David E Kling
Affiliation: Massachusetts General Hospital
- Vitamin A deficiency (VAD), teratogenic, and surgical models of congenital diaphragmatic hernia (CDH)David E Kling
Massachusetts General Hospital, Department of Pediatric Surgery, Boston, MA 02114, USA
Am J Med Genet C Semin Med Genet 145:139-57. 2007..Continued exploration of these models will bring forth a clearer understanding of CDH and its molecular underpinnings, which will ultimately facilitate development of therapeutic strategies...
- Nitrofen induces a redox-dependent apoptosis associated with increased p38 activity in P19 teratocarcinoma cellsD E Kling
Pediatric Surgical Research Laboratories, Pediatric Surgical Services, The Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, WRN 1122, Boston, MA 02114 2696, USA
Toxicol In Vitro 19:1-10. 2005..Therefore, nitrofen induces P19 cell apoptosis that is cell-redox-dependent and is associated with increases in p38 activity and ROS and may play a role in nitrofen-mediated birth defects...
- Distribution of ERK1/2 and ERK3 during normal rat fetal lung developmentDavid E Kling
Department of Pediatric Surgery CPZ 6 100, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
Anat Embryol (Berl) 211:139-53. 2006..These observations will facilitate detailed functional analysis of these kinases to assess their roles in pulmonary development and diseases...
- Lactic acid is a potential virulence factor for group B StreptococcusDavid E Kling
Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRJ 1402, Boston, MA 02114, USA
Microb Pathog 46:43-52. 2009..6 mM lactic acid produced dramatic tissue autofluorescence; the basis for this is currently unknown. These studies demonstrate that GBS-produced lactic acid is a potential virulence factor and may contribute to GBS invasive disease...
- Retinoic acid decreases fetal lung mesenchymal cell proliferation in vivo and in vitroSussie Dalvin
Pediatric Pulmonary Unit, Department of Pediatrics, Massachusetts General Hospital for Children, Harvard Medical School, Boston, Massachusetts 02114, USA
Dev Growth Differ 46:275-82. 2004..Our results suggest that RA decreases proliferation of lung mesenchyme via a G(i)-protein and the erk-1/2 signaling cascade...
- Oxidation-reduction (redox) controls fetal hypoplastic lung growthJason C Fisher
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
J Surg Res 106:287-91. 2002..We have shown previously that three antioxidants (vitamin C, glutathione, and vitamin E) could accelerate the growth of fetal hypoplastic lungs grown in culture. We hypothesize that this occurs via a reductant mechanism...
- Retinoic acid-mediated differentiation protects against nitrofen-induced apoptosisJeremy T Aidlen
Pediatric Surgical Research Laboratories, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Birth Defects Res B Dev Reprod Toxicol 80:406-16. 2007....
- The principal fucosylated oligosaccharides of human milk exhibit prebiotic properties on cultured infant microbiotaZhuo Teng Yu
Department of Pediatric Gastroenterology and Nutrition, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02129, USA
Glycobiology 23:169-77. 2013..Thus, these simple glycans could mediate beneficial effects of human milk on infant health...
- MEK-1/2 inhibition reduces branching morphogenesis and causes mesenchymal cell apoptosis in fetal rat lungsDavid E Kling
Pediatric Surgical Research Laboratories, Pediatric Surgical Services, and the Department of Surgery, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Physiol Lung Cell Mol Physiol 282:L370-8. 2002..Thus U-0126 causes specific inhibition of ERK-1/2 signaling, diminished branching morphogenesis, characterized by increased mesenchymal apoptosis, and decreased epithelial proliferation in fetal lung explants...
- Human milk mucin 1 and mucin 4 inhibit Salmonella enterica serovar Typhimurium invasion of human intestinal epithelial cells in vitroBo Liu
Department of Pediatric Gastroenterology and Nutrition, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA
J Nutr 142:1504-9. 2012..Thus, mucins may prove useful as a basis for developing novel oral prophylactic and therapeutic agents that inhibit infant diseases caused by Salmonella and related pathogens...