Dennis Kim

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc An essential role for XBP-1 in host protection against immune activation in C. elegans
    Claire E Richardson
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 463:1092-5. 2010
  2. pmc Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans
    Robert P Shivers
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Genet 6:e1000892. 2010
  3. pmc A decline in p38 MAPK signaling underlies immunosenescence in Caenorhabditis elegans
    Matthew J Youngman
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Genet 7:e1002082. 2011
  4. pmc Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour
    Howard C Chang
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 480:525-9. 2011
  5. pmc Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity
    Claire E Richardson
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Genet 7:e1002391. 2011
  6. doi request reprint Bacteria and the aging and longevity of Caenorhabditis elegans
    Dennis H Kim
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 email
    Annu Rev Genet 47:233-46. 2013
  7. pmc Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans
    Dennis Kim
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dis Model Mech 1:205-8. 2008

Research Grants

Collaborators

  • Claire E Richardson
  • Matthew J Youngman
  • Howard C Chang
  • Robert P Shivers
  • Tristan Kooistra
  • ZoĆ« N Rogers
  • Jennifer Paek
  • Stephanie Kinkel
  • Kunihiro Matsumoto
  • Naoki Hisamoto
  • Janelle K Whitney
  • Kirthi C Reddy
  • Daniel J Pagano
  • Odile Kamanzi

Detail Information

Publications7

  1. pmc An essential role for XBP-1 in host protection against immune activation in C. elegans
    Claire E Richardson
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 463:1092-5. 2010
    ..elegans development and indicate that an ancient, conserved role for XBP-1 may be to protect the host organism from the detrimental effects of mounting an innate immune response to microbes...
  2. pmc Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans
    Robert P Shivers
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Genet 6:e1000892. 2010
    ....
  3. pmc A decline in p38 MAPK signaling underlies immunosenescence in Caenorhabditis elegans
    Matthew J Youngman
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Genet 7:e1002082. 2011
    ..elegans in terms of the age-dependent dynamics of the PMK-1 innate immune signaling pathway, and they suggest that a cycle of intestinal tissue aging, immunosenescence, and bacterial proliferation leads to death in aging C. elegans...
  4. pmc Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour
    Howard C Chang
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 480:525-9. 2011
    ..aeruginosa lawn avoidance behaviour. Our data establish a molecular basis for natural variation in a C. elegans behaviour that may undergo adaptive changes in response to microbial pathogens...
  5. pmc Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity
    Claire E Richardson
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Genet 7:e1002391. 2011
    ....
  6. doi request reprint Bacteria and the aging and longevity of Caenorhabditis elegans
    Dennis H Kim
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 email
    Annu Rev Genet 47:233-46. 2013
    ..elegans will uncover basic insights into the cellular and organismal physiology that governs aging and longevity...
  7. pmc Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans
    Dennis Kim
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dis Model Mech 1:205-8. 2008
    ..elegans continues to provide an ancient evolutionary perspective on innate immunity, which may generate insights into the conserved processes in phylogenetically diverse host organisms, including humans...

Research Grants5

  1. Genetic analysis of innate immunity in C elegans
    Dennis Kim; Fiscal Year: 2007
    ..The basic underlying hypothesis of this proposal is that the study of C. elegans immunity will reveal evolutionarily conserved mechanisms of innate defense against pathogen attack. ..
  2. Molecular Genetics of Innate Immunity in C. elegans
    Dennis H Kim; Fiscal Year: 2010
    ....
  3. Molecular Genetics of Innate Immunity in C. elegans
    Dennis Kim; Fiscal Year: 2007
    ....