Michael G Kharas

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
    Michael G Kharas
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Nat Med 16:903-8. 2010
  2. pmc Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
    Ann Mullally
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 17:584-96. 2010
  3. pmc Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice
    Michael G Kharas
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 115:1406-15. 2010
  4. pmc Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models
    Melanie G Cornejo
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 113:2746-54. 2009
  5. pmc In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling
    Peter G Miller
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 24:45-58. 2013
  6. ncbi Akt: a double-edged sword for hematopoietic stem cells
    Michael G Kharas
    Brigham and Women s Hospital, Boston, MA
    Cell Cycle 9:1223-4. 2010
  7. pmc The Lin28/let-7 axis regulates glucose metabolism
    Hao Zhu
    Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA, USA
    Cell 147:81-94. 2011
  8. pmc Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis
    Inga Hofmann
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cell Stem Cell 4:559-67. 2009

Detail Information

Publications8

  1. pmc Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
    Michael G Kharas
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Nat Med 16:903-8. 2010
    ....
  2. pmc Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
    Ann Mullally
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 17:584-96. 2010
    ..These findings provide insights into the consequences of JAK2 activation on HSC differentiation and function and have the potential to inform therapeutic approaches to JAK2V617F-positive MPN...
  3. pmc Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice
    Michael G Kharas
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 115:1406-15. 2010
    ..This study demonstrates that enhanced AKT activation is an important mechanism of transformation in AML and that HSCs are highly sensitive to excess AKT/mTOR signaling...
  4. pmc Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models
    Melanie G Cornejo
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 113:2746-54. 2009
    ..These data demonstrate that constitutive JAK3 activation disrupts T-cell homeostasis and induces lymphoproliferative diseases in mice...
  5. pmc In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling
    Peter G Miller
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 24:45-58. 2013
    ..Our results establish the significance of the Itgb3 signaling pathway as a potential therapeutic target in AML. ..
  6. ncbi Akt: a double-edged sword for hematopoietic stem cells
    Michael G Kharas
    Brigham and Women s Hospital, Boston, MA
    Cell Cycle 9:1223-4. 2010
  7. pmc The Lin28/let-7 axis regulates glucose metabolism
    Hao Zhu
    Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA, USA
    Cell 147:81-94. 2011
    ..These data establish the Lin28/let-7 pathway as a central regulator of mammalian glucose metabolism...
  8. pmc Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis
    Inga Hofmann
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cell Stem Cell 4:559-67. 2009
    ..Furthermore, the Hh pathway may not be a compelling target in certain hematopoietic malignancies...