Sekar Kathiresan

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:334-41. 2009
  2. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
  3. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
  4. pmc Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study
    Qiong Yang
    The National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S12. 2007
  5. pmc Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study
    Mary E Keebler
    Massachusetts General Hospital, Boston, MA 02115, USA
    Circ Cardiovasc Genet 3:358-64. 2010
  6. pmc Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study
    Rahul C Deo
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    PLoS Genet 5:e1000342. 2009
  7. pmc Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III
    Mary E Keebler
    Massachusetts General Hospital, Boston, MA 02115, USA
    Circ Cardiovasc Genet 2:238-43. 2009
  8. pmc Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study
    Thomas M Tadros
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:1039-45. 2010
  9. pmc From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
    Kiran Musunuru
    Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 466:714-9. 2010
  10. doi request reprint Polymorphisms associated with cholesterol and risk of cardiovascular events
    Sekar Kathiresan
    Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, MA 02114, USA
    N Engl J Med 358:1240-9. 2008

Detail Information

Publications38

  1. pmc Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:334-41. 2009
    ..SNPs at nine loci were reproducibly associated with myocardial infarction, but tests of common and rare CNVs failed to identify additional associations with myocardial infarction risk...
  2. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
    ..We conducted a genome-wide association study (GWAS) in the community-based Framingham Heart Study...
  3. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
    ..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations...
  4. pmc Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study
    Qiong Yang
    The National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S12. 2007
    ..We sought to confirm known putative loci and identify novel loci that may influence either trait in genome-wide association and linkage analyses using the Affymetrix GeneChip 100K single nucleotide polymorphism (SNP) set...
  5. pmc Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study
    Mary E Keebler
    Massachusetts General Hospital, Boston, MA 02115, USA
    Circ Cardiovasc Genet 3:358-64. 2010
    ..Genome-wide association studies in cohorts of European descent have identified novel genomic regions as associated with lipids, but their relevance in African Americans remains unclear...
  6. pmc Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study
    Rahul C Deo
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    PLoS Genet 5:e1000342. 2009
    ....
  7. pmc Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III
    Mary E Keebler
    Massachusetts General Hospital, Boston, MA 02115, USA
    Circ Cardiovasc Genet 2:238-43. 2009
    ..Whether these same SNPs associate with lipids in a broader range of ethnicities is unknown...
  8. pmc Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study
    Thomas M Tadros
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:1039-45. 2010
    ..Multiple markers of inflammation and oxidative stress correlated with pericardial and intrathoracic fat volumes, extending the known association between regional adiposity and inflammation and oxidative stress...
  9. pmc From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
    Kiran Musunuru
    Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 466:714-9. 2010
    ..We also demonstrate that common noncoding DNA variants identified by GWASs can directly contribute to clinical phenotypes...
  10. doi request reprint Polymorphisms associated with cholesterol and risk of cardiovascular events
    Sekar Kathiresan
    Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, MA 02114, USA
    N Engl J Med 358:1240-9. 2008
    ..We tested the hypothesis that a combination of such SNPs contributes to the risk of cardiovascular disease...
  11. pmc Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Genet 41:348-53. 2009
    ..85-0.95, P = 2 x 10(-4), respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension...
  12. pmc Inflammation, kidney function and albuminuria in the Framingham Offspring cohort
    Ashish Upadhyay
    Division of Nephrology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
    Nephrol Dial Transplant 26:920-6. 2011
    ..Whether inflammatory biomarkers are associated with kidney function and albuminuria after accounting for traditional CVD risk factors is not completely understood...
  13. pmc Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk
    Kiran Musunuru
    Center for Human Genetic Research, Cardiology Division, Massachusetts General Hospital, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 29:1975-80. 2009
    ....
  14. doi request reprint Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes
    Jason Flannick
    1 Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology MIT, Cambridge, Massachusetts, USA 2 Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA 4
    Nat Genet 45:1380-5. 2013
    ..Accurate estimates of variant effect sizes from population-based sequencing are needed to avoid falsely predicting a substantial fraction of individuals as being at risk for MODY or other Mendelian diseases...
  15. pmc Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study
    M Kyla Shea
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Epidemiol 167:313-20. 2008
    ..The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation...
  16. pmc Common variants at 30 loci contribute to polygenic dyslipidemia
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:56-65. 2009
    ..These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia...
  17. pmc Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states
    Pablo Perez-Martinez
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 89:391-9. 2009
    ..Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR) genes has been associated with fasting plasma triacylglycerol...
  18. pmc Genome-wide association study identifies eight loci associated with blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Genet 41:666-76. 2009
    ..These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease...
  19. doi request reprint Genetics of coronary artery disease
    Kiran Musunuru
    Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02108, USA
    Annu Rev Genomics Hum Genet 11:91-108. 2010
    ..A key challenge now is to move from mapping loci to pinpointing causal genes and variants, and to develop a molecular understanding of how these genes lead to coronary disease...
  20. pmc Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
    Eli A Stahl
    Division of Rheumatology Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 44:483-9. 2012
    ..These analyses suggest that GWAS will continue to be highly productive for the discovery of additional susceptibility loci for common diseases...
  21. pmc HapMap and mapping genes for cardiovascular disease
    Kiran Musunuru
    Cardiovascular Research Center and Cardiology Division, and Center for Human Genetic Research, Massachusetts General Hospital, Boston and Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Mass
    Circ Cardiovasc Genet 1:66-71. 2008
    ..We review the following: (1) the concept of linkage disequilibrium orallelic association, (2) the HapMap project, and (3) several examples of the utility of HapMap data in genetic mapping for cardiovascular disease phenotypes...
  22. pmc Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    Sekar Kathiresan
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:189-97. 2008
    ..Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care...
  23. doi request reprint Common variants associated with plasma triglycerides and risk for coronary artery disease
    Ron Do
    1 Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA 4 Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 45:1345-52. 2013
    ..These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD. ..
  24. pmc Exome sequencing and complex disease: practical aspects of rare variant association studies
    Ron Do
    Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
    Hum Mol Genet 21:R1-9. 2012
    ..Here, we provide practical guidance in the design and analysis of complex trait association studies focused on rare, coding variants...
  25. pmc Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts
    Alexander G Bick
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 91:513-9. 2012
    ..3) in the FHS cohort, suggesting that cardiovascular risk assessment in the general population can benefit from rare variant analysis...
  26. doi request reprint Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitus
    Masumi Ai
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Chim Acta 406:71-4. 2009
    ....
  27. pmc Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia
    Kiran Musunuru
    Cardiovascular Research Center, Massachusetts General Hospital, and Department of Medicine, Boston University School of Public Health, Boston, MA 02114, USA
    N Engl J Med 363:2220-7. 2010
    ..Funded by the National Human Genome Research Institute and others.)...
  28. pmc Testing for an unusual distribution of rare variants
    Benjamin M Neale
    The Center for Human Genetic Research, Massachusetts General Hospital, Boston, United States of America
    PLoS Genet 7:e1001322. 2011
    ..Through simulations and analysis of case/control data, we demonstrate good power relative to existing methods that assess the burden of rare variants in individuals...
  29. ncbi request reprint PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Obesity (Silver Spring) 14:753-8. 2006
    ..Elevated PAI-1 levels may be associated with an increased risk for diabetes as a marker for underlying endothelial dysfunction rather than by a direct effect of genetically mediated elevated levels...
  30. ncbi request reprint Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study
    Karla M Pou
    Division of Endocrinology, Metabolism, and Diabetes, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 116:1234-41. 2007
    ..Excess adiposity is associated with greater systemic inflammation. Whether visceral adiposity is more proinflammatory than subcutaneous abdominal adiposity is unclear...
  31. doi request reprint Genetics of lipid disorders
    James Pirruccello
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Cardiol 25:238-42. 2010
    ..In this review, we will highlight recent advances in identifying genes and gene regions responsible for the variation in serum lipid levels. We will also consider the next directions for research based on these advances...
  32. pmc Meta-analysis identifies six new susceptibility loci for atrial fibrillation
    Patrick T Ellinor
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Nat Genet 44:670-5. 2012
    ..The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules...
  33. pmc Genetics of human cardiovascular disease
    Sekar Kathiresan
    Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 148:1242-57. 2012
    ....
  34. doi request reprint Defining the spectrum of alleles that contribute to blood lipid concentrations in humans
    Sekar Kathiresan
    Cardiovascular Disease Prevention Center, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Lipidol 19:122-7. 2008
    ..This review summarizes recent genome-wide association studies for lipid phenotypes, and evaluates the next steps needed to obtain a full picture of genotype-phenotype correlation and apply these findings to inform clinical practice...
  35. pmc Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorder
    Michael E Talkowski
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Hum Genet 89:551-63. 2011
    ....
  36. doi request reprint Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
    Martin Dichgans
    From the Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians Universitat, Munich, Germany M D, R Malik Munich Cluster for Systems Neurology SyNergy, Munich, Germany M D Institut für Medizinische Biometrie und Statistik I R K, and Institut für integrative und experimentelle Genomik J E, Universitat zu Lubeck, Lubeck, Germany Universitätsklinikum Schleswig Holstein, Campus Lubeck, Germany I R K Department of Neurology and Center for Human Genetic Research J R, and Cardiology Division C J O D, Massachusetts General Hospital, Boston Harvard Medical School, Boston, MA J R Program in Medical and Population Genetics J R, and Program in Medical and Population Genetics S K, Broad Institute of Harvard and MIT, Cambridge, MA Clinical Trial Service Unit and Epidemiological Studies Unit R C, J C H, Wellcome Trust Centre for Human Genetics H W, M Farrall, Department of Cardiovascular Medicine M Farrall, and Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience P M R, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom deCODE Genetics, Reykjavik, Iceland S G, G T, U T
    Stroke 45:24-36. 2014
    ..Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases...
  37. ncbi request reprint New opportunities for identification and reduction of coronary risk: treatment of vulnerable patients, arteries, and plaques
    James E Muller
    Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 47:C2-6. 2006
    ..If vulnerable plaques and patients can be successfully identified and treated, there will be immense clinical benefits, accompanied by cost savings...
  38. pmc Aging syndrome genes and premature coronary artery disease
    Adrian F Low
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 6:38. 2005
    ..We evaluated whether common variants at the LMNA or KLOTHO genes are associated with rigorously defined premature CAD...