Manolis Kellis

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Sequencing and comparison of yeast species to identify genes and regulatory elements
    Manolis Kellis
    Whitehead MIT Center for Genome Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 423:241-54. 2003
  2. pmc Analysis of variation at transcription factor binding sites in Drosophila and humans
    Mikhail Spivakov
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK
    Genome Biol 13:R49. 2012
  3. pmc High depth, whole-genome sequencing of cholera isolates from Haiti and the Dominican Republic
    Rachel Sealfon
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
    BMC Genomics 13:468. 2012
  4. pmc Position specific variation in the rate of evolution in transcription factor binding sites
    Alan M Moses
    Graduate Group in Biophysics, University of California, Berkeley, CA 94720, USA
    BMC Evol Biol 3:19. 2003
  5. pmc The changing face of genomics
    Manolis Kellis
    The Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02138, USA
    Genome Biol 5:324. 2004
  6. ncbi request reprint Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae
    Manolis Kellis
    The Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 428:617-24. 2004
  7. pmc Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures
    Alexander Stark
    The Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02140, USA
    Nature 450:219-32. 2007
  8. pmc Locating protein-coding sequences under selection for additional, overlapping functions in 29 mammalian genomes
    Michael F Lin
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genome Res 21:1916-28. 2011
  9. pmc A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands
    Alexander Stark
    Broad Institute of Massachussetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02141, USA
    Genes Dev 22:8-13. 2008
  10. pmc Predictive regulatory models in Drosophila melanogaster by integrative inference of transcriptional networks
    Daniel Marbach
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Genome Res 22:1334-49. 2012

Detail Information

Publications57

  1. ncbi request reprint Sequencing and comparison of yeast species to identify genes and regulatory elements
    Manolis Kellis
    Whitehead MIT Center for Genome Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 423:241-54. 2003
    ..We inferred a putative function for most of these motifs, and provided insights into their combinatorial interactions. The results have implications for genome analysis of diverse organisms, including the human...
  2. pmc Analysis of variation at transcription factor binding sites in Drosophila and humans
    Mikhail Spivakov
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK
    Genome Biol 13:R49. 2012
    ....
  3. pmc High depth, whole-genome sequencing of cholera isolates from Haiti and the Dominican Republic
    Rachel Sealfon
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
    BMC Genomics 13:468. 2012
    ..cholerae isolates to a high depth of coverage (>2000x); four of the seven isolates were previously sequenced...
  4. pmc Position specific variation in the rate of evolution in transcription factor binding sites
    Alan M Moses
    Graduate Group in Biophysics, University of California, Berkeley, CA 94720, USA
    BMC Evol Biol 3:19. 2003
    ..Comparison of non-coding DNA from related species has shown considerable promise in identifying these functional non-coding sequences, even though relatively little is known about their evolution...
  5. pmc The changing face of genomics
    Manolis Kellis
    The Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02138, USA
    Genome Biol 5:324. 2004
  6. ncbi request reprint Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae
    Manolis Kellis
    The Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 428:617-24. 2004
    ..Strikingly, 95% of cases of accelerated evolution involve only one member of a gene pair, providing strong support for a specific model of evolution, and allowing us to distinguish ancestral and derived functions...
  7. pmc Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures
    Alexander Stark
    The Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02140, USA
    Nature 450:219-32. 2007
    ..We also study how discovery power scales with the divergence and number of species compared, and we provide general guidelines for comparative studies...
  8. pmc Locating protein-coding sequences under selection for additional, overlapping functions in 29 mammalian genomes
    Michael F Lin
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genome Res 21:1916-28. 2011
    ..Our results show that overlapping functional elements are common in mammalian genes, despite the vast genomic landscape...
  9. pmc A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands
    Alexander Stark
    Broad Institute of Massachussetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02141, USA
    Genes Dev 22:8-13. 2008
    ..We also report sense/antisense miRNAs in mouse and find antisense transcripts close to many miRNAs in both flies and mammals, suggesting that additional sense/antisense pairs exist...
  10. pmc Predictive regulatory models in Drosophila melanogaster by integrative inference of transcriptional networks
    Daniel Marbach
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Genome Res 22:1334-49. 2012
    ....
  11. pmc A high-resolution map of human evolutionary constraint using 29 mammals
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 478:476-82. 2011
    ..Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease...
  12. pmc Identification of functional elements and regulatory circuits by Drosophila modENCODE
    Sushmita Roy
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology MIT, Cambridge, MA 02139, USA
    Science 330:1787-97. 2010
    ..Our results provide a foundation for directed experimental and computational studies in Drosophila and related species and also a model for systematic data integration toward comprehensive genomic and functional annotation...
  13. pmc Distinguishing protein-coding and noncoding genes in the human genome
    Michele Clamp
    Broad Institute of Massachusetts Institute of Technology and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:19428-33. 2007
    ..It also provides a principled methodology for evaluating future proposed additions to the human gene catalog. Finally, the results indicate that there has been relatively little true innovation in mammalian protein-coding genes...
  14. pmc Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites
    Xiaohui Xie
    Broad Institute of MIT and Harvard, Massachusetts Institute of Technology and Harvard Medical School, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:7145-50. 2007
    ..These sites may thus partition the human genome into domains of expression...
  15. pmc Accurate gene-tree reconstruction by learning gene- and species-specific substitution rates across multiple complete genomes
    Matthew D Rasmussen
    MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts 02139, USA
    Genome Res 17:1932-42. 2007
    ....
  16. pmc Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes
    Alexander Stark
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Genome Res 17:1865-79. 2007
    ..For mir-10 in particular, both arms show abundant processing, and both show highly conserved target sites in Hox genes, suggesting a possible cooperation of the two arms, and their role as a master Hox regulator...
  17. pmc Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells
    Oren Ram
    Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Cell 147:1628-39. 2011
    ..Our work provides a multiplex method that substantially enhances the ability to monitor CR binding, presents a large resource of CR maps, and reveals common principles for combinatorial CR function...
  18. pmc Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs
    J Graham Ruby
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genome Res 17:1850-64. 2007
    ....
  19. pmc PhyloCSF: a comparative genomics method to distinguish protein coding and non-coding regions
    Michael F Lin
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street 32 D510, Cambridge, MA 02139, USA
    Bioinformatics 27:i275-82. 2011
    ....
  20. pmc RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo
    Julia Zeitlinger
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1512-6. 2007
    ..We propose that Pol II stalling facilitates rapid temporal and spatial changes in gene activity during development...
  21. pmc Reliable prediction of regulator targets using 12 Drosophila genomes
    Pouya Kheradpour
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genome Res 17:1919-31. 2007
    ..The resulting regulatory network suggests significant redundancy between pre- and post-transcriptional regulation of gene expression...
  22. pmc Evidence of abundant stop codon readthrough in Drosophila and other metazoa
    Irwin Jungreis
    MIT Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genome Res 21:2096-113. 2011
    ....
  23. pmc Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay
    Pouya Kheradpour
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genome Res 23:800-11. 2013
    ....
  24. pmc Computational analysis of noncoding RNAs
    Stefan Washietl
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
    Wiley Interdiscip Rev RNA 3:759-78. 2012
    ....
  25. pmc Wisdom of crowds for robust gene network inference
    Daniel Marbach
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Methods 9:796-804. 2012
    ..coli, of which 23 (43%) were supported. Our results establish community-based methods as a powerful and robust tool for the inference of transcriptional gene regulatory networks...
  26. pmc Unified modeling of gene duplication, loss, and coalescence using a locus tree
    Matthew D Rasmussen
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genome Res 22:755-65. 2012
    ..Going forward, we believe that this unified model can offer insights to questions in both phylogenetics and population genetics...
  27. pmc Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay
    Alexandre Melnikov
    Broad Institute, Cambridge, Massachusetts, USA
    Nat Biotechnol 30:271-7. 2012
    ..We show that QSAMs from two cellular states can be combined to design enhancer variants that optimize potentially conflicting objectives, such as maximizing induced activity while minimizing basal activity...
  28. pmc Revisiting the protein-coding gene catalog of Drosophila melanogaster using 12 fly genomes
    Michael F Lin
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
    Genome Res 17:1823-36. 2007
    ..These results affect >10% of annotated fly genes and demonstrate the power of comparative genomics to enhance our understanding of genome organization, even in a model organism as intensively studied as Drosophila melanogaster...
  29. pmc Mapping and analysis of chromatin state dynamics in nine human cell types
    Jason Ernst
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 473:43-9. 2011
    ..Our study presents a general framework for deciphering cis-regulatory connections and their roles in disease...
  30. pmc Efficient algorithms for the reconciliation problem with gene duplication, horizontal transfer and loss
    Mukul S Bansal
    Computer Science and Artificial Intelligence Laboratory, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Bioinformatics 28:i283-91. 2012
    ..Yet, even the fastest existing algorithms for DTL reconciliation are too slow for reconciling large gene families and for use in more sophisticated applications such as gene tree or species tree reconstruction...
  31. pmc TreeFix: statistically informed gene tree error correction using species trees
    Yi Chieh Wu
    Department of Electrical Engineering and Computer Science, Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Syst Biol 62:110-20. 2013
    ..The source code and a sample data set are available at http://compbio.mit.edu/treefix...
  32. ncbi request reprint Genome sequence, comparative analysis and haplotype structure of the domestic dog
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, Massachusetts 02141, USA
    Nature 438:803-19. 2005
    ..The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health...
  33. pmc The evolutionary dynamics of the Saccharomyces cerevisiae protein interaction network after duplication
    Aviva Presser
    School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 105:950-4. 2008
    ..This could suggest a structural difference between the modern and ancestral networks, preferential addition or retention of interactions between ohnologs, or selective pressure to preserve duplicates of self-interacting proteins...
  34. ncbi request reprint Methods in comparative genomics: genome correspondence, gene identification and regulatory motif discovery
    Manolis Kellis
    Whitehead Institute Center for Genome Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J Comput Biol 11:319-55. 2004
    ..Our methods are validated by the extensive experimental knowledge in yeast and will be invaluable in the study of complex genomes like that of the human...
  35. pmc Transcriptional regulatory code of a eukaryotic genome
    Christopher T Harbison
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 431:99-104. 2004
    ..We find that environment-specific use of regulatory elements predicts mechanistic models for the function of a large population of yeast's transcriptional regulators...
  36. pmc Long noncoding RNAs regulate adipogenesis
    Lei Sun
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 110:3387-92. 2013
    ..RNAi-mediated loss of function screens identified functional lncRNAs with varying impact on adipogenesis. Collectively, we have identified numerous lncRNAs that are functionally required for proper adipogenesis...
  37. ncbi request reprint Evidence of abundant purifying selection in humans for recently acquired regulatory functions
    Lucas D Ward
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology MIT, Cambridge, MA 02139, USA
    Science 337:1675-8. 2012
    ..Our results suggest continued turnover in regulatory regions, with at least an additional 4% of the human genome subject to lineage-specific constraint...
  38. pmc HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
    Lucas D Ward
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology and The Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA
    Nucleic Acids Res 40:D930-4. 2012
    ..HaploReg will be useful to researchers developing mechanistic hypotheses of the impact of non-coding variants on clinical phenotypes and normal variation. The HaploReg database is available at http://compbio.mit.edu/HaploReg...
  39. pmc Discovery and characterization of chromatin states for systematic annotation of the human genome
    Jason Ernst
    MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts, USA
    Nat Biotechnol 28:817-25. 2010
    ..This approach provides a complementary functional annotation of the human genome that reveals the genome-wide locations of diverse classes of epigenetic function...
  40. pmc Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
    Mitchell Guttman
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 458:223-7. 2009
    ..Together, these results define a unique collection of functional lincRNAs that are highly conserved and implicated in diverse biological processes...
  41. pmc RNA folding with soft constraints: reconciliation of probing data and thermodynamic secondary structure prediction
    Stefan Washietl
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA
    Nucleic Acids Res 40:4261-72. 2012
    ..We further demonstrate that the pseudo-energies correlate with biophysical effects that are known to affect RNA folding such as chemical nucleotide modifications and protein binding...
  42. pmc Sequences to systems
    Manolis Kellis
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA
    Genome Biol 11:303. 2010
    ..A report of the seventh annual meeting on Systems Biology: Global Regulation of Gene Expression, 23-27 March 2010, Cold Spring Harbor, USA...
  43. pmc Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
    Xiaohui Xie
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Nature 434:338-45. 2005
    ..The overall results provide a systematic view of gene regulation in the human, which will be refined as additional mammalian genomes become available...
  44. pmc Arboretum: reconstruction and analysis of the evolutionary history of condition-specific transcriptional modules
    Sushmita Roy
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Genome Res 23:1039-50. 2013
    ..Arboretum and its associated analyses provide a comprehensive framework to systematically study regulatory evolution of condition-specific responses...
  45. pmc Network deconvolution as a general method to distinguish direct dependencies in networks
    Soheil Feizi
    1 Computer Science and Artificial Intelligence Laboratory CSAIL, Massachusetts Institute of Technology MIT, Cambridge, Massachusetts, USA 2 Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA 3 Research Laboratory of Electronics at MIT, Cambridge, Massachusetts, USA
    Nat Biotechnol 31:726-33. 2013
    ..In addition to its theoretical impact as a foundational graph theoretic tool, our results suggest network deconvolution is widely applicable for computing direct dependencies in network science across diverse disciplines. ..
  46. pmc Interpreting noncoding genetic variation in complex traits and human disease
    Lucas D Ward
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Biotechnol 30:1095-106. 2012
    ..Ultimately, advances in regulatory and systems genomics can help unleash the value of whole-genome sequencing for personalized genomic risk assessment, diagnosis and treatment...
  47. pmc Large-scale discovery and validation of functional elements in the human genome
    Bradley E Bernstein
    Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Genome Biol 6:312. 2005
    ..A report on the genomics workshop 'Identification of Functional Elements in Mammalian Genomes', Cold Spring Harbor, New York, 11-13 November 2004...
  48. pmc The NIH Roadmap Epigenomics Mapping Consortium
    Bradley E Bernstein
    Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
    Nat Biotechnol 28:1045-8. 2010
    ....
  49. pmc Whole-genome ChIP-chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryo
    Julia Zeitlinger
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Genes Dev 21:385-90. 2007
    ..Thus, the ChIP-chip data uncover a much larger than expected regulatory network, which integrates diverse patterning processes during development...
  50. ncbi request reprint Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype
    Olivier Jaillon
    UMR 8030 Genoscope, CNRS and Université d Evry, 2 rue Gaston Cremieux, 91057 Evry Cedex, France
    Nature 431:946-57. 2004
    ....
  51. ncbi request reprint Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila
    Julius Brennecke
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA
    Cell 128:1089-103. 2007
    ..Thus, sense piRNAs, formed following cleavage of transposon mRNAs may enhance production of antisense piRNAs, complementary to active elements, by directing cleavage of transcripts from master control loci...
  52. pmc Performance and scalability of discriminative metrics for comparative gene identification in 12 Drosophila genomes
    Michael F Lin
    Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 4:e1000067. 2008
    ..Our results have implications for comparative genomics analyses in any species, including the human...
  53. pmc Phylogenetically and spatially conserved word pairs associated with gene-expression changes in yeasts
    Derek Y Chiang
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Genome Biol 4:R43. 2003
    ..We extend this concept of functional conservation to higher-order features of transcription control regions...
  54. pmc Genome analysis of the platypus reveals unique signatures of evolution
    Wesley C Warren
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 453:175-83. 2008
    ..Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation...
  55. ncbi request reprint Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
    ..These may prove to underlie differences in the ecology and behaviour of these diverse species...
  56. pmc Conservation of small RNA pathways in platypus
    Elizabeth P Murchison
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genome Res 18:995-1004. 2008
    ..Platypus and echidna testes contain a robust Piwi-interacting (piRNA) system, which appears to be participating in ongoing transposon defense...
  57. pmc An endogenous small interfering RNA pathway in Drosophila
    Benjamin Czech
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 453:798-802. 2008
    ..These observations expand the repertoire of small RNAs in Drosophila, adding a class that blurs distinctions based on known biogenesis mechanisms and functional roles...

Research Grants5

  1. Regulatory Morif Discovery in the Human Genome Using Comparative Genomics
    Manolis Kellis; Fiscal Year: 2007
    ..A global map of regulatory motifs constitutes a necessary knowledge infrastructure towards a comprehensive understanding of regulation, development, and disease. ..
  2. Regulatory Morif Discovery in the Human Genome Using Comparative Genomics
    Manolis Kellis; Fiscal Year: 2009
    ..A global map of regulatory motifs constitutes a necessary knowledge infrastructure towards a comprehensive understanding of regulation, development, and disease. ..
  3. Regulatory Morif Discovery in the Human Genome Using Comparative Genomics
    Manolis Kellis; Fiscal Year: 2010
    ..A global map of regulatory motifs constitutes a necessary knowledge infrastructure towards a comprehensive understanding of regulation, development, and disease. ..
  4. Regulatory Morif Discovery in the Human Genome Using Comparative Genomics
    Manolis Kellis; Fiscal Year: 2010
    ..A global map of regulatory motifs constitutes a necessary knowledge infrastructure towards a comprehensive understanding of regulation, development, and disease. ..