M Krieger

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Degeneration of dopaminergic neurons triggers an expression of individual enzymes of dopamine synthesis in non-dopaminergic neurons of the arcuate nucleus in adult rats
    P V Ershov
    Laboratory of Neurohistology, Institute of Normal Physiology, Russian Academy of Medical Sciences, 8 Baltiiskaya St, Moscow, Russia
    J Chem Neuroanat 30:27-33. 2005
  2. ncbi request reprint Charting the fate of the "good cholesterol": identification and characterization of the high-density lipoprotein receptor SR-BI
    M Krieger
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Annu Rev Biochem 68:523-58. 1999
  3. ncbi request reprint Regulation by adrenocorticotropic hormone of the in vivo expression of scavenger receptor class B type I (SR-BI), a high density lipoprotein receptor, in steroidogenic cells of the murine adrenal gland
    A Rigotti
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 271:33545-9. 1996
  4. ncbi request reprint Influence of the HDL receptor SR-BI on atherosclerosis
    M Krieger
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Curr Opin Lipidol 10:491-7. 1999
  5. pmc Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex
    J E Chatterton
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 96:915-20. 1999
  6. ncbi request reprint Identification of scavenger receptor SR-BI as a high density lipoprotein receptor
    S Acton
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Science 271:518-20. 1996
  7. pmc Expression cloning of dSR-CI, a class C macrophage-specific scavenger receptor from Drosophila melanogaster
    A Pearson
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Proc Natl Acad Sci U S A 92:4056-60. 1995
  8. ncbi request reprint Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II
    L Rohrer
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02168
    Nature 343:570-2. 1990
  9. pmc Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology
    B Trigatti
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 96:9322-7. 1999
  10. ncbi request reprint Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake
    S Xu
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Lipid Res 38:1289-98. 1997

Collaborators

  • A Rigotti
  • M Freeman
  • S Xu
  • Q Guo
  • E Vasile
  • T Kodama
  • B Trigatti
  • X Huang
  • A Braun
  • S D Podos
  • H H Hobbs
  • J Herz
  • H Steller
  • Olivier N Kocher
  • Vassilis Zannis
  • Hudson Freeze
  • Jay M Edelberg
  • Thomas J F Nieland
  • Ayce Yesilaltay
  • Toshihiko Oka
  • Daniel Ungar
  • Sharon L Karackattu
  • Frederick M Hughson
  • Tomas Kirchhausen
  • Marsha Penman
  • Janka Kisucka
  • Vandana S Dole
  • Sara A Fenske
  • Denisa D Wagner
  • Jay L Duffner
  • Jared T Shaw
  • Angela N Koehler
  • Firoz A Jaipuri
  • Rinku Pal
  • Francois Foulquier
  • Zoltan Maliga
  • Songwen Zhang
  • P V Ershov
  • Michael H Picard
  • Veronica Quinones
  • Ludwig Amigo
  • Xiaohua Wu
  • Marisa Vinals
  • Scott D Covey
  • Horng Yuan Kan
  • Xiaoping Li
  • J E Chatterton
  • Tong Liu
  • Teresa M Holm
  • Pablo Mardones
  • Bin Liu
  • H E Miettinen
  • D Gachotte
  • Wolfgang Bergmeier
  • Jana Matuskova
  • Richard A Van Etten
  • Michael Bernimoulin
  • Sotirios Banakos
  • Carola Neumann
  • Kathleen Daniels
  • Ian S Patten
  • Anil K Chauhan
  • Philippa Mills
  • Maria Gabriela Morales
  • Tim Raemaekers
  • Dulce Quelhas
  • Andrea Leiva
  • Bryan Winchester
  • Els Schollen
  • Karen F Kozarsky
  • Gert Matthijs
  • Jaak Jaeken
  • Nico Callewaert
  • Silvana Zanlungo
  • Mary H Donahee
  • Wim Annaert
  • Karl H Weisgraber
  • Yu Zhu
  • Marcelo Ehrlich
  • M V Ugrumov
  • Carl D Novina
  • Derek M Dykxhoorn
  • J Thibault
  • Robert L Raffai
  • A Calas
  • S Acton
  • Ognian Bohorov
  • Richard A Steet
  • Jaap Bakker
  • Stuart Kornfeld

Detail Information

Publications61

  1. ncbi request reprint Degeneration of dopaminergic neurons triggers an expression of individual enzymes of dopamine synthesis in non-dopaminergic neurons of the arcuate nucleus in adult rats
    P V Ershov
    Laboratory of Neurohistology, Institute of Normal Physiology, Russian Academy of Medical Sciences, 8 Baltiiskaya St, Moscow, Russia
    J Chem Neuroanat 30:27-33. 2005
    ..Thus, degeneration of dopaminergic neurons in the arcuate nucleus of adult rats is accompanied by the expression of individual enzymes of DA synthesis in non-dopaminergic neurons that may be an adaptive reaction...
  2. ncbi request reprint Charting the fate of the "good cholesterol": identification and characterization of the high-density lipoprotein receptor SR-BI
    M Krieger
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Annu Rev Biochem 68:523-58. 1999
    ..SR-BI may play a similar role in humans; thus, modulation of its activity may provide the basis of future approaches to the treatment and prevention of atherosclerotic disease...
  3. ncbi request reprint Regulation by adrenocorticotropic hormone of the in vivo expression of scavenger receptor class B type I (SR-BI), a high density lipoprotein receptor, in steroidogenic cells of the murine adrenal gland
    A Rigotti
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 271:33545-9. 1996
    ..These data provide strong support for the hypothesis that SR-BI is a physiologically relevant HDL receptor that provides substrate cholesterol for steroid hormone synthesis...
  4. ncbi request reprint Influence of the HDL receptor SR-BI on atherosclerosis
    M Krieger
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Curr Opin Lipidol 10:491-7. 1999
    ..If SR-BI has a similar activity in humans, it may become an attractive target for therapeutic intervention...
  5. pmc Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex
    J E Chatterton
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 96:915-20. 1999
    ..Normal assembly of this complex is ldlBp-dependent and may be required for Golgi association of ldlCp and for the normal activities of multiple luminal Golgi processes...
  6. ncbi request reprint Identification of scavenger receptor SR-BI as a high density lipoprotein receptor
    S Acton
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Science 271:518-20. 1996
    ..SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway...
  7. pmc Expression cloning of dSR-CI, a class C macrophage-specific scavenger receptor from Drosophila melanogaster
    A Pearson
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Proc Natl Acad Sci U S A 92:4056-60. 1995
    ..Genetic and physiologic analysis of dSR-CI function in Drosophila should provide further insights into the roles played by scavenger receptors in host defense and development...
  8. ncbi request reprint Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II
    L Rohrer
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02168
    Nature 343:570-2. 1990
    ..Therefore one or both of the extracellular fibrous domains are responsible for the unusual ligand-binding specificity of the receptor...
  9. pmc Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology
    B Trigatti
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 96:9322-7. 1999
    ..If SR-BI has similar activities in humans, it may become an attractive target for therapeutic intervention in a variety of diseases...
  10. ncbi request reprint Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake
    S Xu
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Lipid Res 38:1289-98. 1997
    ....
  11. pmc Disruptions in Golgi structure and membrane traffic in a conditional lethal mammalian cell mutant are corrected by epsilon-COP
    Q Guo
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    J Cell Biol 125:1213-24. 1994
    ..Thus, along with biochemical and yeast genetics methods, mammalian somatic cell mutants can provide powerful tools for the elucidation of the mechanisms underlying intracellular membrane traffic...
  12. pmc Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)-deficient mice
    H E Miettinen
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 108:1717-22. 2001
    ..This suggests that abnormal lipoprotein metabolism can cause murine infertility--implying a functional hepatic-ovarian axis--and may contribute to some forms of human female infertility...
  13. ncbi request reprint Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors
    J Ashkenas
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    J Lipid Res 34:983-1000. 1993
    ..5-12.8 micrograms protein/ml) affinity binding of 125I-labeled AcLDL. The ability of ReLPS (1 mg/ml) to inhibit either or both of these two classes of binding interactions varied depending on the species and type of receptor...
  14. ncbi request reprint Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolae
    J Babitt
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 272:13242-9. 1997
    ..Thus, mSR-BI colocalizes with caveolae, and this raises the possibility that the unique properties of these specialized cell surface domains may play a critical role in SR-BI-mediated transfer of lipids between lipoproteins and cells...
  15. pmc A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism
    A Rigotti
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 94:12610-5. 1997
    ..If it has a similar role in controlling plasma HDL in humans, SR-BI may influence the development and progression of atherosclerosis and may be an attractive candidate for therapeutic intervention in this disease...
  16. ncbi request reprint Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils
    T Kodama
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Nature 343:531-5. 1990
    ..This stalk structure, composed of an alpha-helical coiled coil and a collagen-like triple helix, has not previously been observed in an integral membrane protein...
  17. ncbi request reprint A single point mutation in epsilon-COP results in temperature-sensitive, lethal defects in membrane transport in a Chinese hamster ovary cell mutant
    Q Guo
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Biol Chem 271:11191-6. 1996
    ..ldlF cells should be useful for the future analysis of the structure and function of epsilon-COP, the assembly of COPs into coatomers, and the participation of coatomers in intracellular membrane transport...
  18. ncbi request reprint Expression cloning of SR-BI, a CD36-related class B scavenger receptor
    S L Acton
    Department of Biology, Massachusetts Institute of Technology, Cambridge
    J Biol Chem 269:21003-9. 1994
    ..Thus, the tissue distribution of expression and ligand binding properties of SR-BI raise the possibility that this cell surface receptor may play an important role in lipid metabolism...
  19. pmc LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function
    S D Podos
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    J Cell Biol 127:679-91. 1994
    ....
  20. ncbi request reprint Structures of class A macrophage scavenger receptors. Electron microscopic study of flexible, multidomain, fibrous proteins and determination of the disulfide bond pattern of the scavenger receptor cysteine-rich domain
    D Resnick
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 271:26924-30. 1996
    ..The apparent juxtaposition of the fibrous domains at neutral pH provides a framework for future structure-function studies of these unusual multiligand receptors...
  21. pmc An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors
    M Freeman
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Proc Natl Acad Sci U S A 87:8810-4. 1990
    ..Highly homologous SRCR domains (one, three, or four per polypeptide chain) are found in diverse secreted and cell-surface proteins from humans (e.g., CD5, complement factor I), mice (Ly-1), and sea urchins (speract receptor)...
  22. pmc Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation
    D Gachotte
    Department of Biology, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 96:12655-60. 1999
    ..In addition, a fifth intermediate was isolated and identified by (1)H NMR as a 4-methyl-24, 25-epoxy-cholesta-7-en-3-one. Implications of these results are discussed...
  23. pmc Macrophages in Drosophila embryos and L2 cells exhibit scavenger receptor-mediated endocytosis
    J M Abrams
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Proc Natl Acad Sci U S A 89:10375-9. 1992
    ..They also establish additional systems for the investigation of endocytosis in Drosophila and scavenger receptor function in disease, host defense, and development...
  24. ncbi request reprint Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:52820-5. 2003
    ..The PDZK1-dependent regulation of hepatic SR-BI and, thus, lipoprotein metabolism supports the proposal that this adaptor may represent a new target for therapeutic intervention in cardiovascular disease...
  25. ncbi request reprint Lymphocytes are not required for the rapid onset of coronary heart disease in scavenger receptor class B type I/apolipoprotein E double knockout mice
    Sharon L Karackattu
    Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Arterioscler Thromb Vasc Biol 25:803-8. 2005
    ..Here we determined the influence of B and T lymphocytes, which can contribute to atherosclerosis, ischemia-reperfusion injury, and cardiomyocyte death, on pathology in dKO mice...
  26. ncbi request reprint Regulation of SR-BI-mediated high-density lipoprotein metabolism by the tissue-specific adaptor protein PDZK1
    Ayce Yesilaltay
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Opin Lipidol 16:147-52. 2005
    ..This review will focus on one of these lipoprotein receptor-adaptor pairs, the high-density lipoprotein receptor SR-BI (scavenger receptor class B, type I) and its adaptor PDZK1...
  27. ncbi request reprint Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI
    Thomas J F Nieland
    Department of Cell Biology, Harvard Medical School and the CBR Institute for Biomedical Research, 200 Longwood Avenue, Room 134, Boston, MA 02115, USA
    Biochim Biophys Acta 1734:44-51. 2005
    ..These findings suggest that mSR-BI-mediated selective uptake occurs at the cell surface upon the association of lipoproteins with mSR-BI and does not require endocytosis of HDL or LDL particles...
  28. ncbi request reprint Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide
    Thomas J F Nieland
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Lipid Res 45:1256-65. 2004
    ..The reciprocal inhibition of SR-BI and ABCA1 by BLT-4 and glyburide raises the possibility that these proteins may share similar or common steps in their mechanisms of lipid transport...
  29. ncbi request reprint PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function
    Ayce Yesilaltay
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 281:28975-80. 2006
    ..Thus, PDZK1 is important for maintaining adequate steady state levels of SR-BI in the liver but is not essential for cell surface expression or function of hepatic SR-BI...
  30. ncbi request reprint Effects of hepatic expression of the high-density lipoprotein receptor SR-BI on lipoprotein metabolism and female fertility
    Ayce Yesilaltay
    Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Endocrinology 147:1577-88. 2006
    ....
  31. pmc Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity
    Thomas J F Nieland
    Department of Biology, Massachusetts Institute of Technology, Room 68 483, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Biochemistry 47:460-72. 2008
    ..Consequently, BLTs may help determine the therapeutic potential of SR-BI-targeted pharmaceutical drugs...
  32. pmc Influence of PDZK1 on lipoprotein metabolism and atherosclerosis
    Olivier Kocher
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Biochim Biophys Acta 1782:310-6. 2008
    ..They also define PDZK1 as a member of the family of proteins that is instrumental in preventing cardiovascular disease by maintaining normal lipoprotein metabolism...
  33. pmc Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient mice
    Vandana S Dole
    Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Arterioscler Thromb Vasc Biol 28:1111-6. 2008
    ..Here we examined the influence of SR-BI deficiency on platelets...
  34. ncbi request reprint Influence of the HDL receptor SR-BI on lipoprotein metabolism and atherosclerosis
    Bernardo L Trigatti
    Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada
    Arterioscler Thromb Vasc Biol 23:1732-8. 2003
    ..Remarkably, SR-BI/apolipoprotein E double-knockout mice develop complex coronary artery disease, myocardial infarction, and heart failure. Additional studies should help to define the importance of SR-BI in human health and disease...
  35. ncbi request reprint Scavenger receptor class B type I-mediated protection against atherosclerosis in LDL receptor-negative mice involves its expression in bone marrow-derived cells
    Scott D Covey
    Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada
    Arterioscler Thromb Vasc Biol 23:1589-94. 2003
    ..To determine if this is a general effect of a lack of SR-BI, we generated mice deficient in both SR-BI and the LDL receptor...
  36. ncbi request reprint The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues
    Attilio Rigotti
    Departamento de Gastroenterologia, Facultad de Medicina, Pontificia Universidad Catolica, Santiago, Chile
    Endocr Rev 24:357-87. 2003
    ..If SR-BI plays similar physiological and pathophysiological roles in humans, it may be an attractive target for therapeutic intervention in cardiovascular and reproductive diseases...
  37. ncbi request reprint The effects of mutations in helices 4 and 6 of ApoA-I on scavenger receptor class B type I (SR-BI)-mediated cholesterol efflux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR-BI is required for efficien
    Tong Liu
    Section of Molecular Genetics, Whitaker Cardiovascular Institute, Department of Medicine and Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 277:21576-84. 2002
    ..Some mutations in apoA-I and/or SR-BI can result in high affinity, but non-productive, binding that does not permit efficient cholesterol efflux...
  38. ncbi request reprint Highly purified scavenger receptor class B, type I reconstituted into phosphatidylcholine/cholesterol liposomes mediates high affinity high density lipoprotein binding and selective lipid uptake
    Bin Liu
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Biol Chem 277:34125-35. 2002
    ..Thus, SR-BI-mediated HDL binding and selective lipid uptake are intrinsic properties of the receptor that do not require the intervention of other proteins or specific cellular structures or compartments...
  39. ncbi request reprint Identification of the N-linked glycosylation sites on the high density lipoprotein (HDL) receptor SR-BI and assessment of their effects on HDL binding and selective lipid uptake
    Marisa Vinals
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 278:5325-32. 2003
    ..The ability to uncouple the HDL binding and lipid transport activities of mSR-BI by in vitro mutagenesis should provide a powerful tool for further analysis of the mechanism of SR-BI-mediated selective lipid uptake...
  40. ncbi request reprint Reconstituted discoidal ApoE-phospholipid particles are ligands for the scavenger receptor BI. The amino-terminal 1-165 domain of ApoE suffices for receptor binding
    Xiaoping Li
    Section of Molecular Genetics, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 277:21149-57. 2002
    ..SR-BI-apoE interactions may contribute to cholesterol homeostasis in tissues and cells expressing SR-BI that are accessible to apoE-containing lipoproteins...
  41. pmc Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI
    Thomas J F Nieland
    Department of Cell Biology, Harvard Medical School, and Center for Blood Research, Boston, MA 02115 5701, USA
    Proc Natl Acad Sci U S A 99:15422-7. 2002
    ....
  42. ncbi request reprint Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice
    Anne Braun
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Mass 02139, USA
    Circ Res 90:270-6. 2002
    ..Furthermore, these animals may be useful for preclinical testing of potential genetic and/or pharmacological therapies for CHD...
  43. pmc Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouse
    Anne Braun
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:7283-8. 2003
    ....
  44. ncbi request reprint Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI
    Teresa M Holm
    Division of Hematology Oncology, Children s Hospital, Boston, MA 02115, USA
    Blood 99:1817-24. 2002
    ..We propose that autophagocytosis and phagolysosome expulsion are essential steps in erythroid maturation and that expulsion is inhibited in the presence of markedly increased cellular cholesterol...
  45. ncbi request reprint Alpha-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice
    Pablo Mardones
    Departamento de Gastroenterologia, Facultad de Medicina, Pontificia Universidad Catolica, Santiago, Chile
    J Nutr 132:443-9. 2002
    ..Defective tissue uptake of lipoprotein alpha-T in SR-BI-deficient mice may contribute to the reproductive and cardiovascular pathologies exhibited by these animals...
  46. pmc Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I by altering its abundance and cellular localization
    Sara A Fenske
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 283:22097-104. 2008
    ....
  47. pmc Inhibition of intestinal absorption of cholesterol by ezetimibe or bile acids by SC-435 alters lipoprotein metabolism and extends the lifespan of SR-BI/apoE double knockout mice
    Anne Braun
    Department of Biology, Massachusetts Institute of Technology, Building 68 483, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Atherosclerosis 198:77-84. 2008
    ..The SR-BI/apoE dKO murine model of atherosclerotic occlusive, arterial CHD appears to provide a useful system to evaluate compounds that modulate cholesterol homeostasis and atherosclerosis...
  48. ncbi request reprint Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI
    Thomas J F Nieland
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Lipid Res 48:1832-45. 2007
    ..HDL376 and other inhibitors may help elucidate SR-BI function in diverse mammalian models and determine the therapeutic potential of SR-BI-directed pharmaceuticals...
  49. ncbi request reprint Subunit architecture of the conserved oligomeric Golgi complex
    Daniel Ungar
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 280:32729-35. 2005
    ..Vasile, E., Penman, M., Novina, C. D., Dykxhoorn, D. M., Ungar, D., Hughson, F. M., and Krieger, M. (2005) J. Biol. Chem. 280, 32736-32745)...
  50. pmc Conserved oligomeric Golgi complex subunit 1 deficiency reveals a previously uncharacterized congenital disorder of glycosylation type II
    Francois Foulquier
    Laboratory for Molecular Diagnostics, Center for Human Genetics, Gasthuisberg, Belgium
    Proc Natl Acad Sci U S A 103:3764-9. 2006
    ..We propose naming this disorder CDG-II/Cog1, or CDG-II caused by Cog1 deficiency...
  51. ncbi request reprint Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL
    Vassilis I Zannis
    Molecular Genetics, Whitaker Cardiovascular Institute and Department of Biochemistry, Boston University School of Medicine, MA 02118, USA
    J Mol Med (Berl) 84:276-94. 2006
    ....
  52. ncbi request reprint Retrograde transport on the COG railway
    Daniel Ungar
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Trends Cell Biol 16:113-20. 2006
    ..This hypothesis explains the impact of COG mutations by postulating that they impair the retrograde flow of resident Golgi proteins needed to maintain normal Golgi structure and function...
  53. pmc The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins
    Toshihiko Oka
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Biol Cell 15:2423-35. 2004
    ..COG and COPI may work in concert to ensure the proper retention or retrieval of a subset of proteins in the Golgi, and COG helps prevent the endoplasmic reticulum accumulation and degradation of some GEARs...
  54. ncbi request reprint Structural integrity of the Golgi is temperature sensitive in conditional-lethal mutants with no detectable GM130
    Eliza Vasile
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Traffic 4:254-72. 2003
    ....
  55. ncbi request reprint Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder
    Xiaohua Wu
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 10:518-23. 2004
    ..These cases represent a new type of CDG in which the molecular defect lies in a protein that affects the trafficking and function of the glycosylation machinery...
  56. ncbi request reprint Multi-component protein complexes and Golgi membrane trafficking
    Toshihiko Oka
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 0054
    J Biochem 137:109-14. 2005
    ..We here review recent studies exploring the structures and functions of these three oligomeric complexes...
  57. pmc Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function
    Daniel Ungar
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Cell Biol 157:405-15. 2002
    ..Consideration of biochemical and genetic data for mammalian COG and its yeast homologue suggests a model for the subunit distribution within this complex, which plays critical roles in Golgi structure and function...
  58. ncbi request reprint Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice
    Songwen Zhang
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Circulation 111:3457-64. 2005
    ..Mice in which similar features of CHD could be induced with a lipid-rich diet would represent a powerful tool to study CHD...
  59. ncbi request reprint Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells
    Toshihiko Oka
    Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 280:32736-45. 2005
    ..Only one or two of the seven Cog1- or Cog2-dependent Golgi membrane proteins called GEARs are also sensitive to Cog5 or Cog7 deficiency, indicating that the COG subunits play distinctive roles in controlling Golgi structure and function...
  60. ncbi request reprint Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice
    Sharon L Karackattu
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Arterioscler Thromb Vasc Biol 26:548-54. 2006
    ..Here we determined the effects on this pathology of hepatic lipase (HL) deficiency, which has been shown to significantly modulate atherosclerosis...
  61. doi request reprint Peroxiredoxin1 prevents excessive endothelial activation and early atherosclerosis
    Janka Kisucka
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 103:598-605. 2008
    ..Thus, Prdx1 protects against excessive endothelial activation and atherosclerosis, and the Prdx1(-/-) mice could serve as an animal model susceptible to chronic inflammation...

Research Grants28

  1. Scavenger Receptors: Ligand Binding and Pathophysiology
    Monty Krieger; Fiscal Year: 2009
    ....
  2. Scavenger Receptors: Ligand Binding and Pathophysiology
    Monty Krieger; Fiscal Year: 2010
    ....
  3. GENES CONTROLLING LDL RECEPTOR STRUCTURE AND FUNCTION
    Monty Krieger; Fiscal Year: 2003
    ..This should further our understanding of the complex physiologic and pathophysiologic (e.g., familial hypercholesterolemia, atherosclerosis) processes which are based on the function and dysfunction of the LDLR. ..
  4. SCAVANGER RECEPTOR-LIGAND BINDING AND PATHOPHYSIOLOGY
    Monty Krieger; Fiscal Year: 2003
    ..g., multidrug resistance. ..
  5. THE ATHEROPROTECTIVE EFFECTS OF SR-BI
    Monty Krieger; Fiscal Year: 2004
    ....
  6. Scavenger Receptors - Ligand Binding and Pathophysiology
    Monty Krieger; Fiscal Year: 2007
    ..In addition, clarification of the molecular bases of the broad bind specificities of scavenger receptors may provide insight into other biological systems in which broad binding specificity is important, e.g., multidrug resistance. ..
  7. Molecular Analysis of Cardiovascular Biology and Pathology
    Monty Krieger; Fiscal Year: 2007
    ..abstract_text> ..