Research Topics
| Michael KlompasSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Does this patient have an acute thoracic aortic dissection?Michael Klompas
Department of Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
JAMA 287:2262-72. 2002..The diagnosis of acute thoracic aortic dissection is difficult to make and often missed...- Does this patient have ventilator-associated pneumonia?Michael Klompas
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
JAMA 297:1583-93. 2007..Ventilator-associated pneumonia (VAP) is a common and serious nosocomial infection. Accurate, timely diagnosis enables affected patients to receive appropriate therapy and avoids mistreatment of patients having other conditions... 
Development of an algorithm for surveillance of ventilator-associated pneumonia with electronic data and comparison of algorithm results with clinician diagnoses Michael Klompas
Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts, USA
Infect Control Hosp Epidemiol 29:31-7. 2008..We sought to improve the efficiency and objectivity of VAP surveillance by adapting the CDC criteria to make them amenable to evaluation with electronic data...
Automated detection and classification of type 1 versus type 2 diabetes using electronic health record dataMichael Klompas
Corresponding author Michael Klompas
Diabetes Care 36:914-21. 2013..CONCLUSIONS Algorithms applied to EHR data detect more cases of diabetes than claims codes and reasonably discriminate between type 1 and type 2 diabetes...- Objective surveillance definitions for ventilator-associated pneumoniaMichael Klompas
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
Crit Care Med 40:3154-61. 2012..We explored the feasibility of creating objective surveillance definitions for ventilator-associated pneumonia... - Integrating clinical practice and public health surveillance using electronic medical record systemsMichael Klompas
Harvard Medical School and Harvard Pilgrim Health Care Institute, Department of Population Medicine, Boston, Massachusetts 02215, USA
Am J Prev Med 42:S154-62. 2012..The ESP platform provides live, automated surveillance for notifiable diseases, influenza-like illness, and diabetes prevalence, care, and complications. Results are automatically transmitted to state health departments... - Integrating clinical practice and public health surveillance using electronic medical record systemsMichael Klompas
Harvard Medical School, and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
Am J Public Health 102:S325-32. 2012..The ESP platform provides live, automated surveillance for notifiable diseases, influenza-like illness, and diabetes prevalence, care, and complications. Results are automatically transmitted to state health departments... - Variability in mean duration of mechanical ventilation among community hospitalsMichael Klompas
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
Infect Control Hosp Epidemiol 33:635-7. 2012..Mean ventilator-days per patient varied 4-fold within a network of community hospitals despite adjusting for multiple patient and hospital factors. Further assessment of this metric is warranted... - Is a ventilator-associated pneumonia rate of zero really possible?Michael Klompas
Infection Control Department, Brigham and Women s Hospital, Boston, Massachusetts, USA
Curr Opin Infect Dis 25:176-82. 2012..This article explores the significance of very low VAP rates, reviews differences in surveillance and clinical rates, proposes reasons for their discrepancies, and suggests possible objective alternatives for surveillance... - Rapid and reproducible surveillance for ventilator-associated pneumoniaMichael Klompas
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02215, USA
Clin Infect Dis 54:370-7. 2012..The complexity and subjectivity of ventilator-associated pneumonia (VAP) surveillance limit its value in assessing and comparing quality of care for ventilated patients. A simpler, more quantitative VAP definition may increase utility... - Herpes zoster and postherpetic neuralgia surveillance using structured electronic dataMichael Klompas
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
Mayo Clin Proc 86:1146-53. 2011..To develop electronic algorithms for rapid, automated surveillance for herpes zoster and postherpetic neuralgia (PHN) using codified electronic health data... - Multicenter evaluation of a novel surveillance paradigm for complications of mechanical ventilationMichael Klompas
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, United States of America
PLoS ONE 6:e18062. 2011..We therefore evaluated a novel surveillance paradigm for ventilator-associated complications (VAC) defined by sustained increases in patients' ventilator settings after a period of stable or decreasing support... - Prevention of ventilator-associated pneumoniaMichael Klompas
Infection Control Department, Brigham and Women s Hospital, Boston, MA 02115, USA
Expert Rev Anti Infect Ther 8:791-800. 2010..This article will review selected VAP prevention methods using this framework and advocate for the development of a new surveillance definition that will more reliably predict patient outcomes... - Interobserver variability in ventilator-associated pneumonia surveillanceMichael Klompas
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02245, USA
Am J Infect Control 38:237-9. 2010..Infection control personnel labelled between 11 and 20 patients with VAP (kappa = 0.40). The physician diagnosed 7 cases. Interobserver variability in the assessment of ventilator-associated pneumonia is high... - Risk of misleading ventilator-associated pneumonia rates with use of standard clinical and microbiological criteriaMichael Klompas
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
Clin Infect Dis 46:1443-6. 2008..The addition of microbiological criteria to standard clinical criteria decreased the range of apparent VAP to 3.5%-15.5%. These wide margins of variability suggest that VAP rates are an unreliable measure of quality of care... - Automated identification of acute hepatitis B using electronic medical record data to facilitate public health surveillanceMichael Klompas
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, United States of America
PLoS ONE 3:e2626. 2008..We describe the development and implementation of an algorithm for prospective surveillance of patients with acute hepatitis B using electronic medical record data... - The paradox of ventilator-associated pneumonia prevention measuresMichael Klompas
Infection Control Department, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Crit Care 13:315. 2009..The paradox makes changes in VAP rates alone an unreliable measure of whether VAP prevention measures are truly beneficial to patients and behooves us to measure their impact on patient outcomes before advocating their adoption... - Automated surveillance of health care-associated infectionsMichael Klompas
Infection Control Department, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Clin Infect Dis 48:1268-75. 2009..The efficiency and objectivity of these methods make them promising candidates for more manageable and meaningful benchmarking within and between facilities... - Inclusion of 30-day postdischarge detection triples the incidence of hospital-onset methicillin-resistant Staphylococcus aureusTaliser R Avery
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02215, USA
Infect Control Hosp Epidemiol 33:114-21. 2012..Hospitalized patients are at increased risk for acquisition of methicillin-resistant Staphylococcus aureus (MRSA). As hospital length of stay shortens, hospital-acquired MRSA events may be more likely to be detected after discharge... - Electronic Support for Public Health: validated case finding and reporting for notifiable diseases using electronic medical dataRoss Lazarus
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
J Am Med Inform Assoc 16:18-24. 2009..Source code for this highly interoperable application is freely available under an approved open-source license at http://esphealth.org... - Real-time surveillance for tuberculosis using electronic health record data from an ambulatory practice in eastern MassachusettsMichael S Calderwood
Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Public Health Rep 125:843-50. 2010..We report on the development and validation of a TB detection algorithm for EHR data followed by implementation in a live surveillance and reporting system... - Comparison of electronic laboratory reports, administrative claims, and electronic health record data for acute viral hepatitis surveillanceJoshua Allen-Dicker
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
J Public Health Manag Pract 18:209-14. 2012..Public health surveillance systems for acute hepatitis are limited: clinician reporting is insensitive and electronic laboratory reporting is nonspecific. Insurance claims and electronic health records are potential alternative sources... - Fonsecaea monophora cerebral phaeohyphomycosis: case report of successful surgical excision and voriconazole treatment and reviewSophia Koo
Division of Infectious Diseases, Brigham and Women s Hospital, 75 Francis Street, PBB A4, Boston, MA 02115, USA
Med Mycol 48:769-74. 2010..She discontinued antifungal therapy after an 18-month treatment course, and has remained free of any clinical or radiographic evidence of recurrent abscess formation three years later... - A compendium of strategies to prevent healthcare-associated infections in acute care hospitalsDeborah S Yokoe
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Infect Control Hosp Epidemiol 29:S12-21. 2008.... - Ventilator-associated pneumonia--the wrong quality measure for benchmarkingMichael Klompas
Department of Ambulatory Care and Prevention, Harvard Medical School, Harvard Pilgrim Health Care, and Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
Ann Intern Med 147:803-5. 2007..Ventilator-associated pneumonia should be excluded from compulsory reporting initiatives until we develop and validate more objective outcome measures that meaningfully reflect quality of care for ventilated patients...