Kevin R Kozak

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Hypertrophic osteoarthropathy pathogenesis: a case highlighting the potential role for cyclo-oxygenase-2-derived prostaglandin E2
    Kevin R Kozak
    Harvard Radiation Oncology Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Nat Clin Pract Rheumatol 2:452-6; quiz following 456. 2006
  2. doi request reprint Cardiac blood biomarkers in patients receiving thoracic (chemo)radiation
    Kevin R Kozak
    Harvard Radiation Oncology Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Lung Cancer 62:351-5. 2008
  3. ncbi request reprint Dosimetric comparison of proton and photon three-dimensional, conformal, external beam accelerated partial breast irradiation techniques
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 65:1572-8. 2006
  4. pmc AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    Tracy T Batchelor
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cancer Cell 11:83-95. 2007
  5. ncbi request reprint Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiation
    Alphonse G Taghian
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 64:1092-9. 2006
  6. ncbi request reprint Accelerated partial breast irradiation using proton beams: Initial dosimetric experience
    Alphonse G Taghian
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 65:1404-10. 2006
  7. ncbi request reprint Dosimetric comparison of two different three-dimensional conformal external beam accelerated partial breast irradiation techniques
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 65:340-6. 2006
  8. ncbi request reprint Accelerated partial-breast irradiation using proton beams: initial clinical experience
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 66:691-8. 2006
  9. doi request reprint A dosimetric comparison of proton and intensity-modulated photon radiotherapy for pediatric parameningeal rhabdomyosarcomas
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 74:179-86. 2009
  10. pmc Cardiac and inflammatory biomarkers do not correlate with volume of heart or lung receiving radiation
    Angera H Kuo
    Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital and Harvard Medical School, Cox 737, 100 Blossom Street, Boston, MA, 02114, USA
    Radiat Oncol 10:5. 2015

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Hypertrophic osteoarthropathy pathogenesis: a case highlighting the potential role for cyclo-oxygenase-2-derived prostaglandin E2
    Kevin R Kozak
    Harvard Radiation Oncology Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Nat Clin Pract Rheumatol 2:452-6; quiz following 456. 2006
    ..Surgical history included a right carotid endarterectomy. The patient's history was remarkable for 50+ pack-years of smoking...
  2. doi request reprint Cardiac blood biomarkers in patients receiving thoracic (chemo)radiation
    Kevin R Kozak
    Harvard Radiation Oncology Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Lung Cancer 62:351-5. 2008
    ..Thus, contemporary thoracic (chemo)radiation does not commonly result in elevations of serum TnT, CK-MB or NT-proBNP. Elevations in these markers during treatment merit further evaluation...
  3. ncbi request reprint Dosimetric comparison of proton and photon three-dimensional, conformal, external beam accelerated partial breast irradiation techniques
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 65:1572-8. 2006
    ..To compare the dosimetry of proton and photon-electron three-dimensional, conformal, external beam accelerated partial breast irradiation (3D-CPBI)...
  4. pmc AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    Tracy T Batchelor
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cancer Cell 11:83-95. 2007
    ..Our study provides insight into different mechanisms of action of this class of drugs in recurrent glioblastoma patients and suggests that the timing of combination therapy may be critical for optimizing activity against this tumor...
  5. ncbi request reprint Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiation
    Alphonse G Taghian
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 64:1092-9. 2006
    ..Several accelerated partial-breast irradiation (APBI) techniques are being investigated in patients with early-stage breast cancer. We present our initial experience using three-dimensional conformal radiation therapy (3D-CRT)...
  6. ncbi request reprint Accelerated partial breast irradiation using proton beams: Initial dosimetric experience
    Alphonse G Taghian
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 65:1404-10. 2006
    ..We present our initial experience with protons for three-dimensional, conformal, external-beam accelerated partial breast irradiation (3D-CPBI)...
  7. ncbi request reprint Dosimetric comparison of two different three-dimensional conformal external beam accelerated partial breast irradiation techniques
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 65:340-6. 2006
    ..We compare the dosimetry of two techniques for three-dimensional, conformal, external beam, accelerated partial breast irradiation (3D-CPBI) in the supine position...
  8. ncbi request reprint Accelerated partial-breast irradiation using proton beams: initial clinical experience
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 66:691-8. 2006
    ..We present our initial clinical experience with proton, three-dimensional, conformal, external beam, partial-breast irradiation (3D-CPBI)...
  9. doi request reprint A dosimetric comparison of proton and intensity-modulated photon radiotherapy for pediatric parameningeal rhabdomyosarcomas
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 74:179-86. 2009
    ..We compared tumor and normal tissue dosimetry of proton radiation therapy with intensity-modulated radiation therapy (IMRT) for pediatric parameningeal rhabdomyosarcomas (PRMS)...
  10. pmc Cardiac and inflammatory biomarkers do not correlate with volume of heart or lung receiving radiation
    Angera H Kuo
    Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital and Harvard Medical School, Cox 737, 100 Blossom Street, Boston, MA, 02114, USA
    Radiat Oncol 10:5. 2015
    ..In this study, we explore whether dose-volume metrics and biomarkers for cardiac damage, inflammation or angiogenesis could identify patients receiving thoracic radiation who would later have cardiac or pulmonary complications...
  11. pmc Changes in biomarkers of inflammation and angiogenesis during androgen deprivation therapy for prostate cancer
    Philip J Saylor
    Division of Hematology Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA
    Oncologist 17:212-9. 2012
    ..We measured inflammatory and angiogenic biomarkers in ADT-treated and control groups of men with prostate cancer...
  12. pmc Proton radiotherapy for parameningeal rhabdomyosarcoma: clinical outcomes and late effects
    Stephanie K Childs
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 82:635-42. 2012
    ..To report the clinical outcome and late side effect profile of proton radiotherapy in the treatment of children with parameningeal rhabdomyosarcoma (PM-RMS)...
  13. ncbi request reprint Dosimetric feasibility of hypofractionated proton radiotherapy for neoadjuvant pancreatic cancer treatment
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 68:1557-66. 2007
    ..To evaluate tumor and normal tissue dosimetry of a 5 cobalt gray equivalent (CGE) x 5 fraction proton radiotherapy schedule, before initiating a clinical trial of neoadjuvant, short-course proton radiotherapy for pancreatic adenocarcinoma...
  14. pmc Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib
    Timothy P Padera
    Edwin L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Mol Cancer Ther 7:2272-9. 2008
    ..Collectively, these data indicate that the response of lymphatic vessels to a TKI can determine the incidence of lymphatic metastasis, independent of the effect of the TKI on blood vessels...
  15. doi request reprint The survival impact of the intergroup 0116 trial on patients with gastric cancer
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 72:517-21. 2008
    ..The Intergroup 0116 (INT 0116) trial demonstrated a survival benefit for a broad group of fully resected gastric cancer patients. This study examined the impact on survival of the release of this landmark trial...
  16. ncbi request reprint Oxidative metabolism of endocannabinoids by COX-2
    Kevin R Kozak
    Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Pharm Des 10:659-67. 2004
    ..The available biochemical evidence supporting a role for COX-2 in endocannabinoid metabolism will be presented. Finally, the potential biological consequences of COX-2-mediated endocannabinoid oxygenation will be discussed...
  17. ncbi request reprint Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides
    Kevin R Kozak
    Department of Biochemistry, Vanderbilt Ingram Cancer Center, and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 277:44877-85. 2002
    ..These results define the in vitro diversity of endocannabinoid-derived prostanoids and will permit focused investigations into their production and potential biological actions in vivo...
  18. ncbi request reprint Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide
    Kevin R Kozak
    Department of Biochemistry, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochemistry 42:9041-9. 2003
    ..Coupled with earlier observations with the endocannabinoid 2-arachidonylglycerol, these results indicate that one possible function of the highly conserved COX-2 active site side pocket is to promote endocannabinoid oxygenation...
  19. ncbi request reprint Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites
    Rory P Remmel
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Drug Metab Dispos 32:113-22. 2004
    ..The glucuronides of 2'hydroxy-LM-4108 and O-desmethyl-2'-hydroxy-LM-4108 were also identified in rat bile...
  20. pmc Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice
    Christopher G Willett
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Semin Oncol 33:S35-40. 2006
    ..Phase II evaluation of bevacizumab in this setting is under way...
  21. pmc The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells
    Chaitanya S Nirodi
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Proc Natl Acad Sci U S A 101:1840-5. 2004
    ..The results indicate that PGE(2)-G triggers Ca(2+) mobilization, IP(3) synthesis, and activation of PKC in RAW264.7 macrophage cells at low concentrations. These responses are independent of the hydrolysis of PGE(2)-G to PGE(2)...
  22. ncbi request reprint Enantiospecific, selective cyclooxygenase-2 inhibitors
    Kevin R Kozak
    Department of Biochemistry, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Bioorg Med Chem Lett 12:1315-8. 2002
    ..The transformation of non-selective alpha-(S)-substituted indomethacin ethanolamides to potent, COX-2 selective inhibitors by simple stereocenter inversion highlights this property...