James I Kim

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Generation of adaptive regulatory T cells by alloantigen is required for some but not all transplant tolerance protocols
    James I Kim
    Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Transplantation 91:707-13. 2011
  2. pmc TGF-β-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance
    Kang Mi Lee
    Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Eur J Immunol 44:1728-36. 2014
  3. pmc Inhibition of transplantation tolerance by immune senescence is reversed by endocrine modulation
    Gaoping Zhao
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Sci Transl Med 3:87ra52. 2011
  4. pmc Blockade of GITR-GITRL interaction maintains Treg function to prolong allograft survival
    James I Kim
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Eur J Immunol 40:1369-74. 2010
  5. pmc Islet alone versus islet after kidney transplantation: metabolic outcomes and islet graft survival
    Shaoping Deng
    Harrison Department of Surgical Research, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Transplantation 88:820-5. 2009
  6. pmc An immunosufficient murine model for the study of human islets
    Gaoping Zhao
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Sichuan Provincial Key Laboratory for Translational Medicine of Organ Transplantation, Department of Surgery, Sichuan Academy of Medical Science and Sichuan Provincial People s Hospital, Chengdu, Sichuan Province, China School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China
    Xenotransplantation 21:567-73. 2014
  7. pmc Inhibition of ICAM-1/LFA-1 interactions prevents B-cell-dependent anti-CD45RB-induced transplantation tolerance
    Xiaolun Huang
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Transplantation 85:675-80. 2008
  8. pmc B-cell depletion improves islet allograft survival with anti-CD45RB
    Kang Mi Lee
    Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Cell Transplant 23:51-8. 2014
  9. pmc Elevated levels of interferon-γ production by memory T cells do not promote transplant tolerance resistance in aged recipients
    James I Kim
    Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e82856. 2013
  10. pmc Therapeutic siRNA silencing in inflammatory monocytes in mice
    Florian Leuschner
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Biotechnol 29:1005-10. 2011

Collaborators

Detail Information

Publications15

  1. pmc Generation of adaptive regulatory T cells by alloantigen is required for some but not all transplant tolerance protocols
    James I Kim
    Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Transplantation 91:707-13. 2011
    ..We examined whether the immune response to a transplant allograft results in the peripheral generation of aTregs...
  2. pmc TGF-β-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance
    Kang Mi Lee
    Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Eur J Immunol 44:1728-36. 2014
    ..Collectively, these findings suggest that in this model of antibody-induced transplantation tolerance, Breg cells promote graft survival by promoting Treg-cell development, possibly via TGF-β production. ..
  3. pmc Inhibition of transplantation tolerance by immune senescence is reversed by endocrine modulation
    Gaoping Zhao
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Sci Transl Med 3:87ra52. 2011
    ..The aging of the immune system ("immune senescence") is a significant barrier to immune tolerance, but this barrier can be overcome by targeting sex steroid production with commonly used clinical therapeutics...
  4. pmc Blockade of GITR-GITRL interaction maintains Treg function to prolong allograft survival
    James I Kim
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Eur J Immunol 40:1369-74. 2010
    ..These results demonstrate that disruption of binding of GITR with GITR ligand may be an important strategy in prolonging allograft survival...
  5. pmc Islet alone versus islet after kidney transplantation: metabolic outcomes and islet graft survival
    Shaoping Deng
    Harrison Department of Surgical Research, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Transplantation 88:820-5. 2009
    ....
  6. pmc An immunosufficient murine model for the study of human islets
    Gaoping Zhao
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Sichuan Provincial Key Laboratory for Translational Medicine of Organ Transplantation, Department of Surgery, Sichuan Academy of Medical Science and Sichuan Provincial People s Hospital, Chengdu, Sichuan Province, China School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China
    Xenotransplantation 21:567-73. 2014
    ..This new system will facilitate study of human islets and accelerate the dissection of the critical mechanisms underlying islet health in human disease. ..
  7. pmc Inhibition of ICAM-1/LFA-1 interactions prevents B-cell-dependent anti-CD45RB-induced transplantation tolerance
    Xiaolun Huang
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Transplantation 85:675-80. 2008
    ..We have investigated the hypothesis that alteration in ICAM-1 expression is required for tolerance induction...
  8. pmc B-cell depletion improves islet allograft survival with anti-CD45RB
    Kang Mi Lee
    Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Cell Transplant 23:51-8. 2014
    ..These findings may help elucidate the varied action of B-cells in promoting tolerance versus rejection. ..
  9. pmc Elevated levels of interferon-γ production by memory T cells do not promote transplant tolerance resistance in aged recipients
    James I Kim
    Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e82856. 2013
    ..Defining these factors may be relevant to design of tolerogenic strategies for aged recipients. ..
  10. pmc Therapeutic siRNA silencing in inflammatory monocytes in mice
    Florian Leuschner
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Biotechnol 29:1005-10. 2011
    ....
  11. pmc Mechanisms of regulatory T cell counter-regulation by innate immunity
    Heidi Yeh
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Transplant Rev (Orlando) 27:61-4. 2013
    ..Since the transplantation procedure involves surgical trauma, organ ischemia, and exposure to environmental microbes, Treg counter-regulation represents a key area of intervention to improve strategies for promoting allograft tolerance...
  12. ncbi request reprint Progress toward antibody-induced transplantation tolerance
    Daniel J Moore
    Harrison Department of Surgical Research, Department of Surgery, University of Pennsylvania, USA
    Crit Rev Immunol 27:167-218. 2007
    ....
  13. ncbi request reprint Availability of suitable islet donors in the United States
    Paige M Porrett
    Department of Surgery, The University of Pennsylvania, Philadelphia, PA, USA
    Transplantation 84:280-2. 2007
    ..We characterize donor utilization for islet transplantation and estimate the number of recipients who could achieve normoglycemia through islet transplantation if the current donor pool were used...
  14. pmc Role of B cells in tolerance induction
    James I Kim
    aCenter for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts bThomas E Starzl Transplantation Institute, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA
    Curr Opin Organ Transplant 20:369-75. 2015
    ..Finally, recent evidence suggesting that plasma cells may be an essential component of Bregs raises new concerns about targeting antibody producing cells...
  15. ncbi request reprint Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development
    Helen E MacLean
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Dev Biol 262:51-63. 2003
    ..5 in the c-maf-null. MMP-13 is known to be regulated by AP-1 and may also be a target of c-Maf. Thus, cartilage is a novel system in which c-Maf acts during development, where c-Maf is required for normal chondrocyte differentiation...