Research Topics
| R L KradinSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Placebo response: a consideration of its role in therapeuticsRichard L Kradin
Departments of Medicine and Pathology, Center for Psychoanalytic Studies, Massachusetts General Hospital, Boston, 02114, USA
Curr Psychiatry Rep 13:37-42. 2011....
Guiding the pulmonologist's hand: What they need to know about lung pathology and what is lost in translationRichard L Kradin
Pulmonary and Critical Care Unit, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA
Arch Pathol Lab Med 136:1528-32. 2012..This article, written by a pathologist who also practices pulmonology at a large, academic hospital, highlights his perspective on the important role of the pathologist in guiding the hand of the pulmonary clinician...
Malacoplakia of the tongue complicating the site of irradiation for squamous cell carcinoma with review of the literatureRichard L Kradin
Department of Pathology of the Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Ann Diagn Pathol 16:214-8. 2012..The clinical features of this case, a review of previously reported cases, and a consideration of pathogenesis are presented...
The pathology of pulmonary disorders due to Aspergillus sppRichard L Kradin
Department of Pathology, Warren 253, Massachusetts General Hospital, Boston, MA 02114, USA
Arch Pathol Lab Med 132:606-14. 2008..This article reviews the spectrum of pulmonary disorders due to infection by Aspergillus spp, with emphasis on the clinical implications of diagnosis...
Distinguishing benign mesothelial hyperplasia from neoplasia: a practical approachRichard L Kradin
Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
Semin Diagn Pathol 23:4-14. 2006..Practical guidelines are offered that should reduce the risk of diagnostic error in this problematic area of surgical pathology...
Iatrogenic Trichuris suis infection in a patient with Crohn diseaseRichard L Kradin
Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
Arch Pathol Lab Med 130:718-20. 2006..This report examines the morphology of the immature and adult T suis, the effects of this intervention on the immunophenotype of the bowel mucosa, and it also raises the possibility of persistent active infection in man...
Endothelial nitric oxide synthase expression in pulmonary capillary hemangiomatosisRichard Kradin
Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
Exp Mol Pathol 79:194-7. 2005..These findings suggest that NOS-III is specifically reduced in PCH when pulmonary arterial hypertensive remodeling is concomitantly present...
The roots of empathy and aggression in analysisRichard Kradin
Center for Psychoanalytical Studies, Massachusetts General Hospital, Boston 02114, USA
J Anal Psychol 50:431-49. 2005..Case material is examined to elucidate the benefits and limits of analytic aggression...
The placebo response: its putative role as a functional salutogenic mechanism of the central nervous systemRichard L Kradin
Department of Medicine, Massachusetts General Hospital, Boston 02114, USA
Perspect Biol Med 47:328-38. 2004....
IL-10 inhibits inflammation but does not affect fibrosis in the pulmonary response to bleomycinRichard L Kradin
The Immunopathology and Pulmonary and Critical Care Units, Massachusetts General Hospital, Boston, MA 02114, USA
Exp Mol Pathol 76:205-11. 2004..The findings suggest an immunomodulatory role for IL-10 in the inflammatory response but not in the pulmonary fibrosis yielded by bleomycin...
The placebo response: an attachment strategy that counteracts the effects of stress-related dysfunctionRichard Kradin
Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Perspect Biol Med 54:438-54. 2011..A range of behaviors by caregivers that mimic those achieved during secure attachment are suggested to promote placebo responses...
Epinephrine yields translocation of lymphocytes to the lungR Kradin
Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Exp Mol Pathol 70:1-6. 2001..Directed traffic of immune lymphocytes may be a feature of the adaptive immune response to stress at mucosal barrier surfaces...
Pulmonary immunity to Listeria is enhanced by elimination of alveolar macrophagesR L Kradin
Departments of Pathology and Medicine, Massachusetts General Hospital, Boston, Massachusetts and Department of Histology, Amsterdam, The Netherlands
Am J Respir Crit Care Med 159:1967-74. 1999..We conclude that eliminating AM in vivo reduces local production of NO and promotes pulmonary cell-mediated immunity to HKL...
Accumulation of macrophages with dendritic cell characteristics in the pulmonary response to ListeriaR L Kradin
Departments of Pathology and Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Respir Crit Care Med 161:535-42. 2000..We conclude that a subset of RMA(dim) exudate macrophages shows phenotypic and functional evidence of dendritic cell differentiation...
Case records of the Massachusetts General Hospital. Case 21-2008. An 11-month-old boy with fever and pulmonary infiltratesJason B Harris
Department of Pediatrics-Pediatric Infectious Disease, Massachusetts General Hospital, USA
N Engl J Med 359:178-87. 2008
Shirt-sleeve or scanning magnification as an aid to the diagnosis of commonly encountered medical lung diseasesEugene J Mark
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02155, USA
Arch Pathol Lab Med 132:539-47. 2008..In our experience, this system also proves useful in arriving at some therapeutic decisions...
Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlationsDavid C Wilbur
Department of Pathology, James Homer Wright Pathology Laboratories, Massachusetts General Hospital, and the Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
Arch Pathol Lab Med 133:1949-53. 2009..Before implementation, technical issues, pathologist adaptability, and morphologic pitfalls must be well characterized...
Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10Andrew M Tager
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Building 149 8301, 13th Street, Charlestown, MA 02129, USA
Am J Respir Cell Mol Biol 31:395-404. 2004..Our findings suggest that interruption of fibroblast recruitment may represent a novel therapeutic strategy for pulmonary fibrosis, which could have applicability to a wide range of fibrotic illnesses...
Idiopathic tracheal stenosis: a clinicopathologic study of 63 cases and comparison of the pathology with chondromalaciaEugene J Mark
Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
Am J Surg Pathol 32:1138-43. 2008..ITS is a rare disease and restricted to females. It may represent some form of fibromatosis. ITS can be distinguished histologically from CM in tracheal resection specimens in most cases...
Immune cell subsets in necrotizing fasciitis: an immunohistochemical analysisA J Saenz
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Virchows Arch 455:87-92. 2009..We conclude that immune lymphocytes and accessory immune cells are represented in substantial numbers in the early lesions of NF, and their presence supports current concepts with respect to the pathophysiology of this disorder...
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 39-2004. A 52-year-old woman with recurrent episodes of atypical pneumoniaRichard L Kradin
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, USA
N Engl J Med 351:2741-9. 2004
Case records of the Massachusetts General Hospital. Case 1-2006. A 64-year-old male lung-transplant recipient with fever, cough, hemoptysis, and abdominal painRobert H Rubin
Division of Infectious Disease, Brigham and Women's Hospital, Boston, USA
N Engl J Med 354:180-7. 2006
Bactericidal/permeability-increasing protein ameliorates acute lung injury in porcine endotoxemiaT J VanderMeer
Department of Surgery, Massachusetts General Hospital, Boston 02114
J Appl Physiol 76:2006-14. 1994..The salutory effects of BPI23 on acute lung injury in endotoxemic pigs may be mediated, at least in part, by inhibition of direct activation of phagocytes by LPS...
Pulmonary "inflammatory myofibroblastic" tumors: a critical examination of the diagnostic category based on quantitative immunohistochemical analysisA B Farris
Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
Virchows Arch 450:585-90. 2007..Although the multiplicity of terms previously applied to these lesions is cumbersome, retaining a descriptive phenomenological terminology may ultimately promote accurate elucidation of pathogenesis...
Epinephrine promotes pulmonary angiitis: evidence for a beta1-adrenoreceptor-mediated mechanismFelipe A Jain
Immunopathology and Pulmonary and Critical Care Units, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Physiol Lung Cell Mol Physiol 285:L232-9. 2003..05) yielded by Epi, whereas all alpha/beta-AR blockers inhibited airway inflammation. We conclude that Epi-EP selectively promotes vascular inflammation in vivo via a beta1-receptor-mediated mechanism...
Organizing pneumonia and pulmonary lymphatic architecture in diffuse alveolar damageRajni V Mandal
Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
Hum Pathol 39:1234-8. 2008..12). We conclude that lung biopsy histopathology and pulmonary lymphatic morphology may predict survival in acute respiratory distress syndrome...
Nodular amiodarone lung diseaseRuchira Ruangchira-urai
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Am J Surg Pathol 32:1654-60. 2008..The necrotizing nature of the massed histiocytes in the absence of infection or obstruction suggests the correct etiologic diagnosis even when the history of administration of the drug is not available at initial review...
Pathological recognition of diffuse malignant mesothelioma of the pleura: the significance of the historical perspective as regards this signal tumorEugene J Mark
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Semin Diagn Pathol 23:25-34. 2006....
Case records of the Massachusetts General Hospital. Case 26-2007 - a 61-year-old man with recurrent feversGregg S Meyer
Department of Medicine, Massachusetts General Hospital, USA
N Engl J Med 357:807-16. 2007
Megakaryocytes and platelet homeostasis in diffuse alveolar damageRajni V Mandal
Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
Exp Mol Pathol 83:327-31. 2007..The mechanisms of altered platelet homeostasis in DAD merit further investigation...
Case records of the Massachusetts General Hospital. Case 29-2007. A 51-year-old man with gastric cancer and lung nodulesEdward T Ryan
Division of Infectious Disease, Massachusetts General Hospital, USA
N Engl J Med 357:1239-46. 2007
Hemorrhagic pulmonary oxalosis secondary to a noninvasive Aspergillus niger fungus ballMichael H A Roehrl
Department of Pathology and Laboratory Medicine, James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Virchows Arch 451:1067-73. 2007..Furthermore, non-necrotizing granulomatous lesions were identified in the lungs, liver, and spleen, consistent with sarcoidosis, and may have predisposed this patient to developing pulmonary aspergillomas...
Case records of the Massachusetts General Hospital. Case 9-2006. A 35-year-old woman with recurrent right-upper-quadrant painRocio M Hurtado
Infectious Disease Unit, Massachusetts General Hospital, USA
N Engl J Med 354:1295-303. 2006
Diffuse cellular and fibrosing interstitial pneumonitis with desquamative interstitial pneumonitis-like features associated with myeloid neoplasiaAlton B Farris
Pathology Service, Massachusetts General Hospital, Boston, MA, USA
Am J Surg Pathol 33:1485-93. 2009....
Case records of the Massachusetts General Hospital. Case 27-2006. A 17-year-old boy with fever and lesions in the liver and spleenStephen I Pelton
Department of Pediatric Infectious Disease, Boston Medical Center, Massachusetts General Hospital and Harvard Medical School, Boston, USA
N Engl J Med 355:941-8. 2006
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 9-2004. An 18-year-old man with respiratory symptoms and shockJulie L Gerberding
Centers for Disease Control and Prevention, Atlanta, USA
N Engl J Med 350:1236-47. 2004
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 18-2002. A 48-year-old man with a cough and bloody sputumRichard L Kradin
N Engl J Med 346:1892-9. 2002
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 17-2002. A 55-year-old man with second-degree atrioventricular block and chest painRoger J Hajjar
N Engl J Med 346:1732-8. 2002
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 1-2002. A 24-year-old woman with paresthesias and muscle cramps after a stay in AfricaThomas B Nutman
Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
N Engl J Med 346:115-22. 2002
Case records of the Massachusetts General Hospital. Case 5-2007. A 53-year-old man with a prosthetic aortic valve and recent onset of fatigue, dyspnea, weight loss, and sweatsDidier Raoult
Department of Clinical Microbiology, , , , Marseilles, France
N Engl J Med 356:715-25. 2007
