ANNE contact KLIBANSKI

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Adolescent girls with anorexia nervosa have impaired cortical and trabecular microarchitecture and lower estimated bone strength at the distal radius
    Alexander T Faje
    Neuroendocrine Unit, Massachusetts General Hospital for Children, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 98:1923-9. 2013
  2. pmc Marrow fat and bone--new perspectives
    Pouneh K Fazeli
    MD, Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, Boston, Massachusetts 02114
    J Clin Endocrinol Metab 98:935-45. 2013
  3. pmc Waist to hip ratio and trunk to extremity fat (DXA) are better surrogates for IMCL and for visceral fat respectively than for subcutaneous fat in adolescent girls
    Eray Savgan-Gurol
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA
    Nutr Metab (Lond) 7:86. 2010
  4. pmc The endocrine tumor summit 2008: appraising therapeutic approaches for acromegaly and carcinoid syndrome
    Anne Klibanski
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Pituitary 13:266-86. 2010
  5. ncbi request reprint Growth hormone and cardiovascular risk markers
    Anne Klibanski
    Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, BUL457B, Boston, MA 02114, USA
    Growth Horm IGF Res 13:S109-15. 2003
  6. ncbi request reprint Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls
    Madhusmita Misra
    Neuroendocrine Unit, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Pediatrics 114:1574-83. 2004
  7. pmc Effects of recombinant human growth hormone in anorexia nervosa: a randomized, placebo-controlled study
    Pouneh K Fazeli
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:4889-97. 2010
  8. ncbi request reprint Ghrelin and bone metabolism in adolescent girls with anorexia nervosa and healthy adolescents
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:5082-7. 2005
  9. ncbi request reprint Elevated peptide YY levels in adolescent girls with anorexia nervosa
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:1027-33. 2006
  10. pmc Hormonal and nutritional effects on cardiovascular risk markers in young women
    Elizabeth A Lawson
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 92:3089-94. 2007

Research Grants

Detail Information

Publications89

  1. pmc Adolescent girls with anorexia nervosa have impaired cortical and trabecular microarchitecture and lower estimated bone strength at the distal radius
    Alexander T Faje
    Neuroendocrine Unit, Massachusetts General Hospital for Children, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 98:1923-9. 2013
    ..Because microarchitectural abnormalities and FEA may predict fracture risk independent of aBMD, these data are important to obtain...
  2. pmc Marrow fat and bone--new perspectives
    Pouneh K Fazeli
    MD, Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, Boston, Massachusetts 02114
    J Clin Endocrinol Metab 98:935-45. 2013
    ....
  3. pmc Waist to hip ratio and trunk to extremity fat (DXA) are better surrogates for IMCL and for visceral fat respectively than for subcutaneous fat in adolescent girls
    Eray Savgan-Gurol
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA
    Nutr Metab (Lond) 7:86. 2010
    ..abstract:..
  4. pmc The endocrine tumor summit 2008: appraising therapeutic approaches for acromegaly and carcinoid syndrome
    Anne Klibanski
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Pituitary 13:266-86. 2010
    ..Panel opinions, based on the level of available scientific evidence, were polled. Finally, their views were compared with those of surveyed community-based endocrinologists and neurosurgeons...
  5. ncbi request reprint Growth hormone and cardiovascular risk markers
    Anne Klibanski
    Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, BUL457B, Boston, MA 02114, USA
    Growth Horm IGF Res 13:S109-15. 2003
    ..The contribution of specific hormonal factors and prior irradiation to the development of vascular disease remains controversial...
  6. ncbi request reprint Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls
    Madhusmita Misra
    Neuroendocrine Unit, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Pediatrics 114:1574-83. 2004
    ..The prevalence of AN is increasing in adolescents, and it is the third most common chronic disease in adolescent girls. Therefore, it is important to determine the medical effects of this disorder in this young population...
  7. pmc Effects of recombinant human growth hormone in anorexia nervosa: a randomized, placebo-controlled study
    Pouneh K Fazeli
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:4889-97. 2010
    ..The effects of supraphysiological recombinant human GH (rhGH) on GH resistance in AN are not currently known...
  8. ncbi request reprint Ghrelin and bone metabolism in adolescent girls with anorexia nervosa and healthy adolescents
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:5082-7. 2005
    ..Anorexia nervosa (AN) in adolescents is associated with low bone mineral density (BMD) and increases in ghrelin secretion, an orexigenic GH secretagogue that stimulates osteoblast proliferation in vitro...
  9. ncbi request reprint Elevated peptide YY levels in adolescent girls with anorexia nervosa
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:1027-33. 2006
    ..In addition, known regulators of bone turnover, such as GH, cortisol, and estrogen, explain only a fraction of the variability in bone turnover marker levels...
  10. pmc Hormonal and nutritional effects on cardiovascular risk markers in young women
    Elizabeth A Lawson
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 92:3089-94. 2007
    ..Moreover, oral estrogens, known to increase hsCRP in other populations, are commonly prescribed in AN. To date, hsCRP levels and their physiological determinants have not been reported in women with AN...
  11. ncbi request reprint Anorexia nervosa and osteoporosis
    Madhusmita Misra
    Pediatric Endocrine Unit, Massachusetts General Hospital for Children, Boston, MA, USA
    Rev Endocr Metab Disord 7:91-9. 2006
    ..This is particularly so for adolescents, who are in the process of accruing peak bone mass, and in whom a failure to attain peak bone mass may occur in AN in addition to loss of established bone...
  12. pmc Preadipocyte factor-1 is associated with marrow adiposity and bone mineral density in women with anorexia nervosa
    Pouneh K Fazeli
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:407-13. 2010
    ..Adipocytes and osteoblasts differentiate from a common progenitor cell, the human mesenchymal stem cell. Therefore, understanding factors that regulate this differentiation process may provide insight into bone loss in AN...
  13. ncbi request reprint Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity
    Madhusmita Misra
    BUL 457B, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 89:3486-95. 2004
    ..Resumption of menses is associated with significant increases in the FLI, suggesting that free leptin may be an important determinant of menstrual recovery...
  14. ncbi request reprint Secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 289:E373-81. 2005
    ..Leptin predicts GH and cortisol parameters and with ghrelin predicts GH burst frequency. Low leptin and high ghrelin may be dual stimuli for high GH concentrations in undernutrition...
  15. pmc Visceral fat is a negative predictor of bone density measures in obese adolescent girls
    Melissa Russell
    M P H, BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:1247-55. 2010
    ..Conclusion: VAT is an independent inverse determinant of bone density in obesity. This association may be mediated by adipokines and a chronic inflammatory state...
  16. ncbi request reprint Reciprocal changes in endogenous ghrelin and growth hormone during fasting in healthy women
    Polyxeni Koutkia
    Program in Nutritional Metabolism, Mass General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 289:E814-22. 2005
    ..Our data provide new evidence of the physiological relationship of GH and ghrelin in response to changes in protein-energy metabolism...
  17. pmc Growth hormone decreases visceral fat and improves cardiovascular risk markers in women with hypopituitarism: a randomized, placebo-controlled study
    Catherine Beauregard
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 93:2063-71. 2008
    ..Data regarding gender-specific efficacy of GH on critical endpoints are lacking. There are no randomized, placebo-controlled studies of physiological GH therapy solely in women...
  18. pmc Fibroblast growth factor-21 may mediate growth hormone resistance in anorexia nervosa
    Pouneh K Fazeli
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:369-74. 2010
    ..In a transgenic mouse model, FGF-21 reduces IGF-I levels by inhibiting signal transducer and activator of transcription-5, a mediator of the intracellular effects of GH...
  19. ncbi request reprint Cardiovascular risk factors in acromegaly before and after normalization of serum IGF-I levels with the GH antagonist pegvisomant
    Gemma Sesmilo
    Neuroendocrine Clinical Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:1692-9. 2002
    ..Administration of pegvisomant increases CRP levels. We propose that GH secretory status is an important determinant of serum CRP levels, although additional studies are needed to determine the mechanism and significance of this finding...
  20. pmc Peptide YY levels across pubertal stages and associations with growth hormone
    Benjamin Lloyd
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:2957-62. 2010
    ..Peptide YY (PYY) is an anorexigenic hormone that is high in anorexia nervosa and low in obesity, inhibits GnRH secretion, and is suppressed by GH administration. The relationship between PYY and GH has not been examined across puberty...
  21. ncbi request reprint Alterations in cortisol secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:4972-80. 2004
    ..Therefore, high cortisol values in AN may contribute to the low bone density observed in adolescents with this disorder by decreasing bone formation...
  22. ncbi request reprint Effects of psychiatric disorders and psychotropic medications on prolactin and bone metabolism
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 65:1607-18; quiz 1590, 1760-1. 2004
    ..Few reviews have thus far addressed this issue. We have consolidated information from studies that examined effects of psychiatric conditions and their treatment on bone metabolism...
  23. ncbi request reprint Growth hormone and ghrelin responses to an oral glucose load in adolescent girls with anorexia nervosa and controls
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:1605-12. 2004
    ..Further studies are needed to define GH suppression in an adolescent population...
  24. ncbi request reprint Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 289:E347-56. 2005
    ..The most important predictor of ghrelin concentration is insulin resistance, and ghrelin in turn predicts GH and cortisol burst frequency...
  25. ncbi request reprint Alterations in growth hormone secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:5615-23. 2003
    ..Acquired GH resistance may play a role in the osteopenia and decreased peak bone mass frequently associated with AN...
  26. pmc Peptide YY in adolescent athletes with amenorrhea, eumenorrheic athletes and non-athletic controls
    Melissa Russell
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 45:104-9. 2009
    ..The role of other nutritionally regulated hormones such as peptide YY (PYY) and adiponectin in mediating gonadal status and bone metabolism remains to be determined...
  27. ncbi request reprint Regional body composition in adolescents with anorexia nervosa and changes with weight recovery
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Am J Clin Nutr 77:1361-7. 2003
    ..Little is known about fat distribution in adolescents with AN, especially with weight recovery...
  28. pmc Acylated ghrelin and leptin in adolescent athletes with amenorrhea, eumenorrheic athletes and controls: a cross-sectional study
    Karla Christo
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Endocrinol (Oxf) 69:628-33. 2008
    ..We hypothesized that adolescent athletes with amenorrhea (AA) would have higher ghrelin and lower leptin levels than eumenorrheic athletes (EA) and would predict levels of gonadal steroids...
  29. pmc Peptide YY (PYY) levels and bone mineral density (BMD) in women with anorexia nervosa
    Andrea L Utz
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 43:135-9. 2008
    ..Y2 receptor knockout mice have increased bone mineral density (BMD) and thus PYY may play a role in regulating bone mass. We hypothesized that PYY levels would be inversely associated with BMD in women with AN...
  30. ncbi request reprint Hormonal determinants of regional body composition in adolescent girls with anorexia nervosa and controls
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, BUL 457, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:2580-7. 2005
    ..High cortisol levels in AN predict a redistribution of lean body mass such that extremity lean mass decreases. Further studies are necessary to better understand the implications of these data...
  31. ncbi request reprint Serum osteoprotegerin in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:3816-22. 2003
    ..OPG values correlate negatively with markers of nutritional status and lumbar bone density z-scores and may be a compensatory response to the bone loss seen in this population...
  32. pmc Growth hormone deficiency is associated with decreased quality of life in patients with prior acromegaly
    Tamara Wexler
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:2471-7. 2009
    ..However, it is unknown whether patients with GHD after treatment for acromegaly have a poorer quality of life than those with normal GH levels after cure of acromegaly...
  33. pmc Increased bone marrow fat in anorexia nervosa
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Yawkey 6E, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:2129-36. 2009
    ..Recent data suggest that marrow fat measured by 1H-magnetic resonance spectroscopy (MRS) in combination with bone mineral density (BMD) may be more valuable than either parameter alone in detecting bone weakness...
  34. doi request reprint Simultaneous initiation (coinitiation) of pharmacotherapy with triiodothyronine and a selective serotonin reuptake inhibitor for major depressive disorder: a quantitative synthesis of double-blind studies
    George I Papakostas
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Int Clin Psychopharmacol 24:19-25. 2009
    ..Clearly, further work is needed to help determine whether there are specific MDD populations that can, indeed, benefit from T3-SSRI coinitiation therapy...
  35. pmc Selective loss of MEG3 expression and intergenic differentially methylated region hypermethylation in the MEG3/DLK1 locus in human clinically nonfunctioning pituitary adenomas
    Roger Gejman
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:4119-25. 2008
    ..MEG3 is an imprinted gene encoding a novel noncoding RNA that suppresses tumor cell growth. Although highly expressed in the normal human pituitary, it is unknown which of the normal pituitary cell types and pituitary tumors express MEG3...
  36. pmc Lower growth hormone and higher cortisol are associated with greater visceral adiposity, intramyocellular lipids, and insulin resistance in overweight girls
    Madhusmita Misra
    Neuroendocrine Unit and Pediatric Endocrine Unit, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 295:E385-92. 2008
    ..Our data indicate that lower peak GH and higher UFC in overweight girls are associated with visceral adiposity, insulin resistance, and lipids...
  37. pmc Bone metabolism in adolescent boys with anorexia nervosa
    Madhusmita Misra
    BUL 457, Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:3029-36. 2008
    ..Although primarily a disease in females, AN is increasingly being recognized in males. However, there are few or no data regarding BMD, bone turnover markers or their predictors in adolescent AN boys...
  38. pmc Bone metabolism in adolescent athletes with amenorrhea, athletes with eumenorrhea, and control subjects
    Karla Christo
    Massachusetts General Hospital, Neuroendocrine Unit, BUL 457, 55 Fruit St, Boston, MA 02114, USA
    Pediatrics 121:1127-36. 2008
    ....
  39. ncbi request reprint Effects of growth hormone secretion on body composition in patients with Crohn's disease
    Laurence Katznelson
    Neuroendocrine Unit and General Clinical Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:5468-72. 2003
    ..These data show that GH has an important role in modulating visceral fat distribution in patients with Crohn's disease...
  40. ncbi request reprint Measurement of free testosterone in normal women and women with androgen deficiency: comparison of methods
    Karen K Miller
    Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:525-33. 2004
    ..0001), but is a unitless number without reference to the physical reality of free T. We conclude that the mass action equation and equilibrium dialysis are the preferred methods for use in diagnosing androgen deficiency in women...
  41. doi request reprint Gender effects on cardiac valvular function in hyperprolactinaemic patients receiving cabergoline: a retrospective study
    Lisa B Nachtigall
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Clin Endocrinol (Oxf) 72:53-8. 2010
    ..Ergot-derived dopamine agonists are associated with increased risk of valvular dysfunction in Parkinson's disease. The risk of valvular disease associated with lower doses of cabergoline used to treat prolactinomas remains controversial...
  42. pmc Effects of rhIGF-1 administration on surrogate markers of bone turnover in adolescents with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 45:493-8. 2009
    ..Although IGF-1 is key to pubertal bone accretion, and effects have been demonstrated in adults, there are no data regarding the effect of recombinant human (rh) IGF-1 administration in adolescents with AN...
  43. pmc Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosa
    Elizabeth A Lawson
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 46:458-63. 2010
    ..We concluded that bone microarchitecture is abnormal in women with AN. Endogenous IGF-I, leptin, and androgen levels predict bone microarchitecture independent of BMI...
  44. ncbi request reprint Androgens and bone density in women with hypopituitarism
    Karen K Miller
    Department of Medicine, Neuroendocrine Unit, Clinical Research Center, Bulfinch 457B, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 87:2770-6. 2002
    ..It remains to be determined whether androgen replacement therapy itself or an increase in lean body mass achieved as a result of androgen administration will result in an improvement in BMD in this population...
  45. pmc Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene
    Yunli Zhou
    Massachusetts General Hospital, Boston, MA 02114, USA
    Development 137:2643-52. 2010
    ..These data strongly indicate that activation of Gtl2 and its downstream maternal genes play an essential role in regulating Dlk1-Gtl2 imprinting, possibly by maintaining active status of the IG-DMR...
  46. pmc Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 19:49-53. 2011
    ..This suggests that the detrimental effect of visceral fat on bone health may be mediated in part by IGF-1 as an important regulator of the fat and bone lineage...
  47. doi request reprint Clinical Review#: Potential cardiac valve effects of dopamine agonists in hyperprolactinemia
    Elena Valassi
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, Boston, Massachusetts 02114
    J Clin Endocrinol Metab 95:1025-33. 2010
    ..Clinicians should recommend the lowest possible doses of dopamine agonists and address the question of echocardiographic monitoring on an individual basis...
  48. pmc Comparison of DXA and CT in the assessment of body composition in premenopausal women with obesity and anorexia nervosa
    Miriam A Bredella
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:2227-33. 2010
    ..The level of hydration does not significantly affect most DXA body composition measurements, with the exceptions of thigh fat...
  49. pmc Growth hormone deficiency after treatment of acromegaly: a randomized, placebo-controlled study of growth hormone replacement
    Karen K Miller
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:567-77. 2010
    ....
  50. ncbi request reprint Effects of recombinant human insulin-like growth factor (IGF)-I and estrogen administration on IGF-I, IGF binding protein (IGFBP)-2, and IGFBP-3 in anorexia nervosa: a randomized-controlled study
    Steven Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:1142-9. 2003
    ..In conclusion, our data suggest that chronic rhIGF-I administration increases IGF-I and IGFBP-2 and decreases IGFBP-3 in women with anorexia nervosa. IGFBP-2 and IGFBP-3 may be important determinants of bone density in this population...
  51. pmc Neuroendocrine consequences of anorexia nervosa in adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Endocr Dev 17:197-214. 2010
    ..Weight gain is associated with a stabilization of bone density, although residual deficits persist in the short term, and in some cases, long term...
  52. pmc Reduced amylin levels are associated with low bone mineral density in women with anorexia nervosa
    Monica H Wojcik
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 46:796-800. 2010
    ..Peptide hormones, including amylin, GIP, and GLP2, are released immediately after nutrient intake and may be involved in the regulation of bone turnover...
  53. pmc Weight gain and restoration of menses as predictors of bone mineral density change in adolescent girls with anorexia nervosa-1
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:1231-7. 2008
    ..We hypothesized that menstrual recovery and weight gain (> or =10% increase in body mass index) would predict an increase in these measures of bone density...
  54. pmc Prognostic indicators of changes in bone density measures in adolescent girls with anorexia nervosa-II
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:1292-7. 2008
    ..We hypothesized that baseline levels of nutritionally regulated hormones and of bone turnover markers would predict DeltaBMD overall...
  55. pmc Determinants of skeletal loss and recovery in anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 91:2931-7. 2006
    ..Anorexia nervosa (AN) is complicated by severe bone loss. The effects of persistent undernutrition and consequent neuroendocrine dysfunction on bone mass and the factors influencing skeletal recovery have not been well characterized...
  56. ncbi request reprint Diagnostic errors after inferior petrosal sinus sampling
    Brooke Swearingen
    Neuroendocrine Clinical Center, Division of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:3752-63. 2004
    ....
  57. ncbi request reprint Role of cortisol in menstrual recovery in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Pediatr Res 59:598-603. 2006
    ..Baseline cortisol level strongly predicted increases in the percentage of body fat. We demonstrate that 1) high baseline cortisol level predicts increases in body fat and 2) increases in body fat predict menses recovery in AN...
  58. ncbi request reprint Regional cerebral brain metabolism correlates of neuroticism and extraversion
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Depress Anxiety 23:133-8. 2006
    ..No significant correlations were found involving anterior cingulate, amygdala, or ventral striatum. Neuroticism and Extraversion are associated with activity in insular cortex and orbitofrontal cortex, respectively...
  59. ncbi request reprint Uncoupling of cardiovascular risk markers in adolescent girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, and the Eating Disorders Unit, Child Psychiatry Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Pediatr 149:763-769. 2006
    ..We hypothesized that in AN, growth hormone (GH) resistance and hypercortisolemia would increase CV risk through effects on pro-inflammatory cytokines and lipid status despite low weight...
  60. ncbi request reprint Differential effects of metformin and exercise on muscle adiposity and metabolic indices in human immunodeficiency virus-infected patients
    Susan D Driscoll
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:2171-8. 2004
    ..Reduction in muscle adiposity may be an important mechanism by which exercise improves hyperinsulinemia in this population...
  61. ncbi request reprint Effects of risedronate on bone density in anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:3903-6. 2004
    ..S. for premenopausal women other than those receiving glucocorticoids. Further studies are needed to establish the efficacy and safety of bisphosphonate therapy in this population...
  62. ncbi request reprint Growth hormone suppression after an oral glucose load in children
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 92:4623-9. 2007
    ..Adult data cannot be extrapolated to children given the pubertal increase in GH concentration. In addition, because GH levels are higher in pubertal girls than boys, nadir GH may differ across gender...
  63. ncbi request reprint Medical findings in outpatients with anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Arch Intern Med 165:561-6. 2005
    ..However, few clinical data exist regarding community-dwelling women with anorexia nervosa. The objective of this study was to determine the prevalences of common medical findings for these women...
  64. ncbi request reprint Androgen deficiency: association with increased anxiety and depression symptom severity in anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 68:959-65. 2007
    ..Because androgens are known to affect mood and behavior, we hypothesized that low endogenous androgen production in anorexia nervosa would predict anxiety and depression severity...
  65. pmc Increased expression of angiogenic genes in the brains of mouse meg3-null embryos
    Francesca E Gordon
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Endocrinology 151:2443-52. 2010
    ..In conclusion, Meg3 may play an important role in control of vascularization in the brain and may function as a tumor suppressor in part by inhibiting angiogenesis...
  66. pmc Delayed remission after transsphenoidal surgery in patients with Cushing's disease
    Elena Valassi
    Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Bulfinch 457B, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 95:601-10. 2010
    ..Expectant management and retesting may spare some patients from unnecessary further treatment. Optimal timing to determine the need for further therapy after TSS remains to be determined...
  67. ncbi request reprint Evaluation and treatment of low bone density in anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, USA
    Nutr Clin Care 5:298-308. 2002
    ..To do this, it is necessary to understand the mechanisms underlying low bone density in anorexia nervosa. This article discusses current concepts related to bone loss associated with anorexia nervosa, including how to prevent it...
  68. ncbi request reprint Effects of estrogen and recombinant human insulin-like growth factor-I on ghrelin secretion in severe undernutrition
    Steven Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:3988-93. 2004
    ..The mechanisms of these effects are unknown and may relate to direct effects on ghrelin or changes in GH. Further studies are needed to determine the mechanisms by which rhIGF-I and E increase ghrelin in human physiology...
  69. ncbi request reprint The role of the clinical laboratory in the diagnosis of Cushing syndrome
    Christine Garcia
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Am J Clin Pathol 120:S38-45. 2003
    ..These tests are also essential for guiding the clinician to the correct surgical procedure to potentially cure the patient...
  70. ncbi request reprint Testosterone administration attenuates regional brain hypometabolism in women with anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, BUL 457B, Boston, MA 02114, USA
    Psychiatry Res 132:197-207. 2004
    ..Further study is warranted to replicate these findings, as well as to determine their physiological and clinical significance...
  71. ncbi request reprint Antipsychotic medication, prolactin elevation, and ovarian function in women with schizophrenia and schizoaffective disorder
    Carla M Canuso
    Commonwealth Research Center, Boston, MA 02115, USA
    Psychiatry Res 111:11-20. 2002
    ....
  72. ncbi request reprint Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa
    Steven Grinspoon
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 87:2883-91. 2002
    ..Further long-term studies are needed to investigate the effects of rhIGF-I and combined anabolic/antiresorptive strategies on bone in women with anorexia nervosa...
  73. ncbi request reprint Cyclic AMP stimulates MEG3 gene expression in cells through a cAMP-response element (CRE) in the MEG3 proximal promoter region
    Jing Zhao
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Biochem Cell Biol 38:1808-20. 2006
    ..Together with the anti-proliferative function of cAMP, our data suggest that MEG3 may interact with the cAMP-dependent signaling pathway to be involved in the control of cell proliferation and other cAMP-related physiological functions...
  74. ncbi request reprint Serum prolactin levels among outpatients with major depressive disorder during the acute phase of treatment with fluoxetine
    George I Papakostas
    Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 67:952-7. 2006
    ..To determine changes in serum prolactin levels in outpatients with DSM-IV-diagnosed major depressive disorder (MDD) following a 12-week open-label trial of fluoxetine...
  75. ncbi request reprint Growth hormone (GH) replacement therapy in adult-onset gh deficiency: effects on body composition in men and women in a double-blind, randomized, placebo-controlled trial
    Andrew R Hoffman
    Veterans Affairs Palo Alto Health Care System and Stanford University, Palo Alto, California 94304, USA
    J Clin Endocrinol Metab 89:2048-56. 2004
    ..GH treatment was generally well tolerated. Subjects with AGHD should receive individualized GH therapy to maintain IGF-I between the mean value and +2 SD and improve body composition and cardiovascular risk factors...
  76. ncbi request reprint Effects of exercise training and metformin on body composition and cardiovascular indices in HIV-infected patients
    Susan D Driscoll
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02144 2696, USA
    AIDS 18:465-73. 2004
    ..To determine whether exercise training in combination with metformin improves cardiovascular risk indices and insulin in comparison to metformin alone among HIV-infected patients...
  77. ncbi request reprint Relationships between serum adipokines, insulin levels, and bone density in girls with anorexia nervosa
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Endocrinol Metab 92:2046-52. 2007
    ..Adolescents with anorexia nervosa (AN) have low bone mineral density (BMD). Adipokines and insulin play an important role in bone metabolism in healthy individuals. However, their association with bone metabolism in AN is unknown...
  78. ncbi request reprint Cardiovascular risk in patients with growth hormone deficiency: effects of growth hormone substitution
    Albert G Burger
    Department of Medicine, University of Geneva, Cologny Geneva, Switzerland
    Endocr Pract 12:682-9. 2006
    ..To review the literature on the increased cardiovascular risk in patients with growth hormone (GH) deficiency and the positive effects of GH replacement...
  79. doi request reprint Determinants of height in adolescent girls with anorexia nervosa
    Rajani Prabhakaran
    BUL 457, MassGeneral Hospital, Neuroendocrine Unit, 55 Fruit St, Boston, MA 02114, USA
    Pediatrics 121:e1517-23. 2008
    ..In addition, growth hormone may have direct effects on the growth plate independent of insulin-like growth factor 1 to increase statural growth...
  80. pmc Nutrient intake in community-dwelling adolescent girls with anorexia nervosa and in healthy adolescents
    Madhusmita Misra
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 84:698-706. 2006
    ..Adolescence is a common time for the onset of anorexia nervosa (AN), a condition associated with long-term medical and hormonal consequences...
  81. ncbi request reprint Abnormal bone mineral accrual in adolescent girls with anorexia nervosa
    Leslie A Soyka
    Department of Pediatrics, University of Massachusetts Medical School, Worcester 01655, USA
    J Clin Endocrinol Metab 87:4177-85. 2002
    ..A rise in bone turnover markers may be an early indicator of increase in BMD in recovering girls with AN...
  82. ncbi request reprint Activation of p53 by MEG3 non-coding RNA
    Yunli Zhou
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 282:24731-42. 2007
    ..These data suggest that MEG3 non-coding RNA may function as a tumor suppressor, whose action is mediated by both p53-dependent and p53-independent pathways...
  83. ncbi request reprint Proton stereotactic radiosurgery in management of persistent acromegaly
    Joshua H Petit
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Endocr Pract 13:726-34. 2007
    ..To evaluate the efficacy and safety of proton stereotactic radiosurgery (PSRS) for acromegaly that is refractory to surgical treatment and medication...
  84. ncbi request reprint Fear conditioning and extinction: influence of sex and menstrual cycle in healthy humans
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Behav Neurosci 120:1196-203. 2006
    ..On Day 2, men and early cycle women expressed greater extinction memory than midcycle women. These data confirm sex differences in conditioned fear acquisition and suggest that midcycle hormones attenuate extinction recall...
  85. doi request reprint Changing patterns in diagnosis and therapy of acromegaly over two decades
    Lisa Nachtigall
    Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Endocrinol Metab 93:2035-41. 2008
    ....
  86. pmc Regulation of growth hormone expression by Delta-like protein 1 (Dlk1)
    Peter J Ansell
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Bulfinch 457B, 55 Fruit Street, Boston, MA 02114, United States
    Mol Cell Endocrinol 271:55-63. 2007
    ..The observation that Dlk1 regulates GH expression identifies the first endocrine function of Dlk1, establishes GH as a Dlk1-regulated target gene, and provides a model system to facilitate studies of Dlk1-mediated signaling...
  87. ncbi request reprint A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells
    Xun Zhang
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:5119-26. 2003
    ..Taken together, our data suggest that MEG3 may represent a novel growth suppressor, which may play an important role in the development of human pituitary adenomas...
  88. ncbi request reprint Case records of the Massachusetts General Hospital. Case 36-2006. A 35-year-old pregnant woman with new hypertension
    Anne Klibanski
    Neuroendocrine Unit, Massachusetts General Hospital, USA
    N Engl J Med 355:2237-45. 2006
  89. ncbi request reprint Optimizing control of acromegaly: integrating a growth hormone receptor antagonist into the treatment algorithm
    David R Clemmons
    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Endocrinol Metab 88:4759-67. 2003
    ..Pegvisomant is the most effective drug treatment for acromegaly in normalizing IGF-I and producing a clinical response; it is the preferred agent in patients resistant to or intolerant of somatostatin analogs...

Research Grants44

  1. HORMONE REGULATION AND PATHOGENESIS OF PITUITARY TUMORS
    Anne Klibanski; Fiscal Year: 2010
    ..These tumors commonly lead to visual loss and many other severe neurologic and endocrine deficits. ..
  2. TESTOSTERONE AND EXERCISE IN MEN AND WOMEN WITH AIDS
    Anne Klibanski; Fiscal Year: 2004
    ....
  3. Hormonal Factors in the Treatment of Anorexia Nervosa
    ANNE contact KLIBANSKI; Fiscal Year: 2010
    ..We propose to investigate whether long-term testosterone replacement improves symptoms of anorexia nervosa. ..
  4. IGF-1 and Bone Loss in Women Anorexia Nervosa
    Anne Klibanski; Fiscal Year: 2007
    ..We will determine whether a combined anabolic and anti-resorptive strategy using testosterone and Actonel will increase bone formation, decrease resorption and increase bone density. ..
  5. Effects of Anorexia Nervosa on Peak Bone Mass
    Anne Klibanski; Fiscal Year: 2007
    ..These studies will be essential in developing strategies to address the profound loss of bone accrual seen in this large population of adolescent girls at high fracture risk. ..
  6. HORMONE REGULATION AND PATHOGENESIS OF PITUITARY TUMORS
    Anne Klibanski; Fiscal Year: 2006
    ..Investigation of the mechanism for the loss of PDAP expression in human tumors will provide important information regarding the pathogenesis of human pituitary adenomas, and, potentially, other human tumors. ..
  7. HORMONE REGULATION AND PATHOGENESIS OF PITUITARY TUMORS
    Anne Klibanski; Fiscal Year: 2002
    ..Our proposal focuses on the molecular, mechanisms of pituitary tumorigenesis and the potential anti-proliferative role of activin and its receptors in regulating pituitary tumor growth. ..
  8. IGF-I AND BONE LOSS IN WOMEN WITH ANOREXIA NERVOSA
    Anne Klibanski; Fiscal Year: 2001
    ..They will determine whether chronic administration of rhIGF-I increases bone mass, and the interaction of IGF-I and gonadal steroids to both increases bone formation and decreases resorption. ..
  9. HORMONE REGULATION AND PATHOGENESIS OF PITUITARY TUMORS
    Anne Klibanski; Fiscal Year: 1991
    ..The studies outlined in this application should provide information about hormone regulation and pathogenesis of these common pituitary-tumors...
  10. HORMONE REGULATION AND PATHOGENESIS OF PITUITARY TUMORS
    Anne Klibanski; Fiscal Year: 1993
    ..b) alpha-subunit hypersecretion and regulation in pleurihormonal somatotroph tumors identifies somatotroph adenomas in which G-protein mutations occur. c) Ras mutations can be identified in specific pituitary tumor phenotypes...