Research Topics
| Alexa B KimballSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
New antifungal therapies for the treatment of onychomycosisSandeep Kumar
Massachusetts General Hospital, 50 Staniford Street 246, Boston, MA 02114, USA
Expert Opin Investig Drugs 18:727-34. 2009..Currently, many new therapies for onychomycosis are under investigation which includes new formulations of azoles, improvement of existing topical treatments through addition of ungual enhancers and new drugs with better nail permeation..
Efficacy and safety of adalimumab among patients with moderate to severe psoriasis with co-morbidities: Subanalysis of results from a randomized, double-blind, placebo-controlled, phase III trialAlexa B Kimball
Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Clin Dermatol 12:51-62. 2011..Psoriasis is associated with a variety of major physical and mental co-morbidities...- OBSERVE-5 interim analysis: An observational postmarketing safety registry of etanercept for the treatment of psoriasisAlexa B Kimball
Massachusetts General Hospital, Boston, Massachusetts Electronic address
J Am Acad Dermatol 68:756-64. 2013..Etanercept is approved for the treatment of chronic moderate to severe plaque psoriasis in adults... - Adalimumab for the treatment of moderate to severe Hidradenitis suppurativa: a parallel randomized trialAlexa B Kimball
Clinical Unit for Research Trials and Outcomes in Skin, Massachusetts General Hospital, Harvard Medical School, 50 Staniford Street, No 246, Boston, MA 02114, USA
Ann Intern Med 157:846-55. 2012..Hidradenitis suppurativa (HS) is a chronic, painful skin disease characterized by abscesses, nodules, and draining fistulas in the axilla and groin of young adults... - Risks of developing psychiatric disorders in pediatric patients with psoriasisAlexa B Kimball
Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Am Acad Dermatol 67:651-7.e1-2. 2012..Symptoms of psoriasis can be embarrassing and distressing, and may increase risk of developing psychiatric disorders in young people... - Long-term efficacy of ustekinumab in patients with moderate-to-severe psoriasis: results from the PHOENIX 1 trial through up to 3 yearsA B Kimball
Department of Dermatology, Harvard Medical School, Boston, MA 02114, USA
Br J Dermatol 166:861-72. 2012..An unmet need remains for safe and effective long-term treatments of psoriasis... - The effects of adalimumab treatment and psoriasis severity on self-reported work productivity and activity impairment for patients with moderate to severe psoriasisAlexa Boer Kimball
Harvard Medical School, Boston, Massachusetts 02114, USA
J Am Acad Dermatol 66:e67-76. 2012..Psoriasis significantly impairs work productivity and daily activities... - Advances in the treatment of acneAlexa B Kimball
Department of Dermatology, Massachusetts General Hospital, 50 Staniford Street, 246, Boston, MA 02114, USA
J Reprod Med 53:742-52. 2008..This drospirenone-containing COC has been shown to be effective in reducing both inflammatory and noninflammatory acne lesions... - Future perspectives/quo vadis psoriasis treatment? Immunology, pharmacogenomics, and epidemiologyAlexa B Kimball
Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02114, USA
Clin Dermatol 26:554-61. 2008..Although a cure may not be imminent, there are some strategies under examination that may lead us closer to this goal... - Reductions in healthcare resource utilization in psoriatic arthritis patients receiving etanercept therapy: results from the educate trialAlexa Boer Kimball
Massachusetts General and Brigham and Women s Hospitals, Harvard Medical School, Boston, MA 02114, USA
J Drugs Dermatol 6:299-306. 2007..These results could translate into savings on both direct and indirect costs and improvements in health-related quality of life for patients with PsA... - Safety and efficacy of ABT-874, a fully human interleukin 12/23 monoclonal antibody, in the treatment of moderate to severe chronic plaque psoriasis: results of a randomized, placebo-controlled, phase 2 trialAlexa B Kimball
Clinical Unit for Research Trials in Skin CURTIS, Massachusetts General and Brigham and Women s Hospitals, Harvard Medical School, 50 Staniford St, No 246, Boston, MA 02114, USA
Arch Dermatol 144:200-7. 2008..To investigate the efficacy and safety of ABT-874, an interleukin 12/23 monoclonal antibody, in psoriasis... - National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screeningAlexa B Kimball
Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Am Acad Dermatol 58:1031-42. 2008.... - Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trialA B Kimball
Harvard Medical School, Boston, MA 02114, USA
Br J Dermatol 162:435-41. 2010..In small clinical studies, niacinamide-containing and NAG-containing formulations reduced the appearance of hyperpigmentation... - Economic burden of comorbidities in patients with psoriasis is substantialA B Kimball
Harvard Medical School, Boston, MA, USA
J Eur Acad Dermatol Venereol 25:157-63. 2011..Psoriasis is frequently associated with comorbidities... - Efficacy and safety of ABT-874, a monoclonal anti-interleukin 12/23 antibody, for the treatment of chronic plaque psoriasis: 36-week observation/retreatment and 60-week open-label extension phases of a randomized phase II trialAlexa B Kimball
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
J Am Acad Dermatol 64:263-74. 2011..We report here safety and efficacy data of ABT-874 during subsequent phases of this study... - The psychosocial burden of psoriasisAlexa B Kimball
Harvard Medical School, Boston, Massachusetts, USA
Am J Clin Dermatol 6:383-92. 2005..Psoriasis affects all aspects of quality of life, including physical, psychologic, social, sexual, and occupational elements... - The effect of systemic psoriasis therapies on the incidence of myocardial infarction: a cohort studyK Abuabara
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA
Br J Dermatol 165:1066-73. 2011..Anti-inflammatory treatment could theoretically reduce the risk of cardiovascular disease, and initial data suggest that treatment may reduce the incidence of cardiovascular risk factors... - Patient-reported outcomes and health-care resource utilization in patients with psoriasis treated with etanercept: continuous versus interrupted treatmentJoel M Gelfand
Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
Value Health 11:400-7. 2008..The objective of this analysis was to assess patient-reported outcomes (PROs) and health-care resource utilization (HRU) data from the EASE study... - Association between biologic therapies for chronic plaque psoriasis and cardiovascular events: a meta-analysis of randomized controlled trialsCaitriona Ryan
Department of Dermatology, Baylor Research Institute, 3900 Junius St, Ste 125, Dallas, TX 75246, USA
JAMA 306:864-71. 2011..Preliminary reports of major adverse cardiovascular events (MACEs) in psoriasis patients receiving anti-IL-12/23 agents have prompted concern... - A single-blinded, randomized pilot study to evaluate the effect of exercise-induced sweat on truncal acneRebecca W Short
Malcolm Grow Medical Center, Department of Dermatology, Andrews AFB, Maryland, USA
Pediatr Dermatol 25:126-8. 2008..No statistically significant differences in truncal acne were noted between (p = 0.84) nor within (p = 0.74 for group 1, 0.07 for group 2, and 0.09 for group 3) study groups at the end of the study period... - The burden of autoimmune disease: a comparison of prevalence ratios in patients with psoriatic arthritis and psoriasisMaryanne Makredes
Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
J Am Acad Dermatol 61:405-10. 2009..Psoriasis is an AI, manifesting as a chronic inflammatory skin condition and is clearly associated with other conditions, most obviously psoriatic arthritis (PsA)... - Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skinAnnie E Chiu
Department of Dermatology, Emory University, USA
Dermatol Surg 31:855-60; discussion 860. 2005..Longer supplementation may be required for clinically observable improvements... - Quality of life and treatment satisfaction among patients with psoriasis and psoriatic arthritis and patients with psoriasis only : results of the 2005 Spring US National Psoriasis Foundation SurveyDavid H Ciocon
Department of Dermatology, Albert Einstein College of Medicine, Bronx, New York, USA
Am J Clin Dermatol 9:111-7. 2008..Five to forty percent of patients with cutaneous psoriasis develop an inflammatory, oligoarticular spondyloarthropathy known as psoriatic arthritis... - Innovative care, medical research, and the ethics of informed consentJoanna Mimi Choi
Harvard Medical School, Boston, Massachusetts, USA
J Am Acad Dermatol 56:330-2. 2007 - Underdiagnosis and undertreatment of cardiovascular risk factors in patients with moderate to severe psoriasisAlexa B Kimball
Department of Dermatology, Harvard Medical School, Boston, Massachusetts, USA
J Am Acad Dermatol 67:76-85. 2012..Patients with psoriasis are known to have an increased number of cardiovascular (CV) risk factors and be at increased risk for CV events... - Biologicals in the treatment of psoriasisAndreas Boker
Brigham and Women s Hospital, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, 50 Staniford Street 240, Boston, MA 02114, USA
Curr Opin Investig Drugs 8:939-46. 2007..Preliminary safety and efficacy data for the newer therapeutic agents, such as CNTO-1275 and ABT-874, are also described... - Survey research in dermatology: guidelines for successAdam Asarch
Tufts University School of Medicine, Boston, MA 02111, USA
Dermatol Clin 27:121-31, vi. 2009..We provide recommendations for limiting error and producing interpretable results, followed by an outline for achieving publication. We conclude with a discussion of previous successful uses of survey studies in dermatologic literature... - Acne vulgaris in women: prevalence across the life spanAlexis C Perkins
Department of Dermatology, Harvard Medical School, Boston, Massachusetts, USA
J Womens Health (Larchmt) 21:223-30. 2012..Our objectives were to determine acne prevalence in a large, diverse group of women and to examine acne by subtype and in relation to other skin findings, measurements, and lifestyle factors... - Melanoma in Hong Kong between 1983 and 2002: a decreasing trend in incidence observed in a complex socio-political and economic settingMaryanne Makredes
Department of Dermatology, University of Massachusetts Medical Center, Worcester, MA, USA
Melanoma Res 20:427-30. 2010..In addition, the mortality of melanoma increased between 1940 and 1990 in most parts of the world, but in Hong Kong, the mortality rate in the past 20 years reveals a modest upward trend. Its significance requires further investigation... - A single-blinded, randomized, controlled clinical trial evaluating the effect of face washing on acne vulgarisJoanna Mimi Choi
Harvard Medical School, Boston, Massachusetts, USA
Pediatr Dermatol 23:421-7. 2006..We concluded that slight support exists, both in terms of efficacy and convenience, for the recommendation to wash the face twice daily with a mild cleanser. However, excessive face washing may not be as culpable as previously thought... - A randomized controlled clinical trial assessing the effect of betamethasone valerate 0.12% foam on the short-term treatment of stasis dermatitisStefan C Weiss
Department of Dermatology, Stanford University Medical Center, Stanford, CA, USA
J Drugs Dermatol 4:339-45. 2005..Furthermore, these results are the first to suggest that the application of effective topical anti-inflammatory therapy can lead to improvement in HRQL... - Psoriasis epidemiology: the interplay of genes and the environmentMonica Enamandram
Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Invest Dermatol 133:287-9. 2013..In this issue, Parisi et al. performed a systematic review to explore the global prevalence and incidence of psoriasis... - Topical chemotherapy in cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis fungoidesStuart R Lessin
Division of Dermatology, Department of Pathology, Fox Chase Cancer Center, University of Pennsylvania, Philadelphia, USA
JAMA Dermatol 149:25-32. 2013..Tumor response and adverse events were assessed every month between months 1 and 6 and every 2 months between months 7 and 12. Serum drug levels were evaluated in a subset of patients... - Accessibility to air travel correlates strongly with increasing melanoma incidenceYolanda Z Agredano
Department of Dermatology, Stanford University Medical Center, Stanford, California, USA
Melanoma Res 16:77-81. 2006.... - Increased diagnosis of thin superficial spreading melanomas: A 20-year studyJason E Frangos
Department of Dermatology, Harvard Medical School, Boston, Massachusetts, USA
J Am Acad Dermatol 67:387-94. 2012..Diagnostic practice by dermatopathologists evaluating pigmented lesions may have evolved over time... - Co-occurrence and comorbidities in patients with immune-mediated inflammatory disorders: an exploration using US healthcare claims data, 2001-2002Don Robinson
MSPH, Centocor, Inc, Malvern, PA, USA
Curr Med Res Opin 22:989-1000. 2006..A common pathogenesis may present as similar patterns of disease co-occurrence and comorbidity, which could be observed through the analysis of healthcare claims datasets... - The response of skin disease to stress: changes in the severity of acne vulgaris as affected by examination stressAnnie Chiu
Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305-5334, USA
Arch Dermatol 139:897-900. 2003..Furthermore, changes in acne severity correlate highly with increasing stress, suggesting that emotional stress from external sources may have a significant influence on acne... - Skin differences, needs, and disorders across global populationsAlexa B Kimball
Clinical Unit for Research Trials in Skin, Massachusetts General and Brigham and Women s Hospitals, Harvard Medical School, Boston, Massachusetts 02114, USA
J Investig Dermatol Symp Proc 13:2-5. 2008..This discussion will be followed by a brief overview of cultural practices and environmental factors that are known to have significant impact on skin disease and a summary of the most common conditions that are encountered worldwide... - Clobetasol propionate foam in the treatment of psoriasisDavid C Reid
Harvard Medical School, Clinical Unit for Research Trials in Skin, Massachusetts General Hospital, 275 Cambridge Street, Professional Office Building, 402, MA, USA
Expert Opin Pharmacother 6:1735-40. 2005..Because patient preference is an important determinant of medication efficacy in clinical practice, clobetasol foam is a useful new formulation in the treatment of psoriasis and other skin conditions... - Metronidazole in the treatment of rosacea: do formulation, dosing, and concentration matter?Jane Yoo
Clinical Unit for Research Trials in Skin, Harvard Medical School, Boston, MA 02114, USA
J Drugs Dermatol 5:317-9. 2006..Topical metronidazole is commonly used in the management of rosacea. No consensus on the optimal formulation, concentration, or dosing regimen exists... - Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acneElizabeth M Seidler
Clinical Unit for Research Trials in Skin, Massachusetts General Hospital, Boston, Massachusetts 02139, USA
J Am Acad Dermatol 63:52-62. 2010..Comparative efficacy of the multiple treatments containing benzoyl peroxide (BPO) and clindamycin (CL) is not established... - Who else is providing care in dermatology practices? Trends in the use of nonphysician cliniciansJack S Resneck
Department of Dermatology, and Institute for Health Policy Studies, University of California, San Francisco School of Medicine, San Francisco, California 94143 0316, USA
J Am Acad Dermatol 58:211-6. 2008..Little is known about which dermatology practices use these practitioners, how they are supervised, and the services they are providing... - Controlled nail trephination for subungual hematomaSharon A Salter
Department of Dermatology, Brigham and Women's Hospital, Boston, MA 02115, USA
Am J Emerg Med 24:875-7. 2006..This technique appears to be a quick and convenient method of evacuating subungual hematomas with minimal discomfort and minimal risk... - Cutaneous manifestations of thyroid diseaseDaven N Doshi
Department of Dermatology, Harvard Medical School, Boston, MA 02114, USA
Clin Dermatol 26:283-7. 2008..This article reviews the pathophysiology of thyroid disease, characteristic cutaneous findings of the hypothyroid and hyperthyroid states, and cutaneous conditions associated with thyroid disease... - How low should you go: novel device for nail trephinationDavid Ciocon
Clinical Unit for Research Trials in Skin, Brigham and Women's Hospital and Massachusetts General Hospital, Boston, Massachusetts 02115, USA
Dermatol Surg 32:828-33. 2006..The follow-up period was only 1 week and did not allow for evaluation of permanent nail plate deformity. CONCLUSION: Mesoscission may be a controlled and practical alternative to traditional nail trephining methods... - US dermatology residents' satisfaction with training and mentoring: survey results from the 2005 and 2006 Las Vegas Dermatology SeminarsScott R Freeman
Department of Dermatology, University of Colorado Denver, USA
Arch Dermatol 144:896-900. 2008..To evaluate residents' satisfaction with dermatology training and mentorship... - Quality of life considerations in psoriasis treatmentStefan C Weiss
Department of Dermatology, Stanford University Medical Center, Stanford, CA, USA
Dermatol Nurs 15:120, 123-7; quiz 128. 2003..Psychosocial evaluation of patients at risk allows for early interventions that will promote positive patient outcomes and compliance with the treatment pathways... - Reporting of ethical review of clinical research submitted to the Journal of the American Academy of DermatologyAlexis C Perkins
Department of Dermatology, Harvard Medical School, Boston, Massachusetts, USA
J Am Acad Dermatol 56:279-84. 2007..quot;.. - Striae and pelvic relaxation: two disorders of connective tissue with a strong associationSharon A Salter
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
J Invest Dermatol 126:1745-8. 2006....