Research Topics
Species | Henry KronenbergSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
PTHrP and skeletal developmentHenry M Kronenberg
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Ann N Y Acad Sci 1068:1-13. 2006..These pathways and undoubtedly others cooperate to regulate the pace of differentiation of growth plate chondrocytes in response to PTHrP...
Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursorsRazvan L Miclea
Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
BMC Dev Biol 9:26. 2009..Adenomatous polyposis coli (Apc) is a key controller of beta-catenin turnover by down-regulating intracellular levels of beta-catenin...- Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTHJun Guo
Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Endocrinology 151:3502-13. 2010..Furthermore, PTH stimulated proliferation and increased mRNAs encoding cyclin D1 in primary osteoblasts derived from Wt but not from DSEL mice. Our data indicate that PLC signaling through the PTHR is required for skeletal homeostasis... 
Gs signaling in osteoblasts and hematopoietic stem cellsHenry M Kronenberg
Harvard Medical School, Boston, Massachusetts, USA
Ann N Y Acad Sci 1192:327-9. 2010....- The role of the perichondrium in fetal bone developmentHenry M Kronenberg
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Ann N Y Acad Sci 1116:59-64. 2007..Here I illustrate briefly examples of the complicated interactions between the perichondrium and the underlying growth cartilage... - Minireview: transcriptional regulation in development of boneTatsuya Kobayashi
Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Endocrinology 146:1012-7. 2005..Further study of these molecules will lead to deeper understanding in mechanisms that govern development of bone... - BMP signaling stimulates cellular differentiation at multiple steps during cartilage developmentTatsuya Kobayashi
Endocrine Unit, Massachusetts General Hospital, Boston, 02114, USA
Proc Natl Acad Sci U S A 102:18023-7. 2005..These results suggest that BMP signaling in prechondrogenic cells and in growth plate chondrocytes stimulates their chondrocytic differentiation and maturation toward hypertrophy, respectively... - Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturationSylvain Provot
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Development 133:651-62. 2006..Taken together, these results suggest that PTHrP signals block chondrocyte hypertrophy by, in part, maintaining the expression of Nkx3.2/Bapx1, which in turn represses the expression of genes required for chondrocyte maturation... - PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathwaysJun Guo
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Dev Biol 292:116-28. 2006..These data indicate that the delayed hypertrophy induced by PTHrP is mediated by both Runx2-dependent and -independent mechanisms... - PTH regulates the hematopoietic stem cell niche in boneHenry M Kronenberg
Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School Boston, MA, USA
Adv Exp Med Biol 602:57-60. 2007 - A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytesSylvain Provot
Massachusetts General Hospital Harvard Medical School, Endocrine Unit, 50 Blossom Street, Thier 1101, Boston, MA 02114 2696, USA
Mol Cell Biol 28:344-57. 2008.... - A novel transgenic mouse model to study the osteoblast lineage in vivoChrista Maes
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Ann N Y Acad Sci 1116:149-64. 2007..Here, we developed a transgenic mouse system to study stage-specific subsets of osteoblast lineage cells. We believe that this system will prove to be a helpful tool in deciphering multiple aspects of osteoblast biology in vivo... - Dicer-dependent pathways regulate chondrocyte proliferation and differentiationTatsuya Kobayashi
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 105:1949-54. 2008..Our results demonstrate the critical role of the Dicer-dependent pathway in the regulation of chondrocyte proliferation and differentiation during skeletal development... - Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiationMatthew J Hilton
Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
Nat Med 14:306-14. 2008..Thus, mesenchymal progenitors may be expanded in vitro by activating the Notch pathway, whereas bone formation in vivo may be enhanced by transiently suppressing this pathway... - Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophyKinglun Kingston Mak
Genetic Disease Research Branch, National Human Genome Research Institute, 49 Convent Drive, MSC 4472, Bethesda, MD 20892, USA
Development 135:1947-56. 2008..In addition, we found that bone morphogenetic protein (Bmp) and Wnt/beta-catenin signaling in the cartilage may both mediate the effect of upregulated Ihh signaling in promoting chondrocyte hypertrophy... - Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34Dengshun Miao
Calcium Research Laboratory and Department of Medicine, Royal Victoria Hospital of the McGill University Health Centre, Montreal, Quebec, Canada
J Clin Invest 115:2402-11. 2005.... - Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrPTatsuya Kobayashi
Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA
J Clin Invest 115:1734-42. 2005..These results demonstrate that Ihh acts on periarticular chondrocytes to stimulate their differentiation, thereby regulating the columnar cell mass independently of PTHrP... - PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple stepsTatsuya Kobayashi
Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Development 129:2977-86. 2002..Thus, chondrocyte differentiation is controlled at multiple steps by PTHrP and Ihh through the mutual regulation of their activities... - p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone developmentFerdinand Rossi
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, 10032, USA
Dev Biol 247:271-85. 2002..The results suggest that Cbfa1 links a p107- and p130-mediated cell cycle arrest to chondrocyte terminal differentiation... - The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase CJun Guo
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Dev Cell 3:183-94. 2002.... - Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone developmentHelen E MacLean
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Dev Biol 262:51-63. 2003..5 in the c-maf-null. MMP-13 is known to be regulated by AP-1 and may also be a target of c-Maf. Thus, cartilage is a novel system in which c-Maf acts during development, where c-Maf is required for normal chondrocyte differentiation... - Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitroHong In Shin
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Endocrinology 145:1376-85. 2004..These studies demonstrate the importance of gp130 signaling for osteoblast function and calcium homeostasis... - Ihh signaling is directly required for the osteoblast lineage in the endochondral skeletonFanxin Long
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Development 131:1309-18. 2004..We suggest that Ihh acts in vivo on a potential progenitor cell to promote osteoblast and prevent chondrocyte differentiation... - The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytesHelen E MacLean
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Invest 113:1334-43. 2004..These studies suggest that the effects of PTHrP on both the rate and extent of chondrocyte proliferation are mediated, at least in part, through suppression of p57 expression... - Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivoMurat Bastepe
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 101:14794-9. 2004..These data suggest that Gsalpha is the primary mediator of the actions of PPR in growth plate chondrocytes and that there is haploinsufficiency of Gsalpha signaling in Gnas(+/E2-) chondrocytes... - Localization of Indian hedgehog and PTH/PTHrP receptor expression in relation to chondrocyte proliferation during mouse bone developmentHelen E MacLean
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Dev Growth Differ 47:59-63. 2005..This study provides further evidence that in the developing growth plate, cell cycle exit and upregulation of Ihh and PPR mRNA expression are coupled... - Expression of Stra13 during mouse endochondral bone developmentHelen E MacLean
Endocrine Unit, WEL501, Massachusetts General Hospital, 50 Blossom St, Boston, MA 02114, USA
Gene Expr Patterns 4:633-6. 2004..Thus, there was a large degree of overlap in the expression patterns of Stra13 and VEGF in chondrocytes during embryonic development... - The interplay of osteogenesis and hematopoiesis: expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrowSergei A Kuznetsov
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Biol 167:1113-22. 2004..Thus, PTH/PTHrP signaling is a major regulator of the ontogeny of the bone marrow and its stromal tissue, and of the skeletal stem cell compartment... - Chondrocyte-specific knockout of the G protein G(s)alpha leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formationAkio Sakamoto
Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Bone Miner Res 20:663-71. 2005..These results show that G(s)alpha negatively regulates chondrocyte differentiation and is the critical signaling mediator of the PTH/PTH-rP receptor in growth plate chondrocytes... - Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related proteinLewis P Rubin
Department of Pediatrics, Brown Medical School and Women and Infants Hospital, Providence, Rhode Island 02905 2499, USA
Dev Dyn 230:278-89. 2004.... - Developmental regulation of the growth plateHenry M Kronenberg
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 2696, USA
Nature 423:332-6. 2003..The past few years have seen an enormous increase in understanding of the signalling pathways and the transcription factors that control endochondral bone development... - Osteopontin negatively regulates parathyroid hormone receptor signaling in osteoblastsNoriaki Ono
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, 113 8510, Tokyo, Japan
J Biol Chem 283:19400-9. 2008..Thus, in addition to the well known calcemic feedback system for PTH, local feedback regulation by the bone matrix protein OPN also plays a significant role in the regulation of PTH actions... - Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivoHeather E Fleming
Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Cell Stem Cell 2:274-83. 2008..Wnt pathway activation in the niche is required to limit HSC proliferation and preserve the reconstituting function of endogenous hematopoietic stem cells... - Constitutively active parathyroid hormone receptor signaling in cells in osteoblastic lineage suppresses mechanical unloading-induced bone resorptionNoriaki Ono
Department of Molecular Pharmacology, Medical Research Institute, Graduate School, Tokyo Medical and Dental University, and Endocrine Unit, Massachusetts General Hospital, Boston 02114, USA
J Biol Chem 282:25509-16. 2007..These results indicated that constitutive activation of PTH/PTHrP receptor signaling in osteoblastic cells suppresses unloading-induced bone loss specifically through the regulation of osteoclastic activity... - Reduced expression of the PTH/PTHrP receptor during development of the mammary gland influences the function of the nipple during lactationTatsuya Kobayashi
Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
Dev Dyn 233:794-803. 2005..Reduced smooth muscle appears to underlie the majority of nipple deficiencies in mice with lower levels of the Ppr expression...
Research Grants
- Gene Expression Core FacilityHenry Kronenberg; Fiscal Year: 2003..lectures given by Core Facility Scientific directors to explain the technology and its uses; D. a lecture series involving invited speakers from the Boston area using the technology in imaginative ways. ..
- FUNCTION OF STIMULATORY G PROTEIN (GS) IN BONE IN VIVOHenry Kronenberg; Fiscal Year: 2003..Together, these studies will define the interactions of Gs signaling with other important signaling pathways and the role of Gs in regulating normal bone development. ..
- Specialized Center for Research in OsteoporosisHenry Kronenberg; Fiscal Year: 2004..An Administrative Core will assure that communication between the various projects is optimal and will monitor the progress of each project. ..
- 2007 CARTILAGE BIOLOGY & PATHOLOGY GORDON RESEARCH CONFERENCEHenry Kronenberg; Fiscal Year: 2007..Special attention has been given to assure that the meeting takes full advantage of substantial representation of woman scientists as speakers and session chairs. ..