S Kinlay

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Inflammatory biomarkers in stable atherosclerosis
    Scott Kinlay
    Cardiovascular Division, Veterans Affairs Boston Health Care System, West Roxbury Campus, Boston, Massachusetts, USA
    Am J Cardiol 98:2P-8P. 2006
  2. ncbi request reprint Comparison of effect of intensive lipid lowering with atorvastatin to less intensive lowering with lovastatin on C-reactive protein in patients with stable angina pectoris and inducible myocardial ischemia
    Scott Kinlay
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Cardiol 89:1205-7. 2002
  3. ncbi request reprint Early statin therapy in acute coronary syndromes
    S Kinlay
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Minerva Cardioangiol 51:577-84. 2003
  4. ncbi request reprint Inflammation, statin therapy, and risk of stroke after an acute coronary syndrome in the MIRACL study
    Scott Kinlay
    Cardiovascular Division, Veterans Affairs Boston Healthcare System, West Roxbury, Mass, USA
    Arterioscler Thromb Vasc Biol 28:142-7. 2008
  5. ncbi request reprint Long-term effect of combined vitamins E and C on coronary and peripheral endothelial function
    Scott Kinlay
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 43:629-34. 2004
  6. doi request reprint Endogenous tissue plasminogen activator and risk of recurrent cardiac events after an acute coronary syndrome in the MIRACL study
    Scott Kinlay
    Cardiovascular Division, Veterans Affairs Boston Healthcare System, West Roxbury, MA, United States
    Atherosclerosis 206:551-5. 2009
  7. ncbi request reprint High-dose atorvastatin enhances the decline in inflammatory markers in patients with acute coronary syndromes in the MIRACL study
    Scott Kinlay
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
    Circulation 108:1560-6. 2003
  8. ncbi request reprint Early statin therapy in acute coronary syndromes
    Scott Kinlay
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Semin Vasc Med 3:419-24. 2003
  9. ncbi request reprint Potential vascular benefits of statins
    Scott Kinlay
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Med 118:62-7. 2005
  10. ncbi request reprint Low-density lipoprotein-dependent and -independent effects of cholesterol-lowering therapies on C-reactive protein: a meta-analysis
    Scott Kinlay
    Veteran s Affairs Boston Healthcare System, West Roxbury Campus, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02132, USA
    J Am Coll Cardiol 49:2003-9. 2007

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Inflammatory biomarkers in stable atherosclerosis
    Scott Kinlay
    Cardiovascular Division, Veterans Affairs Boston Health Care System, West Roxbury Campus, Boston, Massachusetts, USA
    Am J Cardiol 98:2P-8P. 2006
    ..Each biomarker has passionate supporters who advocate these applications, but, at this stage, no inflammatory biomarker has universal support for clinical use and their potential for fulfilling this role requires further study...
  2. ncbi request reprint Comparison of effect of intensive lipid lowering with atorvastatin to less intensive lowering with lovastatin on C-reactive protein in patients with stable angina pectoris and inducible myocardial ischemia
    Scott Kinlay
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Cardiol 89:1205-7. 2002
  3. ncbi request reprint Early statin therapy in acute coronary syndromes
    S Kinlay
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Minerva Cardioangiol 51:577-84. 2003
    ..Early statin therapy is also related to improved compliance and use of statins several years after a coronary event. Thus early statin therapy may improve both early and long-term secondary prevention efforts...
  4. ncbi request reprint Inflammation, statin therapy, and risk of stroke after an acute coronary syndrome in the MIRACL study
    Scott Kinlay
    Cardiovascular Division, Veterans Affairs Boston Healthcare System, West Roxbury, Mass, USA
    Arterioscler Thromb Vasc Biol 28:142-7. 2008
    ..We measured markers of inflammation in the MIRACL study, a randomized trial of atorvastatin versus placebo in acute coronary syndromes, to assess the relationship of inflammation to stroke...
  5. ncbi request reprint Long-term effect of combined vitamins E and C on coronary and peripheral endothelial function
    Scott Kinlay
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 43:629-34. 2004
    ..We tested whether long-term administration of antioxidant vitamins C and E improves coronary and brachial artery endothelial function in patients with coronary artery disease (CAD)...
  6. doi request reprint Endogenous tissue plasminogen activator and risk of recurrent cardiac events after an acute coronary syndrome in the MIRACL study
    Scott Kinlay
    Cardiovascular Division, Veterans Affairs Boston Healthcare System, West Roxbury, MA, United States
    Atherosclerosis 206:551-5. 2009
    ..To examine the relationship of baseline tissue plasminogen activator (t-PA) to early cardiovascular risk after an acute coronary syndrome, and the effect of intensive statin therapy...
  7. ncbi request reprint High-dose atorvastatin enhances the decline in inflammatory markers in patients with acute coronary syndromes in the MIRACL study
    Scott Kinlay
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
    Circulation 108:1560-6. 2003
    ..Although statins reduce inflammatory markers in asymptomatic adults or in patients with stable angina, the effect of statins on the markedly heightened inflammation in patients with acute coronary syndromes is unknown...
  8. ncbi request reprint Early statin therapy in acute coronary syndromes
    Scott Kinlay
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Semin Vasc Med 3:419-24. 2003
    ..Early statin therapy is also related to improved compliance and use of statins several years after a coronary event. Thus, early statin therapy may improve both early and long-term secondary prevention efforts...
  9. ncbi request reprint Potential vascular benefits of statins
    Scott Kinlay
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Med 118:62-7. 2005
    ..From a purely pragmatic viewpoint, the debate of lipid versus nonlipid effects of statins matters little to clinical practice. Their proven effect on vascular biology and risk reduction justifies their important therapeutic role...
  10. ncbi request reprint Low-density lipoprotein-dependent and -independent effects of cholesterol-lowering therapies on C-reactive protein: a meta-analysis
    Scott Kinlay
    Veteran s Affairs Boston Healthcare System, West Roxbury Campus, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02132, USA
    J Am Coll Cardiol 49:2003-9. 2007
    ..This study sought to assess the contribution of low-density lipoprotein (LDL)-dependent and LDL-independent effects of LDL-lowering therapies to changes in C-reactive protein (CRP) in healthy or stable subjects...
  11. ncbi request reprint Impact of coronary endothelial function on the progression of cardiac transplant-associated arteriosclerosis: effect of anti-oxidant vitamins C and E
    Dominik Behrendt
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Heart Lung Transplant 25:426-33. 2006
    ..Endothelial dysfunction is a key feature of TxAA and reflects oxidant stress. We hypothesized that coronary endothelial dysfunction portends greater TxAA progression and a larger therapeutic response to anti-oxidant vitamins...
  12. ncbi request reprint Plasma alpha-tocopherol and coronary endothelium-dependent vasodilator function
    S Kinlay
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 100:219-21. 1999
    ..We tested the hypothesis that the plasma concentration of alpha-tocopherol is associated with the preservation of nitric oxide-mediated endothelium-dependent vasomotion...
  13. ncbi request reprint Effect of atorvastatin on risk of recurrent cardiovascular events after an acute coronary syndrome associated with high soluble CD40 ligand in the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study
    Scott Kinlay
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circulation 110:386-91. 2004
    ..Statins inhibit CD40L signaling in vitro, but there are no prospective studies of statins and sCD40L in acute coronary syndromes...
  14. ncbi request reprint Lipid lowering improves endothelial functions
    P Libby
    Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, LMRC 307, Boston, MA 02115, USA
    Int J Cardiol 74:S3-S10. 2000
    ..Continued probing of the basic mechanisms of endothelial dysfunction and its treatment may lead to new therapies that offer clinical benefits in patients with atherosclerosis, including reductions in coronary events...
  15. ncbi request reprint Role of endothelin-1 in the active constriction of human atherosclerotic coronary arteries
    S Kinlay
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Circulation 104:1114-8. 2001
    ..We tested the hypothesis that endothelin-1 (ET-1), a potent vasoconstrictor, contributes to the heightened tone of atherosclerotic human coronary arteries...
  16. ncbi request reprint Effects of statins on inflammation in patients with acute and chronic coronary syndromes
    Scott Kinlay
    Cardiovascular Division and the Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Cardiol 91:9B-13B. 2003
    ..Although these inflammatory markers are valuable tools for studying the mechanisms of atherosclerosis, their use in clinical practice to stratify cardiovascular risk or assess treatment in individual patients requires further evaluation...
  17. ncbi request reprint Circulating autoantibodies to oxidized LDL correlate with impaired coronary endothelial function after cardiac transplantation
    James C Fang
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Arterioscler Thromb Vasc Biol 22:2044-8. 2002
    ..Because endothelial dysfunction is key in the initiation of transplant-associated arteriosclerosis, we postulated that the level of OxLDL autoantibody is associated with the degree of impairment of coronary endothelial function...
  18. ncbi request reprint Reproducibility of coronary lumen, plaque, and vessel wall reconstruction and of endothelial shear stress measurements in vivo in humans
    Ahmet U Coskun
    Department of Mechanical, Industrial and Manufacturing Engineering, Northeastern University, Boston, Massachusetts, USA
    Catheter Cardiovasc Interv 60:67-78. 2003
    ..This methodology provides a tool to examine the effect of ESS on atherogenesis, remodeling, and restenosis; the contribution of arterial remodeling and plaque growth to changes in the lumen; and the impact of new therapies...
  19. ncbi request reprint Endothelial function and coronary artery disease
    S Kinlay
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Lipidol 12:383-9. 2001
    ..Such genetic heterogeneity may nonetheless offer new insights into the variability of endothelial function...
  20. ncbi request reprint Effect of transient abrupt vessel closure during otherwise successful angioplasty for unstable angina on clinical outcome at six months. Hirulog Angioplasty Study Investigators
    R N Piana
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 33:73-8. 1999
    ..The objective of this study was to identify predictors of major adverse cardiac events after successful coronary angioplasty...
  21. ncbi request reprint Relationship of clinical presentation and calcification of culprit coronary artery stenoses
    J A Beckman
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arterioscler Thromb Vasc Biol 21:1618-22. 2001
    ..These findings have implications for the understanding of the biology of acute coronary syndromes as well as for the identification of coronary stenoses by methods that rely solely on the presence of calcium...
  22. ncbi request reprint Regions of low endothelial shear stress are the sites where coronary plaque progresses and vascular remodelling occurs in humans: an in vivo serial study
    Peter H Stone
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur Heart J 28:705-10. 2007
    ..Local haemodynamic factors are critical determinants of plaque progression, vascular remodelling, and clinical CAD manifestations...
  23. ncbi request reprint Prediction of sites of coronary atherosclerosis progression: In vivo profiling of endothelial shear stress, lumen, and outer vessel wall characteristics to predict vascular behavior
    Peter H Stone
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Cardiol 18:458-70. 2003
    ..Accurate identification of arterial segments at high risk for progression may permit preemptive intervention strategies to avoid adverse coronary events...
  24. ncbi request reprint Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells
    Uwe Schonbeck
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 106:2888-93. 2002
    ....
  25. ncbi request reprint Effect of intensive lipid lowering, with or without antioxidant vitamins, compared with moderate lipid lowering on myocardial ischemia in patients with stable coronary artery disease: the Vascular Basis for the Treatment of Myocardial Ischemia Study
    Peter H Stone
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 111:1747-55. 2005
    ..Lipid lowering with statins prevents adverse cardiac events. Both lipid-lowering and antioxidant therapies may favorably affect vasomotor function and thereby improve ischemia...
  26. ncbi request reprint Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial
    James C Fang
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet 359:1108-13. 2002
    ..We postulated that treatment with antioxidant vitamins C and E would retard the progression of transplant-associated arteriosclerosis...
  27. ncbi request reprint Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans: in vivo 6-month follow-up study
    Peter H Stone
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, Mass 02115, USA
    Circulation 108:438-44. 2003
    ..The endothelium controls local arterial responses by transduction of shear stress. Characterization of endothelial shear stress (ESS) may allow for prediction of progression of atherosclerosis and in-stent restenosis...
  28. ncbi request reprint Vascular basis for the treatment of myocardial ischemia study: trial design and baseline characteristics
    Peter H Stone
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Am Heart J 147:875-82. 2004
    ....
  29. ncbi request reprint Remodeling characteristics of minimally diseased coronary arteries are consistent along the length of the artery
    Charles L Feldman
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Cardiol 97:13-6. 2006
    ..Each artery was consistent in its remodeling characteristics from proximal to distal portions of the artery, and the remodeling pattern of each artery was independent within the same patient...
  30. ncbi request reprint Coronary flow velocity and disturbed flow predict adverse clinical outcome after coronary angioplasty
    Scott Kinlay
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Arterioscler Thromb Vasc Biol 22:1334-40. 2002
    ..We hypothesized that disturbed blood flow after coronary angioplasty is associated with adverse long-term clinical outcome...
  31. ncbi request reprint Chlamydia pneumoniae infection is frequent but not associated with coronary arteriosclerosis in cardiac transplant recipients
    J C Fang
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Cardiol 82:1479-83. 1998
    ....
  32. doi request reprint Ischemic steal syndrome following arm arteriovenous fistula for hemodialysis
    Payman Zamani
    Cardiovascular Division, Veterans Affairs Boston Healthcare System and Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, USA
    Vasc Med 14:371-6. 2009
    ..We describe the percutaneous treatments and surgical revisions that attempt to restore flow to the hand without compromising the fistula...
  33. ncbi request reprint Endothelium-derived nitric oxide regulates arterial elasticity in human arteries in vivo
    S Kinlay
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Hypertension 38:1049-53. 2001
    ..02). NO, an endothelium-derived vasodilator, augments arterial elasticity in the human brachial artery. Loss of constitutively released NO associated with cardiovascular risk factors may adversely affect arterial elasticity in humans...
  34. ncbi request reprint What has intravascular ultrasound taught us about plaque biology?
    S Kinlay
    Intravascular Ultrasound, Cardiac Catheterization Laboratory, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Curr Atheroscler Rep 3:260-6. 2001
    ....
  35. ncbi request reprint Usefulness of intravascular ultrasound in preventing stenting of hazy areas adjacent to coronary stents and its support of support spot-stenting
    J Grewal
    Cardiac Catheterization Laboratory, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Am J Cardiol 87:1246-9. 2001
    ..037). Thus, haziness at the margins of coronary stents is often caused by calcified plaque. IVUS can differentiate calcified plaques from intimal tears and thereby obviate unnecessary stenting...
  36. ncbi request reprint Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging
    Eric Larose
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 112:2324-31. 2005
    ..Surface MRI can characterize tissue content of carotid but not deeper arteries. This study evaluated the usefulness of intravascular MRI (IVMRI) to discern the composition of human iliac arteries in vivo...
  37. ncbi request reprint Endothelin-1 and vascular tone in subjects with atherogenic risk factors
    Anju Nohria
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Hypertension 42:43-8. 2003
    ..These results indicate that ET-1 contributes more to the pathophysiology of hypertension than of other risk factors in subjects without overt atherosclerosis...
  38. ncbi request reprint Rheolytic thrombectomy for in-stent thrombosis: creating a diagnostic window
    M R Adams
    Cardiovascular Division Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA
    J Interv Cardiol 14:27-31. 2001
    ..This case illustrates that rheolytic thrombectomy is feasible in subacute thrombosis, and that this approach facilitates diagnostic evaluation and treatment of underlying factors involved in stent thrombosis...
  39. ncbi request reprint Percutaneous coronary intervention and subsequent endovascular beta-radiation brachytherapy in a 14-year-old with repaired anomalous left coronary artery from pulmonary artery
    O H Kwok
    Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Invasive Cardiol 13:494-500. 2001
    ..This represents the first report of coronary stenting in the setting of ALCAPA, and the first report of catheter-based intracoronary radiation therapy in a pediatric patient...
  40. ncbi request reprint Clopidogrel inhibits shear-induced platelet function
    James L Orford
    Cardiac Catheterization Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Platelets 13:187-9. 2002
    ..This study suggests that the Xylum Clot Signature Analyzer can measure changes in platelet function in response to a modest platelet inhibitor, and may be a useful clinical tool for the monitoring of antiplatelet therapies in patients...
  41. ncbi request reprint Thoughts on the role of the healing professions and the events of September 11, 2001
    Donald Baim
    Circulation 105:1509-10. 2002
  42. doi request reprint Vascular form and function: two mechanisms for cardiovascular prevention
    Scott Kinlay
    Eur Heart J 29:1711-3. 2008
  43. ncbi request reprint Is the Framingham coronary heart disease absolute risk function applicable to Aboriginal people?
    Scott Kinlay
    Med J Aust 182:597-8; author reply 598. 2005