Research Topics
| Daniel B KopansSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
The 2009 US Preventive Services Task Force (USPSTF) guidelines are not supported by science: the scientific support for mammography screeningDaniel B Kopans
Department of Radiology, Harvard Medical School, Shattuck Street, Boston, MA, USA
Radiol Clin North Am 48:843-57. 2010..Mammography screening does not find all breast cancers and does not find all cancers early enough to result in a cure, but it is a major advance, and women should not be denied access to its benefits...
Cutaneous caves and subcutaneous adipose columns in the breast: radiologic-pathologic correlationDaniel B Kopans
Breast Imaging Division, Department of Radiology, Massachusetts General Hospital, Avon Comprehensive Breast Evaluation Center, Wang Ambulatory Care Center, 15 Parkman St, Suite 240, Boston, MA 02114, USA
Radiology 249:779-84. 2008..To investigate the histologic correlations of the innumerable 2-3-mm radiolucencies that project over the breast, as seen on mammograms...
Just the facts: mammography saves lives with little if any radiation risk to the mature breastDaniel B Kopans
Harvard Medical School ACC 240, 15 Parkman Street, Boston, Massachusetts 02115, USA
Health Phys 101:578-82. 2011..In fact, it is decreasing. Women need to be provided with this information to be reassured that mammograms save lives and that the radiation risk is minimal...
The recent US preventive services task force guidelines are not supported by the scientific evidence and should be rescindedDaniel B Kopans
Department of Radiology, Harvard Medical School, Boston, Massachusetts 02114, USA
J Am Coll Radiol 7:260-4. 2010..The USPSTF admits that its guidelines will result in unnecessary deaths from breast cancer that could be avoided by screening annually beginning at the age of 40 years...
The age at which women begin mammographic screeningJames A Colbert
Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Cancer 101:1850-9. 2004..These results also indicate that public health efforts to encourage women to start screening may be less critical than interventions to improve prompt return once they have entered the screening system...
Characterization of masses in digital breast tomosynthesis: comparison of machine learning in projection views and reconstructed slicesHeang Ping Chan
Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109, USA
Med Phys 37:3576-86. 2010....
Cost-effectiveness of breast MR imaging and screen-film mammography for screening BRCA1 gene mutation carriersJanie M Lee
Department of Radiology, Institute for Technology Assessment, Division of Hematology Oncology, Department of Medicine, Massachusetts General Hospital, 101 Merrimac St, 10th Floor, Boston, MA 02114, USA
Radiology 254:793-800. 2010..c) RSNA, 2010 Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.09091086/-/DC1...
Long-term risk of false-positive screening results and subsequent biopsy as a function of mammography useKaren Blanchard
Department of Surgery, Massachusetts General Hospital, Yawkey 7939, 55 Fruit St, Boston, MA 02114, USA
Radiology 240:335-42. 2006..CONCLUSION: Prompt annual attendance for mammographic screening reduces the occurrence of false-positive mammographic results...
Physiologic changes in breast magnetic resonance imaging during the menstrual cycle: perfusion imaging, signal enhancement, and influence of the T1 relaxation time of breast tissueJean-Paul Delille
Division of Breast Imaging, Department of Radiology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02135, USA
Breast J 11:236-41. 2005....
Blinded comparison of computer-aided detection with human second reading in screening mammographyDianne Georgian-Smith
Department of Radiology, Breast Imaging, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
AJR Am J Roentgenol 189:1135-41. 2007..The purpose of this study was to compare a human second reader with computer-aided detection (CAD) for the reduction of false-negative cases by a primary radiologist. We retrospectively reviewed our clinical practice...
Prevalence of hereditary breast/ovarian carcinoma risk in patients with a personal history of breast or ovarian carcinoma in a mammography populationFrancisco J Dominguez
Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Cancer 104:1849-53. 2005..This prevalence was considerably higher than the rate reported among women with no personal history of cancer, and has significant implications for their management, as well as for the capacity for risk assessment and testing...
Evaluation of hereditary risk in a mammography populationJulie L Jones
Division of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Clin Breast Cancer 6:38-44. 2005..New approaches to risk assessment and counseling are needed to apply our knowledge of hereditary risk to a broad population in a practical manner...
The American Cancer Society guidelines for breast screening with magnetic resonance imaging: an argument for genetic testingColleen D Murphy
Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
Cancer 113:3116-20. 2008....
Detecting nonpalpable recurrent breast cancer: the role of routine mammographic screening of transverse rectus abdominis myocutaneous flap reconstructionsJanie M Lee
Department of Radiology, Massachusetts General Hospital, 101 Merrimac St, 10th Floor, Boston, MA 02114, USA
Radiology 248:398-405. 2008....
Prospective comparison of mammography, sonography, and MRI in patients undergoing neoadjuvant chemotherapy for palpable breast cancerEren Yeh
Department of Radiology, Massachusetts General Hospital, 15 Parkman St, ACC 219, Boston, MA 02114, USA
AJR Am J Roentgenol 184:868-77. 2005....
Voting strategy for artifact reduction in digital breast tomosynthesisTao Wu
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Med Phys 33:2461-71. 2006..The combination of one-step classification and projection segmentation removes artifacts from both large and small calcifications...
Computer-aided detection of masses in digital tomosynthesis mammography: comparison of three approachesHeang Ping Chan
Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109 5842, USA
Med Phys 35:4087-95. 2008..02 and 0.01, respectively) as estimated by alternative FROC analysis. The combined system is a promising approach to improving automated mass detection on DBTs...
Mammographic screening: patterns of use and estimated impact on breast carcinoma survivalKaren Blanchard
Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Cancer 101:495-507. 2004..Improvements in the promptness with which women return to screening appear to have the potential to lead to considerable reductions in breast carcinoma death...
Accuracy of self-reported personal history of cancer in an outpatient breast centerFrancisco J Dominguez
Surgical Oncology Division, Massachusetts General Hospital, Harvard Medical School, 32 Fruit street YAW 7, Boston, Massachusetts, USA
J Genet Couns 16:341-5. 2007..008), and those with Jewish ancestry more accurately than non-Jewish (p=0.0435). These results will help us to improve data collection and thus improve medical decision-making...
Hormone replacement therapy in postmenopausal women: breast tissue perfusion determined with MR imaging--initial observationsJean-Paul Delille
Division of Breast Imaging and NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Radiology 235:36-41. 2005..1). Differences in T1 between all groups were not significant (P > .5). CONCLUSION: Higher breast tissue perfusion is observed in postmenopausal women receiving HRT...
Computer-aided detection system for breast masses on digital tomosynthesis mammograms: preliminary experienceHeang Ping Chan
Department of Radiology, University of Michigan, 1500 E Medical Center Dr, UHB1F510B, Ann Arbor, MI 48109 0030, USA
Radiology 237:1075-80. 2005..03 (standard error of mean). The CAD system achieved a sensitivity of 85%, with 2.2 false-positive objects per case. The results demonstrate the feasibility of the authors' approach to the development of a CAD system for DBT mammography...
Invasive lobular carcinoma: spectrum of enhancement and morphology on magnetic resonance imagingEren D Yeh
Division of Breast Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Breast J 9:13-8. 2003..However, there was a variable morphologic appearance and contrast enhancement pattern on MRI. A few lesions were difficult to distinguish from normal tissue. This suggests that some cases of ILC may be difficult to detect on MRI...
Case records of the Massachusetts General Hospital. Case 24-2005. A 58-year-old woman with early-stage estrogen-receptor-positive breast cancerPaula D Ryan
Department of Hematology, Massachusetts General Hospital, USA
N Engl J Med 353:617-22. 2005
Mammographic breast density and raceMarcela G del Carmen
Division of Gynecologic Oncology, Massachusetts General Hospital, 55 Fruit St, Yawkey 9E, Boston, MA 02114, USA
AJR Am J Roentgenol 188:1147-50. 2007..We first compared breast density among white, African American, and Asian women and then correlated breast density and race with age, body mass index (BMI), and breast or cup size...
The lactating breast: MRI findings and literature reviewAnjali C Talele
Division of Breast Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA
Breast J 9:237-40. 2003..Physiologic changes from pregnancy and lactation can complicate breast imaging. We report the MRI appearance of the lactating breast and address potential difficulties that may be encountered in this clinical situation...
Invasive ductal breast carcinoma response to neoadjuvant chemotherapy: noninvasive monitoring with functional MR imaging pilot studyJean-Paul Delille
NMR Center and Division of Breast Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
Radiology 228:63-9. 2003..Functional MR imaging of the breast may be useful in monitoring tumor response to neoadjuvant chemotherapy...
Breast cancer screening in BRCA1 mutation carriers: effectiveness of MR imaging--Markov Monte Carlo decision analysisJanie M Lee
Department of Radiology, Institute for Technology Assessment, Division of Hematology Oncology, Department of Medicine, Massachusetts General Hospital, 101 Merrimac St, 10th Floor, Boston, MA 02114, USA
Radiology 246:763-71. 2008..To project intermediate and long-term clinical outcomes of magnetic resonance (MR) imaging screening for breast cancer in women with BRCA1 gene mutations...
Radiological reasoning: male breast mass with calcificationsAnn A Shi
AVON Breast Comprehensive Center, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
AJR Am J Roentgenol 185:S205-10. 2005..The clinical and radiologic diagnosis of breast hemangioma is often difficult, but different imaging techniques, when used together, can provide important information for differential diagnosis and management. A biopsy is required...
A simple model of breast carcinoma growth may provide explanations for observations of apparently complex phenomenaDaniel B Kopans
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Cancer 97:2951-9. 2003..A simple model provides some insight that may simplify the explanation of these observations...
Informed decision making: age of 50 is arbitrary and has no demonstrated influence on breast cancer screening in womenDaniel B Kopans
Department of Radiology, Harvard Medical School, Boston, MA 02114, USA
AJR Am J Roentgenol 185:177-82. 2005..Women and their physicians should be informed that the age of 50 is an arbitrary threshold in terms of mammography screening so that they can make informed decisions about their own health care...
Enhanced imaging of microcalcifications in digital breast tomosynthesis through improved image-reconstruction algorithmsEmil Y Sidky
Department of Radiology, University of Chicago, 5841 S Maryland Avenue Chicago, Illinois 60637, USA
Med Phys 36:4920-32. 2009..The authors develop a practical, iterative algorithm for image-reconstruction in undersampled tomographic systems, such as digital breast tomosynthesis (DBT)...
Effect of tamoxifen on breast tissue density in premenopausal breast cancerPriscilla J Slanetz
Division of Breast Imaging, Department of Radiology, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
Breast J 10:27-32. 2004..The clinical significance of resumption of a dense breast pattern following discontinuation of tamoxifen remains to be determined...
Combined optical and X-ray tomosynthesis breast imagingQianqian Fang
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
Radiology 258:89-97. 2011..To explore the optical and physiologic properties of normal and lesion-bearing breasts by using a combined optical and digital breast tomosynthesis (DBT) imaging system...
Bias in the medical journals: a commentaryDaniel B Kopans
Department of Radiology, Harvard Medical School, Boston, MA 02114, USA
AJR Am J Roentgenol 185:176-7. 2005..Consequently, women have been led to believe that the age of 50 has some real significance with regard to screening when the fact is that it has none...
Coregistered tomographic x-ray and optical breast imaging: initial resultsQuan Zhang
Harvard Medical School, Massachusetts General Hospital, The Martinos Center for Biomedical Imaging, 13th Street, Building 149, Room 2301, Charlestown, Massachusetts 02129, USA
J Biomed Opt 10:024033. 2005..This comparison will ultimately lead to a better understanding of the relationship between the functional contrast afforded by optical imaging and the structural contrast provided by x-ray imaging...
Predicting the survival of patients with breast carcinoma using tumor sizeJames S Michaelson
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Cancer 95:713-23. 2002..In this report, the authors provide such a method...
Occult contralateral breast carcinoma incidentally detected by breast magnetic resonance imagingPriscilla J Slanetz
Department of Radiology, Beth Israel Deaconess Medical Center and the Harvard Medical School, Boston, Massachusetts 02215, USA
Breast J 8:145-8. 2002..Breast MR imaging of the contralateral breast may be of value as a routine screen in those patients with a known or suspected malignancy...
The mammary hamartoma: appreciation of additional imaging characteristicsDianne Georgian-Smith
Department of Radiology, Massachusetts General Hospital, Wang Ambulatory Care Center 219Q, 15 Parkman St, Boston, MA 02114, USA
J Ultrasound Med 23:1267-73. 2004....
A comparison of reconstruction algorithms for breast tomosynthesisTao Wu
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Med Phys 31:2636-47. 2004....
Basic physics and doubts about relationship between mammographically determined tissue density and breast cancer riskDaniel B Kopans
Department of Radiology, Breast Imaging Division, Massachusetts General Hospital, Ambulatory Care Bldg, Suite 219, 15 Parkman St, Boston, MA 02114, USA
Radiology 246:348-53. 2008..Studies that purport to show small percentage differences between groups are likely inaccurate. Future investigations need to use three-dimensional information...
The most recent breast cancer screening controversy about whether mammographic screening benefits women at any age: nonsense and nonscienceDaniel B Kopans
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
AJR Am J Roentgenol 180:21-6. 2003
Sonography should not be used for breast cancer screening until its efficacy has been proven scientificallyDaniel B Kopans
Department of Radiology, Massachusetts General Hospital and the Harvard Medical School, Boston, MA 02114, USA
AJR Am J Roentgenol 182:489-91. 2004
The pattern of breast cancer screening utilization and its consequencesJames Michaelson
Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Cancer 94:37-43. 2002....
Screening for cancer: when is it valid?--Lessons from the mammography experienceDaniel B Kopans
Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Avon Foundation Comprehensive Breast Evaluation Center, Wang Ambulatory Care Center, Suite 240, 15 Parkman Street, Boston, MA 02114, USA
Radiology 229:319-27. 2003..Many important lessons have been learned from the issues that have been raised with regard to mammographic screening. Those interested in developing new screening tests can learn from the mammography experience...
Breast cancer: regional blood flow and blood volume measured with magnetic susceptibility-based MR imaging--initial resultsJean-Paul Delille
Department of Radiology, NMR Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Radiology 223:558-65. 2002..002) than those for benign or normal tissue. The method allows independent measurement of regional blood flow and blood volume in breast cancers...
Regional admittivity spectra with tomosynthesis images for breast cancer detectionTzu Jen Kao
Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
Conf Proc IEEE Eng Med Biol Soc 2007:4142-5. 2007..These findings are confirmed by simultaneous, co-registered 3-D mammograms or tomosynthesis images and are verified with biopsy reports...
Screening mammography for women age 40 to 49 yearsDaniel B Kopans
Ann Intern Med 147:740-1; author reply 741. 2007
LCIS found at core needle biopsy may not need surgical excisionDaniel B Kopans
AJR Am J Roentgenol 191:W152; author reply W153. 2008
Negative mammographic and US findings do not help exclude breast cancerDaniel B Kopans
Radiology 222:857-8; author reply 858-9. 2002
Beyond randomized controlled trials: organized mammographic screening substantially reduces breast carcinoma mortalityDaniel B Kopans
Cancer 94:580-1; author reply 581-3. 2002
History repeatsDaniel B Kopans
Radiology 246:645; author reply 645-6. 2008
The science is neededDaniel B Kopans
Radiology 249:719; author reply 719-20. 2008
Specificity of mammography and US in the evaluation of a palpable abnormality: retrospective reviewLinda Moy
Breast Imaging Center, New York University School of Medicine, 530 First Ave, FPT Suite 8N, New York, NY 10016 6497, USA
Radiology 225:176-81. 2002..To determine the number of patients who received a diagnosis of breast cancer after having an area of clinical concern at presentation and combined negative mammographic and ultrasonographic (US) findings...
Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomographyGregory Boverman
Biomedical Engineering Department, Rensselaer Polytechnic Institute, Jonsson Engineering Center, Troy, NY 12180, USA
Phys Med Biol 52:3619-41. 2007..We are able to quantify the global return of blood to the breast following compression, and, in addition, localized changes are observed which correspond to the glandular region of the breast...
Case records of the Massachusetts General Hospital. Case 35-2005. A 56-year-old woman with breast cancer and isolated tumor cells in a sentinel lymph nodeNancy E Davidson
Johns Hopkins University School of Medicine, Baltimore, USA
N Engl J Med 353:2177-85. 2005
Mammographic breast densityDaniel B Kopans
N Engl J Med 356:1885-7; author reply 1885-7. 2007
Breast imaging and the symptomatic patient: enough with the "diagnostic" mammographyDaniel B Kopans
AJR Am J Roentgenol 181:1423; author reply 1423-4. 2003
Breast sonographic screening is not ready for prime timeDaniel B Kopans
AJR Am J Roentgenol 181:1426-7; author reply 1427-8. 2003
What is wrong with this picture? Screening mammographyDaniel B Kopans
AJR Am J Roentgenol 181:1429. 2003
Re: Decreasing women's anxieties after abnormal mammograms: a controlled trialDaniel B Kopans
J Natl Cancer Inst 96:1186-7; author reply 1187. 2004
Ten criteria for effective screeningDaniel B Kopans
AJR Am J Roentgenol 178:508-10. 2002
Lobular neoplasia on core-needle biopsy--clinical significanceDaniel B Kopans
Cancer 101:2902-3; author reply 2903. 2004
Be careful to not willingly suspend disbeliefDaniel B Kopans
Radiology 233:645-7. 2004
Get the facts straightDaniel B Kopans
J Clin Oncol 22:4859; author reply 4860-2. 2004
Re: Association of volume and volume-independent factors with accuracy in screening mammogram interpretationDaniel B Kopans
J Natl Cancer Inst 95:758-9. 2003
Another view of mammography and beyondDaniel B Kopans
AJR Am J Roentgenol 180:860; author reply 860. 2003
DMIST results: technologic or observer variability?Daniel B Kopans
Radiology 248:703; author reply 703. 2008
Re: Detection of ductal carcinoma in situ in women undergoing screening mammographyDaniel B Kopans
J Natl Cancer Inst 95:487; author reply 487-8. 2003
Tomographic mammography using a limited number of low-dose cone-beam projection imagesTao Wu
Rosenstiel Basic Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454, USA
Med Phys 30:365-80. 2003..The method is illustrated with images from mastectomy specimens, a phantom, and human volunteers. The results show how image quality is affected by various data-collection protocols...
Breast cancer screeningDaniel B Kopans
Ann Intern Med 138:690; author reply 690. 2003
Tomographic optical breast imaging guided by three-dimensional mammographyAng Li
Department of Physics, Tufts University, Medford, Massachusetts 02155, USA
Appl Opt 42:5181-90. 2003..We suggest an approach to find the optimal regularization parameters. The presented preliminary clinical result indicates the utility of the method...
Mammography screening is saving thousands of lives, but will it survive medical malpractice?Daniel B Kopans
Radiology 230:20-4. 2004
Chopped liver...all over againDaniel B Kopans
AJR Am J Roentgenol 178:1288; author reply 1288-9. 2002
Older is betterDaniel B Kopans
AJR Am J Roentgenol 181:593; author reply 593-4. 2003
Mammographic screening for breast cancerDaniel B Kopans
N Engl J Med 349:610-2; author reply 610-2. 2003
Re: All-cause mortality in randomized trials of cancer screeningDaniel B Kopans
J Natl Cancer Inst 94:863; author reply 865-6. 2002
Research Grants
- Specificity/Sensitivity in Mammographic ScreeningDaniel Kopans; Fiscal Year: 2006..Tomosynthesis may result in improved detection, characterization and visualization of breast lesions which may ultimately reduce mortality from breast cancer, while dramatically reducing callback imaging studies. ..
