Michael G Kharas

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
    Michael G Kharas
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Nat Med 16:903-8. 2010
  2. ncbi Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
    Ann Mullally
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 17:584-96. 2010
  3. ncbi Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice
    Michael G Kharas
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 115:1406-15. 2010
  4. ncbi Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models
    Melanie G Cornejo
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 113:2746-54. 2009
  5. ncbi Akt: a double-edged sword for hematopoietic stem cells
    Michael G Kharas
    Brigham and Women s Hospital, Boston, MA
    Cell Cycle 9:1223-4. 2010
  6. ncbi The Lin28/let-7 axis regulates glucose metabolism
    Hao Zhu
    Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA, USA
    Cell 147:81-94. 2011
  7. ncbi Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis
    Inga Hofmann
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cell Stem Cell 4:559-67. 2009

Collaborators

Detail Information

Publications7

  1. ncbi Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
    Michael G Kharas
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Nat Med 16:903-8. 2010
    ....
  2. ncbi Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
    Ann Mullally
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 17:584-96. 2010
    ..These findings provide insights into the consequences of JAK2 activation on HSC differentiation and function and have the potential to inform therapeutic approaches to JAK2V617F-positive MPN...
  3. ncbi Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice
    Michael G Kharas
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 115:1406-15. 2010
    ..This study demonstrates that enhanced AKT activation is an important mechanism of transformation in AML and that HSCs are highly sensitive to excess AKT/mTOR signaling...
  4. ncbi Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models
    Melanie G Cornejo
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 113:2746-54. 2009
    ..These data demonstrate that constitutive JAK3 activation disrupts T-cell homeostasis and induces lymphoproliferative diseases in mice...
  5. ncbi Akt: a double-edged sword for hematopoietic stem cells
    Michael G Kharas
    Brigham and Women s Hospital, Boston, MA
    Cell Cycle 9:1223-4. 2010
  6. ncbi The Lin28/let-7 axis regulates glucose metabolism
    Hao Zhu
    Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA, USA
    Cell 147:81-94. 2011
    ..These data establish the Lin28/let-7 pathway as a central regulator of mammalian glucose metabolism...
  7. ncbi Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis
    Inga Hofmann
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Cell Stem Cell 4:559-67. 2009
    ..Furthermore, the Hh pathway may not be a compelling target in certain hematopoietic malignancies...