  9. ncbi request reprint Disruption of the nuclear hormone receptor RORalpha in staggerer mice
    B A Hamilton
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nature 379:736-9. 1996

Collaborators

Detail Information

Publications9

  1. pmc Parametric and nonparametric linkage analysis: a unified multipoint approach
    L Kruglyak
    Whitehead Institute for Biomedical Research, Cambridge
    Am J Hum Genet 58:1347-63. 1996
    ..The package allows efficient multipoint analysis of pedigree data to be performed rapidly in a single user-friendly environment...
  2. ncbi request reprint The use of a genetic map of biallelic markers in linkage studies
    L Kruglyak
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02139, USA
    Nat Genet 17:21-4. 1997
    ..I conclude that a map of 700-900 moderately polymorphic biallelic markers is equivalent--and a map of 1,500-3,000 superior--to the current 300-400 microsatellite marker sets...
  3. ncbi request reprint Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome
    D G Wang
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 280:1077-82. 1998
    ..The results provide a characterization of human diversity at the nucleotide level and demonstrate the feasibility of large-scale identification of human SNPs...
  4. ncbi request reprint Sib-pair collection strategies for complex diseases
    M I McCarthy
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Genet Epidemiol 15:317-40. 1998
    ..In addition, these findings suggest that a further explanation for failure to replicate positive complex trait linkages lies in differences in ascertainment strategy between data sets...
  5. pmc Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion
    K Ardlie
    Center for Genome Research, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    Am J Hum Genet 69:582-9. 2001
    ..This estimate is an order of magnitude higher than most estimates based on nucleotide diversity. The most likely explanation of this discrepancy is that gene conversion increases the apparent rate of recombination between nearby loci...
  6. ncbi request reprint Building human genome maps with radiation hybrids
    D Slonim
    Whitehead MIT Center for Genome Research, Cambridge 02139, USA
    J Comput Biol 4:487-504. 1997
    ..Finally, we show results validating our software on simulated data, and we describe our genome-wide human radiation hybrid maps and the evidence supporting them...
  7. ncbi request reprint Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families
    M M Mahtani
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nat Genet 14:90-4. 1996
    ..We infer the existence of a gene NIDDM2 causing NIDDM associated with low insulin secretion, and suggest that NIDDM2 and MODY3 may represent different alleles of the same gene...
  8. ncbi request reprint The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression
    B A Hamilton
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Neuron 18:711-22. 1997
    ..The vibrator phenotype is suppressed in one intercross. We performed a complete genome scan and mapped a major suppressor locus (Mvb-1) to proximal chromosome 19...
  9. ncbi request reprint Disruption of the nuclear hormone receptor RORalpha in staggerer mice
    B A Hamilton
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nature 379:736-9. 1996
    ..We propose a model based on these results, in which RORalpha interacts with the thyroid hormone signalling pathway to induce Purkinje-cell maturation...