Kimberly A Kelly

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration
    Kimberly A Kelly
    Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Leukoc Biol 81:748-56. 2007
  2. pmc Detection of early prostate cancer using a hepsin-targeted imaging agent
    Kimberly A Kelly
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Cancer Res 68:2286-91. 2008
  3. pmc Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma
    Kimberly A Kelly
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS Med 5:e85. 2008
  4. ncbi request reprint High-throughput identification of phage-derived imaging agents
    Kimberly A Kelly
    Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    Mol Imaging 5:24-30. 2006
  5. ncbi request reprint In vivo phage display selection yields atherosclerotic plaque targeted peptides for imaging
    Kimberly A Kelly
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149, 13th Street, Rm 5404, Charlestown, MA 02129, USA
    Mol Imaging Biol 8:201-7. 2006
  6. ncbi request reprint Detection of vascular adhesion molecule-1 expression using a novel multimodal nanoparticle
    Kimberly A Kelly
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Circ Res 96:327-36. 2005
  7. ncbi request reprint Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
    Circulation 114:1504-11. 2006
  8. pmc Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries
    Kimberly A Kelly
    Center for Molecular Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Rm 5420, Charlestown, MA 02129, USA
    Integr Biol (Camb) 1:311-7. 2009
  9. ncbi request reprint In vivo imaging of activated endothelium using an anti-VCAM-1 magnetooptical probe
    Andrew Tsourkas
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    Bioconjug Chem 16:576-81. 2005
  10. pmc Novel peptide sequence ("IQ-tag") with high affinity for NIR fluorochromes allows protein and cell specific labeling for in vivo imaging
    Kimberly A Kelly
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 2:e665. 2007

Detail Information

Publications19

  1. ncbi request reprint SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration
    Kimberly A Kelly
    Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Leukoc Biol 81:748-56. 2007
    ..These findings provide new insight into the mechanisms of transendothelial leukocyte migration and suggest a potential, targetable interaction for therapeutic intervention...
  2. pmc Detection of early prostate cancer using a hepsin-targeted imaging agent
    Kimberly A Kelly
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Cancer Res 68:2286-91. 2008
    ..HPN imaging may provide a new method for detection of prostate cancer...
  3. pmc Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma
    Kimberly A Kelly
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS Med 5:e85. 2008
    ..Here we sought to identify novel molecular markers and to test their potential as targeted imaging agents...
  4. ncbi request reprint High-throughput identification of phage-derived imaging agents
    Kimberly A Kelly
    Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    Mol Imaging 5:24-30. 2006
    ..The new methodology should be useful in identifying phage hits and is extendable to other library screening methods such as small-molecule and nanoparticle libraries...
  5. ncbi request reprint In vivo phage display selection yields atherosclerotic plaque targeted peptides for imaging
    Kimberly A Kelly
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149, 13th Street, Rm 5404, Charlestown, MA 02129, USA
    Mol Imaging Biol 8:201-7. 2006
    ..Atherosclerosis is a leading cause of morbidity and mortality in the Western world, yet specific imaging agents to detect and map inflammatory plaques are still lacking...
  6. ncbi request reprint Detection of vascular adhesion molecule-1 expression using a novel multimodal nanoparticle
    Kimberly A Kelly
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Circ Res 96:327-36. 2005
    ....
  7. ncbi request reprint Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
    Circulation 114:1504-11. 2006
    ....
  8. pmc Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries
    Kimberly A Kelly
    Center for Molecular Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Rm 5420, Charlestown, MA 02129, USA
    Integr Biol (Camb) 1:311-7. 2009
    ..Overall, this work presents a generalizable approach to the unbiased discovery of in vivo imaging probes, and may guide the further development of novel endothelial imaging probes...
  9. ncbi request reprint In vivo imaging of activated endothelium using an anti-VCAM-1 magnetooptical probe
    Andrew Tsourkas
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    Bioconjug Chem 16:576-81. 2005
    ..In contrast, nontargeted nanoparticles did not exhibit any specific labeling of the endothelium. These studies suggest that the developed nanoparticle would be useful for MR and optical detection of activated endothelium...
  10. pmc Novel peptide sequence ("IQ-tag") with high affinity for NIR fluorochromes allows protein and cell specific labeling for in vivo imaging
    Kimberly A Kelly
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 2:e665. 2007
    ..Probes that allow site-specific protein labeling have become critical tools for visualizing biological processes...
  11. pmc In vivo imaging of molecularly targeted phage
    Kimberly A Kelly
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neoplasia 8:1011-8. 2006
    ..The described method should find widespread application in the rapid in vivo discovery and validation of affinity ligands and, importantly, in the use of fluorochrome-labeled phage clones as in vivo imaging agents...
  12. pmc Plectin-1 as a novel biomarker for pancreatic cancer
    Dirk Bausch
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 2622, USA
    Clin Cancer Res 17:302-9. 2011
    ..Plectin-1 (Plec1) was recently identified as one such biomarker. However, its suitability as a specific biomarker for human pancreatic cancer, and its usability as an imaging target, remain to be assessed...
  13. ncbi request reprint Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials
    Farouc A Jaffer
    Harvard Medical School, Charlestown, MA 02129, USA
    Mol Imaging 5:85-92. 2006
    ..To better understand their cellular targeting and imaging capabilities in atherosclerosis, we investigated prototypical dextran-coated near-infrared fluorescent MFNPs in the apolipoprotein E-deficient (apo E-/-) mouse model...
  14. ncbi request reprint Targeted delivery of multifunctional magnetic nanoparticles
    Jason R McCarthy
    Center for Molecular Imaging Research, Harvard Medical School and Massachusetts General Hospital, 149 13th St, Rm 5406, Charlestown, MA 02129, USA
    Nanomedicine (Lond) 2:153-67. 2007
    ..Next-generation magnetic nanoparticles are expected to be truly multifunctional, incorporating therapeutic functionalities and further enhancing an already diverse repertoire of capabilities...
  15. pmc Plectin-1 is a biomarker of malignant pancreatic intraductal papillary mucinous neoplasms
    Dirk Bausch
    Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 2622, USA
    J Gastrointest Surg 13:1948-54; discussion 1954. 2009
    ..Improved detection of malignancy using novel biomarkers may therefore improve diagnostic accuracy. One such promising novel biomarker is Plectin-1 (Plec-1)...
  16. ncbi request reprint Fluorescein isothiocyanate-hapten immunoassay for determination of peptide-cell interactions
    Kimberly A Kelly
    Center for Molecular Imaging Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Anal Biochem 330:181-5. 2004
    ..In addition, the FITC-labeled peptide can be used to visualize receptors in fluorescent-activated cell sorting or fluorescent microscopy...
  17. pmc In vivo selection of phage for the optical imaging of PC-3 human prostate carcinoma in mice
    Jessica R Newton
    Department of Biochemistry, University of Missouri, Columbia, MO 65212, USA
    Neoplasia 8:772-80. 2006
    ..These results show proof of principle that disease-specific library-derived fluorescent probes can be rapidly developed for use in the early detection of cancers by optical means...
  18. pmc Isolation of a colon tumor specific binding peptide using phage display selection
    Kimberly A Kelly
    Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
    Neoplasia 5:437-44. 2003
    ..These studies suggest that RPMrel may be a promising lead candidate in the development of a useful colon tumor diagnostic and targeted drug delivery agent...
  19. pmc Near infrared fluorescence-based bacteriophage particles for ratiometric pH imaging
    Scott A Hilderbrand
    Center for Molecular Imaging Research and Center for Systems Biology, Massachusetts General Hospital Harvard Medical School, USA
    Bioconjug Chem 19:1635-9. 2008
    ..With the pH-responsive construct, measurement of intracellular pH and accurate determination of pH through optically diffuse biological tissue is demonstrated...